{"id":"https://openalex.org/W2124939395","doi":"https://doi.org/10.1093/bioinformatics/btr236","title":"Small sets of interacting proteins suggest functional linkage mechanisms via Bayesian analogical reasoning","display_name":"Small sets of interacting proteins suggest functional linkage mechanisms via Bayesian analogical reasoning","publication_year":2011,"publication_date":"2011-06-14","ids":{"openalex":"https://openalex.org/W2124939395","doi":"https://doi.org/10.1093/bioinformatics/btr236","mag":"2124939395","pmid":"https://pubmed.ncbi.nlm.nih.gov/21685095"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btr236","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr236","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/13/i374/48871509/bioinformatics_27_13_i374.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/27/13/i374/48871509/bioinformatics_27_13_i374.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035398709","display_name":"Edoardo M. Airoldi","orcid":"https://orcid.org/0000-0002-3512-0542"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Edoardo M. Airoldi","raw_affiliation_strings":["1 Department of Statistics and FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, 2Brain and Cognitive Sciences, Massachussetts Institute of Technology, Cambridge, MA 02114, USA and 3Department of Statistical Science, University College London, 1-19 Torrington Place, London WC1E 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Statistics and FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, 2Brain and Cognitive Sciences, Massachussetts Institute of Technology, Cambridge, MA 02114, USA and 3Department of Statistical Science, University College London, 1-19 Torrington Place, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014018142","display_name":"Katherine Heller","orcid":"https://orcid.org/0000-0002-4848-7466"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Katherine A. Heller","raw_affiliation_strings":["1 Department of Statistics and FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, 2Brain and Cognitive Sciences, Massachussetts Institute of Technology, Cambridge, MA 02114, USA and 3Department of Statistical Science, University College London, 1-19 Torrington Place, London WC1E 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Statistics and FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, 2Brain and Cognitive Sciences, Massachussetts Institute of Technology, Cambridge, MA 02114, USA and 3Department of Statistical Science, University College London, 1-19 Torrington Place, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100372639","display_name":"Ricardo Silva","orcid":"https://orcid.org/0000-0002-6502-9563"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Ricardo Silva","raw_affiliation_strings":["1 Department of Statistics and FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, 2Brain and Cognitive Sciences, Massachussetts Institute of Technology, Cambridge, MA 02114, USA and 3Department of Statistical Science, University College London, 1-19 Torrington Place, London WC1E 6BT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Statistics and FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, 2Brain and Cognitive Sciences, Massachussetts Institute of Technology, Cambridge, MA 02114, USA and 3Department of Statistical Science, University College London, 1-19 Torrington Place, London WC1E 6BT, UK","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419","https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014018142","https://openalex.org/A5035398709","https://openalex.org/A5100372639"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419","https://openalex.org/I45129253"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11223892,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"13","first_page":"i374","last_page":"i382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8345999717712402,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8345999717712402,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.03550000116229057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6073593497276306},{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.6049515008926392},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5865862369537354},{"id":"https://openalex.org/keywords/ranking","display_name":"Ranking (information retrieval)","score":0.515753984451294},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.5096383094787598},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5036992430686951},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.47137510776519775},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.4399564862251282},{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.423225462436676},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3642021119594574},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2502681016921997},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16068243980407715}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6073593497276306},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.6049515008926392},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5865862369537354},{"id":"https://openalex.org/C189430467","wikidata":"https://www.wikidata.org/wiki/Q7293293","display_name":"Ranking (information retrieval)","level":2,"score":0.515753984451294},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.5096383094787598},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5036992430686951},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.47137510776519775},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.4399564862251282},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.423225462436676},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3642021119594574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2502681016921997},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16068243980407715},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004718","descriptor_name":"Saccharomycetales","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004718","descriptor_name":"Saccharomycetales","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004718","descriptor_name":"Saccharomycetales","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004718","descriptor_name":"Saccharomycetales","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/btr236","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr236","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/13/i374/48871509/bioinformatics_27_13_i374.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21685095","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21685095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:3117334","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3117334","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.403.4734","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.403.4734","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.people.fas.harvard.edu/~airoldi/pub/journals/j017.AiroldiHellerSilva2011Bioinformatics.pdf","raw_type":"text"},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:27/13/i374","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/27/13/i374","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btr236","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr236","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/13/i374/48871509/bioinformatics_27_13_i374.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1032756016","display_name":null,"funder_award_id":"R01 GM096193","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3399630736","display_name":"III:  Small:  Representation, Modeling and Inference for Large Biological and Information Networks","funder_award_id":"1017967","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3424214519","display_name":null,"funder_award_id":"58153-MA-MUR","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G4159024607","display_name":"Collaborative Research: Models for Network Evolution:  A Study of Growth and Structure in the Wikipedia","funder_award_id":"0907009","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309622","display_name":"Harvard University","ror":"https://ror.org/03vek6s52"},{"id":"https://openalex.org/F4320333591","display_name":"Multidisciplinary University Research Initiative","ror":null},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320338281","display_name":"Army Research Office","ror":"https://ror.org/05epdh915"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124939395.pdf","grobid_xml":"https://content.openalex.org/works/W2124939395.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W1485582261","https://openalex.org/W1496451467","https://openalex.org/W1516111018","https://openalex.org/W1517816201","https://openalex.org/W1532325895","https://openalex.org/W1599724644","https://openalex.org/W1604959358","https://openalex.org/W1606232948","https://openalex.org/W1971045545","https://openalex.org/W1977186059","https://openalex.org/W1992077705","https://openalex.org/W2006124679","https://openalex.org/W2017200304","https://openalex.org/W2022633023","https://openalex.org/W2025651303","https://openalex.org/W2033358618","https://openalex.org/W2037036397","https://openalex.org/W2037383462","https://openalex.org/W2046618236","https://openalex.org/W2050721857","https://openalex.org/W2055043387","https://openalex.org/W2065304353","https://openalex.org/W2068223736","https://openalex.org/W2075578689","https://openalex.org/W2077997913","https://openalex.org/W2080498142","https://openalex.org/W2094945089","https://openalex.org/W2100990314","https://openalex.org/W2101674614","https://openalex.org/W2103017472","https://openalex.org/W2104080300","https://openalex.org/W2105877777","https://openalex.org/W2107107106","https://openalex.org/W2109248504","https://openalex.org/W2111565546","https://openalex.org/W2112811019","https://openalex.org/W2113613985","https://openalex.org/W2113654464","https://openalex.org/W2116117181","https://openalex.org/W2119043225","https://openalex.org/W2121893605","https://openalex.org/W2123500593","https://openalex.org/W2124166542","https://openalex.org/W2124285343","https://openalex.org/W2124354935","https://openalex.org/W2124876377","https://openalex.org/W2133138357","https://openalex.org/W2134725489","https://openalex.org/W2136316164","https://openalex.org/W2136850043","https://openalex.org/W2137683543","https://openalex.org/W2137810087","https://openalex.org/W2141885858","https://openalex.org/W2147214562","https://openalex.org/W2149310258","https://openalex.org/W2152336513","https://openalex.org/W2152360905","https://openalex.org/W2157142163","https://openalex.org/W2158266097","https://openalex.org/W2159482845","https://openalex.org/W2159495802","https://openalex.org/W2163296115","https://openalex.org/W2165533101","https://openalex.org/W2166558964","https://openalex.org/W2167120442","https://openalex.org/W2169805130","https://openalex.org/W2174335055","https://openalex.org/W2293997450","https://openalex.org/W2427890794","https://openalex.org/W2753765968","https://openalex.org/W2964646613","https://openalex.org/W3099289621","https://openalex.org/W4210323379","https://openalex.org/W4211177544","https://openalex.org/W4213009331","https://openalex.org/W4233799529","https://openalex.org/W4242156070","https://openalex.org/W4247367207","https://openalex.org/W4285719527","https://openalex.org/W4294216483","https://openalex.org/W6676274861","https://openalex.org/W6697127918","https://openalex.org/W6816238802"],"related_works":["https://openalex.org/W2188500270","https://openalex.org/W2303858293","https://openalex.org/W2798198862","https://openalex.org/W2915512527","https://openalex.org/W51364034","https://openalex.org/W2494523064","https://openalex.org/W2793336762","https://openalex.org/W2091548507","https://openalex.org/W2368816706","https://openalex.org/W2943623134"],"abstract_inverted_index":{"MOTIVATION:":[0],"Proteins":[1],"and":[2,24,162,182,238,251],"protein":[3,33,83,118,124,150,178],"complexes":[4],"coordinate":[5],"their":[6],"activity":[7],"to":[8,115,130,138,148,160,171,200,211,255],"execute":[9],"cellular":[10],"functions.":[11],"In":[12],"a":[13,29,110,127,145,192,220,269,274],"number":[14],"of":[15,32,35,49,64,95,104,123,133,177,186,224,235],"experimental":[16],"settings,":[17],"including":[18],"synthetic":[19],"genetic":[20,22],"arrays,":[21],"perturbations":[23],"RNAi":[25],"screens,":[26],"scientists":[27],"identify":[28],"small":[30,121,128,221],"set":[31,94,122,176,223],"interactions":[34,44,84,125,151,179,217],"interest.":[36],"A":[37,120],"working":[38],"hypothesis":[39],"is":[40,54,169,180,197,249,273,285],"often":[41],"that":[42,156,196,208,265],"these":[43,99],"are":[45],"the":[46,74,88,91,102,105,158,174,184,187],"observable":[47],"phenotypes":[48],"some":[50,245],"functional":[51,76,236],"process,":[52],"which":[53,228],"not":[55],"directly":[56],"observable.":[57],"Confirmatory":[58],"analysis":[59],"requires":[60],"finding":[61,81],"other":[62],"pairs":[63],"proteins":[65,107,189],"whose":[66],"interaction":[67],"may":[68],"be":[69,242,253],"additional":[70,82,216],"phenotypical":[71],"evidence":[72,222],"about":[73],"same":[75],"process.":[77],"Extant":[78],"methods":[79,100],"for":[80,227,278],"rely":[85],"heavily":[86],"on":[87],"information":[89],"in":[90,109,113,153,191,203,214,233],"newly":[92],"identified":[93],"interactions.":[96],"For":[97],"instance,":[98],"leverage":[101],"attributes":[103,185],"individual":[106,188],"directly,":[108],"supervised":[111],"setting,":[112],"order":[114],"find":[116,207],"relevant":[117],"pairs.":[119],"provides":[126],"sample":[129],"train":[131],"parameters":[132],"prediction":[134],"methods,":[135],"thus":[136],"leading":[137],"low":[139],"confidence.":[140,246],"RESULTS:":[141],"We":[142,206],"develop":[143],"RBSets,":[144],"computational":[146,260],"approach":[147,168,248,277],"ranking":[149,194,271],"rooted":[152],"analogical":[154,266],"reasoning;":[155],"is,":[157],"ability":[159],"learn":[161],"generalize":[163],"relations":[164],"between":[165],"objects.":[166],"Our":[167,247,262],"tailored":[170],"situations":[172],"where":[173],"training":[175],"small,":[181],"leverages":[183],"indirectly,":[190],"Bayesian":[193,270],"setting":[195],"perhaps":[198],"closest":[199],"propensity":[201],"scoring":[202],"mathematical":[204],"psychology.":[205],"RBSets":[209],"leads":[210],"good":[212],"performance":[213],"identifying":[215],"starting":[218],"from":[219],"interacting":[225],"proteins,":[226],"an":[229],"underlying":[230],"biological":[231,280],"logic":[232],"terms":[234],"processes":[237],"signaling":[239],"pathways":[240],"can":[241,252],"established":[243],"with":[244,258],"scalable":[250],"applied":[254],"large":[256],"databases":[257],"minimal":[259],"overhead.":[261],"results":[263],"suggest":[264],"reasoning":[267],"within":[268],"problem":[272],"promising":[275],"new":[276],"real-time":[279],"discovery.":[281],"AVAILABILITY:":[282],"Java":[283],"code":[284],"available":[286],"at:":[287],"www.gatsby.ucl.ac.uk/~rbas.":[288],"CONTACT:":[289],"airoldi@fas.harvard.edu;":[290],"kheller@mit.edu;":[291],"ricardo@stats.ucl.ac.uk.":[292]},"counts_by_year":[],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}
