{"id":"https://openalex.org/W2129908184","doi":"https://doi.org/10.1093/bioinformatics/btq456","title":"A Bayesian method for 3D macromolecular structure inference using class average images from single particle electron microscopy","display_name":"A Bayesian method for 3D macromolecular structure inference using class average images from single particle electron microscopy","publication_year":2010,"publication_date":"2010-08-11","ids":{"openalex":"https://openalex.org/W2129908184","doi":"https://doi.org/10.1093/bioinformatics/btq456","mag":"2129908184","pmid":"https://pubmed.ncbi.nlm.nih.gov/20702397"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btq456","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq456","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112445699","display_name":"Navdeep Jaitly","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Navdeep Jaitly","raw_affiliation_strings":["1 Department of Computer Science, University of Toronto, 2Molecular Structure and Function Program, The Hospital for Sick Children Research Institute, 3Department of Biochemistry and 4Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Computer Science, University of Toronto, 2Molecular Structure and Function Program, The Hospital for Sick Children Research Institute, 3Department of Biochemistry and 4Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069522766","display_name":"Marcus A. Brubaker","orcid":"https://orcid.org/0000-0002-7892-9026"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcus A. Brubaker","raw_affiliation_strings":["1 Department of Computer Science, University of Toronto, 2Molecular Structure and Function Program, The Hospital for Sick Children Research Institute, 3Department of Biochemistry and 4Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Computer Science, University of Toronto, 2Molecular Structure and Function Program, The Hospital for Sick Children Research Institute, 3Department of Biochemistry and 4Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044073683","display_name":"John L. Rubinstein","orcid":"https://orcid.org/0000-0003-0566-2209"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John L. Rubinstein","raw_affiliation_strings":["1 Department of Computer Science, University of Toronto, 2Molecular Structure and Function Program, The Hospital for Sick Children Research Institute, 3Department of Biochemistry and 4Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Computer Science, University of Toronto, 2Molecular Structure and Function Program, The Hospital for Sick Children Research Institute, 3Department of Biochemistry and 4Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071031693","display_name":"Ryan Lilien","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryan H. Lilien","raw_affiliation_strings":["1 Department of Computer Science, University of Toronto, 2Molecular Structure and Function Program, The Hospital for Sick Children Research Institute, 3Department of Biochemistry and 4Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Computer Science, University of Toronto, 2Molecular Structure and Function Program, The Hospital for Sick Children Research Institute, 3Department of Biochemistry and 4Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5112445699"],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":2.351,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.90375854,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"26","issue":"19","first_page":"2406","last_page":"2415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12039","display_name":"Electron and X-Ray Spectroscopy Techniques","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.6394819021224976},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5655869841575623},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.5007963180541992},{"id":"https://openalex.org/keywords/cryo-electron-microscopy","display_name":"Cryo-electron microscopy","score":0.41522255539894104},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.34635603427886963},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3461431860923767},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3328040540218353},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3312217593193054},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.258293092250824},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.09348782896995544}],"concepts":[{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6394819021224976},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5655869841575623},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.5007963180541992},{"id":"https://openalex.org/C20702342","wikidata":"https://www.wikidata.org/wiki/Q5190506","display_name":"Cryo-electron microscopy","level":2,"score":0.41522255539894104},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.34635603427886963},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3461431860923767},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3328040540218353},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3312217593193054},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.258293092250824},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.09348782896995544},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btq456","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq456","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20702397","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20702397","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W36187607","https://openalex.org/W636061944","https://openalex.org/W956186043","https://openalex.org/W1487992279","https://openalex.org/W1492556495","https://openalex.org/W1966132497","https://openalex.org/W1967303488","https://openalex.org/W1967489089","https://openalex.org/W1983599491","https://openalex.org/W1983751391","https://openalex.org/W1987087256","https://openalex.org/W1987420415","https://openalex.org/W1994988233","https://openalex.org/W1995379336","https://openalex.org/W2005240547","https://openalex.org/W2007484502","https://openalex.org/W2013831456","https://openalex.org/W2019912800","https://openalex.org/W2030088437","https://openalex.org/W2032347855","https://openalex.org/W2034527511","https://openalex.org/W2046338564","https://openalex.org/W2048826637","https://openalex.org/W2052484225","https://openalex.org/W2055515293","https://openalex.org/W2055970489","https://openalex.org/W2056101326","https://openalex.org/W2056432923","https://openalex.org/W2058716938","https://openalex.org/W2067143036","https://openalex.org/W2068654340","https://openalex.org/W2075704767","https://openalex.org/W2076519823","https://openalex.org/W2077096052","https://openalex.org/W2085066576","https://openalex.org/W2108984838","https://openalex.org/W2112755089","https://openalex.org/W2116888204","https://openalex.org/W2119981825","https://openalex.org/W2140092984","https://openalex.org/W2150938882","https://openalex.org/W2154327689","https://openalex.org/W2155688047","https://openalex.org/W2157532189","https://openalex.org/W2159907419","https://openalex.org/W2165242943","https://openalex.org/W2285487681","https://openalex.org/W2545779695","https://openalex.org/W3029645440","https://openalex.org/W4300448178","https://openalex.org/W6601468767","https://openalex.org/W6629229894"],"related_works":["https://openalex.org/W2055243143","https://openalex.org/W1838872057","https://openalex.org/W4312462505","https://openalex.org/W1988881631","https://openalex.org/W2277205612","https://openalex.org/W2089966385","https://openalex.org/W2057020274","https://openalex.org/W2725604878","https://openalex.org/W2054889627","https://openalex.org/W4321636575"],"abstract_inverted_index":{"The":[0],"software":[1],"and":[2],"source":[3],"code":[4],"for":[5,10],"this":[6],"method":[7],"is":[8],"available":[9],"download":[11],"from":[12],"our":[13],"website:":[14],"http://compbio.cs.toronto.edu/cryoem/.":[15]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}