{"id":"https://openalex.org/W2127261350","doi":"https://doi.org/10.1093/bioinformatics/btq527","title":"Sequencing delivers diminishing returns for homology detection: implications for mapping the protein universe","display_name":"Sequencing delivers diminishing returns for homology detection: implications for mapping the protein universe","publication_year":2010,"publication_date":"2010-09-15","ids":{"openalex":"https://openalex.org/W2127261350","doi":"https://doi.org/10.1093/bioinformatics/btq527","mag":"2127261350","pmid":"https://pubmed.ncbi.nlm.nih.gov/20843957"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btq527","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq527","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/21/2664/48852124/bioinformatics_26_21_2664.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/26/21/2664/48852124/bioinformatics_26_21_2664.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084782084","display_name":"Daniel Chubb","orcid":"https://orcid.org/0000-0002-3813-0981"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Daniel Chubb","raw_affiliation_strings":["Department of Life Science, Imperial College London, London, UK"],"affiliations":[{"raw_affiliation_string":"Department of Life Science, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070368103","display_name":"Benjamin R. Jefferys","orcid":null},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Benjamin R. Jefferys","raw_affiliation_strings":["Department of Life Science, Imperial College London, London, UK"],"affiliations":[{"raw_affiliation_string":"Department of Life Science, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023619547","display_name":"Michael J.E. Sternberg","orcid":"https://orcid.org/0000-0002-1884-5445"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael J. E. Sternberg","raw_affiliation_strings":["Department of Life Science, Imperial College London, London, UK"],"affiliations":[{"raw_affiliation_string":"Department of Life Science, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000287650","display_name":"Lawrence A. Kelley","orcid":"https://orcid.org/0000-0002-3210-2656"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lawrence A. Kelley","raw_affiliation_strings":["Department of Life Science, Imperial College London, London, UK"],"affiliations":[{"raw_affiliation_string":"Department of Life Science, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5084782084"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.8976,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.85443402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"26","issue":"21","first_page":"2664","last_page":"2671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5631914734840393},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5577625036239624},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.519332766532898},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.470927894115448},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.4700183868408203},{"id":"https://openalex.org/keywords/homology","display_name":"Homology (biology)","score":0.46153414249420166},{"id":"https://openalex.org/keywords/universe","display_name":"Universe","score":0.45958369970321655},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.43676960468292236},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.36553919315338135},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.28256648778915405},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1503937840461731}],"concepts":[{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5631914734840393},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5577625036239624},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.519332766532898},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.470927894115448},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4700183868408203},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.46153414249420166},{"id":"https://openalex.org/C84999194","wikidata":"https://www.wikidata.org/wiki/Q1","display_name":"Universe","level":2,"score":0.45958369970321655},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.43676960468292236},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36553919315338135},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28256648778915405},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1503937840461731},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btq527","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq527","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/21/2664/48852124/bioinformatics_26_21_2664.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20843957","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20843957","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1298330","is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1298330/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"   BIOINFORMATICS , 26  (21)   2664 - 2671.   (2010)      ","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btq527","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq527","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/21/2664/48852124/bioinformatics_26_21_2664.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","score":0.4300000071525574,"id":"https://metadata.un.org/sdg/17"}],"awards":[{"id":"https://openalex.org/G5403572220","display_name":null,"funder_award_id":"BB/G003912/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6677488832","display_name":null,"funder_award_id":"BB/G022569/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2127261350.pdf","grobid_xml":"https://content.openalex.org/works/W2127261350.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1561365779","https://openalex.org/W1791999417","https://openalex.org/W1810634920","https://openalex.org/W1976514666","https://openalex.org/W1984497398","https://openalex.org/W1986347357","https://openalex.org/W1992502768","https://openalex.org/W2036845870","https://openalex.org/W2042033548","https://openalex.org/W2056930789","https://openalex.org/W2060259273","https://openalex.org/W2060393639","https://openalex.org/W2076048958","https://openalex.org/W2085277871","https://openalex.org/W2097744604","https://openalex.org/W2110434201","https://openalex.org/W2113231090","https://openalex.org/W2115843776","https://openalex.org/W2118597789","https://openalex.org/W2120251063","https://openalex.org/W2121125726","https://openalex.org/W2125555860","https://openalex.org/W2130956021","https://openalex.org/W2135083016","https://openalex.org/W2136430304","https://openalex.org/W2145268834","https://openalex.org/W2145358391","https://openalex.org/W2155520400","https://openalex.org/W2156125289","https://openalex.org/W2158714788","https://openalex.org/W2161062388","https://openalex.org/W2161732286","https://openalex.org/W2163000619","https://openalex.org/W2166995419","https://openalex.org/W2915868289","https://openalex.org/W4211000692","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2086525401","https://openalex.org/W2006735166","https://openalex.org/W2079327011","https://openalex.org/W2053325634","https://openalex.org/W3178279768","https://openalex.org/W193851735","https://openalex.org/W2773861473","https://openalex.org/W1971903861","https://openalex.org/W3047903919","https://openalex.org/W40194678"],"abstract_inverted_index":{"We":[0,57],"have":[1],"plotted":[2],"our":[3,63],"progress":[4],"in":[5,23,55],"protein":[6,71],"sequencing":[7],"over":[8],"the":[9,16,31,44,70],"last":[10],"two":[11],"decades":[12],"and":[13,73],"found":[14],"that":[15],"rate":[17],"of":[18,27,46,69],"novel":[19,47],"sequence":[20,48],"discovery":[21],"is":[22,50],"a":[24,53,66],"sustained":[25],"period":[26],"decline.":[28],"Consequently,":[29],"PSI-BLAST,":[30],"most":[32],"widely":[33],"used":[34],"method":[35],"to":[36,65],"detect":[37],"remote":[38],"evolutionary":[39],"relationships,":[40],"which":[41],"relies":[42],"upon":[43],"accumulation":[45],"data,":[49],"now":[51],"showing":[52],"plateau":[54],"performance.":[56],"interpret":[58],"this":[59],"trend":[60],"as":[61],"signalling":[62],"approach":[64],"representative":[67],"map":[68],"universe":[72],"discuss":[74],"its":[75],"implications.":[76]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}
