{"id":"https://openalex.org/W2120098186","doi":"https://doi.org/10.1093/bioinformatics/btq053","title":"Gene function prediction from synthetic lethality networks via ranking on demand","display_name":"Gene function prediction from synthetic lethality networks via ranking on demand","publication_year":2010,"publication_date":"2010-02-12","ids":{"openalex":"https://openalex.org/W2120098186","doi":"https://doi.org/10.1093/bioinformatics/btq053","mag":"2120098186","pmid":"https://pubmed.ncbi.nlm.nih.gov/20154010"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btq053","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq053","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/7/912/48856992/bioinformatics_26_7_912.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/26/7/912/48856992/bioinformatics_26_7_912.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074204533","display_name":"Christoph Lippert","orcid":"https://orcid.org/0000-0001-6363-2556"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210165766","display_name":"Max Planck Institute for Biology","ror":"https://ror.org/0243gzr89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210165766"]}],"countries":["DE","GB"],"is_corresponding":true,"raw_author_name":"Christoph Lippert","raw_affiliation_strings":["1 Machine Learning & Computational Biology Research Group, Max Planck Institutes, T\u00fcbingen, Germany and 2 Department of Engineering, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"1 Machine Learning & Computational Biology Research Group, Max Planck Institutes, T\u00fcbingen, Germany and 2 Department of Engineering, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I4210165766","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010820865","display_name":"Zoubin Ghahramani","orcid":"https://orcid.org/0000-0002-7464-6475"},"institutions":[{"id":"https://openalex.org/I4210165766","display_name":"Max Planck Institute for Biology","ror":"https://ror.org/0243gzr89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210165766"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"Zoubin Ghahramani","raw_affiliation_strings":["1 Machine Learning & Computational Biology Research Group, Max Planck Institutes, T\u00fcbingen, Germany and 2 Department of Engineering, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"1 Machine Learning & Computational Biology Research Group, Max Planck Institutes, T\u00fcbingen, Germany and 2 Department of Engineering, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I4210165766","https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074540538","display_name":"Karsten Borgwardt","orcid":"https://orcid.org/0000-0001-7221-2393"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210165766","display_name":"Max Planck Institute for Biology","ror":"https://ror.org/0243gzr89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210165766"]}],"countries":["DE","GB"],"is_corresponding":false,"raw_author_name":"Karsten M. Borgwardt","raw_affiliation_strings":["1 Machine Learning & Computational Biology Research Group, Max Planck Institutes, T\u00fcbingen, Germany and 2 Department of Engineering, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"1 Machine Learning & Computational Biology Research Group, Max Planck Institutes, T\u00fcbingen, Germany and 2 Department of Engineering, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I4210165766","https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5074204533"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210165766"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.4909,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.81642011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"26","issue":"7","first_page":"912","last_page":"918"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9858999848365784,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9684000015258789,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"Synthetic lethality","score":0.8770796060562134},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49377283453941345},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4885590970516205},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.47999781370162964},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4669063687324524},{"id":"https://openalex.org/keywords/lethality","display_name":"Lethality","score":0.45004141330718994},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4107135832309723},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33648520708084106},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.324402391910553},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32169491052627563},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.10376322269439697}],"concepts":[{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.8770796060562134},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49377283453941345},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4885590970516205},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.47999781370162964},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4669063687324524},{"id":"https://openalex.org/C20379349","wikidata":"https://www.wikidata.org/wiki/Q1720706","display_name":"Lethality","level":2,"score":0.45004141330718994},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4107135832309723},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33648520708084106},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.324402391910553},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32169491052627563},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.10376322269439697}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005804","descriptor_name":"Genes, Lethal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005804","descriptor_name":"Genes, Lethal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005804","descriptor_name":"Genes, Lethal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/bioinformatics/btq053","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq053","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/7/912/48856992/bioinformatics_26_7_912.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20154010","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20154010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pure.mpg.de:item_1788847","is_oa":true,"landing_page_url":"https://hdl.handle.net/11858/00-001M-0000-0013-C0AE-3","pdf_url":"http://hdl.handle.net/11858/00-001M-0000-0013-C0AE-3","source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:edoc.mpg.de:548400","is_oa":false,"landing_page_url":"http://edoc.mpg.de/548400","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, v.26, 912-918 (2010)","raw_type":"Article"},{"id":"pmh:oai:edoc.mpg.de:561626","is_oa":false,"landing_page_url":"http://edoc.mpg.de/561626","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, v.26, 912-918 (2010)","raw_type":"Article"},{"id":"pmh:oai:generic.eprints.org:342017","is_oa":false,"landing_page_url":"http://publications.eng.cam.ac.uk/342017/","pdf_url":null,"source":{"id":"https://openalex.org/S4406922847","display_name":"Cambridge University Engineering Department Publications Database","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btq053","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq053","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/7/912/48856992/bioinformatics_26_7_912.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2120098186.pdf","grobid_xml":"https://content.openalex.org/works/W2120098186.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W14071851","https://openalex.org/W1479807131","https://openalex.org/W1542652324","https://openalex.org/W1774304772","https://openalex.org/W1875876066","https://openalex.org/W1976386441","https://openalex.org/W2013520054","https://openalex.org/W2014594785","https://openalex.org/W2039366890","https://openalex.org/W2089306171","https://openalex.org/W2097282516","https://openalex.org/W2098013039","https://openalex.org/W2103017472","https://openalex.org/W2125865219","https://openalex.org/W2129997546","https://openalex.org/W2131456688","https://openalex.org/W2133075481","https://openalex.org/W2138312771","https://openalex.org/W2139027526","https://openalex.org/W2150749732","https://openalex.org/W2152871646","https://openalex.org/W2159460045","https://openalex.org/W2162891889","https://openalex.org/W2163485494","https://openalex.org/W2166468869","https://openalex.org/W2293997450","https://openalex.org/W2990138404","https://openalex.org/W6600552058","https://openalex.org/W6638285678","https://openalex.org/W6697127918"],"related_works":["https://openalex.org/W2116506288","https://openalex.org/W3093199425","https://openalex.org/W1508071893","https://openalex.org/W2123596976","https://openalex.org/W3097247875","https://openalex.org/W4280520494","https://openalex.org/W2161566038","https://openalex.org/W2604531394","https://openalex.org/W2518938096","https://openalex.org/W4362639343"],"abstract_inverted_index":{"In":[0],"this":[1],"article,":[2],"we":[3],"present":[4],"a":[5,61],"novel":[6,26],"technique":[7],"called":[8],"kernelROD":[9],"for":[10],"gene":[11,45],"function":[12,46],"prediction":[13,33,47,65],"from":[14],"synthetic":[15],"lethal":[16],"interaction":[17],"networks":[18,58],"based":[19],"on":[20],"kernel":[21],"machines.":[22],"We":[23],"apply":[24],"our":[25,40],"algorithm":[27],"to":[28,43,60],"Gene":[29],"Ontology":[30],"functional":[31],"annotation":[32],"in":[34,64],"yeast.":[35],"Our":[36],"experiments":[37],"show":[38],"that":[39,53],"method":[41],"leads":[42,59],"improved":[44],"compared":[48],"with":[49],"state-of-the-art":[50],"competitors":[51],"and":[52,56],"combining":[54],"genetic":[55],"congruence":[57],"further":[62],"improvement":[63],"accuracy.":[66]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}