{"id":"https://openalex.org/W2098157753","doi":"https://doi.org/10.1093/bioinformatics/btq220","title":"Quantifying the distribution of probes between subcellular locations using unsupervised pattern unmixing","display_name":"Quantifying the distribution of probes between subcellular locations using unsupervised pattern unmixing","publication_year":2010,"publication_date":"2010-06-01","ids":{"openalex":"https://openalex.org/W2098157753","doi":"https://doi.org/10.1093/bioinformatics/btq220","mag":"2098157753","pmid":"https://pubmed.ncbi.nlm.nih.gov/20529939"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btq220","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq220","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/12/i7/48854702/bioinformatics_26_12_i7.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/26/12/i7/48854702/bioinformatics_26_12_i7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078114370","display_name":"Lu\u00eds Pedro Coelho","orcid":"https://orcid.org/0000-0002-9280-7885"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Luis Pedro Coelho","raw_affiliation_strings":["1 Lane Center for Computational Biology, 2 Center for Bioimage informatics, Carnegie Mellon University, Pittsburgh, PA 15213, 3 Joint Carnegie Mellon University\u2013University of Pittsburgh Ph.D. Program in Computational Biology, 4 Department of Biomedical Engineering, 5 Department of Biological Sciences, 6 Department of Machine Learning, Carnegie Mellon University, Pittsburgh, PA 15213, USA and 7 Freiburg Institute for Advanced Studies, Albert Ludwig University of Freiburg, 79104 Freiburg, Germany"],"affiliations":[{"raw_affiliation_string":"1 Lane Center for Computational Biology, 2 Center for Bioimage informatics, Carnegie Mellon University, Pittsburgh, PA 15213, 3 Joint Carnegie Mellon University\u2013University of Pittsburgh Ph.D. Program in Computational Biology, 4 Department of Biomedical Engineering, 5 Department of Biological Sciences, 6 Department of Machine Learning, Carnegie Mellon University, Pittsburgh, PA 15213, USA and 7 Freiburg Institute for Advanced Studies, Albert Ludwig University of Freiburg, 79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I74973139","https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024540054","display_name":"Tao Peng","orcid":"https://orcid.org/0000-0003-1085-7246"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Tao Peng","raw_affiliation_strings":["1 Lane Center for Computational Biology, 2 Center for Bioimage informatics, Carnegie Mellon University, Pittsburgh, PA 15213, 3 Joint Carnegie Mellon University\u2013University of Pittsburgh Ph.D. Program in Computational Biology, 4 Department of Biomedical Engineering, 5 Department of Biological Sciences, 6 Department of Machine Learning, Carnegie Mellon University, Pittsburgh, PA 15213, USA and 7 Freiburg Institute for Advanced Studies, Albert Ludwig University of Freiburg, 79104 Freiburg, Germany"],"affiliations":[{"raw_affiliation_string":"1 Lane Center for Computational Biology, 2 Center for Bioimage informatics, Carnegie Mellon University, Pittsburgh, PA 15213, 3 Joint Carnegie Mellon University\u2013University of Pittsburgh Ph.D. Program in Computational Biology, 4 Department of Biomedical Engineering, 5 Department of Biological Sciences, 6 Department of Machine Learning, Carnegie Mellon University, Pittsburgh, PA 15213, USA and 7 Freiburg Institute for Advanced Studies, Albert Ludwig University of Freiburg, 79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I74973139","https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061773929","display_name":"Robert F. Murphy","orcid":"https://orcid.org/0000-0003-0358-901X"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Robert F. Murphy","raw_affiliation_strings":["1 Lane Center for Computational Biology, 2 Center for Bioimage informatics, Carnegie Mellon University, Pittsburgh, PA 15213, 3 Joint Carnegie Mellon University\u2013University of Pittsburgh Ph.D. Program in Computational Biology, 4 Department of Biomedical Engineering, 5 Department of Biological Sciences, 6 Department of Machine Learning, Carnegie Mellon University, Pittsburgh, PA 15213, USA and 7 Freiburg Institute for Advanced Studies, Albert Ludwig University of Freiburg, 79104 Freiburg, Germany"],"affiliations":[{"raw_affiliation_string":"1 Lane Center for Computational Biology, 2 Center for Bioimage informatics, Carnegie Mellon University, Pittsburgh, PA 15213, 3 Joint Carnegie Mellon University\u2013University of Pittsburgh Ph.D. Program in Computational Biology, 4 Department of Biomedical Engineering, 5 Department of Biological Sciences, 6 Department of Machine Learning, Carnegie Mellon University, Pittsburgh, PA 15213, USA and 7 Freiburg Institute for Advanced Studies, Albert Ludwig University of Freiburg, 79104 Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I74973139","https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5078114370"],"corresponding_institution_ids":["https://openalex.org/I161046081","https://openalex.org/I170201317","https://openalex.org/I74973139"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":6.5762,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.95827188,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"26","issue":"12","first_page":"i7","last_page":"i12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10638","display_name":"Optical measurement and interference techniques","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6246927380561829},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4965127110481262},{"id":"https://openalex.org/keywords/distribution","display_name":"Distribution (mathematics)","score":0.4923969507217407},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4520450234413147},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.13853928446769714}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6246927380561829},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4965127110481262},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.4923969507217407},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4520450234413147},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13853928446769714},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013347","descriptor_name":"Subcellular Fractions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1093/bioinformatics/btq220","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq220","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/12/i7/48854702/bioinformatics_26_12_i7.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20529939","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20529939","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:repository.cmu.edu:cbd-1024","is_oa":true,"landing_page_url":"http://repository.cmu.edu/cbd/33","pdf_url":null,"source":{"id":"https://openalex.org/S4306400668","display_name":"Research Showcase @ Carnegie Mellon University (Carnegie Mellon University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I74973139","host_organization_name":"Carnegie Mellon University","host_organization_lineage":["https://openalex.org/I74973139"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational Biology Department","raw_type":"text"},{"id":"pmh:doi:10.1184/r1/6702203","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4406922384","display_name":"Open MIND","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal contribution"},{"id":"pmh:oai:figshare.com:article/6702203","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Quantifying_the_distribution_of_probes_between_subcellular_locations_using_unsupervised_pattern_unmixing_/6702203","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2881404","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2881404","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"doi:10.1184/r1/6702203.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1184/r1/6702203.v1","pdf_url":null,"source":{"id":"https://openalex.org/S7407050927","display_name":"KiltHub Repository","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btq220","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq220","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/12/i7/48854702/bioinformatics_26_12_i7.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5788981491","display_name":null,"funder_award_id":"GM075205","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2098157753.pdf","grobid_xml":"https://content.openalex.org/works/W2098157753.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1547714734","https://openalex.org/W1625255723","https://openalex.org/W1880262756","https://openalex.org/W1902027874","https://openalex.org/W1963884621","https://openalex.org/W1996517960","https://openalex.org/W2076927398","https://openalex.org/W2102324552","https://openalex.org/W2104311408","https://openalex.org/W2107080660","https://openalex.org/W2110163763","https://openalex.org/W2115444722","https://openalex.org/W2118718620","https://openalex.org/W2119462282","https://openalex.org/W2153944330","https://openalex.org/W2169805130","https://openalex.org/W4231510805","https://openalex.org/W6636494156","https://openalex.org/W6639619044","https://openalex.org/W6675741738","https://openalex.org/W6677759377"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W2382290278","https://openalex.org/W2478288626","https://openalex.org/W2350741829","https://openalex.org/W2033914206","https://openalex.org/W2042327336"],"abstract_inverted_index":{"http://murphylab.web.cmu.edu/software.":[0]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}