{"id":"https://openalex.org/W2137875903","doi":"https://doi.org/10.1093/bioinformatics/bts423","title":"Algorithms and complexity of enumerating minimal precursor sets in genome-wide metabolic networks","display_name":"Algorithms and complexity of enumerating minimal precursor sets in genome-wide metabolic networks","publication_year":2012,"publication_date":"2012-07-10","ids":{"openalex":"https://openalex.org/W2137875903","doi":"https://doi.org/10.1093/bioinformatics/bts423","mag":"2137875903","pmid":"https://pubmed.ncbi.nlm.nih.gov/22782547"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bts423","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts423","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3451903","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106184492","display_name":"Vicente Acu\u00f1a","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210110888","display_name":"Toulouse Biotechnology Institute, Bio & Chemical Engineering","ror":"https://ror.org/01yypjb30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210088668","https://openalex.org/I4210095849","https://openalex.org/I4210110888"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210104684","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL","FR"],"is_corresponding":false,"raw_author_name":"Vicente Acu\u00f1a","raw_affiliation_strings":["1 Universit\u00e9 de Lyon, F-69000 Lyon, Universit\u00e9 Lyon 1, CNRS, UMR5558, Laboratoire de Biom\u00e9trie et Biologie Evolutive, F-69622 Villeurbanne, France, 2Mathomics, Center for Genome Regulation (Fondap 15090007) and Center for Mathematical Modeling (UMI 2807 CNRS), University of Chile, Santiago, Chile, 3INRIA Rh\u00f4ne-Alpes, 38330 Montbonnot Saint-Martin, France, 4Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s (LISBP), UMR CNRS 5504, INRA 792, Toulouse, 31000, France, 5Dip. di Informatica e Sistemistica, University of Rome La Sapienza, 00184, Rome, Italy, and 6Department of Economics and Business Administration, VU University, 1087 HV Amsterdam and Centrum voor Wiskunde en Informatica (CWI), 1098 XG Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Universit\u00e9 de Lyon, F-69000 Lyon, Universit\u00e9 Lyon 1, CNRS, UMR5558, Laboratoire de Biom\u00e9trie et Biologie Evolutive, F-69622 Villeurbanne, France, 2Mathomics, Center for Genome Regulation (Fondap 15090007) and Center for Mathematical Modeling (UMI 2807 CNRS), University of Chile, Santiago, Chile, 3INRIA Rh\u00f4ne-Alpes, 38330 Montbonnot Saint-Martin, France, 4Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s (LISBP), UMR CNRS 5504, INRA 792, Toulouse, 31000, France, 5Dip. di Informatica e Sistemistica, University of Rome La Sapienza, 00184, Rome, Italy, and 6Department of Economics and Business Administration, VU University, 1087 HV Amsterdam and Centrum voor Wiskunde en Informatica (CWI), 1098 XG Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I4210110888","https://openalex.org/I69737025","https://openalex.org/I4210135640","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033274444","display_name":"Paulo Vieira Milreu","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210110888","display_name":"Toulouse Biotechnology Institute, Bio & Chemical Engineering","ror":"https://ror.org/01yypjb30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210088668","https://openalex.org/I4210095849","https://openalex.org/I4210110888"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210104684","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL","FR"],"is_corresponding":false,"raw_author_name":"Paulo Vieira Milreu","raw_affiliation_strings":["1 Universit\u00e9 de Lyon, F-69000 Lyon, Universit\u00e9 Lyon 1, CNRS, UMR5558, Laboratoire de Biom\u00e9trie et Biologie Evolutive, F-69622 Villeurbanne, France, 2Mathomics, Center for Genome Regulation (Fondap 15090007) and Center for Mathematical Modeling (UMI 2807 CNRS), University of Chile, Santiago, Chile, 3INRIA Rh\u00f4ne-Alpes, 38330 Montbonnot Saint-Martin, France, 4Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s (LISBP), UMR CNRS 5504, INRA 792, Toulouse, 31000, France, 5Dip. di Informatica e Sistemistica, University of Rome La Sapienza, 00184, Rome, Italy, and 6Department of Economics and Business Administration, VU University, 1087 HV Amsterdam and Centrum voor Wiskunde en Informatica (CWI), 1098 XG Amsterdam, The Netherlands","An algorithmic view on genomes, cells, and environments"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Universit\u00e9 de Lyon, F-69000 Lyon, Universit\u00e9 Lyon 1, CNRS, UMR5558, Laboratoire de Biom\u00e9trie et Biologie Evolutive, F-69622 Villeurbanne, France, 2Mathomics, Center for Genome Regulation (Fondap 15090007) and Center for Mathematical Modeling (UMI 2807 CNRS), University of Chile, Santiago, Chile, 3INRIA Rh\u00f4ne-Alpes, 38330 Montbonnot Saint-Martin, France, 4Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s (LISBP), UMR CNRS 5504, INRA 792, Toulouse, 31000, France, 5Dip. di Informatica e Sistemistica, University of Rome La Sapienza, 00184, Rome, Italy, and 6Department of Economics and Business Administration, VU University, 1087 HV Amsterdam and Centrum voor Wiskunde en Informatica (CWI), 1098 XG Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I4210110888","https://openalex.org/I69737025","https://openalex.org/I4210135640","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"An algorithmic view on genomes, cells, and environments","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001473736","display_name":"Ludovic Cottret","orcid":"https://orcid.org/0000-0001-7418-7750"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210095625","display_name":"Institut National de la Recherche Agronomique du Niger","ror":"https://ror.org/00rnmt205","country_code":"NE","type":"government","lineage":["https://openalex.org/I4210095625"]},{"id":"https://openalex.org/I4210110888","display_name":"Toulouse Biotechnology Institute, Bio & Chemical Engineering","ror":"https://ror.org/01yypjb30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210088668","https://openalex.org/I4210095849","https://openalex.org/I4210110888"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210104684","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL","FR","NE"],"is_corresponding":false,"raw_author_name":"Ludovic Cottret","raw_affiliation_strings":["1 Universit\u00e9 de Lyon, F-69000 Lyon, Universit\u00e9 Lyon 1, CNRS, UMR5558, Laboratoire de Biom\u00e9trie et Biologie Evolutive, F-69622 Villeurbanne, France, 2Mathomics, Center for Genome Regulation (Fondap 15090007) and Center for Mathematical Modeling (UMI 2807 CNRS), University of Chile, Santiago, Chile, 3INRIA Rh\u00f4ne-Alpes, 38330 Montbonnot Saint-Martin, France, 4Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s (LISBP), UMR CNRS 5504, INRA 792, Toulouse, 31000, France, 5Dip. di Informatica e Sistemistica, University of Rome La Sapienza, 00184, Rome, Italy, and 6Department of Economics and Business Administration, VU University, 1087 HV Amsterdam and Centrum voor Wiskunde en Informatica (CWI), 1098 XG Amsterdam, The Netherlands","Institut national de la recherche agronomique"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Universit\u00e9 de Lyon, F-69000 Lyon, Universit\u00e9 Lyon 1, CNRS, UMR5558, Laboratoire de Biom\u00e9trie et Biologie Evolutive, F-69622 Villeurbanne, France, 2Mathomics, Center for Genome Regulation (Fondap 15090007) and Center for Mathematical Modeling (UMI 2807 CNRS), University of Chile, Santiago, Chile, 3INRIA Rh\u00f4ne-Alpes, 38330 Montbonnot Saint-Martin, France, 4Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s (LISBP), UMR CNRS 5504, INRA 792, Toulouse, 31000, France, 5Dip. di Informatica e Sistemistica, University of Rome La Sapienza, 00184, Rome, Italy, and 6Department of Economics and Business Administration, VU University, 1087 HV Amsterdam and Centrum voor Wiskunde en Informatica (CWI), 1098 XG Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I4210110888","https://openalex.org/I69737025","https://openalex.org/I4210135640","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Institut national de la recherche agronomique","institution_ids":["https://openalex.org/I4210095625"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064823807","display_name":"Alberto Marchetti-Spaccamela","orcid":"https://orcid.org/0000-0002-7991-4416"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210110888","display_name":"Toulouse Biotechnology Institute, Bio & Chemical Engineering","ror":"https://ror.org/01yypjb30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210088668","https://openalex.org/I4210095849","https://openalex.org/I4210110888"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210104684","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL","FR"],"is_corresponding":false,"raw_author_name":"Alberto Marchetti-Spaccamela","raw_affiliation_strings":["1 Universit\u00e9 de Lyon, F-69000 Lyon, Universit\u00e9 Lyon 1, CNRS, UMR5558, Laboratoire de Biom\u00e9trie et Biologie Evolutive, F-69622 Villeurbanne, France, 2Mathomics, Center for Genome Regulation (Fondap 15090007) and Center for Mathematical Modeling (UMI 2807 CNRS), University of Chile, Santiago, Chile, 3INRIA Rh\u00f4ne-Alpes, 38330 Montbonnot Saint-Martin, France, 4Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s (LISBP), UMR CNRS 5504, INRA 792, Toulouse, 31000, France, 5Dip. di Informatica e Sistemistica, University of Rome La Sapienza, 00184, Rome, Italy, and 6Department of Economics and Business Administration, VU University, 1087 HV Amsterdam and Centrum voor Wiskunde en Informatica (CWI), 1098 XG Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Universit\u00e9 de Lyon, F-69000 Lyon, Universit\u00e9 Lyon 1, CNRS, UMR5558, Laboratoire de Biom\u00e9trie et Biologie Evolutive, F-69622 Villeurbanne, France, 2Mathomics, Center for Genome Regulation (Fondap 15090007) and Center for Mathematical Modeling (UMI 2807 CNRS), University of Chile, Santiago, Chile, 3INRIA Rh\u00f4ne-Alpes, 38330 Montbonnot Saint-Martin, France, 4Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s (LISBP), UMR CNRS 5504, INRA 792, Toulouse, 31000, France, 5Dip. di Informatica e Sistemistica, University of Rome La Sapienza, 00184, Rome, Italy, and 6Department of Economics and Business Administration, VU University, 1087 HV Amsterdam and Centrum voor Wiskunde en Informatica (CWI), 1098 XG Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I4210110888","https://openalex.org/I69737025","https://openalex.org/I4210135640","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044184077","display_name":"Leen Stougie","orcid":"https://orcid.org/0000-0001-6938-8902"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210110888","display_name":"Toulouse Biotechnology Institute, Bio & Chemical Engineering","ror":"https://ror.org/01yypjb30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210088668","https://openalex.org/I4210095849","https://openalex.org/I4210110888"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210104684","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL","FR"],"is_corresponding":false,"raw_author_name":"Leen Stougie","raw_affiliation_strings":["1 Universit\u00e9 de Lyon, F-69000 Lyon, Universit\u00e9 Lyon 1, CNRS, UMR5558, Laboratoire de Biom\u00e9trie et Biologie Evolutive, F-69622 Villeurbanne, France, 2Mathomics, Center for Genome Regulation (Fondap 15090007) and Center for Mathematical Modeling (UMI 2807 CNRS), University of Chile, Santiago, Chile, 3INRIA Rh\u00f4ne-Alpes, 38330 Montbonnot Saint-Martin, France, 4Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s (LISBP), UMR CNRS 5504, INRA 792, Toulouse, 31000, France, 5Dip. di Informatica e Sistemistica, University of Rome La Sapienza, 00184, Rome, Italy, and 6Department of Economics and Business Administration, VU University, 1087 HV Amsterdam and Centrum voor Wiskunde en Informatica (CWI), 1098 XG Amsterdam, The Netherlands","Department of mathematics and computing science [Eindhoven]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Universit\u00e9 de Lyon, F-69000 Lyon, Universit\u00e9 Lyon 1, CNRS, UMR5558, Laboratoire de Biom\u00e9trie et Biologie Evolutive, F-69622 Villeurbanne, France, 2Mathomics, Center for Genome Regulation (Fondap 15090007) and Center for Mathematical Modeling (UMI 2807 CNRS), University of Chile, Santiago, Chile, 3INRIA Rh\u00f4ne-Alpes, 38330 Montbonnot Saint-Martin, France, 4Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s (LISBP), UMR CNRS 5504, INRA 792, Toulouse, 31000, France, 5Dip. di Informatica e Sistemistica, University of Rome La Sapienza, 00184, Rome, Italy, and 6Department of Economics and Business Administration, VU University, 1087 HV Amsterdam and Centrum voor Wiskunde en Informatica (CWI), 1098 XG Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I4210110888","https://openalex.org/I69737025","https://openalex.org/I4210135640","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Department of mathematics and computing science [Eindhoven]","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110531794","display_name":"Marie-France Sagot","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210110888","display_name":"Toulouse Biotechnology Institute, Bio & Chemical Engineering","ror":"https://ror.org/01yypjb30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210088668","https://openalex.org/I4210095849","https://openalex.org/I4210110888"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210104684","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL","FR"],"is_corresponding":false,"raw_author_name":"Marie-France Sagot","raw_affiliation_strings":["1 Universit\u00e9 de Lyon, F-69000 Lyon, Universit\u00e9 Lyon 1, CNRS, UMR5558, Laboratoire de Biom\u00e9trie et Biologie Evolutive, F-69622 Villeurbanne, France, 2Mathomics, Center for Genome Regulation (Fondap 15090007) and Center for Mathematical Modeling (UMI 2807 CNRS), University of Chile, Santiago, Chile, 3INRIA Rh\u00f4ne-Alpes, 38330 Montbonnot Saint-Martin, France, 4Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s (LISBP), UMR CNRS 5504, INRA 792, Toulouse, 31000, France, 5Dip. di Informatica e Sistemistica, University of Rome La Sapienza, 00184, Rome, Italy, and 6Department of Economics and Business Administration, VU University, 1087 HV Amsterdam and Centrum voor Wiskunde en Informatica (CWI), 1098 XG Amsterdam, The Netherlands","An algorithmic view on genomes, cells, and environments"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Universit\u00e9 de Lyon, F-69000 Lyon, Universit\u00e9 Lyon 1, CNRS, UMR5558, Laboratoire de Biom\u00e9trie et Biologie Evolutive, F-69622 Villeurbanne, France, 2Mathomics, Center for Genome Regulation (Fondap 15090007) and Center for Mathematical Modeling (UMI 2807 CNRS), University of Chile, Santiago, Chile, 3INRIA Rh\u00f4ne-Alpes, 38330 Montbonnot Saint-Martin, France, 4Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s (LISBP), UMR CNRS 5504, INRA 792, Toulouse, 31000, France, 5Dip. di Informatica e Sistemistica, University of Rome La Sapienza, 00184, Rome, Italy, and 6Department of Economics and Business Administration, VU University, 1087 HV Amsterdam and Centrum voor Wiskunde en Informatica (CWI), 1098 XG Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I4210110888","https://openalex.org/I69737025","https://openalex.org/I4210135640","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"An algorithmic view on genomes, cells, and environments","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.6719,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.69430914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"28","issue":"19","first_page":"2474","last_page":"2483"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enumeration","display_name":"Enumeration","score":0.8558828830718994},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.6771434545516968},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6195389032363892},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6085736155509949},{"id":"https://openalex.org/keywords/mathematical-proof","display_name":"Mathematical proof","score":0.515926718711853},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.5091089606285095},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.4160536527633667},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.3426312804222107},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.23518815636634827},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18324381113052368},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.11019104719161987}],"concepts":[{"id":"https://openalex.org/C156340839","wikidata":"https://www.wikidata.org/wiki/Q2704791","display_name":"Enumeration","level":2,"score":0.8558828830718994},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.6771434545516968},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6195389032363892},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6085736155509949},{"id":"https://openalex.org/C108710211","wikidata":"https://www.wikidata.org/wiki/Q11538","display_name":"Mathematical proof","level":2,"score":0.515926718711853},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.5091089606285095},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.4160536527633667},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.3426312804222107},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23518815636634827},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18324381113052368},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.11019104719161987},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":12,"locations":[{"id":"doi:10.1093/bioinformatics/bts423","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts423","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22782547","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22782547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:cwi:oai:cwi.nl:20782","is_oa":false,"landing_page_url":"https://ir.cwi.nl/pub/20782","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, 28, 2474 - 2483","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-00751715v1","is_oa":false,"landing_page_url":"https://inria.hal.science/hal-00751715","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, 2012, 28 (19), pp.2474-2483. ⟨10.1093/bioinformatics/bts423⟩","raw_type":"Journal articles"},{"id":"pmh:oai:americanae.aecid.es:3451903","is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3451903","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:3453370","is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3453370","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dare.ubvu.vu.nl:1871/41078","is_oa":false,"landing_page_url":"http://hdl.handle.net/1871/41078","pdf_url":null,"source":{"id":"https://openalex.org/S4306400546","display_name":"Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I865915315","host_organization_name":"Vrije Universiteit Amsterdam","host_organization_lineage":["https://openalex.org/I865915315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"28","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:iris.uniroma1.it:11573/485002","is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/485002","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:localhost:10533/238462","is_oa":true,"landing_page_url":"http://hdl.handle.net/10533/238462","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:localhost:10533/241434","is_oa":true,"landing_page_url":"http://hdl.handle.net/10533/241434","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositorio.uchile.cl:2250/165814","is_oa":true,"landing_page_url":"https://repositorio.uchile.cl/handle/2250/165814","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Art\u00edculo de revista"},{"id":"pmh:vu:oai:research.vu.nl:publications/35ec651c-8031-4733-96bb-d220cfa133c4","is_oa":false,"landing_page_url":"https://research.vu.nl/en/publications/35ec651c-8031-4733-96bb-d220cfa133c4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, 28(19), 2474 - 2483. Oxford University Press","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:3451903","is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3451903","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1996070840","https://openalex.org/W2003159902","https://openalex.org/W2007940874","https://openalex.org/W2011039300","https://openalex.org/W2017065632","https://openalex.org/W2063389953","https://openalex.org/W2082195055","https://openalex.org/W2085993965","https://openalex.org/W2124096367","https://openalex.org/W2126175129","https://openalex.org/W2137560895","https://openalex.org/W2163410580","https://openalex.org/W2169823165","https://openalex.org/W2486715098","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W108845024","https://openalex.org/W4300125793","https://openalex.org/W2578985712","https://openalex.org/W2406961474","https://openalex.org/W2143566611","https://openalex.org/W2013740965","https://openalex.org/W588267724","https://openalex.org/W4297743441","https://openalex.org/W2952598754","https://openalex.org/W2026779193"],"abstract_inverted_index":{"MOTIVATION:":[0],"In":[1],"the":[2,13,15,37,47,55,83,112,137,140],"context":[3],"of":[4,22,29,40,59,70,79,85,99,104,109,114,119,123,139],"studying":[5],"whole":[6],"metabolic":[7],"networks":[8,151],"and":[9,26,90,122,160],"their":[10],"interaction":[11],"with":[12,152],"environment,":[14],"following":[16],"question":[17],"arises:":[18],"given":[19],"a":[20,27,76,97,116],"set":[21,28,98,103,118],"target":[23],"metabolites":[24,33,48],"T":[25],"possible":[30],"external":[31],"source":[32],",":[34],"which":[35],"are":[36,42,53,166],"minimal":[38,56,126,147],"subsets":[39,52],"that":[41],"able":[43],"to":[44,94,144,154],"produce":[45],"all":[46,69,125,146],"in":[49,150,163],"T.":[50,60,105,129],"Such":[51],"called":[54,88],"precursor":[57,80,102,117,127,148],"sets":[58,81,87,128,149],"The":[61],"problem":[62],"is":[63,101],"then":[64],"whether":[65],"we":[66],"can":[67],"enumerate":[68,145],"them":[71],"efficiently.":[72],"RESULTS:":[73],"We":[74,106,130],"propose":[75,131],"new":[77,133],"characterization":[78],"as":[82],"inputs":[84],"reaction":[86],"factories":[89],"an":[91],"efficient":[92],"algorithm":[93],"decide":[95],"if":[96],"sources":[100],"show":[107],"proofs":[108],"hardness":[110,138],"for":[111,169],"problems":[113],"finding":[115],"minimum":[120],"size":[121],"enumerating":[124],"two":[132],"algorithms":[134],"which,":[135],"despite":[136],"enumeration":[141],"problem,":[142],"allow":[143],"up":[153],"1000":[155],"reactions.":[156],"AVAILABILITY:":[157],"Source":[158],"code":[159],"datasets":[161],"used":[162],"our":[164],"benchmarks":[165],"freely":[167],"available":[168],"download":[170],"at":[171],"http://sites.google.com/site/pitufosoftware/download.":[172],"CONTACT:":[173],"vicente77@gmail.com,":[174],"pvmilreu@gmail.com":[175],"or":[176],"marie-france.sagot@inria.fr.":[177]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}