{"id":"https://openalex.org/W2123207418","doi":"https://doi.org/10.1093/bioinformatics/btr207","title":"Template-free detection of macromolecular complexes in cryo electron tomograms","display_name":"Template-free detection of macromolecular complexes in cryo electron tomograms","publication_year":2011,"publication_date":"2011-06-14","ids":{"openalex":"https://openalex.org/W2123207418","doi":"https://doi.org/10.1093/bioinformatics/btr207","mag":"2123207418","pmid":"https://pubmed.ncbi.nlm.nih.gov/21685103"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btr207","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr207","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3117359","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000807861","display_name":"Min Xu","orcid":"https://orcid.org/0000-0002-0881-5891"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Min Xu","raw_affiliation_strings":["1 Program in Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA and 2European Molecular Biology Laboratory, Computational and Structural Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Program in Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA and 2European Molecular Biology Laboratory, Computational and Structural Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028999855","display_name":"Martin Beck","orcid":"https://orcid.org/0000-0002-7397-1321"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Martin Beck","raw_affiliation_strings":["1 Program in Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA and 2European Molecular Biology Laboratory, Computational and Structural Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Program in Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA and 2European Molecular Biology Laboratory, Computational and Structural Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210153543"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045820772","display_name":"Frank Alber","orcid":"https://orcid.org/0000-0003-1981-8390"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Frank Alber","raw_affiliation_strings":["1 Program in Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA and 2European Molecular Biology Laboratory, Computational and Structural Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Program in Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA and 2European Molecular Biology Laboratory, Computational and Structural Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210153543"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":2.8983,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.90858726,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"27","issue":"13","first_page":"i69","last_page":"i76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11897","display_name":"Digital Holography and Microscopy","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryo-electron-tomography","display_name":"Cryo-electron tomography","score":0.8768488168716431},{"id":"https://openalex.org/keywords/electron-tomography","display_name":"Electron tomography","score":0.7412397861480713},{"id":"https://openalex.org/keywords/tomography","display_name":"Tomography","score":0.6490991115570068},{"id":"https://openalex.org/keywords/resolution","display_name":"Resolution (logic)","score":0.5166094899177551},{"id":"https://openalex.org/keywords/low-resolution","display_name":"Low resolution","score":0.5148888826370239},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5003359317779541},{"id":"https://openalex.org/keywords/wedge","display_name":"Wedge (geometry)","score":0.4405818581581116},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.42323848605155945},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.42188745737075806},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.40262192487716675},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.391191303730011},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.38225921988487244},{"id":"https://openalex.org/keywords/high-resolution","display_name":"High resolution","score":0.2717989683151245},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.23460114002227783},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18850553035736084},{"id":"https://openalex.org/keywords/electron-microscope","display_name":"Electron microscope","score":0.1726207435131073},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.16562116146087646},{"id":"https://openalex.org/keywords/geology","display_name":"Geology","score":0.09030187129974365}],"concepts":[{"id":"https://openalex.org/C2777993257","wikidata":"https://www.wikidata.org/wiki/Q904576","display_name":"Cryo-electron tomography","level":3,"score":0.8768488168716431},{"id":"https://openalex.org/C75806775","wikidata":"https://www.wikidata.org/wiki/Q5358194","display_name":"Electron tomography","level":4,"score":0.7412397861480713},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.6490991115570068},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.5166094899177551},{"id":"https://openalex.org/C3019883945","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Low resolution","level":3,"score":0.5148888826370239},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5003359317779541},{"id":"https://openalex.org/C47422493","wikidata":"https://www.wikidata.org/wiki/Q2755127","display_name":"Wedge (geometry)","level":2,"score":0.4405818581581116},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.42323848605155945},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.42188745737075806},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.40262192487716675},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.391191303730011},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.38225921988487244},{"id":"https://openalex.org/C3020199158","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"High resolution","level":2,"score":0.2717989683151245},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.23460114002227783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18850553035736084},{"id":"https://openalex.org/C93877712","wikidata":"https://www.wikidata.org/wiki/Q132560","display_name":"Electron microscope","level":2,"score":0.1726207435131073},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.16562116146087646},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.09030187129974365},{"id":"https://openalex.org/C62649853","wikidata":"https://www.wikidata.org/wiki/Q199687","display_name":"Remote sensing","level":1,"score":0.0},{"id":"https://openalex.org/C193016168","wikidata":"https://www.wikidata.org/wiki/Q874835","display_name":"Scanning transmission electron microscopy","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055032","descriptor_name":"Electron Microscope Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055032","descriptor_name":"Electron Microscope Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055032","descriptor_name":"Electron Microscope Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/btr207","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr207","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21685103","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21685103","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:open-archive.highwire.org:bioinfo:27/13/i69","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org/cgi/content/short/27/13/i69","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:pubmedcentral.nih.gov:3117359","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3117359","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:pure.mpg.de:item_3251067","is_oa":false,"landing_page_url":"http://hdl.handle.net/21.11116/0000-0006-F3E8-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3117359","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3117359","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1624421702","display_name":null,"funder_award_id":"2U54RR022220-06","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2305312581","display_name":null,"funder_award_id":"1R01GM096089","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3130799967","display_name":null,"funder_award_id":"U54 RR022220","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3175111010","display_name":null,"funder_award_id":"R01 GM096089","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7267699545","display_name":null,"funder_award_id":"U54 GM103511","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W10358750","https://openalex.org/W636061944","https://openalex.org/W1492556495","https://openalex.org/W1535035979","https://openalex.org/W1554544485","https://openalex.org/W1561952261","https://openalex.org/W1599786999","https://openalex.org/W1651266332","https://openalex.org/W1798731098","https://openalex.org/W1974978266","https://openalex.org/W1986114210","https://openalex.org/W2003294049","https://openalex.org/W2005008560","https://openalex.org/W2016367858","https://openalex.org/W2021009195","https://openalex.org/W2023056405","https://openalex.org/W2025042015","https://openalex.org/W2054520331","https://openalex.org/W2061835758","https://openalex.org/W2069604928","https://openalex.org/W2095300452","https://openalex.org/W2114318177","https://openalex.org/W2123176293","https://openalex.org/W2125465188","https://openalex.org/W2126919547","https://openalex.org/W2136573752","https://openalex.org/W2141245797","https://openalex.org/W2157548092","https://openalex.org/W2168857415","https://openalex.org/W2247974340","https://openalex.org/W2626517634","https://openalex.org/W2887067015","https://openalex.org/W4213262319","https://openalex.org/W4246408833","https://openalex.org/W4246936399","https://openalex.org/W4255286169","https://openalex.org/W6633448084","https://openalex.org/W6646836459","https://openalex.org/W6674239672"],"related_works":["https://openalex.org/W4391807066","https://openalex.org/W2074590783","https://openalex.org/W2795257615","https://openalex.org/W1991282399","https://openalex.org/W2027708667","https://openalex.org/W1506774439","https://openalex.org/W4239598820","https://openalex.org/W2978863164","https://openalex.org/W2123207418","https://openalex.org/W63087067"],"abstract_inverted_index":{"MOTIVATION:":[0],"Cryo":[1],"electron":[2,62,99,120,151],"tomography":[3],"(CryoET)":[4],"produces":[5,22],"3D":[6,23],"density":[7],"maps":[8],"of":[9,25,29,71,82,92,113,127,142,163,170],"biological":[10],"specimen":[11],"in":[12,47,97,118,175],"its":[13,132],"near":[14],"native":[15],"states.":[16],"Applied":[17],"to":[18,39,59,85,147],"small":[19,69],"cells,":[20],"cryoET":[21],"snapshots":[24],"the":[26,40,60,90,110,128,140,160,164],"cellular":[27],"distributions":[28,169],"large":[30],"complexes.":[31],"However,":[32,64],"retrieving":[33],"this":[34],"information":[35],"is":[36,156],"non-trivial":[37],"due":[38,146],"low":[41,44],"resolution":[42],"and":[43,130,144,150,167],"signal-to-noise":[45],"ratio":[46],"tomograms.":[48,100,121,178],"Current":[49],"pattern":[50],"recognition":[51],"methods":[52,88],"identify":[53],"complexes":[54,74,96,117,174],"by":[55],"matching":[56],"known":[57],"structures":[58],"cryo":[61,98,119],"tomogram.":[63],"so":[65],"far":[66],"only":[67],"a":[68,124,157],"fraction":[70],"all":[72],"protein":[73,95,116],"have":[75,104],"been":[76],"structurally":[77],"resolved.":[78],"It":[79],"is,":[80],"therefore,":[81],"great":[83],"importance":[84],"develop":[86],"template-free":[87,111,161],"for":[89,109,139],"discovery":[91,112,162],"previously":[93,171],"unknown":[94,172],"RESULTS:":[101],"Here,":[102],"we":[103],"developed":[105],"an":[106],"inference":[107],"method":[108,155],"frequently":[114],"occurring":[115],"We":[122],"provide":[123],"first":[125],"proof-of-principle":[126],"approach":[129],"assess":[131],"applicability":[133],"using":[134],"realistically":[135],"simulated":[136],"tomograms,":[137],"allowing":[138],"inclusion":[141],"noise":[143],"distortions":[145],"missing":[148],"wedge":[149],"optical":[152],"factors.":[153],"Our":[154],"step":[158],"toward":[159],"shapes,":[165],"abundance":[166],"spatial":[168],"macromolecular":[173],"whole":[176],"cell":[177],"CONTACT:":[179],"alber@usc.edu":[180]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
