{"id":"https://openalex.org/W2124701550","doi":"https://doi.org/10.1093/bioinformatics/btq434","title":"Automated analysis of time-lapse fluorescence microscopy images: from live cell images to intracellular foci","display_name":"Automated analysis of time-lapse fluorescence microscopy images: from live cell images to intracellular foci","publication_year":2010,"publication_date":"2010-08-11","ids":{"openalex":"https://openalex.org/W2124701550","doi":"https://doi.org/10.1093/bioinformatics/btq434","mag":"2124701550","pmid":"https://pubmed.ncbi.nlm.nih.gov/20702399"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btq434","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq434","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/19/2424/48857194/bioinformatics_26_19_2424.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/26/19/2424/48857194/bioinformatics_26_19_2424.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006657933","display_name":"Oleh Dzyubachyk","orcid":"https://orcid.org/0000-0003-1344-7189"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Oleh Dzyubachyk","raw_affiliation_strings":["1 Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, 2Department of Cell Biology and Genetics, 3Departments of Radiation Oncology and Vascular Surgery, 4Department of Reproduction and Development, Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands, 5Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, 2Department of Cell Biology and Genetics, 3Departments of Radiation Oncology and Vascular Surgery, 4Department of Reproduction and Development, Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands, 5Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083122927","display_name":"Jeroen Essers","orcid":"https://orcid.org/0000-0003-0605-7211"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jeroen Essers","raw_affiliation_strings":["1 Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, 2Department of Cell Biology and Genetics, 3Departments of Radiation Oncology and Vascular Surgery, 4Department of Reproduction and Development, Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands, 5Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, 2Department of Cell Biology and Genetics, 3Departments of Radiation Oncology and Vascular Surgery, 4Department of Reproduction and Development, Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands, 5Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053244117","display_name":"Wiggert A. van Cappellen","orcid":"https://orcid.org/0000-0001-9059-8365"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wiggert A. van Cappellen","raw_affiliation_strings":["1 Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, 2Department of Cell Biology and Genetics, 3Departments of Radiation Oncology and Vascular Surgery, 4Department of Reproduction and Development, Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands, 5Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, 2Department of Cell Biology and Genetics, 3Departments of Radiation Oncology and Vascular Surgery, 4Department of Reproduction and Development, Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands, 5Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010193282","display_name":"C\u00e9line Baldeyron","orcid":"https://orcid.org/0000-0003-2311-1523"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C\u00e9line Baldeyron","raw_affiliation_strings":["1 Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, 2Department of Cell Biology and Genetics, 3Departments of Radiation Oncology and Vascular Surgery, 4Department of Reproduction and Development, Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands, 5Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, 2Department of Cell Biology and Genetics, 3Departments of Radiation Oncology and Vascular Surgery, 4Department of Reproduction and Development, Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands, 5Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085106104","display_name":"Akiko Inagaki","orcid":"https://orcid.org/0000-0001-9113-5602"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Akiko Inagaki","raw_affiliation_strings":["1 Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, 2Department of Cell Biology and Genetics, 3Departments of Radiation Oncology and Vascular Surgery, 4Department of Reproduction and Development, Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands, 5Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, 2Department of Cell Biology and Genetics, 3Departments of Radiation Oncology and Vascular Surgery, 4Department of Reproduction and Development, Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands, 5Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I98358874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038384386","display_name":"Wiro J. Niessen","orcid":"https://orcid.org/0000-0002-5822-1995"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wiro J. Niessen","raw_affiliation_strings":["1 Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, 2Department of Cell Biology and Genetics, 3Departments of Radiation Oncology and Vascular Surgery, 4Department of Reproduction and Development, Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands, 5Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, 2Department of Cell Biology and Genetics, 3Departments of Radiation Oncology and Vascular Surgery, 4Department of Reproduction and Development, Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands, 5Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I98358874"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023548565","display_name":"Erik Meijering","orcid":"https://orcid.org/0000-0001-8015-8358"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I98358874","display_name":"Delft University of Technology","ror":"https://ror.org/02e2c7k09","country_code":"NL","type":"education","lineage":["https://openalex.org/I98358874"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Erik Meijering","raw_affiliation_strings":["1 Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, 2Department of Cell Biology and Genetics, 3Departments of Radiation Oncology and Vascular Surgery, 4Department of Reproduction and Development, Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands, 5Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, 2Department of Cell Biology and Genetics, 3Departments of Radiation Oncology and Vascular Surgery, 4Department of Reproduction and Development, Optical Imaging Centre, Erasmus MC, Rotterdam, The Netherlands, 5Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands","institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I98358874"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023548565"],"corresponding_institution_ids":["https://openalex.org/I2801952686","https://openalex.org/I98358874"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":5.6828,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.9507288,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"26","issue":"19","first_page":"2424","last_page":"2430"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.6481999754905701,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.6481999754905701,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.22699999809265137,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.7529956698417664},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7100590467453003},{"id":"https://openalex.org/keywords/automation","display_name":"Automation","score":0.6676510572433472},{"id":"https://openalex.org/keywords/matlab","display_name":"MATLAB","score":0.6496467590332031},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.5759220123291016},{"id":"https://openalex.org/keywords/fluorescence-microscope","display_name":"Fluorescence microscope","score":0.5427797436714172},{"id":"https://openalex.org/keywords/tracking","display_name":"Tracking (education)","score":0.5004119873046875},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4938574433326721},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.46571043133735657},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.4391504228115082},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.4206342399120331},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.4107784628868103},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3470610976219177},{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.21660196781158447},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.201838880777359},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.14478889107704163},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.11482882499694824},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.08498546481132507},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.08062386512756348}],"concepts":[{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.7529956698417664},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7100590467453003},{"id":"https://openalex.org/C115901376","wikidata":"https://www.wikidata.org/wiki/Q184199","display_name":"Automation","level":2,"score":0.6676510572433472},{"id":"https://openalex.org/C2780365114","wikidata":"https://www.wikidata.org/wiki/Q169478","display_name":"MATLAB","level":2,"score":0.6496467590332031},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.5759220123291016},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.5427797436714172},{"id":"https://openalex.org/C2775936607","wikidata":"https://www.wikidata.org/wiki/Q466845","display_name":"Tracking (education)","level":2,"score":0.5004119873046875},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4938574433326721},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.46571043133735657},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.4391504228115082},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.4206342399120331},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4107784628868103},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3470610976219177},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.21660196781158447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.201838880777359},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14478889107704163},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11482882499694824},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.08498546481132507},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.08062386512756348},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C19417346","wikidata":"https://www.wikidata.org/wiki/Q7922","display_name":"Pedagogy","level":1,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059008","descriptor_name":"Time-Lapse Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059008","descriptor_name":"Time-Lapse Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059008","descriptor_name":"Time-Lapse Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/bioinformatics/btq434","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq434","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/19/2424/48857194/bioinformatics_26_19_2424.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20702399","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20702399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/4255fa25-3555-4b89-a411-9a04f672a0af","is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/4255fa25-3555-4b89-a411-9a04f672a0af","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dzyubachyk, O, Essers, J, van Cappellen, G, Baldeyron, CJA, Inagaki, A, Niessen, W & Meijering, E 2010, 'Automated analysis of time-lapse fluorescence microscopy images: from live cell images to intracellular foci', Bioinformatics, vol. 26, no. 19, pp. 2424-2430. https://doi.org/10.1093/bioinformatics/btq434","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.908.1250","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.908.1250","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bioinformatics.oxfordjournals.org/content/early/2010/08/11/bioinformatics.btq434.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.924.6513","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.924.6513","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bioinformatics.oxfordjournals.org/content/26/19/2424.full.pdf","raw_type":"text"},{"id":"pmh:oai:pure.eur.nl:publications/4255fa25-3555-4b89-a411-9a04f672a0af","is_oa":false,"landing_page_url":"http://hdl.handle.net/1765/28411","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dzyubachyk , O , Essers , J , van Cappellen , G , Baldeyron , CJA , Inagaki , A , Niessen , W & Meijering , E 2010 , ' Automated analysis of time-lapse fluorescence microscopy images: from live cell images to intracellular foci ' , Bioinformatics , vol. 26 , no. 19 , pp. 2424-2430 . https://doi.org/10.1093/bioinformatics/btq434","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btq434","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq434","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/19/2424/48857194/bioinformatics_26_19_2424.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","score":0.41999998688697815,"id":"https://metadata.un.org/sdg/17"}],"awards":[{"id":"https://openalex.org/G3995027986","display_name":"European Network for Cell Imaging and Tracking Expertise","funder_award_id":"201842","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124701550.pdf","grobid_xml":"https://content.openalex.org/works/W2124701550.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1479894977","https://openalex.org/W1583397949","https://openalex.org/W1594856307","https://openalex.org/W1963656409","https://openalex.org/W1964215413","https://openalex.org/W1978239142","https://openalex.org/W1989493360","https://openalex.org/W1995258838","https://openalex.org/W2001723434","https://openalex.org/W2039808072","https://openalex.org/W2058766022","https://openalex.org/W2065779569","https://openalex.org/W2066130773","https://openalex.org/W2085103039","https://openalex.org/W2092915696","https://openalex.org/W2099519362","https://openalex.org/W2100138660","https://openalex.org/W2105365768","https://openalex.org/W2107294643","https://openalex.org/W2109008952","https://openalex.org/W2111175571","https://openalex.org/W2114173589","https://openalex.org/W2124426078","https://openalex.org/W2124677401","https://openalex.org/W2125809370","https://openalex.org/W2147555557","https://openalex.org/W2152656791","https://openalex.org/W2153803886","https://openalex.org/W2157690852","https://openalex.org/W2158422469","https://openalex.org/W2161390338","https://openalex.org/W2162245111","https://openalex.org/W2162692975","https://openalex.org/W2168469752","https://openalex.org/W2191637929","https://openalex.org/W2320839648","https://openalex.org/W2413430215","https://openalex.org/W2487232184","https://openalex.org/W3203031350","https://openalex.org/W4245368268","https://openalex.org/W4317675606","https://openalex.org/W6635012757","https://openalex.org/W6635465343","https://openalex.org/W6641310172","https://openalex.org/W6676711108","https://openalex.org/W6715468428","https://openalex.org/W7008670586"],"related_works":["https://openalex.org/W4211107619","https://openalex.org/W2161433272","https://openalex.org/W2894139091","https://openalex.org/W1637909","https://openalex.org/W1983780159","https://openalex.org/W659245948","https://openalex.org/W2094643072","https://openalex.org/W4206210906","https://openalex.org/W2793462084","https://openalex.org/W2087957833"],"abstract_inverted_index":{"MOTIVATION:":[0],"Complete,":[1],"accurate":[2],"and":[3,27,33,51,88,123,141],"reproducible":[4],"analysis":[5,62,95],"of":[6,14,20,63,168,175],"intracellular":[7,80],"foci":[8,31,65,81,93],"from":[9],"fluorescence":[10],"microscopy":[11],"image":[12],"sequences":[13],"live":[15],"cells":[16],"requires":[17],"full":[18],"automation":[19],"all":[21],"processing":[22],"steps":[23],"involved:":[24],"cell":[25,49],"segmentation":[26,32,50],"tracking":[28],"followed":[29],"by":[30,73],"pattern":[34,94],"analysis.":[35],"Integrated":[36],"systems":[37],"for":[38,58,119,164,170],"this":[39,176],"purpose":[40],"are":[41,156],"lacking.":[42],"RESULTS:":[43],"Extending":[44],"our":[45],"previous":[46],"work":[47],"in":[48,66,135],"tracking,":[52],"we":[53],"developed":[54],"a":[55],"new":[56],"system":[57,70,105,132],"performing":[59],"fully":[60],"automated":[61],"fluorescent":[64],"single":[67],"cells.":[68],"The":[69,130,149,160],"was":[71,133],"validated":[72],"applying":[74],"it":[75,113],"to":[76,108,143],"two":[77],"common":[78],"tasks:":[79],"counting":[82],"(in":[83,96],"DNA":[84,97],"damage":[85],"repair":[86],"experiments)":[87],"cell-phase":[89],"identification":[90],"based":[91],"on":[92],"replication":[98],"experiments).":[99],"Experimental":[100],"results":[101],"show":[102],"that":[103],"the":[104,120,146],"performs":[106],"comparably":[107],"expert":[109],"human":[110],"observers.":[111],"Thus,":[112],"may":[114],"replace":[115],"tedious":[116],"manual":[117],"analyses":[118],"considered":[121],"tasks,":[122],"enables":[124],"high-content":[125],"screening.":[126],"AVAILABILITY":[127],"AND":[128],"IMPLEMENTATION:":[129],"described":[131],"implemented":[134],"MATLAB":[136,147],"(The":[137],"MathWorks,":[138],"Inc.,":[139],"USA)":[140],"compiled":[142],"run":[144],"within":[145],"environment.":[148],"routines":[150],"together":[151],"with":[152],"four":[153],"sample":[154],"datasets":[155],"available":[157],"at":[158],"http://celmia.bigr.nl/.":[159],"software":[161],"is":[162],"planned":[163],"public":[165],"release,":[166],"free":[167],"charge":[169],"non-commercial":[171],"use,":[172],"after":[173],"publication":[174],"article.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-07-17T09:13:05.818461","created_date":"2025-10-10T00:00:00"}