{"id":"https://openalex.org/W2167759499","doi":"https://doi.org/10.1093/bioinformatics/btq704","title":"Statistical analysis of the cancer cell's molecular entropy using high-throughput data","display_name":"Statistical analysis of the cancer cell's molecular entropy using high-throughput data","publication_year":2010,"publication_date":"2010-12-20","ids":{"openalex":"https://openalex.org/W2167759499","doi":"https://doi.org/10.1093/bioinformatics/btq704","mag":"2167759499","pmid":"https://pubmed.ncbi.nlm.nih.gov/21172912"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btq704","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq704","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/4/556/48865201/bioinformatics_27_4_556.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/27/4/556/48865201/bioinformatics_27_4_556.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090122358","display_name":"Wessel N. van Wieringen","orcid":"https://orcid.org/0000-0002-5100-9123"},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Wessel N. van Wieringen","raw_affiliation_strings":["1 Department of Epidemiology and Biostatistics, VU University Medical Center, PO Box 7075, 1007 MB Amsterdam and 2Department of Mathematics, VU University Amsterdam, De Boelelaan 1081a, 1081 HV Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Epidemiology and Biostatistics, VU University Medical Center, PO Box 7075, 1007 MB Amsterdam and 2Department of Mathematics, VU University Amsterdam, De Boelelaan 1081a, 1081 HV Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015126561","display_name":"Aad van der Vaart","orcid":"https://orcid.org/0000-0002-8074-2375"},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Aad W. van der Vaart","raw_affiliation_strings":["1 Department of Epidemiology and Biostatistics, VU University Medical Center, PO Box 7075, 1007 MB Amsterdam and 2Department of Mathematics, VU University Amsterdam, De Boelelaan 1081a, 1081 HV Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Epidemiology and Biostatistics, VU University Medical Center, PO Box 7075, 1007 MB Amsterdam and 2Department of Mathematics, VU University Amsterdam, De Boelelaan 1081a, 1081 HV Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090122358"],"corresponding_institution_ids":["https://openalex.org/I911458345"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.0739,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.76603459,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"27","issue":"4","first_page":"556","last_page":"563"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.44699999690055847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.44699999690055847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.10999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.08869999647140503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5573703050613403},{"id":"https://openalex.org/keywords/entropy","display_name":"Entropy (arrow of time)","score":0.5203182697296143},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.5003025531768799},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4966889023780823},{"id":"https://openalex.org/keywords/genome-instability","display_name":"Genome instability","score":0.4488796889781952},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.3928278386592865},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3911081552505493},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.38356125354766846},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.35638192296028137},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.20962288975715637},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.11828002333641052},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.0904618501663208}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5573703050613403},{"id":"https://openalex.org/C106301342","wikidata":"https://www.wikidata.org/wiki/Q4117933","display_name":"Entropy (arrow of time)","level":2,"score":0.5203182697296143},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5003025531768799},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4966889023780823},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.4488796889781952},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3928278386592865},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3911081552505493},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38356125354766846},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35638192296028137},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20962288975715637},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11828002333641052},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.0904618501663208},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/btq704","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq704","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/4/556/48865201/bioinformatics_27_4_556.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:21172912","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21172912","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pure.amsterdamumc.nl:publications/f6523923-6ef6-4b61-b9ce-c4b767ae9e5e","is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/f6523923-6ef6-4b61-b9ce-c4b767ae9e5e","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"van Wieringen, W N & van der Vaart, A W 2011, 'Statistical analysis of the cancer cell's molecular entropy using high-throughput data', Bioinformatics, vol. 27, no. 4, pp. 556-563. https://doi.org/10.1093/bioinformatics/btq704","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vu:oai:research.vu.nl:publications/38bb3508-a672-4610-8f09-9ab535fa6f74","is_oa":false,"landing_page_url":"https://research.vu.nl/en/publications/38bb3508-a672-4610-8f09-9ab535fa6f74","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, 27(4), 556 - 563. Oxford University Press","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/4593a53c-1b9f-4d5e-a81b-5a51d5198bae","is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/4593a53c-1b9f-4d5e-a81b-5a51d5198bae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, 27(4), 556 - 563. Oxford University Press","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btq704","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq704","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/4/556/48865201/bioinformatics_27_4_556.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2167759499.pdf","grobid_xml":"https://content.openalex.org/works/W2167759499.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W102481553","https://openalex.org/W1501929801","https://openalex.org/W1526512085","https://openalex.org/W1967342065","https://openalex.org/W1990512452","https://openalex.org/W1997750495","https://openalex.org/W2001258296","https://openalex.org/W2001607987","https://openalex.org/W2021449999","https://openalex.org/W2034269086","https://openalex.org/W2036506152","https://openalex.org/W2059300459","https://openalex.org/W2061908600","https://openalex.org/W2092939357","https://openalex.org/W2096020932","https://openalex.org/W2099111195","https://openalex.org/W2107914009","https://openalex.org/W2110782761","https://openalex.org/W2123558100","https://openalex.org/W2138582512","https://openalex.org/W2150879893","https://openalex.org/W2152147560","https://openalex.org/W2154361640","https://openalex.org/W2159482845","https://openalex.org/W2170989872","https://openalex.org/W2197405840","https://openalex.org/W2199776355","https://openalex.org/W2478708596","https://openalex.org/W2528181771","https://openalex.org/W2530014580","https://openalex.org/W2797816625","https://openalex.org/W4242813980","https://openalex.org/W4245582419","https://openalex.org/W4245662196","https://openalex.org/W6604199897","https://openalex.org/W6728433533"],"related_works":["https://openalex.org/W2399513595","https://openalex.org/W4388386498","https://openalex.org/W2953814733","https://openalex.org/W2056369119","https://openalex.org/W2028462563","https://openalex.org/W1981667064","https://openalex.org/W2942994004","https://openalex.org/W4235840235","https://openalex.org/W1984825396","https://openalex.org/W3155641129"],"abstract_inverted_index":{"MOTIVATION:":[0],"As":[1],"cancer":[2,37,49,64,71,139],"progresses,":[3],"DNA":[4],"copy":[5,90],"number":[6],"aberrations":[7],"accumulate":[8],"and":[9,51,112,134,141],"the":[10,36,43,52,59,63,68,107,110,132,142,146],"genomic":[11,111,133,143],"entropy":[12,56,83,95,114,144,148],"(chromosomal":[13],"disorganization)":[14],"increases.":[15],"For":[16],"this":[17,124],"surge":[18],"to":[19,93,105,152],"have":[20],"any":[21],"oncogenetic":[22],"effect,":[23],"it":[24],"should":[25],"(to":[26],"some":[27,80],"extent)":[28],"be":[29],"reflected":[30],"at":[31],"other":[32],"molecular":[33,60],"levels":[34,61],"of":[35,42,48,54,62,70,119],"cell,":[38],"in":[39,85,97],"particular":[40],"that":[41,78],"transcriptome.":[44],"Such":[45],"a":[46,127],"coincidence":[47],"progression":[50],"propagation":[53],"an":[55,82,94],"increase":[57,84,96],"through":[58],"cell":[65],"would":[66],"enhance":[67],"understanding":[69],"evolution.":[72],"RESULTS:":[73],"A":[74],"statistical":[75],"argument":[76],"reveals":[77],"(under":[79],"assumptions)":[81],"one":[86],"random":[87],"variable":[88],"(DNA":[89],"number)":[91],"leads":[92],"another":[98],"(gene":[99],"expression).":[100],"Statistical":[101],"methodology":[102,125],"is":[103,149],"provided":[104],"investigate":[106],"relation":[108,130],"between":[109],"transcriptomic":[113,135,147],"using":[115,123],"high-throughput":[116,121],"data.":[117],"Analyses":[118],"multiple":[120],"datasets":[122],"show":[126],"close,":[128],"concordant":[129],"among":[131],"entropy.":[136],"Hence,":[137],"as":[138],"evolves,":[140],"increases,":[145],"also":[150],"expected":[151],"surge.":[153]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}
