{"id":"https://openalex.org/W2147166867","doi":"https://doi.org/10.1093/bioinformatics/btq358","title":"An alignment-free method to identify candidate orthologous enhancers in multiple <i>Drosophila</i> genomes","display_name":"An alignment-free method to identify candidate orthologous enhancers in multiple <i>Drosophila</i> genomes","publication_year":2010,"publication_date":"2010-07-11","ids":{"openalex":"https://openalex.org/W2147166867","doi":"https://doi.org/10.1093/bioinformatics/btq358","mag":"2147166867","pmid":"https://pubmed.ncbi.nlm.nih.gov/20624780"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btq358","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq358","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/17/2109/48854942/bioinformatics_26_17_2109.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/26/17/2109/48854942/bioinformatics_26_17_2109.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063450866","display_name":"Manonmani Arunachalam","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210142260","display_name":"Max Planck Institute for Molecular Genetics","ror":"https://ror.org/03ate3e03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210142260"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Manonmani Arunachalam","raw_affiliation_strings":["1 Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany and 2Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany and 2Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I4210142260","https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037076580","display_name":"Karthik Jayasurya","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210142260","display_name":"Max Planck Institute for Molecular Genetics","ror":"https://ror.org/03ate3e03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210142260"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Karthik Jayasurya","raw_affiliation_strings":["1 Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany and 2Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany and 2Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I4210142260","https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042671050","display_name":"Pavel Toman\u010d\u00e1k","orcid":"https://orcid.org/0000-0002-2222-9370"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210142260","display_name":"Max Planck Institute for Molecular Genetics","ror":"https://ror.org/03ate3e03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210142260"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Pavel Tomancak","raw_affiliation_strings":["1 Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany and 2Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany and 2Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I4210142260","https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000077668","display_name":"Uwe Ohler","orcid":"https://orcid.org/0000-0002-0881-3116"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210142260","display_name":"Max Planck Institute for Molecular Genetics","ror":"https://ror.org/03ate3e03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210142260"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Uwe Ohler","raw_affiliation_strings":["1 Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany and 2Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany and 2Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I4210142260","https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.6807,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.70137995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"26","issue":"17","first_page":"2109","last_page":"2115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9851999878883362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9851999878883362,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enhancer","display_name":"Enhancer","score":0.8567773103713989},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7017437815666199},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6741782426834106},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.6688458323478699},{"id":"https://openalex.org/keywords/conserved-sequence","display_name":"Conserved sequence","score":0.5631311535835266},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4946601092815399},{"id":"https://openalex.org/keywords/genome-browser","display_name":"Genome browser","score":0.4489148259162903},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.4450398087501526},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4330231249332428},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.3523295521736145},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.3181801438331604},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.3087211847305298},{"id":"https://openalex.org/keywords/base-sequence","display_name":"Base sequence","score":0.11885419487953186},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.07059893012046814}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.8567773103713989},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7017437815666199},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6741782426834106},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6688458323478699},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.5631311535835266},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4946601092815399},{"id":"https://openalex.org/C2781148417","wikidata":"https://www.wikidata.org/wiki/Q5533486","display_name":"Genome browser","level":5,"score":0.4489148259162903},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.4450398087501526},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4330231249332428},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3523295521736145},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3181801438331604},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.3087211847305298},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.11885419487953186},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.07059893012046814}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004742","descriptor_name":"Enhancer Elements, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049750","descriptor_name":"Genome, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049750","descriptor_name":"Genome, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049750","descriptor_name":"Genome, Insect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btq358","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq358","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/17/2109/48854942/bioinformatics_26_17_2109.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20624780","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20624780","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:2169757","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2922894","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btq358","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq358","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/17/2109/48854942/bioinformatics_26_17_2109.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6600000262260437,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1214546200","https://openalex.org/W1973518241","https://openalex.org/W2006824094","https://openalex.org/W2008867180","https://openalex.org/W2025311633","https://openalex.org/W2041726559","https://openalex.org/W2054624670","https://openalex.org/W2055043387","https://openalex.org/W2064228319","https://openalex.org/W2076313473","https://openalex.org/W2087202849","https://openalex.org/W2097319624","https://openalex.org/W2113206920","https://openalex.org/W2116015974","https://openalex.org/W2117017773","https://openalex.org/W2117549173","https://openalex.org/W2119488386","https://openalex.org/W2127325366","https://openalex.org/W2127346557","https://openalex.org/W2129920058","https://openalex.org/W2135221645","https://openalex.org/W2140538490","https://openalex.org/W2142946358","https://openalex.org/W2144575079","https://openalex.org/W2145191876","https://openalex.org/W2150687466","https://openalex.org/W2153024250","https://openalex.org/W2155940790","https://openalex.org/W2156525687","https://openalex.org/W2165884762","https://openalex.org/W2166444569","https://openalex.org/W2167300924","https://openalex.org/W2170677539","https://openalex.org/W2171963266","https://openalex.org/W2397842714","https://openalex.org/W2400915255","https://openalex.org/W4298849694"],"related_works":["https://openalex.org/W2187207551","https://openalex.org/W2069184423","https://openalex.org/W189065216","https://openalex.org/W1603543036","https://openalex.org/W2516911135","https://openalex.org/W2030180246","https://openalex.org/W332976159","https://openalex.org/W2147166867","https://openalex.org/W2149555173","https://openalex.org/W2020602147"],"abstract_inverted_index":{"MOTIVATION:":[0],"Evolutionarily":[1],"conserved":[2,57,144,170],"non-coding":[3,92],"genomic":[4],"sequences":[5,72],"represent":[6],"a":[7,156],"potentially":[8],"rich":[9],"source":[10],"for":[11],"the":[12,75,127,150,183,201],"discovery":[13],"of":[14,77,81,129,152,159],"gene":[15],"regulatory":[16,37],"region":[17],"such":[18,114],"as":[19,36,115],"transcriptional":[20],"enhancers.":[21],"However,":[22],"detecting":[23,103],"orthologous":[24,104],"enhancers":[25,58,105,140,160],"using":[26],"alignment-based":[27],"methods":[28],"in":[29,59,91,102,106,161,204],"higher":[30],"eukaryotic":[31],"genomes":[32],"is":[33,65,99],"particularly":[34],"challenging,":[35],"regions":[38,172],"can":[39],"undergo":[40],"considerable":[41],"sequence":[42,78,88],"changes":[43,89],"while":[44],"maintaining":[45],"their":[46,82],"functionality.":[47],"RESULTS:":[48],"We":[49,94,148],"have":[50],"developed":[51],"an":[52],"alignment-free":[53],"method":[54,64,98],"which":[55],"identifies":[56],"multiple":[60],"diverged":[61],"species.":[62],"Our":[63,177],"based":[66,73],"on":[67,74,155,182],"similarity":[68,130],"metrics":[69],"between":[70],"two":[71],"co-occurrence":[76],"patterns":[79],"regardless":[80],"order":[83],"and":[84,163,200],"orientation,":[85],"thus":[86],"tolerating":[87],"observed":[90],"evolution.":[93],"show":[95],"that":[96],"our":[97],"highly":[100],"successful":[101],"distantly":[107],"related":[108],"species":[109],"without":[110,146],"requiring":[111],"additional":[112],"information":[113],"knowledge":[116],"about":[117],"transcription":[118],"factors":[119],"involved,":[120],"or":[121],"predicted":[122],"binding":[123],"sites.":[124],"By":[125],"estimating":[126],"significance":[128],"scores,":[131],"we":[132],"are":[133,207],"able":[134],"to":[135,168,185,191],"discriminate":[136],"experimentally":[137],"validated":[138],"functional":[139,171],"from":[141],"seemingly":[142],"equally":[143],"candidates":[145],"function.":[147],"demonstrate":[149],"effectiveness":[151],"this":[153,205],"approach":[154],"wide":[157],"range":[158],"Drosophila,":[162],"also":[164],"present":[165],"encouraging":[166,180],"results":[167,202],"detect":[169],"across":[173],"large":[174],"evolutionary":[175],"distances.":[176],"work":[178],"provides":[179],"steps":[181],"way":[184],"ab":[186],"initio":[187],"unbiased":[188],"enhancer":[189],"prediction":[190],"complement":[192],"ongoing":[193],"experimental":[194],"efforts.":[195],"AVAILABILITY:":[196],"The":[197],"software,":[198],"data":[199],"used":[203],"article":[206],"available":[208],"at":[209],"http://www.genome.duke.edu/labs/ohler/research/transcription/fly_enhancer/.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2016-06-24T00:00:00"}