{"id":"https://openalex.org/W2110860622","doi":"https://doi.org/10.1093/bioinformatics/btq177","title":"Markov dynamic models for long-timescale protein motion","display_name":"Markov dynamic models for long-timescale protein motion","publication_year":2010,"publication_date":"2010-06-01","ids":{"openalex":"https://openalex.org/W2110860622","doi":"https://doi.org/10.1093/bioinformatics/btq177","mag":"2110860622","pmid":"https://pubmed.ncbi.nlm.nih.gov/20529916"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btq177","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq177","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/12/i269/48856559/bioinformatics_26_12_i269.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/26/12/i269/48856559/bioinformatics_26_12_i269.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069869544","display_name":"Tsung-Han Chiang","orcid":"https://orcid.org/0000-0003-1506-2880"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["SG","US"],"is_corresponding":true,"raw_author_name":"Tsung-Han Chiang","raw_affiliation_strings":["1 Department of Computer Science, National University of Singapore, Singapore 117417, Singapore and 2 Department of Computer Science, Stanford University, Stanford, CA 94305, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Computer Science, National University of Singapore, Singapore 117417, Singapore and 2 Department of Computer Science, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082344124","display_name":"David Hsu","orcid":"https://orcid.org/0000-0002-2309-4535"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"David Hsu","raw_affiliation_strings":["1 Department of Computer Science, National University of Singapore, Singapore 117417, Singapore and 2 Department of Computer Science, Stanford University, Stanford, CA 94305, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Computer Science, National University of Singapore, Singapore 117417, Singapore and 2 Department of Computer Science, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114247093","display_name":"Jean\u2010Claude Latombe","orcid":null},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"Jean-Claude Latombe","raw_affiliation_strings":["1 Department of Computer Science, National University of Singapore, Singapore 117417, Singapore and 2 Department of Computer Science, Stanford University, Stanford, CA 94305, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Computer Science, National University of Singapore, Singapore 117417, Singapore and 2 Department of Computer Science, Stanford University, Stanford, CA 94305, USA","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069869544"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I97018004"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.9488,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.74455536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"26","issue":"12","first_page":"i269","last_page":"i277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/markov-chain","display_name":"Markov chain","score":0.7389811873435974},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5745495557785034},{"id":"https://openalex.org/keywords/markov-process","display_name":"Markov process","score":0.522024929523468},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.48963791131973267},{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.4843107759952545},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.4768054187297821},{"id":"https://openalex.org/keywords/protein-folding","display_name":"Protein folding","score":0.4653734862804413},{"id":"https://openalex.org/keywords/markov-model","display_name":"Markov model","score":0.4180909991264343},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4097438156604767},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.23024806380271912},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2122253179550171},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.18580564856529236},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.16826820373535156},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.14210408926010132},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.14185112714767456},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.08139118552207947}],"concepts":[{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.7389811873435974},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5745495557785034},{"id":"https://openalex.org/C159886148","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov process","level":2,"score":0.522024929523468},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.48963791131973267},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.4843107759952545},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.4768054187297821},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.4653734862804413},{"id":"https://openalex.org/C163836022","wikidata":"https://www.wikidata.org/wiki/Q6771326","display_name":"Markov model","level":3,"score":0.4180909991264343},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4097438156604767},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.23024806380271912},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2122253179550171},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18580564856529236},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.16826820373535156},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.14210408926010132},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.14185112714767456},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.08139118552207947},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/bioinformatics/btq177","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq177","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/12/i269/48856559/bioinformatics_26_12_i269.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20529916","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20529916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/39381","is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/39381","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.294.8432","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.294.8432","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ai.stanford.edu/~latombe/papers/ISMB2010/paper.pdf","raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2881362","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2881362","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:repository.kaust.edu.sa:10754/596801","is_oa":true,"landing_page_url":"http://hdl.handle.net/10754/596801","pdf_url":null,"source":{"id":"https://openalex.org/S4306401596","display_name":"King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I71920554","host_organization_name":"King Abdullah University of Science and Technology","host_organization_lineage":["https://openalex.org/I71920554"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btq177","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq177","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/12/i269/48856559/bioinformatics_26_12_i269.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7","score":0.8600000143051147}],"awards":[{"id":"https://openalex.org/G4187378192","display_name":"Applications of Probability Measures on the Self-Motion Manifold of Deformable Fragments in Proteins","funder_award_id":"0443939","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320751","display_name":"Ministry of Education - Singapore","ror":"https://ror.org/01kcva023"},{"id":"https://openalex.org/F4320322320","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2110860622.pdf","grobid_xml":"https://content.openalex.org/works/W2110860622.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1569990960","https://openalex.org/W1581993029","https://openalex.org/W1653812874","https://openalex.org/W1663973292","https://openalex.org/W1766888123","https://openalex.org/W1970440715","https://openalex.org/W1977708375","https://openalex.org/W1977969550","https://openalex.org/W2001008407","https://openalex.org/W2003106667","https://openalex.org/W2017698480","https://openalex.org/W2017776794","https://openalex.org/W2018657646","https://openalex.org/W2031092627","https://openalex.org/W2044201287","https://openalex.org/W2048822589","https://openalex.org/W2049509393","https://openalex.org/W2051339577","https://openalex.org/W2083669917","https://openalex.org/W2086889049","https://openalex.org/W2091707670","https://openalex.org/W2108700551","https://openalex.org/W2125304058","https://openalex.org/W2128990851","https://openalex.org/W2132589721","https://openalex.org/W2147396853","https://openalex.org/W2148839232","https://openalex.org/W2153020133","https://openalex.org/W2155503286","https://openalex.org/W2156540458","https://openalex.org/W2161925317","https://openalex.org/W2165176140","https://openalex.org/W2169632544","https://openalex.org/W2594639291","https://openalex.org/W2951920181","https://openalex.org/W4244545666","https://openalex.org/W4285719527","https://openalex.org/W6636918919","https://openalex.org/W6650720869","https://openalex.org/W6682278043","https://openalex.org/W6683919601"],"related_works":["https://openalex.org/W2379651310","https://openalex.org/W1541249122","https://openalex.org/W2084326697","https://openalex.org/W2113019827","https://openalex.org/W2027903142","https://openalex.org/W2354322608","https://openalex.org/W2186675474","https://openalex.org/W2387462590","https://openalex.org/W2056274461","https://openalex.org/W2077211377"],"abstract_inverted_index":{"Molecular":[0],"dynamics":[1],"(MD)":[2],"simulation":[3,51],"is":[4,18,40,125,145],"a":[5,81,89,128,138],"well-established":[6],"method":[7,100],"for":[8,84,148,166],"studying":[9],"protein":[10,47,76,97,167],"motion":[11,48],"at":[12],"the":[13,31,67,86,116,155],"atomic":[14],"scale.":[15],"However,":[16],"it":[17],"computationally":[19],"intensive":[20],"and":[21,37,108,115,163],"generates":[22],"massive":[23],"amounts":[24],"of":[25,29,34,45,88,132],"data.":[26,52],"One":[27,122],"way":[28],"addressing":[30],"dual":[32],"challenges":[33],"computation":[35],"efficiency":[36],"data":[38],"analysis":[39],"to":[41,58,94,159],"construct":[42],"simplified":[43],"models":[44,61,158],"long-timescale":[46,96,150],"from":[49],"MD":[50],"In":[53],"this":[54],"direction,":[55],"we":[56],"propose":[57,80],"use":[59],"Markov":[60,157],"with":[62,141,178],"hidden":[63],"states,":[64,137],"in":[65,169],"which":[66],"Markovian":[68],"states":[69,144],"represent":[70],"potentially":[71],"overlapping":[72],"probabilistic":[73],"distributions":[74],"over":[75],"conformations.":[77],"We":[78,152],"also":[79,153],"principled":[82],"criterion":[83],"evaluating":[85],"quality":[87],"model":[90,131,140],"by":[91],"its":[92],"ability":[93],"predict":[95],"motions.":[98,151],"Our":[99],"was":[101],"tested":[102],"on":[103],"2D":[104],"synthetic":[105],"energy":[106],"landscapes":[107],"two":[109],"extensively":[110],"studied":[111],"peptides,":[112],"alanine":[113,133],"dipeptide":[114,134],"villin":[117],"headpiece":[118],"subdomain":[119],"(HP-35":[120],"NleNle).":[121],"interesting":[123],"finding":[124],"that":[126],"although":[127],"widely":[129],"accepted":[130],"contains":[135],"six":[136],"simpler":[139],"only":[142],"three":[143],"equally":[146],"good":[147],"predicting":[149],"used":[154],"constructed":[156],"estimate":[160],"important":[161],"kinetic":[162],"dynamic":[164],"quantities":[165],"folding,":[168],"particular,":[170],"mean":[171],"first-passage":[172],"time.":[173],"The":[174],"results":[175],"are":[176],"consistent":[177],"available":[179],"experimental":[180],"measurements.":[181]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}