{"id":"https://openalex.org/W2117405110","doi":"https://doi.org/10.1093/bioinformatics/btr414","title":"Tissue-specific subnetworks and characteristics of publicly available human protein interaction databases","display_name":"Tissue-specific subnetworks and characteristics of publicly available human protein interaction databases","publication_year":2011,"publication_date":"2011-07-28","ids":{"openalex":"https://openalex.org/W2117405110","doi":"https://doi.org/10.1093/bioinformatics/btr414","mag":"2117405110","pmid":"https://pubmed.ncbi.nlm.nih.gov/21798963"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btr414","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr414","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/17/2414/48863661/bioinformatics_27_17_2414.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/27/17/2414/48863661/bioinformatics_27_17_2414.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037557478","display_name":"Tiago J. S. Lopes","orcid":"https://orcid.org/0000-0001-9605-5177"},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I4210118579","display_name":"Systems Biology Institute","ror":"https://ror.org/02c7akf81","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4210118579"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["DE","JP","US"],"is_corresponding":true,"raw_author_name":"Tiago J. S. Lopes","raw_affiliation_strings":["1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I4210118579","https://openalex.org/I74801974","https://openalex.org/I205582932","https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032142988","display_name":"Martin H. Schaefer","orcid":"https://orcid.org/0000-0001-7503-6364"},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I4210118579","display_name":"Systems Biology Institute","ror":"https://ror.org/02c7akf81","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4210118579"]}],"countries":["DE","JP","US"],"is_corresponding":false,"raw_author_name":"Martin Schaefer","raw_affiliation_strings":["1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I4210118579","https://openalex.org/I74801974","https://openalex.org/I205582932","https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011546242","display_name":"Jason E. Shoemaker","orcid":"https://orcid.org/0000-0003-3315-7103"},"institutions":[{"id":"https://openalex.org/I4210118579","display_name":"Systems Biology Institute","ror":"https://ror.org/02c7akf81","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4210118579"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE","JP","US"],"is_corresponding":false,"raw_author_name":"Jason Shoemaker","raw_affiliation_strings":["1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I4210118579","https://openalex.org/I74801974","https://openalex.org/I205582932","https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101616697","display_name":"Yukiko Matsuoka","orcid":"https://orcid.org/0000-0002-5171-9096"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I4210118579","display_name":"Systems Biology Institute","ror":"https://ror.org/02c7akf81","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4210118579"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["DE","JP","US"],"is_corresponding":false,"raw_author_name":"Yukiko Matsuoka","raw_affiliation_strings":["1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I4210118579","https://openalex.org/I74801974","https://openalex.org/I205582932","https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055724941","display_name":"Jean\u2212Fred Fontaine","orcid":"https://orcid.org/0000-0002-1101-4091"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I4210118579","display_name":"Systems Biology Institute","ror":"https://ror.org/02c7akf81","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4210118579"]}],"countries":["DE","JP","US"],"is_corresponding":false,"raw_author_name":"Jean\u2212Fred Fontaine","raw_affiliation_strings":["1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I4210118579","https://openalex.org/I74801974","https://openalex.org/I205582932","https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064426145","display_name":"Gabriele Neumann","orcid":"https://orcid.org/0000-0001-7054-1775"},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I4210118579","display_name":"Systems Biology Institute","ror":"https://ror.org/02c7akf81","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4210118579"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["DE","JP","US"],"is_corresponding":false,"raw_author_name":"Gabriele Neumann","raw_affiliation_strings":["1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I4210118579","https://openalex.org/I74801974","https://openalex.org/I205582932","https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010178662","display_name":"Miguel A. Andrade\u2010Navarro","orcid":"https://orcid.org/0000-0001-6650-1711"},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210118579","display_name":"Systems Biology Institute","ror":"https://ror.org/02c7akf81","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4210118579"]}],"countries":["DE","JP","US"],"is_corresponding":false,"raw_author_name":"Miguel A. Andrade-Navarro","raw_affiliation_strings":["1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I4210118579","https://openalex.org/I74801974","https://openalex.org/I205582932","https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076363097","display_name":"Yoshihiro Kawaoka","orcid":"https://orcid.org/0000-0001-5061-8296"},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I4210118579","display_name":"Systems Biology Institute","ror":"https://ror.org/02c7akf81","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4210118579"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["DE","JP","US"],"is_corresponding":false,"raw_author_name":"Yoshihiro Kawaoka","raw_affiliation_strings":["1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I4210118579","https://openalex.org/I74801974","https://openalex.org/I205582932","https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086835862","display_name":"Hiroaki Kitano","orcid":"https://orcid.org/0000-0002-3589-1953"},"institutions":[{"id":"https://openalex.org/I4210118579","display_name":"Systems Biology Institute","ror":"https://ror.org/02c7akf81","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I4210118579"]},{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["DE","JP","US"],"is_corresponding":false,"raw_author_name":"Hiroaki Kitano","raw_affiliation_strings":["1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"1 JST ERATO KAWAOKA Infection\u2212induced Host Responses Project, Tokyo, Japan, 2Computational Biology and Data Mining, Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany, 3The Systems Biology Institute, Tokyo, Japan, 4Department of Pathobiological Sciences, Influenza Research Institute, University of Wisconsin-Madison, School of Veterinary Medicine, Madison, WI, USA, 5Institute of Medical Science, Division of Virology, Department of Microbiology and Immunology, University of Tokyo, 6Sony Computer Science Laboratories, Inc., Tokyo, 7Open Biology Unit, Okinawa Institute of Science and Technology, Okinawa and 8Division of Cancer Systems Biology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I4210118579","https://openalex.org/I74801974","https://openalex.org/I205582932","https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5037557478"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I205582932","https://openalex.org/I4210118579","https://openalex.org/I74801974"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":2.4012,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.89135674,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"27","issue":"17","first_page":"2414","last_page":"2421"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.6622070670127869},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5889066457748413},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.5835846662521362},{"id":"https://openalex.org/keywords/interaction-information","display_name":"Interaction information","score":0.542141854763031},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.482769638299942},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.4205721616744995},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35589599609375},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3276859521865845},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.30957382917404175},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2223074734210968},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10640019178390503}],"concepts":[{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.6622070670127869},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5889066457748413},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.5835846662521362},{"id":"https://openalex.org/C38764148","wikidata":"https://www.wikidata.org/wiki/Q17098245","display_name":"Interaction information","level":2,"score":0.542141854763031},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.482769638299942},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4205721616744995},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35589599609375},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3276859521865845},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30957382917404175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2223074734210968},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10640019178390503},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btr414","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr414","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/17/2414/48863661/bioinformatics_27_17_2414.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21798963","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21798963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:edoc.mdc-berlin.de:11783","is_oa":false,"landing_page_url":"https://edoc.mdc-berlin.de/11783/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:27/17/2414","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/27/17/2414","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btr414","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr414","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/17/2414/48863661/bioinformatics_27_17_2414.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1007488906","display_name":"Verbundprojekt: Genomnetz Umweltbedingte Erkrankungen: Bioinformatiksupport, Anteil MPI f\u00fcr Informatik","funder_award_id":"01GS0817","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G1861062742","display_name":"Verbundprojekt Neurodegeneration: Erstellung und systematische Analyse von Protein-Protein Interaktionsnetzwerken durch Yeast-2-Hybrid quantitative Proteomics und bioinformatische Methoden.","funder_award_id":"01GS08170","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G352791218","display_name":null,"funder_award_id":"(BMBF)","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G5168466499","display_name":null,"funder_award_id":"Project","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G6955755495","display_name":null,"funder_award_id":"Germany","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320338112","display_name":"Exploratory Research for Advanced Technology","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2117405110.pdf","grobid_xml":"https://content.openalex.org/works/W2117405110.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W80748578","https://openalex.org/W1498834900","https://openalex.org/W1544009106","https://openalex.org/W1869714982","https://openalex.org/W1905023361","https://openalex.org/W1965711561","https://openalex.org/W1974661096","https://openalex.org/W1981644527","https://openalex.org/W1982086574","https://openalex.org/W1984570470","https://openalex.org/W1993591356","https://openalex.org/W1994803330","https://openalex.org/W2000855148","https://openalex.org/W2003516452","https://openalex.org/W2006944023","https://openalex.org/W2008083733","https://openalex.org/W2012852001","https://openalex.org/W2017138237","https://openalex.org/W2022927682","https://openalex.org/W2023531407","https://openalex.org/W2028527911","https://openalex.org/W2033687160","https://openalex.org/W2037442572","https://openalex.org/W2042982138","https://openalex.org/W2047765648","https://openalex.org/W2057545775","https://openalex.org/W2058091579","https://openalex.org/W2060460012","https://openalex.org/W2065769502","https://openalex.org/W2067305633","https://openalex.org/W2083889661","https://openalex.org/W2103796460","https://openalex.org/W2104447833","https://openalex.org/W2107055030","https://openalex.org/W2109108939","https://openalex.org/W2113613985","https://openalex.org/W2113654464","https://openalex.org/W2115190629","https://openalex.org/W2116117181","https://openalex.org/W2119114096","https://openalex.org/W2122310985","https://openalex.org/W2123500593","https://openalex.org/W2128036243","https://openalex.org/W2130790725","https://openalex.org/W2135548107","https://openalex.org/W2143537765","https://openalex.org/W2149148688","https://openalex.org/W2154061034","https://openalex.org/W2155062057","https://openalex.org/W2155740016","https://openalex.org/W2158217645","https://openalex.org/W2160697532","https://openalex.org/W2164683872","https://openalex.org/W2169292636","https://openalex.org/W2171437346","https://openalex.org/W2172049947","https://openalex.org/W2333452860","https://openalex.org/W2916767477","https://openalex.org/W2917375902","https://openalex.org/W2917431650","https://openalex.org/W3103071483","https://openalex.org/W4250616341","https://openalex.org/W6681173526"],"related_works":["https://openalex.org/W4229728790","https://openalex.org/W2800059693","https://openalex.org/W2066232588","https://openalex.org/W4377086792","https://openalex.org/W3087302704","https://openalex.org/W2099913238","https://openalex.org/W2137238644","https://openalex.org/W4389616450","https://openalex.org/W3012858620","https://openalex.org/W2949751838"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
