{"id":"https://openalex.org/W2144857097","doi":"https://doi.org/10.1093/bioinformatics/btr497","title":"iMod: multipurpose normal mode analysis in internal coordinates","display_name":"iMod: multipurpose normal mode analysis in internal coordinates","publication_year":2011,"publication_date":"2011-08-27","ids":{"openalex":"https://openalex.org/W2144857097","doi":"https://doi.org/10.1093/bioinformatics/btr497","mag":"2144857097","pmid":"https://pubmed.ncbi.nlm.nih.gov/21873636"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btr497","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr497","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/20/2843/16900773/btr497.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/27/20/2843/16900773/btr497.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061629048","display_name":"Jos\u00e9 Ram\u00f3n L\u00f3pez\u2010Blanco","orcid":"https://orcid.org/0000-0002-5891-4134"},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Ram\u00f3n Lop\u00e9z-Blanco","raw_affiliation_strings":["1 Department of Biological Chemical Physics, Rocasolano Physical Chemistry Institute, CSIC, Serrano 119, Madrid 28006, Spain and 2Department of Biochemistry and Molecular Biophysics, Center for Computational Biology and Bioinformatics, Howard Hughes Medical Institute, Columbia University, 1130 St. Nicholas Avenue, Room 815, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biological Chemical Physics, Rocasolano Physical Chemistry Institute, CSIC, Serrano 119, Madrid 28006, Spain and 2Department of Biochemistry and Molecular Biophysics, Center for Computational Biology and Bioinformatics, Howard Hughes Medical Institute, Columbia University, 1130 St. Nicholas Avenue, Room 815, New York, NY 10032, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005566175","display_name":"Jos\u00e9 Ignacio Garz\u00f3n","orcid":null},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Ignacio Garz\u00f3n","raw_affiliation_strings":["1 Department of Biological Chemical Physics, Rocasolano Physical Chemistry Institute, CSIC, Serrano 119, Madrid 28006, Spain and 2Department of Biochemistry and Molecular Biophysics, Center for Computational Biology and Bioinformatics, Howard Hughes Medical Institute, Columbia University, 1130 St. Nicholas Avenue, Room 815, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biological Chemical Physics, Rocasolano Physical Chemistry Institute, CSIC, Serrano 119, Madrid 28006, Spain and 2Department of Biochemistry and Molecular Biophysics, Center for Computational Biology and Bioinformatics, Howard Hughes Medical Institute, Columbia University, 1130 St. Nicholas Avenue, Room 815, New York, NY 10032, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016204870","display_name":"Pablo Chac\u00f3n","orcid":"https://orcid.org/0000-0002-3168-4826"},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pablo Chac\u00f3n","raw_affiliation_strings":["1 Department of Biological Chemical Physics, Rocasolano Physical Chemistry Institute, CSIC, Serrano 119, Madrid 28006, Spain and 2Department of Biochemistry and Molecular Biophysics, Center for Computational Biology and Bioinformatics, Howard Hughes Medical Institute, Columbia University, 1130 St. Nicholas Avenue, Room 815, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biological Chemical Physics, Rocasolano Physical Chemistry Institute, CSIC, Serrano 119, Madrid 28006, Spain and 2Department of Biochemistry and Molecular Biophysics, Center for Computational Biology and Bioinformatics, Howard Hughes Medical Institute, Columbia University, 1130 St. Nicholas Avenue, Room 815, New York, NY 10032, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":4.1252,"has_fulltext":true,"cited_by_count":326,"citation_normalized_percentile":{"value":0.94992736,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"27","issue":"20","first_page":"2843","last_page":"2850"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.914900004863739,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.914900004863739,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cartesian-coordinate-system","display_name":"Cartesian coordinate system","score":0.7616809606552124},{"id":"https://openalex.org/keywords/dihedral-angle","display_name":"Dihedral angle","score":0.6960311532020569},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6812317967414856},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.629520833492279},{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.5229966640472412},{"id":"https://openalex.org/keywords/monte-carlo-method","display_name":"Monte Carlo method","score":0.49319881200790405},{"id":"https://openalex.org/keywords/curvilinear-coordinates","display_name":"Curvilinear coordinates","score":0.4669816195964813},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.44098523259162903},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3769848346710205},{"id":"https://openalex.org/keywords/computational-science","display_name":"Computational science","score":0.36583471298217773},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.3432120978832245},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.1737527847290039},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1721147894859314},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.15403863787651062}],"concepts":[{"id":"https://openalex.org/C16038011","wikidata":"https://www.wikidata.org/wiki/Q62912","display_name":"Cartesian coordinate system","level":2,"score":0.7616809606552124},{"id":"https://openalex.org/C89025888","wikidata":"https://www.wikidata.org/wiki/Q911907","display_name":"Dihedral angle","level":4,"score":0.6960311532020569},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6812317967414856},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.629520833492279},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.5229966640472412},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.49319881200790405},{"id":"https://openalex.org/C98343798","wikidata":"https://www.wikidata.org/wiki/Q1790208","display_name":"Curvilinear coordinates","level":2,"score":0.4669816195964813},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.44098523259162903},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3769848346710205},{"id":"https://openalex.org/C459310","wikidata":"https://www.wikidata.org/wiki/Q117801","display_name":"Computational science","level":1,"score":0.36583471298217773},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.3432120978832245},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1737527847290039},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1721147894859314},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.15403863787651062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btr497","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr497","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/20/2843/16900773/btr497.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21873636","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21873636","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:digital.csic.es:10261/253817","is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/253817","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:27/20/2843","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/27/20/2843","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btr497","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr497","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/20/2843/16900773/btr497.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2144857097.pdf","grobid_xml":"https://content.openalex.org/works/W2144857097.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W610636697","https://openalex.org/W1480928214","https://openalex.org/W1546491743","https://openalex.org/W1597817991","https://openalex.org/W1601826890","https://openalex.org/W1969875513","https://openalex.org/W1987104859","https://openalex.org/W1988699270","https://openalex.org/W1991047673","https://openalex.org/W1997310186","https://openalex.org/W1997486650","https://openalex.org/W2002001977","https://openalex.org/W2004067483","https://openalex.org/W2004132124","https://openalex.org/W2015059998","https://openalex.org/W2020446183","https://openalex.org/W2027091745","https://openalex.org/W2027486315","https://openalex.org/W2030193187","https://openalex.org/W2030470356","https://openalex.org/W2031142437","https://openalex.org/W2031340110","https://openalex.org/W2047346757","https://openalex.org/W2048357058","https://openalex.org/W2051893115","https://openalex.org/W2059947280","https://openalex.org/W2066926304","https://openalex.org/W2067763399","https://openalex.org/W2069777230","https://openalex.org/W2069920107","https://openalex.org/W2070701334","https://openalex.org/W2071656198","https://openalex.org/W2076076439","https://openalex.org/W2084258253","https://openalex.org/W2085227451","https://openalex.org/W2089463116","https://openalex.org/W2107268733","https://openalex.org/W2107461274","https://openalex.org/W2110337896","https://openalex.org/W2120781005","https://openalex.org/W2121375023","https://openalex.org/W2122326469","https://openalex.org/W2125304058","https://openalex.org/W2127140872","https://openalex.org/W2131377322","https://openalex.org/W2140599583","https://openalex.org/W2140889378","https://openalex.org/W2142872962","https://openalex.org/W2146770788","https://openalex.org/W2149744037","https://openalex.org/W2152997134","https://openalex.org/W2154623005","https://openalex.org/W2154714625","https://openalex.org/W2155812479","https://openalex.org/W2164548935","https://openalex.org/W2172048860","https://openalex.org/W2328749365","https://openalex.org/W2411994020","https://openalex.org/W4229666556"],"related_works":["https://openalex.org/W4212946320","https://openalex.org/W2042276837","https://openalex.org/W2022295506","https://openalex.org/W2092140010","https://openalex.org/W1567147730","https://openalex.org/W4239038825","https://openalex.org/W4237145378","https://openalex.org/W2576681123","https://openalex.org/W63805299","https://openalex.org/W2002874472"],"abstract_inverted_index":{"MOTIVATION:":[0],"Dynamic":[1],"simulations":[2,120],"of":[3,39,68,80,92,125],"systems":[4],"with":[5,21,51],"biologically":[6],"relevant":[7],"sizes":[8],"and":[9,37,71,89,105,135],"time":[10],"scales":[11],"are":[12,128,143],"critical":[13],"for":[14],"understanding":[15],"macromolecular":[16],"functioning.":[17],"Coarse-grained":[18],"representations":[19],"combined":[20],"normal":[22],"mode":[23],"analysis":[24],"(NMA)":[25],"have":[26],"been":[27],"established":[28],"as":[29,83],"an":[30,107],"alternative":[31],"to":[32,64,110,130],"atomistic":[33],"simulations.":[34],"The":[35],"versatility":[36],"efficiency":[38],"current":[40],"approaches":[41,127],"normally":[42],"based":[43],"on":[44],"Cartesian":[45,94],"coordinates":[46,53],"can":[47],"be":[48],"greatly":[49],"enhanced":[50],"internal":[52],"(IC).":[54],"RESULTS:":[55],"Here,":[56],"we":[57],"present":[58],"a":[59],"new":[60],"versatile":[61],"tool":[62],"chest":[63],"explore":[65],"conformational":[66,113],"flexibility":[67],"both":[69],"protein":[70],"nucleic":[72],"acid":[73],"structures":[74],"using":[75],"NMA":[76,95],"in":[77],"IC.":[78],"Consideration":[79],"dihedral":[81],"angles":[82],"variables":[84],"reduces":[85],"the":[86],"computational":[87],"cost":[88],"non-physical":[90],"distortions":[91],"classical":[93],"methods.":[96],"Our":[97],"proposed":[98],"framework":[99,109],"operates":[100],"at":[101,145],"different":[102],"coarse-grained":[103],"levels":[104],"offers":[106],"efficient":[108],"conduct":[111],"NMA-based":[112],"studies,":[114],"including":[115],"standard":[116],"vibrational":[117],"analysis,":[118],"Monte-Carlo":[119],"or":[121],"pathway":[122],"exploration.":[123],"Examples":[124],"these":[126],"shown":[129],"demonstrate":[131],"its":[132],"applicability,":[133],"robustness":[134],"efficiency.":[136],"CONTACT:":[137],"pablo@chaconlab.org":[138],"SUPPLEMENTARY":[139],"INFORMATION:":[140],"Supplementary":[141],"data":[142],"available":[144],"Bioinformatics":[146],"online.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":57},{"year":2024,"cited_by_count":42},{"year":2023,"cited_by_count":41},{"year":2022,"cited_by_count":34},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":6}],"updated_date":"2026-06-19T17:40:00.097472","created_date":"2025-10-10T00:00:00"}