{"id":"https://openalex.org/W2154219988","doi":"https://doi.org/10.1093/bioinformatics/btq203","title":"Assessing the functional coherence of gene sets with metrics based on the Gene Ontology graph","display_name":"Assessing the functional coherence of gene sets with metrics based on the Gene Ontology graph","publication_year":2010,"publication_date":"2010-06-01","ids":{"openalex":"https://openalex.org/W2154219988","doi":"https://doi.org/10.1093/bioinformatics/btq203","mag":"2154219988","pmid":"https://pubmed.ncbi.nlm.nih.gov/20529941"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btq203","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq203","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/12/i79/48859384/bioinformatics_26_12_i79.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/26/12/i79/48859384/bioinformatics_26_12_i79.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062019583","display_name":"Adam Richards","orcid":null},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam J. Richards","raw_affiliation_strings":["1 Department of Biochemistry and Molecular Biology, 2 Department of Medicine, 3 Department of Ophthalmology and 4 Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry and Molecular Biology, 2 Department of Medicine, 3 Department of Ophthalmology and 4 Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009525535","display_name":"Brian Muller","orcid":"https://orcid.org/0000-0002-4808-427X"},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Muller","raw_affiliation_strings":["1 Department of Biochemistry and Molecular Biology, 2 Department of Medicine, 3 Department of Ophthalmology and 4 Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry and Molecular Biology, 2 Department of Medicine, 3 Department of Ophthalmology and 4 Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015504359","display_name":"Matthew S. Shotwell","orcid":"https://orcid.org/0000-0002-1480-0637"},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Shotwell","raw_affiliation_strings":["1 Department of Biochemistry and Molecular Biology, 2 Department of Medicine, 3 Department of Ophthalmology and 4 Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry and Molecular Biology, 2 Department of Medicine, 3 Department of Ophthalmology and 4 Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038797261","display_name":"L. Ashley Cowart","orcid":"https://orcid.org/0000-0002-5312-5232"},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Ashley Cowart","raw_affiliation_strings":["1 Department of Biochemistry and Molecular Biology, 2 Department of Medicine, 3 Department of Ophthalmology and 4 Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry and Molecular Biology, 2 Department of Medicine, 3 Department of Ophthalmology and 4 Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001129421","display_name":"B\u00e4erbel Rohrer","orcid":null},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B\u00e4erbel Rohrer","raw_affiliation_strings":["1 Department of Biochemistry and Molecular Biology, 2 Department of Medicine, 3 Department of Ophthalmology and 4 Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry and Molecular Biology, 2 Department of Medicine, 3 Department of Ophthalmology and 4 Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046515259","display_name":"Xinghua Lu","orcid":"https://orcid.org/0000-0002-8599-2269"},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinghua Lu","raw_affiliation_strings":["1 Department of Biochemistry and Molecular Biology, 2 Department of Medicine, 3 Department of Ophthalmology and 4 Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry and Molecular Biology, 2 Department of Medicine, 3 Department of Ophthalmology and 4 Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA","institution_ids":["https://openalex.org/I153297377"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I153297377"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":2.4164,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.88988655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"26","issue":"12","first_page":"i79","last_page":"i87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7586488723754883},{"id":"https://openalex.org/keywords/discriminative-model","display_name":"Discriminative model","score":0.4926183819770813},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.491264283657074},{"id":"https://openalex.org/keywords/coherence","display_name":"Coherence (philosophical gambling strategy)","score":0.4879602789878845},{"id":"https://openalex.org/keywords/python","display_name":"Python (programming language)","score":0.4722672700881958},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.45367807149887085},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.44374918937683105},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.410239577293396},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.364146888256073},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.29598748683929443},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.28076791763305664},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.14819389581680298},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.13517040014266968}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7586488723754883},{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.4926183819770813},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.491264283657074},{"id":"https://openalex.org/C2781181686","wikidata":"https://www.wikidata.org/wiki/Q4226068","display_name":"Coherence (philosophical gambling strategy)","level":2,"score":0.4879602789878845},{"id":"https://openalex.org/C519991488","wikidata":"https://www.wikidata.org/wiki/Q28865","display_name":"Python (programming language)","level":2,"score":0.4722672700881958},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.45367807149887085},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.44374918937683105},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.410239577293396},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.364146888256073},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.29598748683929443},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.28076791763305664},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.14819389581680298},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13517040014266968},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btq203","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq203","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/12/i79/48859384/bioinformatics_26_12_i79.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20529941","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20529941","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2881388","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2881388","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btq203","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq203","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/12/i79/48859384/bioinformatics_26_12_i79.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.6700000166893005}],"awards":[{"id":"https://openalex.org/G1526982958","display_name":null,"funder_award_id":"T15 LM007438","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G2013968095","display_name":null,"funder_award_id":"T15LM07438","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G2501515220","display_name":null,"funder_award_id":"R01LM009153","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G3286652883","display_name":null,"funder_award_id":"5R01LM010144","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G3442869068","display_name":null,"funder_award_id":"R01 EY013520","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G6043079783","display_name":null,"funder_award_id":"R01EY13520","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G6161231706","display_name":null,"funder_award_id":"2P20RR107677","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G639457002","display_name":null,"funder_award_id":"R01 LM009153","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G6911071190","display_name":null,"funder_award_id":"R01 LM010144","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2154219988.pdf","grobid_xml":"https://content.openalex.org/works/W2154219988.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W255374182","https://openalex.org/W1483505747","https://openalex.org/W1634075213","https://openalex.org/W1964992489","https://openalex.org/W1971713783","https://openalex.org/W1973233364","https://openalex.org/W1975290397","https://openalex.org/W1976544696","https://openalex.org/W1987971958","https://openalex.org/W2020859582","https://openalex.org/W2059800023","https://openalex.org/W2075177078","https://openalex.org/W2079665010","https://openalex.org/W2082523740","https://openalex.org/W2084168100","https://openalex.org/W2086709935","https://openalex.org/W2100612658","https://openalex.org/W2102794349","https://openalex.org/W2103017472","https://openalex.org/W2104960492","https://openalex.org/W2120024428","https://openalex.org/W2122084873","https://openalex.org/W2128049108","https://openalex.org/W2132022337","https://openalex.org/W2133014144","https://openalex.org/W2133340731","https://openalex.org/W2133465414","https://openalex.org/W2135000328","https://openalex.org/W2135230352","https://openalex.org/W2137297622","https://openalex.org/W2138133187","https://openalex.org/W2148606196","https://openalex.org/W2150926065","https://openalex.org/W2153636826","https://openalex.org/W2155534256","https://openalex.org/W2160483171","https://openalex.org/W2163480486","https://openalex.org/W2165674132","https://openalex.org/W2168745915","https://openalex.org/W2171206351","https://openalex.org/W2171936986","https://openalex.org/W2172136887","https://openalex.org/W2626914210","https://openalex.org/W2950225692","https://openalex.org/W2953332543","https://openalex.org/W6609537351","https://openalex.org/W6636883888","https://openalex.org/W6670200328","https://openalex.org/W6675339850","https://openalex.org/W6677712588"],"related_works":["https://openalex.org/W2965546495","https://openalex.org/W4389116644","https://openalex.org/W2153315159","https://openalex.org/W3103844505","https://openalex.org/W259157601","https://openalex.org/W4205463238","https://openalex.org/W2341492732","https://openalex.org/W3187193180","https://openalex.org/W106542691","https://openalex.org/W2789551765"],"abstract_inverted_index":{"MOTIVATION:":[0],"The":[1,34,110,226],"results":[2],"of":[3,14,21,31,36,44,50,61,73,76,80,90,96,112,121,124,134,142,155,185,211,222,255],"initial":[4],"analyses":[5,164],"for":[6,78,99,217],"many":[7],"high-throughput":[8],"technologies":[9],"commonly":[10,41],"take":[11],"the":[12,22,28,48,58,88,92,118,140,145,153,209,219,239,244,251,256],"form":[13,49],"gene":[15,37,56,97,188,223],"or":[16,65],"protein":[17],"sets,":[18,98],"and":[19,103,126,144,169,193],"one":[20],"ensuing":[23],"tasks":[24],"is":[25,85,137,180,228,248],"to":[26,162,207],"evaluate":[27],"functional":[29,94,156,220],"coherence":[30,95,221],"these":[32,63,135],"sets.":[33,224],"study":[35,84,114],"set":[38],"function":[39],"most":[40],"makes":[42],"use":[43],"controlled":[45],"vocabulary":[46],"in":[47,183,200,243],"ontology":[51],"annotations.":[52,130],"For":[53],"a":[54,71,215,231],"given":[55],"set,":[57],"statistical":[59,104],"significance":[60,79,154],"observing":[62],"annotations":[64,143,148],"'enrichment'":[66],"may":[67],"be":[68],"tested":[69],"using":[70],"number":[72],"methods.":[74],"Instead":[75],"testing":[77],"individual":[81],"terms,":[82],"this":[83,113],"concerned":[86],"with":[87],"task":[89],"assessing":[91],"global":[93],"which":[100],"novel":[101,132],"metrics":[102,111],"methods":[105,136,161],"have":[106],"been":[107],"devised.":[108],"RESULTS:":[109],"are":[115,149,264],"based":[116],"on":[117,165,170],"topological":[119],"properties":[120],"graphs":[122],"comprised":[123],"genes":[125],"their":[127],"Gene":[128],"Ontology":[129],"A":[131],"aspect":[133],"that":[138,177,194],"both":[139],"enrichment":[141],"relationships":[146],"among":[147],"considered":[150],"when":[151],"determining":[152],"coherence.":[157],"We":[158,203],"applied":[159],"our":[160,178],"perform":[163],"an":[166],"existing":[167],"database":[168],"microarray":[171,201],"experimental":[172],"results.":[173],"Here,":[174],"we":[175],"demonstrated":[176],"approach":[179],"highly":[181],"discriminative":[182],"terms":[184],"differentiating":[186],"coherent":[187],"sets":[189],"from":[190],"random":[191],"ones":[192],"it":[195],"provides":[196],"biologically":[197],"sensible":[198],"evaluations":[199],"analysis.":[202],"further":[204],"used":[205],"examples":[206],"show":[208],"utility":[210],"graph":[212],"visualization":[213],"as":[214,230],"tool":[216],"studying":[218],"AVAILABILITY:":[225],"implementation":[227],"provided":[229],"freely":[232],"accessible":[233],"web":[234],"application":[235],"at:":[236],"http://projects.dbbe.musc.edu/gosteiner.":[237],"Additionally,":[238],"source":[240],"code":[241],"written":[242],"Python":[245],"programming":[246],"language,":[247],"available":[249,265],"under":[250],"General":[252],"Public":[253],"License":[254],"Free":[257],"Software":[258],"Foundation.":[259],"SUPPLEMENTARY":[260],"INFORMATION:":[261],"Supplementary":[262],"data":[263],"at":[266],"Bioinformatics":[267],"online.":[268]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}