{"id":"https://openalex.org/W2121387437","doi":"https://doi.org/10.1093/bioinformatics/bts290","title":"Identifying mechanistic similarities in drug responses","display_name":"Identifying mechanistic similarities in drug responses","publication_year":2012,"publication_date":"2012-05-15","ids":{"openalex":"https://openalex.org/W2121387437","doi":"https://doi.org/10.1093/bioinformatics/bts290","mag":"2121387437","pmid":"https://pubmed.ncbi.nlm.nih.gov/22592382"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bts290","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts290","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100750956","display_name":"Chen Zhao","orcid":"https://orcid.org/0000-0003-1373-7637"},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chen Zhao","raw_affiliation_strings":["1 Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, 77843, 2Computational Biology Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, 3Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77845 and 4Department of Bioinformatics and Computational Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, 77843, 2Computational Biology Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, 3Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77845 and 4Department of Bioinformatics and Computational Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1284308235","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100559028","display_name":"Jianping Hua","orcid":null},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]},{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianping Hua","raw_affiliation_strings":["1 Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, 77843, 2Computational Biology Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, 3Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77845 and 4Department of Bioinformatics and Computational Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, 77843, 2Computational Biology Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, 3Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77845 and 4Department of Bioinformatics and Computational Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1284308235","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007353982","display_name":"Michael Bittner","orcid":"https://orcid.org/0000-0003-4293-930X"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]},{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Bittner","raw_affiliation_strings":["1 Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, 77843, 2Computational Biology Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, 3Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77845 and 4Department of Bioinformatics and Computational Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, 77843, 2Computational Biology Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, 3Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77845 and 4Department of Bioinformatics and Computational Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1284308235","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079620688","display_name":"Ivan Ivanov","orcid":"https://orcid.org/0000-0002-5323-8325"},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]},{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan Ivanov","raw_affiliation_strings":["1 Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, 77843, 2Computational Biology Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, 3Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77845 and 4Department of Bioinformatics and Computational Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, 77843, 2Computational Biology Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, 3Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77845 and 4Department of Bioinformatics and Computational Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1284308235","https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001725746","display_name":"and Edward R. Dougherty","orcid":null},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"and Edward R. Dougherty","raw_affiliation_strings":["1 Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, 77843, 2Computational Biology Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, 3Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77845 and 4Department of Bioinformatics and Computational Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, 77843, 2Computational Biology Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, 3Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, 77845 and 4Department of Bioinformatics and Computational Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1284308235","https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100750956"],"corresponding_institution_ids":["https://openalex.org/I1284308235","https://openalex.org/I91045830"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.2627,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.58057248,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"28","issue":"14","first_page":"1902","last_page":"1910"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.6230577826499939},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5683493614196777},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.567957878112793},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5433976054191589},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4545057415962219},{"id":"https://openalex.org/keywords/drug-response","display_name":"Drug response","score":0.4385080933570862},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.35061636567115784},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.25003620982170105},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.14523416757583618}],"concepts":[{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.6230577826499939},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5683493614196777},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.567957878112793},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5433976054191589},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4545057415962219},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.4385080933570862},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35061636567115784},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.25003620982170105},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.14523416757583618},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/bts290","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts290","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22592382","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22592382","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:repository.kaust.edu.sa:10754/598553","is_oa":false,"landing_page_url":"http://hdl.handle.net/10754/598553","pdf_url":null,"source":{"id":"https://openalex.org/S4306401596","display_name":"King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I71920554","host_organization_name":"King Abdullah University of Science and Technology","host_organization_lineage":["https://openalex.org/I71920554"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7300000190734863,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W23639486","https://openalex.org/W96058438","https://openalex.org/W1505353324","https://openalex.org/W1974208182","https://openalex.org/W2017081079","https://openalex.org/W2018843280","https://openalex.org/W2032579724","https://openalex.org/W2061016350","https://openalex.org/W2087072206","https://openalex.org/W2094791588","https://openalex.org/W2107436374","https://openalex.org/W2108400301","https://openalex.org/W2109227373","https://openalex.org/W2121604817","https://openalex.org/W2124167150","https://openalex.org/W2128160875","https://openalex.org/W2132585078","https://openalex.org/W2137632714","https://openalex.org/W2162744351","https://openalex.org/W6600994067","https://openalex.org/W6676546013"],"related_works":["https://openalex.org/W2382997850","https://openalex.org/W2390968135","https://openalex.org/W2382213751","https://openalex.org/W2351750670","https://openalex.org/W1597848696","https://openalex.org/W2354715126","https://openalex.org/W2388563748","https://openalex.org/W2375179084","https://openalex.org/W2366646518","https://openalex.org/W2321880618"],"abstract_inverted_index":{"The":[0],"R":[1],"code":[2],"for":[3],"the":[4],"RLCSS":[5],"algorithm":[6],"is":[7],"available":[8],"at":[9],"http://gsp.tamu.edu/Publications/supplementary/zhao12a.":[10]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
