{"id":"https://openalex.org/W2161098179","doi":"https://doi.org/10.1093/bioinformatics/btr061","title":"HLA*IMP\u2014an integrated framework for imputing classical HLA alleles from SNP genotypes","display_name":"HLA*IMP\u2014an integrated framework for imputing classical HLA alleles from SNP genotypes","publication_year":2011,"publication_date":"2011-02-07","ids":{"openalex":"https://openalex.org/W2161098179","doi":"https://doi.org/10.1093/bioinformatics/btr061","mag":"2161098179","pmid":"https://pubmed.ncbi.nlm.nih.gov/21300701"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btr061","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr061","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/7/968/48870034/bioinformatics_27_7_968.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/27/7/968/48870034/bioinformatics_27_7_968.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061035699","display_name":"Alexander Dilthey","orcid":"https://orcid.org/0000-0002-6394-4581"},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexander T. Dilthey","raw_affiliation_strings":["1 Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG and 2Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG and 2Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040035281","display_name":"Loukas Moutsianas","orcid":"https://orcid.org/0000-0001-5453-345X"},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Loukas Moutsianas","raw_affiliation_strings":["1 Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG and 2Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG and 2Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057439502","display_name":"Stephen Leslie","orcid":"https://orcid.org/0000-0003-3511-3470"},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen Leslie","raw_affiliation_strings":["1 Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG and 2Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG and 2Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000481707","display_name":"Gil McVean","orcid":"https://orcid.org/0000-0002-5012-4162"},"institutions":[{"id":"https://openalex.org/I1336263701","display_name":"Centre for Human Genetics","ror":"https://ror.org/01rjnta51","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Gil McVean","raw_affiliation_strings":["1 Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG and 2Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG and 2Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK","institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5000481707"],"corresponding_institution_ids":["https://openalex.org/I1336263701","https://openalex.org/I40120149"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":8.1009,"has_fulltext":false,"cited_by_count":168,"citation_normalized_percentile":{"value":0.98224905,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"27","issue":"7","first_page":"968","last_page":"972"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.24330000579357147,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.24330000579357147,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.19419999420642853,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.18019999563694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-leukocyte-antigen","display_name":"Human leukocyte antigen","score":0.7744539976119995},{"id":"https://openalex.org/keywords/imputation","display_name":"Imputation (statistics)","score":0.76445472240448},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.5785990953445435},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.566730797290802},{"id":"https://openalex.org/keywords/allele","display_name":"Allele","score":0.5230915546417236},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"Linkage disequilibrium","score":0.49924182891845703},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4931482672691345},{"id":"https://openalex.org/keywords/genetic-architecture","display_name":"Genetic architecture","score":0.43955540657043457},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4306778311729431},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.42593914270401},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4165892004966736},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.4140980541706085},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.37639614939689636},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3229191303253174},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.24506348371505737},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.23642948269844055},{"id":"https://openalex.org/keywords/missing-data","display_name":"Missing data","score":0.20524457097053528},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.15424060821533203},{"id":"https://openalex.org/keywords/haplotype","display_name":"Haplotype","score":0.1302585005760193},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10252717137336731}],"concepts":[{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.7744539976119995},{"id":"https://openalex.org/C58041806","wikidata":"https://www.wikidata.org/wiki/Q1660484","display_name":"Imputation (statistics)","level":3,"score":0.76445472240448},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5785990953445435},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.566730797290802},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5230915546417236},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.49924182891845703},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4931482672691345},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.43955540657043457},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4306778311729431},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.42593914270401},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4165892004966736},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4140980541706085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37639614939689636},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3229191303253174},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.24506348371505737},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.23642948269844055},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.20524457097053528},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.15424060821533203},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.1302585005760193},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10252717137336731},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/bioinformatics/btr061","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr061","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/7/968/48870034/bioinformatics_27_7_968.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21300701","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21300701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:uuid:3b8e377f-8ff5-458a-acbf-f97e3844a9a5","is_oa":false,"landing_page_url":"http://bioinformatics.oxfordjournals.org","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:3b8e377f-8ff5-458a-acbf-f97e3844a9a5","is_oa":false,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:3b8e377f-8ff5-458a-acbf-f97e3844a9a5","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:e216d4ba-31b2-47c2-ac69-1225cdd0281d","is_oa":false,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:e216d4ba-31b2-47c2-ac69-1225cdd0281d","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PubMed (http://www.ncbi.nlm.nih.gov/pubmed/)","raw_type":"Journal article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3065693","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3065693","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btr061","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btr061","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/7/968/48870034/bioinformatics_27_7_968.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6700000166893005,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2288589777","display_name":"WTCCC2 core activities","funder_award_id":"085475","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3071845310","display_name":null,"funder_award_id":"068545/Z/02","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7004411822","display_name":"Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics.","funder_award_id":"090532","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8987205718","display_name":"The genetics of weight, BMI, adiposity and obesity","funder_award_id":"076113","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1962960380","https://openalex.org/W1980429964","https://openalex.org/W1981924240","https://openalex.org/W1987882116","https://openalex.org/W1992406580","https://openalex.org/W1992436001","https://openalex.org/W2009444355","https://openalex.org/W2031082289","https://openalex.org/W2036626452","https://openalex.org/W2059251603","https://openalex.org/W2064570445","https://openalex.org/W2065719278","https://openalex.org/W2066874799","https://openalex.org/W2072002631","https://openalex.org/W2075505924","https://openalex.org/W2094092147","https://openalex.org/W2105842551","https://openalex.org/W2119279196","https://openalex.org/W2125838338","https://openalex.org/W2134783591","https://openalex.org/W2140968934","https://openalex.org/W2148568906","https://openalex.org/W2149791927","https://openalex.org/W2152381343","https://openalex.org/W2161633633"],"related_works":["https://openalex.org/W2187968078","https://openalex.org/W1523912222","https://openalex.org/W1480804049","https://openalex.org/W1965385715","https://openalex.org/W4212923765","https://openalex.org/W1998165549","https://openalex.org/W2477193377","https://openalex.org/W2800726709","https://openalex.org/W2131251647","https://openalex.org/W1603579433"],"abstract_inverted_index":{"MOTIVATION:":[0],"Genetic":[1],"variation":[2],"at":[3,147,157,169,176],"classical":[4,26,44,200],"HLA":[5,27,144,201],"alleles":[6,45],"influences":[7],"many":[8],"phenotypes,":[9],"including":[10],"susceptibility":[11],"to":[12,16,86,100,123],"autoimmune":[13],"disease,":[14],"resistance":[15],"pathogens":[17],"and":[18,72,150,167,173,246,252],"the":[19,57,87,170,177,184,208,221,233,239],"risk":[20,202,237],"of":[21,56,128,160,183,188,235],"adverse":[22],"drug":[23],"reactions.":[24],"However,":[25],"typing":[28],"methods":[29],"are":[30],"often":[31],"prohibitively":[32],"expensive":[33],"for":[34,42,154,193,231,255],"large-scale":[35],"studies.":[36],"We":[37,82,180,205],"previously":[38],"described":[39],"a":[40,54,62,78,93,115,125,133,189,198,228],"method":[41,185],"imputing":[43],"from":[46,250],"linked":[47],"SNP":[48,95,219],"genotype":[49],"data.":[50],"Here,":[51],"we":[52,91,113,136],"present":[53,92],"modification":[55],"original":[58,88],"algorithm":[59,119],"implemented":[60,243],"in":[61,106,109,244],"freely":[63],"available":[64,249],"software":[65],"suite":[66],"that":[67,98,120,138,207],"combines":[68],"local":[69],"data":[70],"preparation":[71],"QC":[73],"with":[74,214],"probabilistic":[75],"imputation":[76,162,224],"through":[77,186],"remote":[79],"server.":[80],"RESULTS:":[81],"introduce":[83],"two":[84],"modifications":[85],"algorithm.":[89],"First,":[90],"novel":[94],"selection":[96],"function":[97],"leads":[99],"pronounced":[101],"increases":[102],"(up":[103],"by":[104],"40%":[105],"some":[107],"scenarios)":[108],"call":[110,158],"rate.":[111],"Second,":[112],"develop":[114],"parallelized":[116],"model":[117],"building":[118],"allows":[121],"us":[122],"process":[124],"reference":[126],"set":[127],"over":[129,174],"2500":[130],"individuals.":[131],"In":[132],"validation":[134],"experiment,":[135],"show":[137,206],"our":[139],"framework":[140],"produces":[141],"highly":[142],"accurate":[143],"type":[145],"imputations":[146],"class":[148,151],"I":[149],"II":[152],"loci":[153],"independent":[155],"datasets:":[156],"rates":[159],"95-99%,":[161],"accuracy":[163],"is":[164,197,248,253],"between":[165],"92%":[166],"98%":[168],"four-digit":[171],"level":[172],"97%":[175],"two-digit":[178],"level.":[179],"demonstrate":[181],"utility":[182],"analysis":[187],"genome-wide":[190],"association":[191,213],"study":[192],"psoriasis":[194],"where":[195],"there":[196],"known":[199],"allele":[203,210],"(HLA-C*06:02).":[204],"imputed":[209],"shows":[211],"stronger":[212],"disease":[215],"than":[216],"any":[217],"single":[218],"within":[220,238],"region.":[222],"The":[223],"framework,":[225],"HLA*IMP,":[226,242],"provides":[227],"powerful":[229],"tool":[230],"dissecting":[232],"architecture":[234],"genetic":[236],"HLA.":[240],"AVAILABILITY:":[241],"C++":[245],"Perl,":[247],"http://oxfordhla.well.ox.ac.uk":[251],"free":[254],"academic":[256],"use.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":20}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}
