{"id":"https://openalex.org/W2107180520","doi":"https://doi.org/10.1093/bioinformatics/btr410","title":"A Lasso regression model for the construction of microRNA-target regulatory networks","display_name":"A Lasso regression model for the construction of microRNA-target regulatory networks","publication_year":2011,"publication_date":"2011-07-08","ids":{"openalex":"https://openalex.org/W2107180520","doi":"https://doi.org/10.1093/bioinformatics/btr410","mag":"2107180520","pmid":"https://pubmed.ncbi.nlm.nih.gov/21743061"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btr410","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr410","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020533472","display_name":"Yiming Lu","orcid":"https://orcid.org/0000-0001-8005-2705"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768116","display_name":"State Key Laboratory of Proteomics","ror":"https://ror.org/019bev041","country_code":null,"type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4391768116"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiming Lu","raw_affiliation_strings":["1 Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Beijing 100850 and 2LMAM, School of Mathematical Sciences and Center for Theoretical Biology, Peking University, Beijing 100871, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Beijing 100850 and 2LMAM, School of Mathematical Sciences and Center for Theoretical Biology, Peking University, Beijing 100871, PR China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047266050","display_name":"Yang Zhou","orcid":"https://orcid.org/0000-0002-6967-421X"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768116","display_name":"State Key Laboratory of Proteomics","ror":"https://ror.org/019bev041","country_code":null,"type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4391768116"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Zhou","raw_affiliation_strings":["1 Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Beijing 100850 and 2LMAM, School of Mathematical Sciences and Center for Theoretical Biology, Peking University, Beijing 100871, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Beijing 100850 and 2LMAM, School of Mathematical Sciences and Center for Theoretical Biology, Peking University, Beijing 100871, PR China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070281759","display_name":"Wubin Qu","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768116","display_name":"State Key Laboratory of Proteomics","ror":"https://ror.org/019bev041","country_code":null,"type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4391768116"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wubin Qu","raw_affiliation_strings":["1 Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Beijing 100850 and 2LMAM, School of Mathematical Sciences and Center for Theoretical Biology, Peking University, Beijing 100871, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Beijing 100850 and 2LMAM, School of Mathematical Sciences and Center for Theoretical Biology, Peking University, Beijing 100871, PR China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101690048","display_name":"Minghua Deng","orcid":"https://orcid.org/0000-0002-2411-9650"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768116","display_name":"State Key Laboratory of Proteomics","ror":"https://ror.org/019bev041","country_code":null,"type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4391768116"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minghua Deng","raw_affiliation_strings":["1 Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Beijing 100850 and 2LMAM, School of Mathematical Sciences and Center for Theoretical Biology, Peking University, Beijing 100871, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Beijing 100850 and 2LMAM, School of Mathematical Sciences and Center for Theoretical Biology, Peking University, Beijing 100871, PR China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768116"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000894136","display_name":"Chenggang Zhang","orcid":"https://orcid.org/0000-0002-4521-3304"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768116","display_name":"State Key Laboratory of Proteomics","ror":"https://ror.org/019bev041","country_code":null,"type":"facility","lineage":["https://openalex.org/I2802541053","https://openalex.org/I4391768116"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenggang Zhang","raw_affiliation_strings":["1 Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Beijing 100850 and 2LMAM, School of Mathematical Sciences and Center for Theoretical Biology, Peking University, Beijing 100871, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Beijing 100850 and 2LMAM, School of Mathematical Sciences and Center for Theoretical Biology, Peking University, Beijing 100871, PR China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768116"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.9427,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.93534463,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"27","issue":"17","first_page":"2406","last_page":"2413"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8349000215530396,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8349000215530396,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.05169999971985817,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lasso","display_name":"Lasso (programming language)","score":0.7642005681991577},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6126374006271362},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5776468515396118},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.5563532114028931},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5453171730041504},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4501323103904724},{"id":"https://openalex.org/keywords/regression-analysis","display_name":"Regression analysis","score":0.448905885219574},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4281390607357025},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39008891582489014},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3765154480934143},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3383881449699402},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.19092106819152832},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.16339942812919617},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15463438630104065},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1536698043346405},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.14222142100334167}],"concepts":[{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.7642005681991577},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6126374006271362},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5776468515396118},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.5563532114028931},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5453171730041504},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4501323103904724},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.448905885219574},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4281390607357025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39008891582489014},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3765154480934143},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3383881449699402},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19092106819152832},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.16339942812919617},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15463438630104065},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1536698043346405},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14222142100334167},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btr410","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr410","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21743061","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21743061","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:27/17/2406","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/27/17/2406","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4300000071525574}],"awards":[],"funders":[{"id":"https://openalex.org/F4320315254","display_name":"Innovative Research Group Project of the National Natural Science Foundation of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1839893894","https://openalex.org/W1964825240","https://openalex.org/W1969761972","https://openalex.org/W1976324983","https://openalex.org/W1978337436","https://openalex.org/W1996376317","https://openalex.org/W2009326616","https://openalex.org/W2017199818","https://openalex.org/W2018433289","https://openalex.org/W2026570544","https://openalex.org/W2034595398","https://openalex.org/W2037986219","https://openalex.org/W2040191060","https://openalex.org/W2041255861","https://openalex.org/W2042004955","https://openalex.org/W2048577371","https://openalex.org/W2049546253","https://openalex.org/W2049868101","https://openalex.org/W2050674265","https://openalex.org/W2050869737","https://openalex.org/W2059073003","https://openalex.org/W2059680452","https://openalex.org/W2063978378","https://openalex.org/W2067884710","https://openalex.org/W2083381199","https://openalex.org/W2090219560","https://openalex.org/W2090629367","https://openalex.org/W2098044274","https://openalex.org/W2101543035","https://openalex.org/W2103005112","https://openalex.org/W2107633226","https://openalex.org/W2109136664","https://openalex.org/W2110891146","https://openalex.org/W2115591535","https://openalex.org/W2116318153","https://openalex.org/W2121412124","https://openalex.org/W2122664985","https://openalex.org/W2125818518","https://openalex.org/W2130979840","https://openalex.org/W2133968430","https://openalex.org/W2135046866","https://openalex.org/W2135810600","https://openalex.org/W2135837360","https://openalex.org/W2141655062","https://openalex.org/W2145126338","https://openalex.org/W2146138309","https://openalex.org/W2146684369","https://openalex.org/W2155142785","https://openalex.org/W2156852055","https://openalex.org/W2157795344","https://openalex.org/W2158217645","https://openalex.org/W2160467221","https://openalex.org/W2161693225","https://openalex.org/W2162674813","https://openalex.org/W3023299375","https://openalex.org/W4229880569","https://openalex.org/W4237011200","https://openalex.org/W4294107304","https://openalex.org/W6733261796"],"related_works":["https://openalex.org/W1515021623","https://openalex.org/W3155171010","https://openalex.org/W2119862467","https://openalex.org/W1615597061","https://openalex.org/W4289356671","https://openalex.org/W2389155397","https://openalex.org/W2165884543","https://openalex.org/W2312753042","https://openalex.org/W3186837933","https://openalex.org/W2368989808"],"abstract_inverted_index":{"MOTIVATION:":[0],"MicroRNAs":[1],"have":[2,46],"recently":[3],"emerged":[4],"as":[5,55],"a":[6,14,66,92,206],"major":[7],"class":[8],"of":[9,17,24,37,58,86,99,183,221],"regulatory":[10,26,159,178,215,248],"molecules":[11],"involved":[12],"in":[13,141,149,161,180],"broad":[15],"range":[16],"biological":[18],"processes":[19],"and":[20,35,42,61,69,76,112,144,163,208,219,246,259],"complex":[21,38,222],"diseases.":[22,39,223],"Construction":[23],"miRNA-target":[25],"networks":[27,179,216],"can":[28,152],"provide":[29],"useful":[30],"information":[31],"for":[32,82,96,211,217,228,257],"the":[33,56,83,97,134,150,157,167,176,189,201,213,234,243],"study":[34],"diagnosis":[36,218],"Many":[40],"sequence-based":[41,73,105],"evolutionary":[43],"information-based":[44],"methods":[45,125],"been":[47],"developed":[48],"to":[49,127,155,261],"identify":[50],"miRNA-mRNA":[51,87,100,230],"targeting":[52,101,231],"relationships.":[53],"However,":[54],"amount":[57],"available":[59,273],"miRNA":[60,108,168,177,214],"gene":[62],"expression":[63,264],"data":[64,79,271],"grows,":[65],"more":[67],"statistical":[68],"systematic":[70],"method":[71],"combining":[72],"binding":[74],"predictions":[75],"expression-based":[77],"correlation":[78],"becomes":[80],"necessary":[81],"accurate":[84],"identification":[85,98],"pairs.":[88],"RESULTS:":[89],"We":[90],"propose":[91],"Lasso":[93,135,202,235],"regression":[94,136,147,203,236],"model":[95,137,151,204,237],"relationships":[102,232],"that":[103,133],"combines":[104],"prediction":[106],"information,":[107],"co-regulation,":[109],"RISC":[110],"availability":[111],"miRNA/mRNA":[113,263],"abundance":[114],"data.":[115,172],"By":[116],"comparing":[117],"this":[118],"modelling":[119],"approach":[120],"with":[121,196,242],"two":[122,181],"other":[123,262],"known":[124],"applied":[126],"three":[128],"different":[129],"datasets,":[130],"we":[131,187],"found":[132,188],"has":[138],"considerable":[139],"advantages":[140],"both":[142],"sensitivity":[143],"specificity.":[145],"The":[146,225,252],"coefficients":[148],"be":[153],"used":[154],"determine":[156],"true":[158],"efficacies":[160],"tissues":[162],"was":[164],"demonstrated":[165],"using":[166,233],"target":[169],"site":[170],"type":[171],"Finally,":[173],"by":[174],"constructing":[175,212],"stages":[182],"prostate":[184],"cancer":[185],"(PCa),":[186],"several":[190],"significant":[191],"miRNA-hubbed":[192],"network":[193],"modules":[194],"associated":[195],"PCa":[197],"metastasis.":[198],"In":[199],"conclusion,":[200],"is":[205,238,255],"robust":[207],"informative":[209],"tool":[210],"treatment":[220],"AVAILABILITY:":[224],"R":[226],"program":[227],"predicting":[229],"freely":[239],"available,":[240],"along":[241],"described":[244],"datasets":[245],"resulting":[247],"network,":[249],"at":[250,274],"http://biocompute.bmi.ac.cn/CZlab/alarmnet/.":[251],"source":[253],"code":[254],"open":[256],"modification":[258],"application":[260],"datasets.":[265],"CONTACT:":[266],"zhangcg@bmi.ac.cn":[267],"SUPPLEMENTARY":[268],"INFORMATION:":[269],"Supplementary":[270],"are":[272],"Bioinformatics":[275],"online.":[276]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":6}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}