{"id":"https://openalex.org/W2137209317","doi":"https://doi.org/10.1093/bioinformatics/btr238","title":"A method for probing the mutational landscape of amyloid structure","display_name":"A method for probing the mutational landscape of amyloid structure","publication_year":2011,"publication_date":"2011-06-14","ids":{"openalex":"https://openalex.org/W2137209317","doi":"https://doi.org/10.1093/bioinformatics/btr238","mag":"2137209317","pmid":"https://pubmed.ncbi.nlm.nih.gov/21685090"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btr238","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr238","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/13/i34/48883874/bioinformatics_27_13_i34.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/27/13/i34/48883874/bioinformatics_27_13_i34.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044279601","display_name":"Colm P. O\u2019Donnell","orcid":"https://orcid.org/0000-0002-8004-450X"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles W. O'Donnell","raw_affiliation_strings":["1 Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, 2Whitehead Institute for Biomedical Research, Cambridge, MA 02142, 3Department of EECS, Massachusetts Institute of Technology, Cambridge, MA 02139, 4School of Computer Science, McGill University, Montreal, QC H3A 2A7, Canada, 5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, 6Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 and 7Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"],"affiliations":[{"raw_affiliation_string":"1 Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, 2Whitehead Institute for Biomedical Research, Cambridge, MA 02142, 3Department of EECS, Massachusetts Institute of Technology, Cambridge, MA 02139, 4School of Computer Science, McGill University, Montreal, QC H3A 2A7, Canada, 5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, 6Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 and 7Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007","https://openalex.org/I4210157710","https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000881484","display_name":"J\u00e9r\u00f4me Waldisp\u00fchl","orcid":"https://orcid.org/0000-0002-2561-7117"},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J\u00e9r\u00f4me Waldisp\u00fchl","raw_affiliation_strings":["1 Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, 2Whitehead Institute for Biomedical Research, Cambridge, MA 02142, 3Department of EECS, Massachusetts Institute of Technology, Cambridge, MA 02139, 4School of Computer Science, McGill University, Montreal, QC H3A 2A7, Canada, 5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, 6Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 and 7Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"],"affiliations":[{"raw_affiliation_string":"1 Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, 2Whitehead Institute for Biomedical Research, Cambridge, MA 02142, 3Department of EECS, Massachusetts Institute of Technology, Cambridge, MA 02139, 4School of Computer Science, McGill University, Montreal, QC H3A 2A7, Canada, 5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, 6Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 and 7Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007","https://openalex.org/I4210157710","https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067207130","display_name":"Mieszko Lis","orcid":"https://orcid.org/0000-0003-3376-4384"},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mieszko Lis","raw_affiliation_strings":["1 Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, 2Whitehead Institute for Biomedical Research, Cambridge, MA 02142, 3Department of EECS, Massachusetts Institute of Technology, Cambridge, MA 02139, 4School of Computer Science, McGill University, Montreal, QC H3A 2A7, Canada, 5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, 6Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 and 7Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"],"affiliations":[{"raw_affiliation_string":"1 Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, 2Whitehead Institute for Biomedical Research, Cambridge, MA 02142, 3Department of EECS, Massachusetts Institute of Technology, Cambridge, MA 02139, 4School of Computer Science, McGill University, Montreal, QC H3A 2A7, Canada, 5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, 6Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 and 7Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007","https://openalex.org/I4210157710","https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057607550","display_name":"Randal Halfmann","orcid":"https://orcid.org/0000-0002-6592-1471"},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randal Halfmann","raw_affiliation_strings":["1 Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, 2Whitehead Institute for Biomedical Research, Cambridge, MA 02142, 3Department of EECS, Massachusetts Institute of Technology, Cambridge, MA 02139, 4School of Computer Science, McGill University, Montreal, QC H3A 2A7, Canada, 5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, 6Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 and 7Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"],"affiliations":[{"raw_affiliation_string":"1 Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, 2Whitehead Institute for Biomedical Research, Cambridge, MA 02142, 3Department of EECS, Massachusetts Institute of Technology, Cambridge, MA 02139, 4School of Computer Science, McGill University, Montreal, QC H3A 2A7, Canada, 5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, 6Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 and 7Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007","https://openalex.org/I4210157710","https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000525449","display_name":"Srinivas Devadas","orcid":"https://orcid.org/0000-0001-8253-7714"},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srinivas Devadas","raw_affiliation_strings":["1 Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, 2Whitehead Institute for Biomedical Research, Cambridge, MA 02142, 3Department of EECS, Massachusetts Institute of Technology, Cambridge, MA 02139, 4School of Computer Science, McGill University, Montreal, QC H3A 2A7, Canada, 5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, 6Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 and 7Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"],"affiliations":[{"raw_affiliation_string":"1 Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, 2Whitehead Institute for Biomedical Research, Cambridge, MA 02142, 3Department of EECS, Massachusetts Institute of Technology, Cambridge, MA 02139, 4School of Computer Science, McGill University, Montreal, QC H3A 2A7, Canada, 5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, 6Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 and 7Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007","https://openalex.org/I4210157710","https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108447414","display_name":"Susan Lindquist","orcid":null},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Lindquist","raw_affiliation_strings":["1 Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, 2Whitehead Institute for Biomedical Research, Cambridge, MA 02142, 3Department of EECS, Massachusetts Institute of Technology, Cambridge, MA 02139, 4School of Computer Science, McGill University, Montreal, QC H3A 2A7, Canada, 5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, 6Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 and 7Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"],"affiliations":[{"raw_affiliation_string":"1 Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, 2Whitehead Institute for Biomedical Research, Cambridge, MA 02142, 3Department of EECS, Massachusetts Institute of Technology, Cambridge, MA 02139, 4School of Computer Science, McGill University, Montreal, QC H3A 2A7, Canada, 5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, 6Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 and 7Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007","https://openalex.org/I4210157710","https://openalex.org/I1344073410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044078921","display_name":"Bonnie Berger","orcid":"https://orcid.org/0000-0002-2724-7228"},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bonnie Berger","raw_affiliation_strings":["1 Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, 2Whitehead Institute for Biomedical Research, Cambridge, MA 02142, 3Department of EECS, Massachusetts Institute of Technology, Cambridge, MA 02139, 4School of Computer Science, McGill University, Montreal, QC H3A 2A7, Canada, 5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, 6Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 and 7Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"],"affiliations":[{"raw_affiliation_string":"1 Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, 2Whitehead Institute for Biomedical Research, Cambridge, MA 02142, 3Department of EECS, Massachusetts Institute of Technology, Cambridge, MA 02139, 4School of Computer Science, McGill University, Montreal, QC H3A 2A7, Canada, 5Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, 6Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142 and 7Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007","https://openalex.org/I4210157710","https://openalex.org/I1344073410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5044279601"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I4210157710","https://openalex.org/I63966007"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":2.2551,"has_fulltext":true,"cited_by_count":71,"citation_normalized_percentile":{"value":0.87612739,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"27","issue":"13","first_page":"i34","last_page":"i42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.7959955930709839},{"id":"https://openalex.org/keywords/amyloid","display_name":"Amyloid (mycology)","score":0.6513004899024963},{"id":"https://openalex.org/keywords/mutagenesis","display_name":"Mutagenesis","score":0.6088030338287354},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5588252544403076},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5007007122039795},{"id":"https://openalex.org/keywords/fibril","display_name":"Fibril","score":0.4759873151779175},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47389286756515503},{"id":"https://openalex.org/keywords/amyloid-disease","display_name":"Amyloid disease","score":0.45573198795318604},{"id":"https://openalex.org/keywords/protein-folding","display_name":"Protein folding","score":0.4512752592563629},{"id":"https://openalex.org/keywords/amyloid-fibril","display_name":"Amyloid fibril","score":0.45020997524261475},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.4500017762184143},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.44490084052085876},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4321436583995819},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.34248822927474976},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.30660226941108704},{"id":"https://openalex.org/keywords/amyloid-\u03b2","display_name":"Amyloid \u03b2","score":0.21502217650413513},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09116879105567932}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7959955930709839},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.6513004899024963},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.6088030338287354},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5588252544403076},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5007007122039795},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.4759873151779175},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47389286756515503},{"id":"https://openalex.org/C2909607560","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid disease","level":5,"score":0.45573198795318604},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.4512752592563629},{"id":"https://openalex.org/C2994168385","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid fibril","level":4,"score":0.45020997524261475},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4500017762184143},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.44490084052085876},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4321436583995819},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34248822927474976},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30660226941108704},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.21502217650413513},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09116879105567932},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/btr238","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr238","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/13/i34/48883874/bioinformatics_27_13_i34.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21685090","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21685090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:dspace.mit.edu:1721.1/65075","is_oa":true,"landing_page_url":"http://hdl.handle.net/1721.1/65075","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oxford Journals","raw_type":"http://purl.org/eprint/type/JournalArticle"},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:27/13/i34","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/27/13/i34","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pubmedcentral.nih.gov:3117379","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3117379","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btr238","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr238","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/13/i34/48883874/bioinformatics_27_13_i34.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.699999988079071,"id":"https://metadata.un.org/sdg/16","display_name":"Peace, Justice and strong institutions"}],"awards":[{"id":"https://openalex.org/G2416958156","display_name":null,"funder_award_id":"R01GM081871","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3611247453","display_name":null,"funder_award_id":"R01GM","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6877200821","display_name":null,"funder_award_id":"1R01GM081871","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8305426332","display_name":null,"funder_award_id":"GM081871","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2137209317.pdf","grobid_xml":"https://content.openalex.org/works/W2137209317.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W225035691","https://openalex.org/W1544578519","https://openalex.org/W1552415503","https://openalex.org/W1964727310","https://openalex.org/W1971650367","https://openalex.org/W1973897761","https://openalex.org/W1975017420","https://openalex.org/W1975304761","https://openalex.org/W1978068955","https://openalex.org/W1982500800","https://openalex.org/W1984675364","https://openalex.org/W1989780699","https://openalex.org/W1991040817","https://openalex.org/W1991388423","https://openalex.org/W1992349385","https://openalex.org/W1993262901","https://openalex.org/W1999650655","https://openalex.org/W1999899839","https://openalex.org/W2003020823","https://openalex.org/W2004098528","https://openalex.org/W2007452453","https://openalex.org/W2011163535","https://openalex.org/W2016875890","https://openalex.org/W2020209643","https://openalex.org/W2025763720","https://openalex.org/W2027839322","https://openalex.org/W2031810922","https://openalex.org/W2040931022","https://openalex.org/W2043876754","https://openalex.org/W2067214887","https://openalex.org/W2069805216","https://openalex.org/W2071461674","https://openalex.org/W2072613948","https://openalex.org/W2075813595","https://openalex.org/W2076938281","https://openalex.org/W2085212975","https://openalex.org/W2087216201","https://openalex.org/W2087357689","https://openalex.org/W2100039848","https://openalex.org/W2100630099","https://openalex.org/W2105908180","https://openalex.org/W2117537971","https://openalex.org/W2119651404","https://openalex.org/W2122294662","https://openalex.org/W2130479394","https://openalex.org/W2134293050","https://openalex.org/W2141690555","https://openalex.org/W2142366168","https://openalex.org/W2147905080","https://openalex.org/W2149184367","https://openalex.org/W2150682434","https://openalex.org/W2158535880","https://openalex.org/W2161004584","https://openalex.org/W2165186407","https://openalex.org/W2171580926","https://openalex.org/W6608915540"],"related_works":["https://openalex.org/W1544926311","https://openalex.org/W2084102110","https://openalex.org/W2024420279","https://openalex.org/W2620272913","https://openalex.org/W2442596115","https://openalex.org/W2070080810","https://openalex.org/W2154502480","https://openalex.org/W2400850526","https://openalex.org/W3168207341","https://openalex.org/W2810848086"],"abstract_inverted_index":{"lindquist_admin@wi.mit.edu;":[0],"bab@csail.mit.edu.":[1]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}