{"id":"https://openalex.org/W2122708083","doi":"https://doi.org/10.1093/bioinformatics/btr626","title":"Inferring gene regulatory networks from gene expression data by path consistency algorithm based on conditional mutual information","display_name":"Inferring gene regulatory networks from gene expression data by path consistency algorithm based on conditional mutual information","publication_year":2011,"publication_date":"2011-11-15","ids":{"openalex":"https://openalex.org/W2122708083","doi":"https://doi.org/10.1093/bioinformatics/btr626","mag":"2122708083"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btr626","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr626","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/1/98/50568558/bioinformatics_28_1_98.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/28/1/98/50568558/bioinformatics_28_1_98.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100720559","display_name":"Xiujun Zhang","orcid":"https://orcid.org/0000-0001-8041-0592"},"institutions":[{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]},{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN","FR","US"],"is_corresponding":true,"raw_author_name":"Xiujun Zhang","raw_affiliation_strings":["1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"affiliations":[{"raw_affiliation_string":"1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I49451733","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049435754","display_name":"Xing\u2010Ming Zhao","orcid":"https://orcid.org/0000-0002-4531-3970"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]},{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]}],"countries":["CN","FR","US"],"is_corresponding":false,"raw_author_name":"Xing-Ming Zhao","raw_affiliation_strings":["1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"affiliations":[{"raw_affiliation_string":"1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I49451733","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004999865","display_name":"Kun He","orcid":"https://orcid.org/0000-0003-3472-419X"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["CN","FR","US"],"is_corresponding":false,"raw_author_name":"Kun He","raw_affiliation_strings":["1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"affiliations":[{"raw_affiliation_string":"1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I49451733","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045227579","display_name":"Le L\u00fc","orcid":"https://orcid.org/0000-0002-6799-9416"},"institutions":[{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]},{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]},{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN","FR","US"],"is_corresponding":false,"raw_author_name":"Le Lu","raw_affiliation_strings":["1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"affiliations":[{"raw_affiliation_string":"1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I49451733","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055412969","display_name":"Yongwei Cao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]},{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["CN","FR","US"],"is_corresponding":false,"raw_author_name":"Yongwei Cao","raw_affiliation_strings":["1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"affiliations":[{"raw_affiliation_string":"1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I49451733","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101493548","display_name":"Jingdong Liu","orcid":"https://orcid.org/0000-0002-5927-6808"},"institutions":[{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["CN","FR","US"],"is_corresponding":false,"raw_author_name":"Jingdong Liu","raw_affiliation_strings":["1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"affiliations":[{"raw_affiliation_string":"1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I49451733","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016332970","display_name":"Jin\u2010Kao Hao","orcid":"https://orcid.org/0000-0001-8813-4377"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]}],"countries":["CN","FR","US"],"is_corresponding":false,"raw_author_name":"Jin-Kao Hao","raw_affiliation_strings":["1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"affiliations":[{"raw_affiliation_string":"1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I49451733","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109218292","display_name":"Zhi\u2010Ping Liu","orcid":"https://orcid.org/0000-0001-7742-9161"},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]}],"countries":["CN","FR","US"],"is_corresponding":false,"raw_author_name":"Zhi-Ping Liu","raw_affiliation_strings":["1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"affiliations":[{"raw_affiliation_string":"1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I49451733","https://openalex.org/I4210106477"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012283696","display_name":"Luonan Chen","orcid":"https://orcid.org/0000-0002-3960-0068"},"institutions":[{"id":"https://openalex.org/I49451733","display_name":"Universit\u00e9 d'Angers","ror":"https://ror.org/04yrqp957","country_code":"FR","type":"education","lineage":["https://openalex.org/I49451733"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["CN","FR","US"],"is_corresponding":false,"raw_author_name":"Luonan Chen","raw_affiliation_strings":["1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China"],"affiliations":[{"raw_affiliation_string":"1 Institute of Systems Biology, Shanghai University, Shanghai 200444, 2School of Communication and Information Engineering, Shanghai University, Shanghai 200072, China, 3Department of Computer Science, Laboratoire d'Etude et de Recherche en Informatique d'Angers, University of Angers, Angers 49045, France, 4Monsanto Company, St Louis, MO 63167, USA and 5Key Laboratory of Systems Biology, SIBS-Novo Nordisk Translational Research Centre for PreDiabetes, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I3148997608","https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I49451733","https://openalex.org/I4210106477"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5100720559"],"corresponding_institution_ids":["https://openalex.org/I113940042","https://openalex.org/I19820366","https://openalex.org/I3148997608","https://openalex.org/I4210106477","https://openalex.org/I49451733"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":5.6033,"has_fulltext":true,"cited_by_count":338,"citation_normalized_percentile":{"value":0.96945155,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"28","issue":"1","first_page":"98","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.6177299618721008},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.6100714802742004},{"id":"https://openalex.org/keywords/consistency","display_name":"Consistency (knowledge bases)","score":0.569858968257904},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5469614863395691},{"id":"https://openalex.org/keywords/covariance","display_name":"Covariance","score":0.5153695940971375},{"id":"https://openalex.org/keywords/conditional-mutual-information","display_name":"Conditional mutual information","score":0.47203341126441956},{"id":"https://openalex.org/keywords/mutual-information","display_name":"Mutual information","score":0.462685227394104},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.441150039434433},{"id":"https://openalex.org/keywords/gaussian","display_name":"Gaussian","score":0.4349656403064728},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4279109537601471},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4247475266456604},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.37276047468185425},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3152787387371063},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3151879906654358},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2956444025039673},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.26677119731903076},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.22332212328910828},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.14683973789215088},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10145428776741028}],"concepts":[{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.6177299618721008},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.6100714802742004},{"id":"https://openalex.org/C2776436953","wikidata":"https://www.wikidata.org/wiki/Q5163215","display_name":"Consistency (knowledge bases)","level":2,"score":0.569858968257904},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5469614863395691},{"id":"https://openalex.org/C178650346","wikidata":"https://www.wikidata.org/wiki/Q201984","display_name":"Covariance","level":2,"score":0.5153695940971375},{"id":"https://openalex.org/C124805900","wikidata":"https://www.wikidata.org/wiki/Q5159269","display_name":"Conditional mutual information","level":3,"score":0.47203341126441956},{"id":"https://openalex.org/C152139883","wikidata":"https://www.wikidata.org/wiki/Q252973","display_name":"Mutual information","level":2,"score":0.462685227394104},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.441150039434433},{"id":"https://openalex.org/C163716315","wikidata":"https://www.wikidata.org/wiki/Q901177","display_name":"Gaussian","level":2,"score":0.4349656403064728},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4279109537601471},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4247475266456604},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37276047468185425},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3152787387371063},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3151879906654358},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2956444025039673},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26677119731903076},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.22332212328910828},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.14683973789215088},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10145428776741028},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btr626","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr626","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/1/98/50568558/bioinformatics_28_1_98.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:HAL:hal-02950738v1","is_oa":false,"landing_page_url":"https://hal.science/hal-02950738","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, 2012, 28 (1), pp.98-104. &#x27E8;10.1093/bioinformatics/btr626&#x27E9;","raw_type":"Journal articles"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btr626","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr626","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/28/1/98/50568558/bioinformatics_28_1_98.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.41999998688697815,"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals"}],"awards":[{"id":"https://openalex.org/G1121271761","display_name":null,"funder_award_id":"Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1276829693","display_name":null,"funder_award_id":"Shanghai","funder_id":"https://openalex.org/F4320321881","funder_display_name":"Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G1426318481","display_name":null,"funder_award_id":"grant","funder_id":"https://openalex.org/F4320322725","funder_display_name":"China Scholarship Council"},{"id":"https://openalex.org/G1665691036","display_name":"\u751f\u7523\u65bd\u8a2d\u306e\u5730\u9707\u6642\u5165\u529b\u3068\u5730\u9707\u6642\u5fdc\u7b54\u306b\u95a2\u3059\u308b\u7814\u7a76","funder_award_id":"91029","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G1877751674","display_name":"\u85e9\u653f\u6751\u306e\u6b74\u53f2\u5730\u7406\u5b66\u7684\u7814\u7a76","funder_award_id":"14027","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2028444658","display_name":null,"funder_award_id":"KSCX2-EW-R-0","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2769064419","display_name":"\u8d64\u304b\u3073\u75c5\u306e\u7279\u6b8a\u63a5\u7a2e\u6cd5\u306b\u3088\u308b\u5c0f\u9ea6\u54c1\u7a2e\u306e\u62b5\u6297\u6027\u306e\u691c\u5b9a","funder_award_id":"61103","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3491903578","display_name":null,"funder_award_id":"61103075","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3674792339","display_name":"\u884c\u52d5\u79d1\u5b66\u306e\u54f2\u5b66\u7684\u57fa\u5e95-\u4fa1\u5024\u8ad6\u306e\u884c\u52d5\u8ad6\u7684\u7814\u7a76\u3068\u306e\u9023\u95a2\u3092\u3081\u3056\u3057\u3066-","funder_award_id":"11009","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G391238517","display_name":null,"funder_award_id":", and","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4020255992","display_name":null,"funder_award_id":"Project","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5082756141","display_name":"\u795e\u7d4c\u6a5f\u80fd\u306e\u7269\u8cea\u7684\u57fa\u790e\u306b\u95a2\u3059\u308b\u7814\u7a76","funder_award_id":"010605","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5246883717","display_name":null,"funder_award_id":"31100949","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5800477032","display_name":null,"funder_award_id":"61072149","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5853313636","display_name":null,"funder_award_id":"Knowledge","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5939423041","display_name":null,"funder_award_id":"Technology","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6495355840","display_name":null,"funder_award_id":"2009CSP002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6963679859","display_name":"\u74b0\u5883\u4fdd\u5168\u306e\u305f\u3081\u306e\u5316\u5b66\u53cd\u5fdc\u5236\u5fa1\u306e\u7814\u7a76","funder_award_id":"110307","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7126264696","display_name":null,"funder_award_id":"FIRST","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G71654678","display_name":"17\u4e16\u7d00\u54f2\u5b66\u7814\u7a76","funder_award_id":"11030","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7213911792","display_name":"\u304c\u3093\u7d30\u80de\u306e\u4eba\u5de5\u7684\u5909\u7570\u3068\u5206\u5316","funder_award_id":"201060","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7323152710","display_name":null,"funder_award_id":"141050","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7537669788","display_name":null,"funder_award_id":"Scholarship","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7627261337","display_name":"\u4e7e\u7530\u76f4\u64ad\u6c34\u7a32\u306b\u95a2\u3059\u308b\u7814\u7a76, \u6642\u306b\u6e5b\u6c34\u5f8c\u306b\u304a\u3051\u308b\u6839\u7cfb\u306e\u66f4\u65b0\u306b\u95a2\u3059\u308b\u751f\u7406\u751f\u614b\u7684\u7814\u7a76","funder_award_id":"61072","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7752643416","display_name":null,"funder_award_id":"Japan","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8023794799","display_name":"\u5730\u57df\u958b\u767a\u306e\u305f\u3081\u306e\u8a08\u753b\u5206\u6790\u30e2\u30c7\u30eb","funder_award_id":"31100","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8426690845","display_name":null,"funder_award_id":"91029301","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G958236208","display_name":"\u598a\u7523\u5a66\u306e\u52d5\u614b\u751f\u7406\u5316\u5b66\u7814\u7a76\u6240\u7a76\u7528\u306e\u7121\u7dda\u30c6\u30ec\u30e1\u30fc\u30bf\u30fc\u88c5\u7f6e\u304a\u3088\u3073\u305d\u306e\u81e8\u5e8a\u4f7f\u7528\u6210\u7e3e\u306b\u3082\u3068\u305a\u304f\u6bcd\u5150\u306e\u52d5\u614b\u751f\u7406\u3068\u5065\u5eb7\u7ba1\u7406(\u7d992\u5e74)","funder_award_id":"72149","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320311508","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321881","display_name":"Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320325855","display_name":"Council for Science and Technology Policy","ror":null},{"id":"https://openalex.org/F4320327803","display_name":"Shanghai Rising-Star Program","ror":null},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320336876","display_name":"National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences","ror":"https://ror.org/00s97k668"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2122708083.pdf","grobid_xml":"https://content.openalex.org/works/W2122708083.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1524326598","https://openalex.org/W1965032353","https://openalex.org/W1972764318","https://openalex.org/W1987782593","https://openalex.org/W1996264210","https://openalex.org/W2000289311","https://openalex.org/W2008358153","https://openalex.org/W2027607571","https://openalex.org/W2028748300","https://openalex.org/W2038920443","https://openalex.org/W2044525257","https://openalex.org/W2048674295","https://openalex.org/W2058670155","https://openalex.org/W2069986908","https://openalex.org/W2076372398","https://openalex.org/W2078149659","https://openalex.org/W2091879895","https://openalex.org/W2104361492","https://openalex.org/W2105129830","https://openalex.org/W2106927126","https://openalex.org/W2110699703","https://openalex.org/W2111123076","https://openalex.org/W2113654344","https://openalex.org/W2115108153","https://openalex.org/W2123584272","https://openalex.org/W2134900891","https://openalex.org/W2135046866","https://openalex.org/W2146264532","https://openalex.org/W2148541040","https://openalex.org/W2148894967","https://openalex.org/W2155573334","https://openalex.org/W2158443938","https://openalex.org/W2158589684","https://openalex.org/W2161409973","https://openalex.org/W2161467890","https://openalex.org/W2161868542","https://openalex.org/W2161922735","https://openalex.org/W2163296115","https://openalex.org/W2163296862","https://openalex.org/W2165533101","https://openalex.org/W3006419771","https://openalex.org/W3099289621","https://openalex.org/W4302423442","https://openalex.org/W6670026339","https://openalex.org/W6681754205","https://openalex.org/W6683167872","https://openalex.org/W6683509102"],"related_works":["https://openalex.org/W4205619203","https://openalex.org/W3135541457","https://openalex.org/W4313429060","https://openalex.org/W3164528651","https://openalex.org/W2074589917","https://openalex.org/W181490901","https://openalex.org/W2337819340","https://openalex.org/W2044289181","https://openalex.org/W3048654224","https://openalex.org/W2012714953"],"abstract_inverted_index":{"Abstract":[0],"Motivation:":[1],"Reconstruction":[2],"of":[3,13,19,42,58,106,129,142,153,165,200],"gene":[4,46,96,146,168],"regulatory":[5,16,33],"networks":[6],"(GRNs),":[7],"which":[8,204],"explicitly":[9],"represent":[10],"the":[11,31,100,123,134,139,162,166,176,180,184,198,229],"causality":[12],"developmental":[14],"or":[15],"process,":[17],"is":[18,131,155,173,216],"utmost":[20],"interest":[21],"and":[22,52,64,103,183,232],"has":[23],"become":[24],"a":[25,89,127,151,158],"challenging":[26],"computational":[27,81],"problem":[28],"for":[29,92],"understanding":[30],"complex":[32],"mechanisms":[34],"in":[35,69,79,191],"cellular":[36],"systems.":[37],"However,":[38],"all":[39],"existing":[40],"methods":[41],"inferring":[43,93],"GRNs":[44,94,107,178],"from":[45,95,179,224],"expression":[47,97,147,169],"profiles":[48],"have":[49],"their":[50],"strengths":[51],"weaknesses.":[53],"In":[54,84,120],"particular,":[55],"many":[56],"properties":[57],"GRNs,":[59],"such":[60],"as":[61],"topology":[62],"sparseness":[63],"non-linear":[65,101],"dependence,":[66],"are":[67,74,234,245],"generally":[68],"regulation":[70],"mechanism":[71],"but":[72],"seldom":[73],"taken":[75],"into":[76],"account":[77],"simultaneously":[78],"one":[80],"method.":[82],"Results:":[83],"this":[85,121],"work,":[86],"we":[87],"present":[88],"novel":[90],"method":[91,172,202,215],"data":[98,231,244],"considering":[99],"dependence":[102,125],"topological":[104],"structure":[105],"by":[108,133,157],"employing":[109],"path":[110],"consistency":[111],"algorithm":[112],"(PCA)":[113],"based":[114],"on":[115,175],"conditional":[116,124],"mutual":[117],"information":[118],"(CMI).":[119],"algorithm,":[122],"between":[126,136,150],"pair":[128,152],"genes":[130,154],"represented":[132],"CMI":[135,149],"them.":[137],"With":[138],"general":[140],"hypothesis":[141],"Gaussian":[143],"distribution":[144],"underlying":[145],"data,":[148],"computed":[156],"concise":[159],"formula":[160],"involving":[161],"covariance":[163],"matrices":[164],"related":[167],"profiles.":[170],"The":[171,194],"validated":[174],"benchmark":[177],"DREAM":[181],"challenge":[182],"widely":[185],"used":[186],"SOS":[187],"DNA":[188],"repair":[189],"network":[190],"Escherichia":[192],"coli.":[193],"cross-validation":[195],"results":[196],"confirmed":[197],"effectiveness":[199],"our":[201,214],"(PCA-CMI),":[203],"outperforms":[205],"significantly":[206],"other":[207],"previous":[208],"methods.":[209],"Besides":[210],"its":[211],"high":[212],"accuracy,":[213],"able":[217],"to":[218],"distinguish":[219],"direct":[220],"(or":[221],"causal)":[222],"interactions":[223],"indirect":[225],"associations.":[226],"Availability:":[227],"All":[228],"source":[230],"code":[233],"available":[235,246],"at:":[236],"http://csb.shu.edu.cn/subweb/grn.htm.":[237],"Contact:":[238],"lnchen@sibs.ac.cn;":[239],"zpliu@sibs.ac.cn":[240],"Supplementary":[241,243],"information:":[242],"at":[247],"Bioinformatics":[248],"online.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":28},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":25},{"year":2019,"cited_by_count":29},{"year":2018,"cited_by_count":29},{"year":2017,"cited_by_count":35},{"year":2016,"cited_by_count":28},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":6}],"updated_date":"2026-04-18T07:56:08.524223","created_date":"2016-06-24T00:00:00"}
