{"id":"https://openalex.org/W2120204563","doi":"https://doi.org/10.1093/bioinformatics/btq628","title":"Predicting <i>in vitro</i> drug sensitivity using Random Forests","display_name":"Predicting <i>in vitro</i> drug sensitivity using Random Forests","publication_year":2010,"publication_date":"2010-12-05","ids":{"openalex":"https://openalex.org/W2120204563","doi":"https://doi.org/10.1093/bioinformatics/btq628","mag":"2120204563"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btq628","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq628","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/2/220/48866858/bioinformatics_27_2_220.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/27/2/220/48866858/bioinformatics_27_2_220.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023268676","display_name":"Gregory Riddick","orcid":null},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory Riddick","raw_affiliation_strings":["1 Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD and 2Carnegie-Mellon University, Pittsburgh, PA, USA"],"affiliations":[{"raw_affiliation_string":"1 Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD and 2Carnegie-Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210110767","https://openalex.org/I1299303238","https://openalex.org/I74973139","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081985656","display_name":"Hua Song","orcid":"https://orcid.org/0000-0002-1857-2440"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Song","raw_affiliation_strings":["1 Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD and 2Carnegie-Mellon University, Pittsburgh, PA, USA"],"affiliations":[{"raw_affiliation_string":"1 Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD and 2Carnegie-Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210110767","https://openalex.org/I1299303238","https://openalex.org/I74973139","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055902091","display_name":"Susie Ahn","orcid":null},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susie Ahn","raw_affiliation_strings":["1 Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD and 2Carnegie-Mellon University, Pittsburgh, PA, USA"],"affiliations":[{"raw_affiliation_string":"1 Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD and 2Carnegie-Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210110767","https://openalex.org/I1299303238","https://openalex.org/I74973139","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044640876","display_name":"Jennifer Walling","orcid":"https://orcid.org/0000-0003-0591-1287"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Walling","raw_affiliation_strings":["1 Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD and 2Carnegie-Mellon University, Pittsburgh, PA, USA"],"affiliations":[{"raw_affiliation_string":"1 Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD and 2Carnegie-Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210110767","https://openalex.org/I1299303238","https://openalex.org/I74973139","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066024863","display_name":"Diego Borges-Rivera","orcid":"https://orcid.org/0000-0002-1650-2289"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diego Borges-Rivera","raw_affiliation_strings":["1 Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD and 2Carnegie-Mellon University, Pittsburgh, PA, USA"],"affiliations":[{"raw_affiliation_string":"1 Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD and 2Carnegie-Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210110767","https://openalex.org/I1299303238","https://openalex.org/I74973139","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118983736","display_name":"Wei Zhang","orcid":"https://orcid.org/0009-0007-9625-1697"},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["1 Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD and 2Carnegie-Mellon University, Pittsburgh, PA, USA"],"affiliations":[{"raw_affiliation_string":"1 Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD and 2Carnegie-Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210110767","https://openalex.org/I1299303238","https://openalex.org/I74973139","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045925835","display_name":"Howard A. Fine","orcid":"https://orcid.org/0000-0002-6169-5702"},"institutions":[{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard A. Fine","raw_affiliation_strings":["1 Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD and 2Carnegie-Mellon University, Pittsburgh, PA, USA"],"affiliations":[{"raw_affiliation_string":"1 Neuro-Oncology Branch, National Cancer Institute, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD and 2Carnegie-Mellon University, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210110767","https://openalex.org/I1299303238","https://openalex.org/I74973139","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5023268676"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767","https://openalex.org/I4210140884","https://openalex.org/I74973139"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.758,"has_fulltext":true,"cited_by_count":181,"citation_normalized_percentile":{"value":0.84282244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"27","issue":"2","first_page":"220","last_page":"224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9853000044822693,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.7385543584823608},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5862494707107544},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.49008309841156006},{"id":"https://openalex.org/keywords/cart","display_name":"Cart","score":0.46195271611213684},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4578186273574829},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.44601866602897644},{"id":"https://openalex.org/keywords/drug-response","display_name":"Drug response","score":0.4241673946380615},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.42260003089904785},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.41588056087493896},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.40827101469039917},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3913300633430481},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3578411936759949},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3544612228870392},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.23932677507400513},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21700680255889893},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.17578774690628052},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15055859088897705},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.11874091625213623},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09065082669258118}],"concepts":[{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.7385543584823608},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5862494707107544},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.49008309841156006},{"id":"https://openalex.org/C2777275308","wikidata":"https://www.wikidata.org/wiki/Q234668","display_name":"Cart","level":2,"score":0.46195271611213684},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4578186273574829},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.44601866602897644},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.4241673946380615},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42260003089904785},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.41588056087493896},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.40827101469039917},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3913300633430481},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3578411936759949},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3544612228870392},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23932677507400513},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21700680255889893},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.17578774690628052},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15055859088897705},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11874091625213623},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09065082669258118},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btq628","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq628","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/2/220/48866858/bioinformatics_27_2_220.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2264501","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3018816","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btq628","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq628","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/27/2/220/48866858/bioinformatics_27_2_220.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4099999964237213}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2120204563.pdf","grobid_xml":"https://content.openalex.org/works/W2120204563.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W273955616","https://openalex.org/W1520812622","https://openalex.org/W2027542963","https://openalex.org/W2033525264","https://openalex.org/W2050377304","https://openalex.org/W2087312216","https://openalex.org/W2098426299","https://openalex.org/W2102435984","https://openalex.org/W2107515803","https://openalex.org/W2122128696","https://openalex.org/W2128066516","https://openalex.org/W2136079102","https://openalex.org/W2149453908","https://openalex.org/W2911964244","https://openalex.org/W6610017368"],"related_works":["https://openalex.org/W4220854656","https://openalex.org/W1986892844","https://openalex.org/W2490137852","https://openalex.org/W3023720143","https://openalex.org/W4310366902","https://openalex.org/W170658859","https://openalex.org/W3141198878","https://openalex.org/W2056932428","https://openalex.org/W1483316219","https://openalex.org/W2412120523"],"abstract_inverted_index":{"Abstract":[0],"Motivation:":[1],"Panels":[2],"of":[3,26,50,76,105],"cell":[4,54,112],"lines":[5,55],"such":[6],"as":[7,162],"the":[8,48,58,146,163],"NCI-60":[9],"have":[10,31],"long":[11],"been":[12,33],"used":[13],"to":[14,21,131,136],"test":[15],"drug":[16,29,51,77,99,159],"candidates":[17],"for":[18,53,101,126],"their":[19],"ability":[20],"inhibit":[22],"proliferation.":[23],"Predictive":[24],"models":[25,46,75],"in":[27,57,97,145],"vitro":[28],"sensitivity":[30],"previously":[32],"constructed":[34],"using":[35,79],"gene":[36,41,120,133,156],"expression":[37,42,134,157],"signatures":[38],"generated":[39],"from":[40],"microarrays.":[43],"These":[44],"statistical":[45],"allow":[47],"prediction":[49],"response":[52,78,100,160],"not":[56],"original":[59],"NCI-60.":[60],"We":[61],"improve":[62],"on":[63,86,118],"existing":[64],"techniques":[65],"by":[66],"developing":[67],"a":[68,103,137],"novel":[69],"multistep":[70],"algorithm":[71],"that":[72,129],"builds":[73],"regression":[74,89],"Random":[80],"Forest,":[81],"an":[82],"ensemble":[83],"approach":[84],"based":[85,117],"classification":[87],"and":[88,109,122,149,158],"trees":[90],"(CART).":[91],"Results:":[92],"This":[93],"method":[94],"proved":[95],"successful":[96],"predicting":[98],"both":[102],"panel":[104],"19":[106],"Breast":[107],"Cancer":[108],"7":[110],"Glioma":[111],"lines,":[113],"outperformed":[114],"other":[115],"methods":[116],"differential":[119],"expression,":[121],"has":[123],"general":[124],"utility":[125],"any":[127],"application":[128],"seeks":[130],"relate":[132],"data":[135,161,173],"continuous":[138],"output":[139],"variable.":[140],"Implementation:":[141],"Software":[142],"was":[143],"written":[144],"R":[147],"language":[148],"will":[150],"be":[151],"available":[152,175],"together":[153],"with":[154],"associated":[155],"package":[164],"ivDrug":[165],"at":[166,176],"http://r-forge.r-project.org.":[167],"Contact:":[168],"riddickgp@mail.nih.gov":[169],"Supplementary":[170,172],"Information:":[171],"are":[174],"Bioinformatics":[177],"online.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":34},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-03-26T15:22:09.906841","created_date":"2016-06-24T00:00:00"}