{"id":"https://openalex.org/W2151665378","doi":"https://doi.org/10.1093/bioinformatics/bts216","title":"Novel domain combinations in proteins encoded by chimeric transcripts","display_name":"Novel domain combinations in proteins encoded by chimeric transcripts","publication_year":2012,"publication_date":"2012-06-09","ids":{"openalex":"https://openalex.org/W2151665378","doi":"https://doi.org/10.1093/bioinformatics/bts216","mag":"2151665378","pmid":"https://pubmed.ncbi.nlm.nih.gov/22689780"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bts216","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts216","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/12/i67/48883462/bioinformatics_28_12_i67.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/28/12/i67/48883462/bioinformatics_28_12_i67.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024312461","display_name":"Milana Frenkel\u2010Morgenstern","orcid":"https://orcid.org/0000-0002-0329-4599"},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Milana Frenkel-Morgenstern","raw_affiliation_strings":["Structural Biology and BioComputing Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Structural Biology and BioComputing Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015217651","display_name":"Alfonso Valencia","orcid":"https://orcid.org/0000-0002-8937-6789"},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Alfonso Valencia","raw_affiliation_strings":["Structural Biology and BioComputing Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Structural Biology and BioComputing Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain","institution_ids":["https://openalex.org/I4210089594"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015217651"],"corresponding_institution_ids":["https://openalex.org/I4210089594"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.8387,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.85380446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"28","issue":"12","first_page":"i67","last_page":"i74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6328081488609314},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.6298274993896484},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"Fusion protein","score":0.5552866458892822},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5385092496871948},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.36461496353149414},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3413088917732239},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.29057398438453674},{"id":"https://openalex.org/keywords/recombinant-dna","display_name":"Recombinant DNA","score":0.2138085663318634},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11724025011062622}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6328081488609314},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.6298274993896484},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.5552866458892822},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5385092496871948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36461496353149414},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3413088917732239},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29057398438453674},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.2138085663318634},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11724025011062622},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020040","descriptor_name":"Trans-Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020040","descriptor_name":"Trans-Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020040","descriptor_name":"Trans-Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050506","descriptor_name":"Mutant Chimeric Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D050506","descriptor_name":"Mutant Chimeric Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D050506","descriptor_name":"Mutant Chimeric Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/bts216","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts216","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/12/i67/48883462/bioinformatics_28_12_i67.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22689780","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22689780","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:2378068","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3371848","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/bts216","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts216","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/12/i67/48883462/bioinformatics_28_12_i67.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2151665378.pdf","grobid_xml":"https://content.openalex.org/works/W2151665378.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W12786353","https://openalex.org/W1510814877","https://openalex.org/W1571243084","https://openalex.org/W1876993892","https://openalex.org/W1969418855","https://openalex.org/W1972017488","https://openalex.org/W1974514875","https://openalex.org/W1974828111","https://openalex.org/W1980765762","https://openalex.org/W1981069958","https://openalex.org/W1986727480","https://openalex.org/W1990305460","https://openalex.org/W1991103421","https://openalex.org/W1992020987","https://openalex.org/W1998319328","https://openalex.org/W1998809018","https://openalex.org/W1999295945","https://openalex.org/W2006349218","https://openalex.org/W2014739284","https://openalex.org/W2018501703","https://openalex.org/W2027963144","https://openalex.org/W2029863584","https://openalex.org/W2032015331","https://openalex.org/W2035017134","https://openalex.org/W2040068950","https://openalex.org/W2042171851","https://openalex.org/W2044741494","https://openalex.org/W2052021933","https://openalex.org/W2061424654","https://openalex.org/W2062774104","https://openalex.org/W2064469303","https://openalex.org/W2066140926","https://openalex.org/W2067638175","https://openalex.org/W2072975842","https://openalex.org/W2073070999","https://openalex.org/W2073347761","https://openalex.org/W2076035318","https://openalex.org/W2089047063","https://openalex.org/W2091260442","https://openalex.org/W2091419711","https://openalex.org/W2092158132","https://openalex.org/W2092670169","https://openalex.org/W2100433487","https://openalex.org/W2101275009","https://openalex.org/W2102225814","https://openalex.org/W2119195082","https://openalex.org/W2121547736","https://openalex.org/W2123121534","https://openalex.org/W2132062710","https://openalex.org/W2132256310","https://openalex.org/W2136145671","https://openalex.org/W2138442186","https://openalex.org/W2141244898","https://openalex.org/W2141885858","https://openalex.org/W2142386866","https://openalex.org/W2142881964","https://openalex.org/W2146527422","https://openalex.org/W2149699485","https://openalex.org/W2153009269","https://openalex.org/W2158714788","https://openalex.org/W2160475182","https://openalex.org/W2162625936","https://openalex.org/W2166564409","https://openalex.org/W2169674658","https://openalex.org/W2169810552","https://openalex.org/W2171925181","https://openalex.org/W2951885409","https://openalex.org/W4210323379","https://openalex.org/W4210400672","https://openalex.org/W4210450218","https://openalex.org/W4293196852","https://openalex.org/W6630633172","https://openalex.org/W6684866392","https://openalex.org/W6842402754"],"related_works":["https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W1971568933","https://openalex.org/W2013243191","https://openalex.org/W2117258802"],"abstract_inverted_index":{"our":[0],"scripts":[1],"are":[2],"available":[3],"upon":[4],"request.":[5]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}