{"id":"https://openalex.org/W2134610619","doi":"https://doi.org/10.1093/bioinformatics/btr416","title":"Inferring statin-induced gene regulatory relationships in primary human hepatocytes","display_name":"Inferring statin-induced gene regulatory relationships in primary human hepatocytes","publication_year":2011,"publication_date":"2011-07-14","ids":{"openalex":"https://openalex.org/W2134610619","doi":"https://doi.org/10.1093/bioinformatics/btr416","mag":"2134610619","pmid":"https://pubmed.ncbi.nlm.nih.gov/21757465"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btr416","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr416","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/18/2473/48865251/bioinformatics_27_18_2473.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/27/18/2473/48865251/bioinformatics_27_18_2473.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102110109","display_name":"Adrian Schr\u00f6der","orcid":"https://orcid.org/0009-0009-1033-9351"},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Adrian Schr\u00f6der","raw_affiliation_strings":["1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany"],"affiliations":[{"raw_affiliation_string":"1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I4210120009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024037438","display_name":"Johannes Wollnik","orcid":null},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes Wollnik","raw_affiliation_strings":["1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany"],"affiliations":[{"raw_affiliation_string":"1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I4210120009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083106620","display_name":"Clemens Wrzodek","orcid":"https://orcid.org/0000-0003-4995-780X"},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Clemens Wrzodek","raw_affiliation_strings":["1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany"],"affiliations":[{"raw_affiliation_string":"1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I4210120009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065854572","display_name":"Andreas Dr\u00e4ger","orcid":"https://orcid.org/0000-0002-1240-5553"},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Dr\u00e4ger","raw_affiliation_strings":["1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany"],"affiliations":[{"raw_affiliation_string":"1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I4210120009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110005169","display_name":"Michael Bonin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Bonin","raw_affiliation_strings":["1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany"],"affiliations":[{"raw_affiliation_string":"1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I4210120009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028915250","display_name":"Oliver Burk","orcid":"https://orcid.org/0000-0001-8990-9656"},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Burk","raw_affiliation_strings":["1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany"],"affiliations":[{"raw_affiliation_string":"1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I4210120009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064898960","display_name":"Maria Thomas","orcid":"https://orcid.org/0000-0001-6394-8710"},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maria Thomas","raw_affiliation_strings":["1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany"],"affiliations":[{"raw_affiliation_string":"1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I4210120009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109159555","display_name":"Wolfgang E. Thasler","orcid":null},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang E. Thasler","raw_affiliation_strings":["1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany"],"affiliations":[{"raw_affiliation_string":"1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I4210120009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044688765","display_name":"Ulrich M. Zanger","orcid":"https://orcid.org/0000-0002-5276-2002"},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]},{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich M. Zanger","raw_affiliation_strings":["1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany"],"affiliations":[{"raw_affiliation_string":"1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I4210120009"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004958444","display_name":"Andreas Zell","orcid":"https://orcid.org/0000-0003-3299-2211"},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Zell","raw_affiliation_strings":["1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany"],"affiliations":[{"raw_affiliation_string":"1 Center for Bioinformatics Tuebingen (ZBIT), 2Department of Medical Genetics, Microarray Facility, University of Tuebingen, Tuebingen, 3Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and 4Department of Surgery, Grosshadern Hospital, Ludwig-Maximilians-University Munich, Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I4210120009"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5102110109"],"corresponding_institution_ids":["https://openalex.org/I4210120009","https://openalex.org/I8204097"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.3029,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.79617663,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"27","issue":"18","first_page":"2473","last_page":"2477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atorvastatin","display_name":"Atorvastatin","score":0.7371888160705566},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6294076442718506},{"id":"https://openalex.org/keywords/statin","display_name":"Statin","score":0.5999958515167236},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.5219559073448181},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5099302530288696},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.4982905387878418},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.46027112007141113},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.45283979177474976},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.44233301281929016},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.44015878438949585},{"id":"https://openalex.org/keywords/hmg-coa-reductase","display_name":"HMG-CoA reductase","score":0.4385102093219757},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4260062873363495},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4223790168762207},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.41333329677581787},{"id":"https://openalex.org/keywords/reductase","display_name":"Reductase","score":0.4034615159034729},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3631216287612915},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"Cytochrome P450","score":0.28869229555130005},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23629656434059143},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.1878753900527954},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.12388768792152405}],"concepts":[{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.7371888160705566},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6294076442718506},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.5999958515167236},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5219559073448181},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5099302530288696},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4982905387878418},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.46027112007141113},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45283979177474976},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44233301281929016},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44015878438949585},{"id":"https://openalex.org/C104950815","wikidata":"https://www.wikidata.org/wiki/Q415607","display_name":"HMG-CoA reductase","level":4,"score":0.4385102093219757},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4260062873363495},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4223790168762207},{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.41333329677581787},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.4034615159034729},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3631216287612915},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.28869229555130005},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23629656434059143},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1878753900527954},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12388768792152405}],"mesh":[{"descriptor_ui":"D000069059","descriptor_name":"Atorvastatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069059","descriptor_name":"Atorvastatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069059","descriptor_name":"Atorvastatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006538","descriptor_name":"Heptanoic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006538","descriptor_name":"Heptanoic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006538","descriptor_name":"Heptanoic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btr416","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr416","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/18/2473/48865251/bioinformatics_27_18_2473.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21757465","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21757465","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:27/18/2473","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/27/18/2473","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btr416","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr416","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/18/2473/48865251/bioinformatics_27_18_2473.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6600000262260437}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320869","display_name":"Robert Bosch Stiftung","ror":"https://ror.org/012kqkf58"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2134610619.pdf","grobid_xml":"https://content.openalex.org/works/W2134610619.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W624706648","https://openalex.org/W1570332345","https://openalex.org/W1874092228","https://openalex.org/W1968535758","https://openalex.org/W1976508599","https://openalex.org/W1977547986","https://openalex.org/W1979778278","https://openalex.org/W1987122345","https://openalex.org/W1991235049","https://openalex.org/W1994610215","https://openalex.org/W1998075825","https://openalex.org/W2001527591","https://openalex.org/W2007287574","https://openalex.org/W2028340122","https://openalex.org/W2040211878","https://openalex.org/W2042469629","https://openalex.org/W2047207059","https://openalex.org/W2094036688","https://openalex.org/W2101960548","https://openalex.org/W2105715793","https://openalex.org/W2106642167","https://openalex.org/W2108571956","https://openalex.org/W2113431222","https://openalex.org/W2113523470","https://openalex.org/W2113613985","https://openalex.org/W2115000268","https://openalex.org/W2117926385","https://openalex.org/W2126052291","https://openalex.org/W2127649624","https://openalex.org/W2135550833","https://openalex.org/W2145653235","https://openalex.org/W2149363804","https://openalex.org/W2156885385","https://openalex.org/W2157207950","https://openalex.org/W2164206878","https://openalex.org/W6677160516"],"related_works":["https://openalex.org/W2086531227","https://openalex.org/W3027098626","https://openalex.org/W2148662519","https://openalex.org/W1880939427","https://openalex.org/W4248434281","https://openalex.org/W2044724235","https://openalex.org/W2112575569","https://openalex.org/W2419267943","https://openalex.org/W4385308459","https://openalex.org/W2375479763"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":8},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}