{"id":"https://openalex.org/W2103691573","doi":"https://doi.org/10.1093/bioinformatics/bts221","title":"Improved synapse detection for mGRASP-assisted brain connectivity mapping","display_name":"Improved synapse detection for mGRASP-assisted brain connectivity mapping","publication_year":2012,"publication_date":"2012-06-09","ids":{"openalex":"https://openalex.org/W2103691573","doi":"https://doi.org/10.1093/bioinformatics/bts221","mag":"2103691573","pmid":"https://pubmed.ncbi.nlm.nih.gov/22689768"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bts221","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts221","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/12/i25/48883969/bioinformatics_28_12_i25.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/28/12/i25/48883969/bioinformatics_28_12_i25.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021915783","display_name":"Linqing Feng","orcid":"https://orcid.org/0000-0002-5084-811X"},"institutions":[{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Linqing Feng","raw_affiliation_strings":["1 Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul, Korea and 2Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul, Korea and 2Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I58716616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085083214","display_name":"Ting Zhao","orcid":"https://orcid.org/0000-0002-8053-412X"},"institutions":[{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ting Zhao","raw_affiliation_strings":["1 Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul, Korea and 2Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul, Korea and 2Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I58716616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100411972","display_name":"Jinhyun Kim","orcid":"https://orcid.org/0000-0001-5429-505X"},"institutions":[{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jinhyun Kim","raw_affiliation_strings":["1 Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul, Korea and 2Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Center for Functional Connectomics, Korea Institute of Science and Technology, Seoul, Korea and 2Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I58716616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I58716616"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.9849,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.71478909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"28","issue":"12","first_page":"i25","last_page":"i31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5013999938964844,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5013999938964844,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.14880000054836273,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.10679999738931656,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thresholding","display_name":"Thresholding","score":0.7295703887939453},{"id":"https://openalex.org/keywords/blob-detection","display_name":"Blob detection","score":0.6737916469573975},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6283893585205078},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.579582154750824},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5589357614517212},{"id":"https://openalex.org/keywords/gaussian","display_name":"Gaussian","score":0.5137687921524048},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.48873066902160645},{"id":"https://openalex.org/keywords/synapse","display_name":"Synapse","score":0.47983548045158386},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.43708962202072144},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.42078298330307007},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.39258742332458496},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2596663236618042},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.16213476657867432},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.15266883373260498},{"id":"https://openalex.org/keywords/image-processing","display_name":"Image processing","score":0.12211135029792786},{"id":"https://openalex.org/keywords/edge-detection","display_name":"Edge detection","score":0.09493222832679749}],"concepts":[{"id":"https://openalex.org/C191178318","wikidata":"https://www.wikidata.org/wiki/Q2256906","display_name":"Thresholding","level":3,"score":0.7295703887939453},{"id":"https://openalex.org/C29168087","wikidata":"https://www.wikidata.org/wiki/Q1026711","display_name":"Blob detection","level":5,"score":0.6737916469573975},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6283893585205078},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.579582154750824},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5589357614517212},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.5137687921524048},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.48873066902160645},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.47983548045158386},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.43708962202072144},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.42078298330307007},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.39258742332458496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2596663236618042},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.16213476657867432},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15266883373260498},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.12211135029792786},{"id":"https://openalex.org/C193536780","wikidata":"https://www.wikidata.org/wiki/Q1513153","display_name":"Edge detection","level":4,"score":0.09493222832679749},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/bts221","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts221","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/12/i25/48883969/bioinformatics_28_12_i25.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22689768","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22689768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:2378073","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3371853","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bts221","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts221","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/12/i25/48883969/bioinformatics_28_12_i25.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6899999976158142,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G6180407326","display_name":null,"funder_award_id":"WCI 2009-003","funder_id":"https://openalex.org/F4320322349","funder_display_name":"Ministry of Education, Science and Technology"},{"id":"https://openalex.org/G6920461260","display_name":null,"funder_award_id":"2012AA011602","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G895352897","display_name":null,"funder_award_id":"WCI 2009-003","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G8969121587","display_name":null,"funder_award_id":"61031002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320322349","display_name":"Ministry of Education, Science and Technology","ror":"https://ror.org/01p262204"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2103691573.pdf","grobid_xml":"https://content.openalex.org/works/W2103691573.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1506806321","https://openalex.org/W1663973292","https://openalex.org/W1978849431","https://openalex.org/W1992621211","https://openalex.org/W1995355073","https://openalex.org/W2018227909","https://openalex.org/W2028754780","https://openalex.org/W2046385387","https://openalex.org/W2075058103","https://openalex.org/W2076927398","https://openalex.org/W2099021265","https://openalex.org/W2105916176","https://openalex.org/W2109365020","https://openalex.org/W2123756340","https://openalex.org/W2125493690","https://openalex.org/W2127510560","https://openalex.org/W2136043254","https://openalex.org/W2142332605","https://openalex.org/W2143623375","https://openalex.org/W2151538727","https://openalex.org/W2157408013","https://openalex.org/W2157840858","https://openalex.org/W2167823677","https://openalex.org/W2168237413","https://openalex.org/W2172085063","https://openalex.org/W3141769294","https://openalex.org/W6669523142"],"related_works":["https://openalex.org/W2953058328","https://openalex.org/W1542224353","https://openalex.org/W1661087619","https://openalex.org/W2750730210","https://openalex.org/W2116854923","https://openalex.org/W2236974868","https://openalex.org/W4312766348","https://openalex.org/W2730764323","https://openalex.org/W4233939244","https://openalex.org/W4377294438"],"abstract_inverted_index":{"MOTIVATION:":[0],"A":[1],"new":[2],"technique,":[3],"mammalian":[4,16],"green":[5],"fluorescence":[6,43],"protein":[7],"(GFP)":[8],"reconstitution":[9],"across":[10],"synaptic":[11,17],"partners":[12],"(mGRASP),":[13],"enables":[14,70],"mapping":[15],"connectivity":[18],"with":[19,45],"light":[20],"microscopy.":[21],"To":[22],"characterize":[23],"the":[24,112],"locations":[25],"and":[26,79,98,119],"distribution":[27],"of":[28,76,86],"synapses":[29],"in":[30],"complex":[31],"neuronal":[32],"networks":[33],"visualized":[34],"by":[35,91,96,101],"mGRASP,":[36],"it":[37],"is":[38,154],"essential":[39],"to":[40,141],"detect":[41],"mGRASP":[42],"signals":[44],"high":[46],"accuracy.":[47],"RESULTS:":[48],"We":[49,137],"developed":[50],"a":[51,65,102,126],"fully":[52],"automatic":[53],"method":[54,69,84,114,124,147],"for":[55,129,148],"detecting":[56],"mGRASP-labeled":[57],"synapse":[58],"puncta.":[59],"By":[60],"modeling":[61,100],"each":[62,130],"punctum":[63,99],"as":[64],"Gaussian":[66,105],"distribution,":[67],"our":[68],"accurate":[71],"detection":[72,90,116],"even":[73],"when":[74],"puncta":[75],"varying":[77],"size":[78],"shape":[80],"partially":[81],"overlap.":[82],"The":[83,123,152],"consists":[85],"three":[87],"stages:":[88],"blob":[89,94],"global":[92],"thresholding;":[93],"separation":[95],"watershed;":[97],"variational":[103],"Bayesian":[104],"mixture":[106],"models.":[107],"Extensive":[108],"testing":[109],"shows":[110],"that":[111],"three-stage":[113],"improved":[115],"accuracy":[117],"markedly,":[118],"especially":[120],"reduces":[121],"under-segmentation.":[122],"provides":[125],"goodness-of-fit":[127],"score":[128],"detected":[131],"punctum,":[132],"allowing":[133],"efficient":[134,145],"error":[135],"detection.":[136],"applied":[138],"this":[139],"advantage":[140],"also":[142],"develop":[143],"an":[144],"interactive":[146],"correcting":[149],"errors.":[150],"AVAILABILITY:":[151],"software":[153],"available":[155],"on":[156],"http://jinny.kist.re.kr.":[157]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}