{"id":"https://openalex.org/W2114813480","doi":"https://doi.org/10.1093/bioinformatics/bts438","title":"iBBiG: iterative binary bi-clustering of gene sets","display_name":"iBBiG: iterative binary bi-clustering of gene sets","publication_year":2012,"publication_date":"2012-07-12","ids":{"openalex":"https://openalex.org/W2114813480","doi":"https://doi.org/10.1093/bioinformatics/bts438","mag":"2114813480","pmid":"https://pubmed.ncbi.nlm.nih.gov/22789589"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bts438","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts438","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/19/2484/48876276/bioinformatics_28_19_2484.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/28/19/2484/48876276/bioinformatics_28_19_2484.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002327693","display_name":"Daniel Gusenleitner","orcid":"https://orcid.org/0000-0002-7428-0880"},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Gusenleitner","raw_affiliation_strings":["1 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA, 2Department of Statistics, University of Oxford, Oxford, UK, 3Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA and 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA, 2Department of Statistics, University of Oxford, Oxford, UK, 3Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA and 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062895512","display_name":"Eleanor Howe","orcid":"https://orcid.org/0000-0003-3085-9281"},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eleanor A. Howe","raw_affiliation_strings":["1 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA, 2Department of Statistics, University of Oxford, Oxford, UK, 3Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA and 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA, 2Department of Statistics, University of Oxford, Oxford, UK, 3Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA and 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025003663","display_name":"Stefan Bentink","orcid":null},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Bentink","raw_affiliation_strings":["1 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA, 2Department of Statistics, University of Oxford, Oxford, UK, 3Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA and 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA, 2Department of Statistics, University of Oxford, Oxford, UK, 3Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA and 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084245470","display_name":"John Quackenbush","orcid":"https://orcid.org/0000-0002-2702-5879"},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Quackenbush","raw_affiliation_strings":["1 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA, 2Department of Statistics, University of Oxford, Oxford, UK, 3Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA and 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA, 2Department of Statistics, University of Oxford, Oxford, UK, 3Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA and 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082180580","display_name":"Aed\u00edn C. Culhane","orcid":"https://orcid.org/0000-0002-1395-9734"},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aed\u00edn C. Culhane","raw_affiliation_strings":["1 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA, 2Department of Statistics, University of Oxford, Oxford, UK, 3Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA and 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA, 2Department of Statistics, University of Oxford, Oxford, UK, 3Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA and 4Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210117453"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":1.4779,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.81646046,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"28","issue":"19","first_page":"2484","last_page":"2492"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.8743000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.8743000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.08500000089406967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.7424123883247375},{"id":"https://openalex.org/keywords/bioconductor","display_name":"Bioconductor","score":0.6893566846847534},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5279250144958496},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4912201762199402},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.4866672158241272},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.47756510972976685},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.4539952874183655},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.42306411266326904},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.40926507115364075},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.347939670085907},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.2081102430820465},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1999693512916565},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.16802769899368286}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.7424123883247375},{"id":"https://openalex.org/C2779694297","wikidata":"https://www.wikidata.org/wiki/Q2888953","display_name":"Bioconductor","level":3,"score":0.6893566846847534},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5279250144958496},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4912201762199402},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.4866672158241272},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.47756510972976685},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4539952874183655},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.42306411266326904},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40926507115364075},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.347939670085907},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2081102430820465},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1999693512916565},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.16802769899368286},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/bts438","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts438","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/19/2484/48876276/bioinformatics_28_19_2484.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22789589","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22789589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:dash.harvard.edu:1/10582097","is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:10582097","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2460803","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3463116","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bts438","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts438","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/19/2484/48876276/bioinformatics_28_19_2484.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6000000238418579}],"awards":[{"id":"https://openalex.org/G3623826592","display_name":null,"funder_award_id":"1U19CA148065","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2114813480.pdf","grobid_xml":"https://content.openalex.org/works/W2114813480.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W42742550","https://openalex.org/W1485231155","https://openalex.org/W1487100330","https://openalex.org/W1493217831","https://openalex.org/W1574719414","https://openalex.org/W1971465952","https://openalex.org/W1995875735","https://openalex.org/W2003409252","https://openalex.org/W2005895632","https://openalex.org/W2021880490","https://openalex.org/W2023416945","https://openalex.org/W2051616601","https://openalex.org/W2064635892","https://openalex.org/W2064787891","https://openalex.org/W2065247458","https://openalex.org/W2082026429","https://openalex.org/W2105769812","https://openalex.org/W2105877777","https://openalex.org/W2105883975","https://openalex.org/W2108671185","https://openalex.org/W2110065044","https://openalex.org/W2113510994","https://openalex.org/W2117446594","https://openalex.org/W2120449613","https://openalex.org/W2123106337","https://openalex.org/W2126017970","https://openalex.org/W2127053639","https://openalex.org/W2128985829","https://openalex.org/W2130158951","https://openalex.org/W2130410032","https://openalex.org/W2133971386","https://openalex.org/W2134736660","https://openalex.org/W2142795379","https://openalex.org/W2146060062","https://openalex.org/W2148564836","https://openalex.org/W2150301509","https://openalex.org/W2150930396","https://openalex.org/W2151190838","https://openalex.org/W2161579136","https://openalex.org/W2162419299","https://openalex.org/W2164291399","https://openalex.org/W2168546553","https://openalex.org/W2169622100","https://openalex.org/W2240470164","https://openalex.org/W2978725006","https://openalex.org/W2993383518","https://openalex.org/W4240680163","https://openalex.org/W6629329278","https://openalex.org/W6667016274","https://openalex.org/W6676994931","https://openalex.org/W6681065176","https://openalex.org/W6682289014"],"related_works":["https://openalex.org/W2135678793","https://openalex.org/W2011682793","https://openalex.org/W2109288169","https://openalex.org/W2157684052","https://openalex.org/W4223449272","https://openalex.org/W2978247079","https://openalex.org/W2166887457","https://openalex.org/W2148708580","https://openalex.org/W2113543740","https://openalex.org/W2594414941"],"abstract_inverted_index":{"MOTIVATION:":[0],"Meta-analysis":[1,29],"of":[2,74,90,99,109,112,127,132,148,157,164],"genomics":[3,114],"data":[4,19,38,115],"seeks":[5],"to":[6,87,136,162],"identify":[7,88],"genes":[8],"associated":[9,96],"with":[10,55,97],"a":[11,81],"biological":[12],"phenotype":[13],"across":[14,101],"multiple":[15,102],"datasets;":[16],"however,":[17],"merging":[18],"from":[20],"different":[21],"platforms":[22],"by":[23,71],"their":[24],"features":[25],"(genes)":[26],"is":[27,40,44,51,105,152],"challenging.":[28],"using":[30],"functionally":[31],"or":[32,130],"biologically":[33,41],"characterized":[34],"gene":[35,63,68,75,91,172],"sets":[36,92],"simplifies":[37],"integration":[39],"intuitive":[42],"and":[43,79,151],"seen":[45],"as":[46],"having":[47],"great":[48],"potential,":[49],"but":[50],"an":[52],"emerging":[53],"field":[54],"few":[56],"established":[57],"statistical":[58],"methods.":[59],"RESULTS:":[60],"We":[61,159],"transform":[62],"expression":[64],"profiles":[65,70],"into":[66],"binary":[67],"set":[69,76],"discretizing":[72],"results":[73],"enrichment":[77],"analyses":[78],"apply":[80,160],"new":[82],"iterative":[83],"bi-clustering":[84],"algorithm":[85],"(iBBiG)":[86],"groups":[89,98],"that":[93,116,175],"are":[94],"coordinately":[95],"phenotypes":[100],"studies.":[103],"iBBiG":[104,169,188],"optimized":[106],"for":[107],"meta-analysis":[108,163],"large":[110],"numbers":[111],"diverse":[113,149],"may":[117],"have":[118],"unmatched":[119],"samples.":[120],"It":[121],"does":[122],"not":[123],"require":[124],"prior":[125],"knowledge":[126],"the":[128,155,185],"number":[129],"size":[131],"clusters.":[133],"When":[134],"applied":[135],"simulated":[137],"data,":[138],"it":[139,161],"outperforms":[140],"commonly":[141],"used":[142],"clustering":[143],"methods,":[144],"discovers":[145],"overlapping":[146],"clusters":[147],"sizes":[150],"robust":[153],"in":[154,184],"presence":[156],"noise.":[158],"breast":[165],"cancer":[166],"studies,":[167],"where":[168],"extracted":[170],"novel":[171],"set-phenotype":[173],"association":[174],"predicted":[176],"tumor":[177,180],"metastases":[178],"within":[179],"subtypes.":[181],"AVAILABILITY:":[182],"Implemented":[183],"Bioconductor":[186],"package":[187],"CONTACT:":[189],"aedin@jimmy.harvard.edu.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":1}],"updated_date":"2026-06-28T08:01:55.173337","created_date":"2025-10-10T00:00:00"}