{"id":"https://openalex.org/W2105938721","doi":"https://doi.org/10.1093/bioinformatics/btr289","title":"A statistical framework for biomarker discovery in metabolomic time course data","display_name":"A statistical framework for biomarker discovery in metabolomic time course data","publication_year":2011,"publication_date":"2011-06-17","ids":{"openalex":"https://openalex.org/W2105938721","doi":"https://doi.org/10.1093/bioinformatics/btr289","mag":"2105938721","pmid":"https://pubmed.ncbi.nlm.nih.gov/21729866"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btr289","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr289","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/14/1979/48933213/bioinformatics_27_14_1979.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/27/14/1979/48933213/bioinformatics_27_14_1979.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103815313","display_name":"Maurice Berk","orcid":null},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maurice Berk","raw_affiliation_strings":["Statistics Section, Department of Mathematics, Imperial College London, Huxley Building, South Kensington, London SW7 2AZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistics Section, Department of Mathematics, Imperial College London, Huxley Building, South Kensington, London SW7 2AZ, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056339769","display_name":"Timothy M. D. Ebbels","orcid":"https://orcid.org/0000-0002-3372-8423"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy Ebbels","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010581004","display_name":"Giovanni Montana","orcid":"https://orcid.org/0000-0003-3942-3900"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giovanni Montana","raw_affiliation_strings":["Biomedical Engineering Department"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Department","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.5968,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.82893256,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"27","issue":"14","first_page":"1979","last_page":"1985"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11667","display_name":"Advanced Chemical Sensor Technologies","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.6988059878349304},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5821006298065186},{"id":"https://openalex.org/keywords/nonparametric-statistics","display_name":"Nonparametric statistics","score":0.48522281646728516},{"id":"https://openalex.org/keywords/smoothing","display_name":"Smoothing","score":0.4581737518310547},{"id":"https://openalex.org/keywords/statistic","display_name":"Statistic","score":0.457316130399704},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44556015729904175},{"id":"https://openalex.org/keywords/parametric-statistics","display_name":"Parametric statistics","score":0.4224185347557068},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.37263941764831543},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.32155364751815796},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2652246654033661},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18625980615615845},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17229583859443665}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.6988059878349304},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5821006298065186},{"id":"https://openalex.org/C102366305","wikidata":"https://www.wikidata.org/wiki/Q1097688","display_name":"Nonparametric statistics","level":2,"score":0.48522281646728516},{"id":"https://openalex.org/C3770464","wikidata":"https://www.wikidata.org/wiki/Q775963","display_name":"Smoothing","level":2,"score":0.4581737518310547},{"id":"https://openalex.org/C89128539","wikidata":"https://www.wikidata.org/wiki/Q1949963","display_name":"Statistic","level":2,"score":0.457316130399704},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44556015729904175},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.4224185347557068},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.37263941764831543},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32155364751815796},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2652246654033661},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18625980615615845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17229583859443665},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001699","descriptor_name":"Biometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001699","descriptor_name":"Biometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001699","descriptor_name":"Biometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001699","descriptor_name":"Biometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001699","descriptor_name":"Biometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/btr289","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr289","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/14/1979/48933213/bioinformatics_27_14_1979.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21729866","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21729866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/cdb542d6-51c6-4401-808a-299827b91447","is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/cdb542d6-51c6-4401-808a-299827b91447","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Berk, M, Ebbels, T & Montana, G 2011, 'A statistical framework for biomarker discovery in metabolomic time course data', Bioinformatics (Oxford, England), vol. 27, no. 14, N/A, pp. 1979-1985. https://doi.org/10.1093/bioinformatics/btr289","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:europepmc.org:2401043","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3129523","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:27/14/1979","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/27/14/1979","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btr289","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr289","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/14/1979/48933213/bioinformatics_27_14_1979.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.6899999976158142,"id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2105938721.pdf"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W166944394","https://openalex.org/W1559087056","https://openalex.org/W1611854178","https://openalex.org/W1797956629","https://openalex.org/W1914762032","https://openalex.org/W1968813633","https://openalex.org/W1983916493","https://openalex.org/W1986211833","https://openalex.org/W2002242662","https://openalex.org/W2004746596","https://openalex.org/W2011635427","https://openalex.org/W2015788892","https://openalex.org/W2037153463","https://openalex.org/W2049633694","https://openalex.org/W2052311868","https://openalex.org/W2065540158","https://openalex.org/W2076889248","https://openalex.org/W2081098333","https://openalex.org/W2087996970","https://openalex.org/W2095442928","https://openalex.org/W2106045204","https://openalex.org/W2109785413","https://openalex.org/W2110065044","https://openalex.org/W2114716229","https://openalex.org/W2120391288","https://openalex.org/W2123934362","https://openalex.org/W2149566602","https://openalex.org/W2153675946","https://openalex.org/W2157291679","https://openalex.org/W2157795344","https://openalex.org/W2159578516","https://openalex.org/W2162870748","https://openalex.org/W2171074980","https://openalex.org/W2182274314","https://openalex.org/W2795407492","https://openalex.org/W3021971632","https://openalex.org/W4205685297","https://openalex.org/W4294107304","https://openalex.org/W6683332849"],"related_works":["https://openalex.org/W2096947471","https://openalex.org/W2011903341","https://openalex.org/W2529605301","https://openalex.org/W2013882407","https://openalex.org/W1981436518","https://openalex.org/W2281539319","https://openalex.org/W1485223389","https://openalex.org/W2164993559","https://openalex.org/W2358971312","https://openalex.org/W2040597492"],"abstract_inverted_index":{"MOTIVATION:":[0],"Metabolomics":[1],"is":[2,123,184],"the":[3,6,41,165,176],"study":[4,55,156],"of":[5,8,43,58,70,112,159],"complement":[7],"small":[9],"molecule":[10],"metabolites":[11,46],"in":[12,152],"cells,":[13],"biofluids":[14],"and":[15,37,83,87,114,140],"tissues.":[16],"Many":[17],"metabolomic":[18],"experiments":[19],"are":[20,173],"designed":[21],"to":[22,144],"compare":[23],"changes":[24],"observed":[25],"over":[26],"time":[27,68,113],"under":[28],"two":[29],"experimental":[30,64],"conditions":[31],"or":[32,47],"groups":[33],"(e.g.":[34],"a":[35,75,96,109,126,153,160],"control":[36],"drug-treated":[38],"group)":[39],"with":[40,175],"goal":[42],"identifying":[44],"discriminatory":[45],"biomarkers":[48],"that":[49,103],"characterize":[50],"each":[51,63,105],"condition.":[52],"A":[53],"common":[54],"design":[56],"consists":[57],"repeated":[59],"measurements":[60],"taken":[61],"on":[62],"unit":[65],"thus":[66],"producing":[67],"courses":[69],"all":[71],"metabolites.":[72],"We":[73],"describe":[74],"statistical":[76],"framework":[77],"for":[78,88,168,187],"estimating":[79],"time-varying":[80],"metabolic":[81],"profiles":[82],"their":[84],"within-group":[85],"variability":[86],"detecting":[89],"between-group":[90],"differences.":[91],"Specifically,":[92],"we":[93],"propose":[94],"(i)":[95],"smoothing":[97],"splines":[98],"mixed":[99],"effects":[100],"(SME)":[101],"model":[102],"treats":[104],"longitudinal":[106],"measurement":[107],"as":[108,157],"smooth":[110],"function":[111],"(ii)":[115],"an":[116],"associated":[117],"functional":[118],"test":[119],"statistic.":[120],"Statistical":[121],"significance":[122],"assessed":[124],"by":[125,164],"non-parametric":[127],"bootstrap":[128],"procedure.":[129],"RESULTS:":[130],"The":[131],"methodology":[132],"has":[133,141],"been":[134,142],"extensively":[135],"evaluated":[136],"using":[137],"simulated":[138],"data":[139,150],"applied":[143],"real":[145],"nuclear":[146],"magnetic":[147],"resonance":[148],"spectroscopy":[149],"collected":[151],"preclinical":[154],"toxicology":[155],"part":[158],"larger":[161],"project":[162],"lead":[163],"COMET":[166],"(Consortium":[167],"Metabonomic":[169],"Toxicology).":[170],"Our":[171],"findings":[172],"compatible":[174],"previously":[177],"published":[178],"studies.":[179],"AVAILABILITY:":[180],"An":[181],"R":[182],"script":[183],"freely":[185],"available":[186],"download":[188],"at":[189],"http://www2.imperial.ac.uk/~gmontana/sme.htm.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}