{"id":"https://openalex.org/W2106965782","doi":"https://doi.org/10.1093/bioinformatics/bts152","title":"Predicting giant transmembrane \u03b2-barrel architecture","display_name":"Predicting giant transmembrane \u03b2-barrel architecture","publication_year":2012,"publication_date":"2012-03-30","ids":{"openalex":"https://openalex.org/W2106965782","doi":"https://doi.org/10.1093/bioinformatics/bts152","mag":"2106965782","pmid":"https://pubmed.ncbi.nlm.nih.gov/22467914"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/bts152","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts152","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017458061","display_name":"Cyril F. Reboul","orcid":"https://orcid.org/0000-0002-6258-2697"},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Cyril F. Reboul","raw_affiliation_strings":["1 Department of Biochemistry and Molecular Biology, 2ARC Centre of Excellence in Structural and Functional Microbial Genomics and 3Department of Microbiology, Monash University, Clayton, VIC 3800, Australia"],"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry and Molecular Biology, 2ARC Centre of Excellence in Structural and Functional Microbial Genomics and 3Department of Microbiology, Monash University, Clayton, VIC 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073553657","display_name":"Khalid Mahmood","orcid":"https://orcid.org/0000-0003-0980-3646"},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Khalid Mahmood","raw_affiliation_strings":["1 Department of Biochemistry and Molecular Biology, 2ARC Centre of Excellence in Structural and Functional Microbial Genomics and 3Department of Microbiology, Monash University, Clayton, VIC 3800, Australia"],"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry and Molecular Biology, 2ARC Centre of Excellence in Structural and Functional Microbial Genomics and 3Department of Microbiology, Monash University, Clayton, VIC 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050620343","display_name":"James C. Whisstock","orcid":"https://orcid.org/0000-0003-4200-5611"},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"James C. Whisstock","raw_affiliation_strings":["1 Department of Biochemistry and Molecular Biology, 2ARC Centre of Excellence in Structural and Functional Microbial Genomics and 3Department of Microbiology, Monash University, Clayton, VIC 3800, Australia"],"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry and Molecular Biology, 2ARC Centre of Excellence in Structural and Functional Microbial Genomics and 3Department of Microbiology, Monash University, Clayton, VIC 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008315680","display_name":"Michelle A. Dunstone","orcid":"https://orcid.org/0000-0002-6026-648X"},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michelle A. Dunstone","raw_affiliation_strings":["1 Department of Biochemistry and Molecular Biology, 2ARC Centre of Excellence in Structural and Functional Microbial Genomics and 3Department of Microbiology, Monash University, Clayton, VIC 3800, Australia"],"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry and Molecular Biology, 2ARC Centre of Excellence in Structural and Functional Microbial Genomics and 3Department of Microbiology, Monash University, Clayton, VIC 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5017458061"],"corresponding_institution_ids":["https://openalex.org/I56590836"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.576,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.82642436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"28","issue":"10","first_page":"1299","last_page":"1302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/barrel","display_name":"Barrel (horology)","score":0.9001648426055908},{"id":"https://openalex.org/keywords/antiparallel","display_name":"Antiparallel (mathematics)","score":0.838189423084259},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.46447837352752686},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.344970166683197},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3304026126861572},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.3290674090385437},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2141110599040985},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14445066452026367},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.1327480971813202}],"concepts":[{"id":"https://openalex.org/C172227984","wikidata":"https://www.wikidata.org/wiki/Q1400397","display_name":"Barrel (horology)","level":2,"score":0.9001648426055908},{"id":"https://openalex.org/C142089489","wikidata":"https://www.wikidata.org/wiki/Q1053976","display_name":"Antiparallel (mathematics)","level":3,"score":0.838189423084259},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.46447837352752686},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.344970166683197},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3304026126861572},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3290674090385437},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2141110599040985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14445066452026367},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.1327480971813202},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C115260700","wikidata":"https://www.wikidata.org/wiki/Q11408","display_name":"Magnetic field","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013301","descriptor_name":"Streptolysins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013301","descriptor_name":"Streptolysins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013301","descriptor_name":"Streptolysins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D052899","descriptor_name":"Pore Forming Cytotoxic Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D052899","descriptor_name":"Pore Forming Cytotoxic Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D052899","descriptor_name":"Pore Forming Cytotoxic Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/bts152","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/bts152","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22467914","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22467914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332162","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1607931568","https://openalex.org/W1892148740","https://openalex.org/W1968991415","https://openalex.org/W1970026235","https://openalex.org/W1974821195","https://openalex.org/W1984564731","https://openalex.org/W1987438054","https://openalex.org/W2001276190","https://openalex.org/W2004691211","https://openalex.org/W2014101652","https://openalex.org/W2017468905","https://openalex.org/W2027408247","https://openalex.org/W2028475005","https://openalex.org/W2030683115","https://openalex.org/W2030695915","https://openalex.org/W2033792177","https://openalex.org/W2038794420","https://openalex.org/W2045227909","https://openalex.org/W2046140230","https://openalex.org/W2050333027","https://openalex.org/W2074178106","https://openalex.org/W2074266029","https://openalex.org/W2076854887","https://openalex.org/W2089934202","https://openalex.org/W2090821297","https://openalex.org/W2093976897","https://openalex.org/W2094789799","https://openalex.org/W2119587675","https://openalex.org/W2127522551","https://openalex.org/W2150981663","https://openalex.org/W2168828889","https://openalex.org/W2171681733","https://openalex.org/W2601797347","https://openalex.org/W4232154957","https://openalex.org/W6636237541"],"related_works":["https://openalex.org/W1978172310","https://openalex.org/W2018639666","https://openalex.org/W3010246857","https://openalex.org/W1591700273","https://openalex.org/W2055717669","https://openalex.org/W3148509690","https://openalex.org/W2056194391","https://openalex.org/W2011433843","https://openalex.org/W2350831561","https://openalex.org/W2791436750"],"abstract_inverted_index":{"Through":[0],"comparison":[1],"of":[2,22,65],"molecular":[3],"models":[4,56],"with":[5,41,79],"experimental":[6],"data,":[7],"we":[8,27],"are":[9],"able":[10],"to":[11,43],"identify":[12],"how":[13,29],"giant":[14,66],"CDC":[15],"\u03b2-barrels":[16,50,67,71],"utilize":[17],"a":[18,75],"'near":[19],"parallel'":[20],"arrangement":[21],"\u03b2-strands":[23],"where":[24],"S=n/2.":[25],"Furthermore,":[26],"show":[28],"side-chain":[30],"packing":[31],"within":[32],"the":[33,44,62],"\u03b2-barrel":[34],"lumen":[35],"is":[36],"an":[37],"important":[38],"limiting":[39],"factor":[40],"respect":[42],"possible":[45],"shear":[46,63],"values":[47],"for":[48],"small":[49],"(n\u226424":[51],"\u03b2-strands).":[52,69],"In":[53],"contrast,":[54],"our":[55],"reveal":[57],"no":[58],"such":[59],"limitation":[60],"restricts":[61],"value":[64],"(n>24":[68],"Giant":[70],"can":[72],"thus":[73],"access":[74],"different":[76],"architecture":[77],"compared":[78],"smaller":[80],"\u03b2-barrels.":[81]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
