{"id":"https://openalex.org/W2145114251","doi":"https://doi.org/10.1093/bioinformatics/bts406","title":"Nonlinear dimension reduction with Wright\u2013Fisher kernel for genotype aggregation and association mapping","display_name":"Nonlinear dimension reduction with Wright\u2013Fisher kernel for genotype aggregation and association mapping","publication_year":2012,"publication_date":"2012-09-03","ids":{"openalex":"https://openalex.org/W2145114251","doi":"https://doi.org/10.1093/bioinformatics/bts406","mag":"2145114251","pmid":"https://pubmed.ncbi.nlm.nih.gov/22962455"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bts406","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts406","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/18/i375/692074/bts406.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/28/18/i375/692074/bts406.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077847368","display_name":"Hongjie Zhu","orcid":"https://orcid.org/0000-0002-2604-033X"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hongjie Zhu","raw_affiliation_strings":["1 Department of Psychiatry and Behavior Science, Duke University, Durham, NC 27710"],"affiliations":[{"raw_affiliation_string":"1 Department of Psychiatry and Behavior Science, Duke University, Durham, NC 27710","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017399049","display_name":"Lexin Li","orcid":"https://orcid.org/0000-0003-2962-1989"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lexin Li","raw_affiliation_strings":["2 Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA","#N# 2Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA"],"affiliations":[{"raw_affiliation_string":"2 Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"#N# 2Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060348530","display_name":"Hua Zhou","orcid":"https://orcid.org/0000-0003-1320-7118"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Zhou","raw_affiliation_strings":["2 Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA","#N# 2Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA"],"affiliations":[{"raw_affiliation_string":"2 Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"#N# 2Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA","institution_ids":["https://openalex.org/I137902535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5077847368"],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.8106,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.76576247,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"28","issue":"18","first_page":"i375","last_page":"i381"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.5698449015617371},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5624511241912842},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.542763888835907},{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.4806055724620819},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.47173774242401123},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.4658445119857788},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.38997548818588257},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.37529945373535156},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.345599889755249},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.3177288770675659},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24808207154273987},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2408609390258789},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2180728018283844},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.17241472005844116}],"concepts":[{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.5698449015617371},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5624511241912842},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.542763888835907},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.4806055724620819},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.47173774242401123},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4658445119857788},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.38997548818588257},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.37529945373535156},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.345599889755249},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.3177288770675659},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24808207154273987},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2408609390258789},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2180728018283844},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17241472005844116},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/bts406","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts406","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/18/i375/692074/bts406.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22962455","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22962455","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:2440705","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3436833","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bts406","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts406","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/18/i375/692074/bts406.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145114251.pdf","grobid_xml":"https://content.openalex.org/works/W2145114251.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1560724230","https://openalex.org/W1965442268","https://openalex.org/W1986333823","https://openalex.org/W2006309149","https://openalex.org/W2006700629","https://openalex.org/W2015849111","https://openalex.org/W2020040634","https://openalex.org/W2024997496","https://openalex.org/W2029387902","https://openalex.org/W2033763868","https://openalex.org/W2041953582","https://openalex.org/W2046247026","https://openalex.org/W2058148991","https://openalex.org/W2067100182","https://openalex.org/W2070984858","https://openalex.org/W2082107832","https://openalex.org/W2082573972","https://openalex.org/W2097247977","https://openalex.org/W2106052906","https://openalex.org/W2120388891","https://openalex.org/W2129380137","https://openalex.org/W2157752701","https://openalex.org/W2161935988","https://openalex.org/W2163490846","https://openalex.org/W2164143816","https://openalex.org/W2171777347","https://openalex.org/W2226060101","https://openalex.org/W2321866396","https://openalex.org/W2581071829","https://openalex.org/W2885727518","https://openalex.org/W3106115947","https://openalex.org/W3195149063","https://openalex.org/W4292058084"],"related_works":["https://openalex.org/W2056355462","https://openalex.org/W2790470715","https://openalex.org/W2283861756","https://openalex.org/W3030331178","https://openalex.org/W2358154819","https://openalex.org/W2382289467","https://openalex.org/W3177672991","https://openalex.org/W2368205087","https://openalex.org/W2164332050","https://openalex.org/W1511048503"],"abstract_inverted_index":{"hongjie.zhu@duke.edu.":[0]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}