{"id":"https://openalex.org/W2113953472","doi":"https://doi.org/10.1093/bioinformatics/btq709","title":"Adjustment for local ancestry in genetic association analysis of admixed populations","display_name":"Adjustment for local ancestry in genetic association analysis of admixed populations","publication_year":2010,"publication_date":"2010-12-17","ids":{"openalex":"https://openalex.org/W2113953472","doi":"https://doi.org/10.1093/bioinformatics/btq709","mag":"2113953472","pmid":"https://pubmed.ncbi.nlm.nih.gov/21169375"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btq709","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq709","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/5/670/48865658/bioinformatics_27_5_670.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/27/5/670/48865658/bioinformatics_27_5_670.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101511802","display_name":"Xuexia Wang","orcid":"https://orcid.org/0000-0002-0613-2608"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xuexia Wang","raw_affiliation_strings":["1 Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, 2Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, 3Department of Preventive Medicine and Epidemiology, Loyola University Chicago School of Medicine, Maywood, IL 6015, 4Department of Biology, University of Pennsylvania, PA 19104, 5Department of Biostatistics and 6Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, 2Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, 3Department of Preventive Medicine and Epidemiology, Loyola University Chicago School of Medicine, Maywood, IL 6015, 4Department of Biology, University of Pennsylvania, PA 19104, 5Department of Biostatistics and 6Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I58956616","https://openalex.org/I200719446","https://openalex.org/I1925986","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007766399","display_name":"Xiaofeng Zhu","orcid":"https://orcid.org/0000-0003-0037-411X"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofeng Zhu","raw_affiliation_strings":["1 Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, 2Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, 3Department of Preventive Medicine and Epidemiology, Loyola University Chicago School of Medicine, Maywood, IL 6015, 4Department of Biology, University of Pennsylvania, PA 19104, 5Department of Biostatistics and 6Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, 2Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, 3Department of Preventive Medicine and Epidemiology, Loyola University Chicago School of Medicine, Maywood, IL 6015, 4Department of Biology, University of Pennsylvania, PA 19104, 5Department of Biostatistics and 6Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I58956616","https://openalex.org/I200719446","https://openalex.org/I1925986","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083380474","display_name":"Huaizhen Qin","orcid":"https://orcid.org/0000-0002-3583-7383"},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huaizhen Qin","raw_affiliation_strings":["1 Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, 2Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, 3Department of Preventive Medicine and Epidemiology, Loyola University Chicago School of Medicine, Maywood, IL 6015, 4Department of Biology, University of Pennsylvania, PA 19104, 5Department of Biostatistics and 6Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, 2Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, 3Department of Preventive Medicine and Epidemiology, Loyola University Chicago School of Medicine, Maywood, IL 6015, 4Department of Biology, University of Pennsylvania, PA 19104, 5Department of Biostatistics and 6Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I58956616","https://openalex.org/I200719446","https://openalex.org/I1925986","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070735232","display_name":"Stephen S. Rich","orcid":"https://orcid.org/0000-0003-3872-7793"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard S. Cooper","raw_affiliation_strings":["1 Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, 2Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, 3Department of Preventive Medicine and Epidemiology, Loyola University Chicago School of Medicine, Maywood, IL 6015, 4Department of Biology, University of Pennsylvania, PA 19104, 5Department of Biostatistics and 6Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, 2Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, 3Department of Preventive Medicine and Epidemiology, Loyola University Chicago School of Medicine, Maywood, IL 6015, 4Department of Biology, University of Pennsylvania, PA 19104, 5Department of Biostatistics and 6Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I58956616","https://openalex.org/I200719446","https://openalex.org/I1925986","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109451252","display_name":"Warren J. Ewens","orcid":null},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warren J. Ewens","raw_affiliation_strings":["1 Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, 2Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, 3Department of Preventive Medicine and Epidemiology, Loyola University Chicago School of Medicine, Maywood, IL 6015, 4Department of Biology, University of Pennsylvania, PA 19104, 5Department of Biostatistics and 6Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, 2Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, 3Department of Preventive Medicine and Epidemiology, Loyola University Chicago School of Medicine, Maywood, IL 6015, 4Department of Biology, University of Pennsylvania, PA 19104, 5Department of Biostatistics and 6Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I58956616","https://openalex.org/I200719446","https://openalex.org/I1925986","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031811109","display_name":"Chun Li","orcid":"https://orcid.org/0000-0002-8819-2443"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chun Li","raw_affiliation_strings":["1 Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, 2Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, 3Department of Preventive Medicine and Epidemiology, Loyola University Chicago School of Medicine, Maywood, IL 6015, 4Department of Biology, University of Pennsylvania, PA 19104, 5Department of Biostatistics and 6Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, 2Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, 3Department of Preventive Medicine and Epidemiology, Loyola University Chicago School of Medicine, Maywood, IL 6015, 4Department of Biology, University of Pennsylvania, PA 19104, 5Department of Biostatistics and 6Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I58956616","https://openalex.org/I200719446","https://openalex.org/I1925986","https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001685590","display_name":"Mingyao Li","orcid":"https://orcid.org/0000-0003-2422-9494"},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingyao Li","raw_affiliation_strings":["1 Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, 2Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, 3Department of Preventive Medicine and Epidemiology, Loyola University Chicago School of Medicine, Maywood, IL 6015, 4Department of Biology, University of Pennsylvania, PA 19104, 5Department of Biostatistics and 6Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, 2Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, 3Department of Preventive Medicine and Epidemiology, Loyola University Chicago School of Medicine, Maywood, IL 6015, 4Department of Biology, University of Pennsylvania, PA 19104, 5Department of Biostatistics and 6Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I58956616","https://openalex.org/I200719446","https://openalex.org/I1925986","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5101511802"],"corresponding_institution_ids":["https://openalex.org/I1925986","https://openalex.org/I200719446","https://openalex.org/I58956616","https://openalex.org/I79576946"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.9836,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.9418525,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"27","issue":"5","first_page":"670","last_page":"677"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/population-stratification","display_name":"Population stratification","score":0.8827220797538757},{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.8259966373443604},{"id":"https://openalex.org/keywords/ancestry-informative-marker","display_name":"Ancestry-informative marker","score":0.7138030529022217},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.5981091260910034},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5820092558860779},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.561118483543396},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5409030318260193},{"id":"https://openalex.org/keywords/association-test","display_name":"Association test","score":0.5347465872764587},{"id":"https://openalex.org/keywords/genetic-genealogy","display_name":"Genetic genealogy","score":0.5318400859832764},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.5318175554275513},{"id":"https://openalex.org/keywords/locus","display_name":"Locus (genetics)","score":0.5074781775474548},{"id":"https://openalex.org/keywords/logistic-regression","display_name":"Logistic regression","score":0.4754452407360077},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"Allele frequency","score":0.46062368154525757},{"id":"https://openalex.org/keywords/type-i-and-type-ii-errors","display_name":"Type I and type II errors","score":0.44898396730422974},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.44600924849510193},{"id":"https://openalex.org/keywords/allele","display_name":"Allele","score":0.35816383361816406},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.3381046652793884},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.28439605236053467},{"id":"https://openalex.org/keywords/demography","display_name":"Demography","score":0.19905367493629456},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1531296968460083}],"concepts":[{"id":"https://openalex.org/C166976648","wikidata":"https://www.wikidata.org/wiki/Q7229824","display_name":"Population stratification","level":5,"score":0.8827220797538757},{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.8259966373443604},{"id":"https://openalex.org/C137132547","wikidata":"https://www.wikidata.org/wiki/Q4752570","display_name":"Ancestry-informative marker","level":5,"score":0.7138030529022217},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5981091260910034},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5820092558860779},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.561118483543396},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5409030318260193},{"id":"https://openalex.org/C2994538360","wikidata":"https://www.wikidata.org/wiki/Q774081","display_name":"Association test","level":5,"score":0.5347465872764587},{"id":"https://openalex.org/C75069973","wikidata":"https://www.wikidata.org/wiki/Q913584","display_name":"Genetic genealogy","level":3,"score":0.5318400859832764},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.5318175554275513},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5074781775474548},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4754452407360077},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.46062368154525757},{"id":"https://openalex.org/C40696583","wikidata":"https://www.wikidata.org/wiki/Q989120","display_name":"Type I and type II errors","level":2,"score":0.44898396730422974},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44600924849510193},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.35816383361816406},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3381046652793884},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.28439605236053467},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.19905367493629456},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1531296968460083},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/btq709","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq709","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/5/670/48865658/bioinformatics_27_5_670.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21169375","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21169375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:info:ark/67531/metadc1757985","is_oa":false,"landing_page_url":"https://digital.library.unt.edu/ark:/67531/metadc1757985/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400792","display_name":"University of North Texas Digital Library (University of North Texas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I123534392","host_organization_name":"University of North Texas","host_organization_lineage":["https://openalex.org/I123534392"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of North Texas Transdisciplinary Conference on Ancestral Genomics Research, November 20-21, 2020.","raw_type":"Video"},{"id":"pmh:oai:repository.lsu.edu:animalsciences_pubs-2725","is_oa":false,"landing_page_url":"https://repository.lsu.edu/animalsciences_pubs/1726","pdf_url":null,"source":{"id":"https://openalex.org/S4210169993","display_name":"Civil War Book Review","issn_l":"1528-6592","issn":["1528-6592"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310315936","host_organization_name":"Louisiana State University","host_organization_lineage":["https://openalex.org/P4310315936"],"host_organization_lineage_names":["Louisiana State University"],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Publications","raw_type":"text"},{"id":"pmh:oai:europepmc.org:2297196","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3042179","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btq709","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq709","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/5/670/48865658/bioinformatics_27_5_670.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7119546023","display_name":null,"funder_award_id":"HG003054","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2113953472.pdf","grobid_xml":"https://content.openalex.org/works/W2113953472.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W48750798","https://openalex.org/W1513122788","https://openalex.org/W1968830266","https://openalex.org/W1974251657","https://openalex.org/W2001115778","https://openalex.org/W2003298782","https://openalex.org/W2008047653","https://openalex.org/W2009588715","https://openalex.org/W2009766041","https://openalex.org/W2025253353","https://openalex.org/W2041593701","https://openalex.org/W2047923046","https://openalex.org/W2058793433","https://openalex.org/W2061585692","https://openalex.org/W2063097062","https://openalex.org/W2064902628","https://openalex.org/W2082043949","https://openalex.org/W2083333719","https://openalex.org/W2084087573","https://openalex.org/W2096303238","https://openalex.org/W2098460741","https://openalex.org/W2106400350","https://openalex.org/W2114688149","https://openalex.org/W2116777908","https://openalex.org/W2123431154","https://openalex.org/W2127831643","https://openalex.org/W2134070988","https://openalex.org/W2135151366","https://openalex.org/W2142979316","https://openalex.org/W2153622221","https://openalex.org/W2157752701","https://openalex.org/W2162854231","https://openalex.org/W2167587120","https://openalex.org/W2169421412","https://openalex.org/W2171074980","https://openalex.org/W2171838950","https://openalex.org/W6601970815","https://openalex.org/W6643777041"],"related_works":["https://openalex.org/W2532802395","https://openalex.org/W2141828160","https://openalex.org/W4320495329","https://openalex.org/W2101633780","https://openalex.org/W2099248143","https://openalex.org/W2152011247","https://openalex.org/W1995515413","https://openalex.org/W2143211805","https://openalex.org/W2054618048","https://openalex.org/W1986915561"],"abstract_inverted_index":{"We":[0,26,72,147],"show":[1],"that":[2,29,79,153],"local":[3,32,55,82,144,181],"ancestry":[4,33,58,65,145,182],"at":[5,34],"a":[6,90],"test":[7,36,86,100,114],"single":[8],"nucleotide":[9],"polymorphism":[10],"(SNP)":[11],"may":[12,68],"confound":[13],"with":[14,141],"the":[15,35,42,47,96,99,126,154,166],"association":[16,44,77,124],"signal":[17],"and":[18,105,151],"ignoring":[19],"it":[20],"can":[21],"lead":[22],"to":[23,40,54,119,180],"spurious":[24,43],"association.":[25],"demonstrate":[27],"theoretically":[28],"adjustment":[30,66,142,168],"for":[31,81,143],"SNP":[37,101],"is":[38,87,133,136,178],"sufficient":[39],"remove":[41],"regardless":[45],"of":[46,49,98,112,123,159],"mechanism":[48],"population":[50],"stratification,":[51],"whether":[52],"due":[53,179],"or":[56],"global":[57,64,167],"differences":[59],"among":[60],"study":[61],"subjects;":[62],"however,":[63,165],"procedures":[67,169],"not":[69],"be":[70],"effective.":[71],"further":[73],"develop":[74],"two":[75],"novel":[76],"tests":[78,161],"adjust":[80],"ancestry.":[83],"Our":[84,129],"first":[85],"based":[88,137],"on":[89,138],"conditional":[91],"likelihood":[92],"framework":[93],"which":[94,132],"models":[95],"distribution":[97],"given":[102],"disease":[103],"status":[104],"flanking":[106],"marker":[107],"genotypes.":[108],"A":[109],"key":[110],"advantage":[111],"this":[113],"lies":[115],"in":[116,125],"its":[117],"ability":[118],"incorporate":[120],"different":[121],"directions":[122],"ancestral":[127],"populations.":[128],"second":[130],"test,":[131],"computationally":[134],"simpler,":[135],"logistic":[139],"regression,":[140],"proportion.":[146],"conducted":[148],"extensive":[149],"simulations":[150],"found":[152],"Type":[155,172],"I":[156,173],"error":[157,174],"rates":[158,175],"our":[160],"are":[162],"under":[163],"control;":[164],"yielded":[170],"inflated":[171],"when":[176],"stratification":[177],"difference.":[183]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}