{"id":"https://openalex.org/W2161432612","doi":"https://doi.org/10.1093/bioinformatics/btq036","title":"Non-linear classification for on-the-fly fractional mass filtering and targeted precursor fragmentation in mass spectrometry experiments","display_name":"Non-linear classification for on-the-fly fractional mass filtering and targeted precursor fragmentation in mass spectrometry experiments","publication_year":2010,"publication_date":"2010-02-04","ids":{"openalex":"https://openalex.org/W2161432612","doi":"https://doi.org/10.1093/bioinformatics/btq036","mag":"2161432612","pmid":"https://pubmed.ncbi.nlm.nih.gov/20134030"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btq036","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq036","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/6/791/48853010/bioinformatics_26_6_791.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/26/6/791/48853010/bioinformatics_26_6_791.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044068960","display_name":"Marc Kirchner","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Kirchner","raw_affiliation_strings":["1 Proteomics Center, Children's Hospital Boston, 2 Department of Pathology, Harvard Medical School and Children's Hospital Boston, Boston, MA and 3 Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Proteomics Center, Children's Hospital Boston, 2 Department of Pathology, Harvard Medical School and Children's Hospital Boston, Boston, MA and 3 Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073967378","display_name":"Wiebke Timm","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wiebke Timm","raw_affiliation_strings":["1 Proteomics Center, Children's Hospital Boston, 2 Department of Pathology, Harvard Medical School and Children's Hospital Boston, Boston, MA and 3 Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Proteomics Center, Children's Hospital Boston, 2 Department of Pathology, Harvard Medical School and Children's Hospital Boston, Boston, MA and 3 Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062168167","display_name":"Peying Fong","orcid":"https://orcid.org/0000-0002-9468-0734"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peying Fong","raw_affiliation_strings":["1 Proteomics Center, Children's Hospital Boston, 2 Department of Pathology, Harvard Medical School and Children's Hospital Boston, Boston, MA and 3 Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Proteomics Center, Children's Hospital Boston, 2 Department of Pathology, Harvard Medical School and Children's Hospital Boston, Boston, MA and 3 Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037292569","display_name":"Philine Wangemann","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philine Wangemann","raw_affiliation_strings":["1 Proteomics Center, Children's Hospital Boston, 2 Department of Pathology, Harvard Medical School and Children's Hospital Boston, Boston, MA and 3 Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Proteomics Center, Children's Hospital Boston, 2 Department of Pathology, Harvard Medical School and Children's Hospital Boston, Boston, MA and 3 Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I189590672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000977764","display_name":"Hanno Steen","orcid":"https://orcid.org/0000-0003-0179-6648"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hanno Steen","raw_affiliation_strings":["1 Proteomics Center, Children's Hospital Boston, 2 Department of Pathology, Harvard Medical School and Children's Hospital Boston, Boston, MA and 3 Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Proteomics Center, Children's Hospital Boston, 2 Department of Pathology, Harvard Medical School and Children's Hospital Boston, Boston, MA and 3 Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I189590672"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000977764"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I189590672"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.0451,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.74370958,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"26","issue":"6","first_page":"791","last_page":"797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9153000116348267,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9153000116348267,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.07660000026226044,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fragmentation","display_name":"Fragmentation (computing)","score":0.7894550561904907},{"id":"https://openalex.org/keywords/analyte","display_name":"Analyte","score":0.6227383017539978},{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"Mass spectrometry","score":0.5785776972770691},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5527514219284058},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.4901733994483948},{"id":"https://openalex.org/keywords/mass-spectrum","display_name":"Mass spectrum","score":0.4776705205440521},{"id":"https://openalex.org/keywords/generalization","display_name":"Generalization","score":0.448478639125824},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4442904591560364},{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"Tandem mass spectrometry","score":0.43202829360961914},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.34561479091644287},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.32262682914733887},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.32088738679885864},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.28908097743988037},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.2138654887676239}],"concepts":[{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.7894550561904907},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.6227383017539978},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5785776972770691},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5527514219284058},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.4901733994483948},{"id":"https://openalex.org/C40325409","wikidata":"https://www.wikidata.org/wiki/Q2360668","display_name":"Mass spectrum","level":3,"score":0.4776705205440521},{"id":"https://openalex.org/C177148314","wikidata":"https://www.wikidata.org/wiki/Q170084","display_name":"Generalization","level":2,"score":0.448478639125824},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4442904591560364},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.43202829360961914},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.34561479091644287},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.32262682914733887},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32088738679885864},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.28908097743988037},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2138654887676239},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btq036","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq036","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/6/791/48853010/bioinformatics_26_6_791.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20134030","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20134030","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:2202655","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3202308","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btq036","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btq036","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/6/791/48853010/bioinformatics_26_6_791.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5699999928474426,"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities"}],"awards":[{"id":"https://openalex.org/G6674030162","display_name":null,"funder_award_id":"P20 RR017686","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W273955616","https://openalex.org/W1480376833","https://openalex.org/W1554944419","https://openalex.org/W1575497636","https://openalex.org/W1980072473","https://openalex.org/W1990030097","https://openalex.org/W2001841288","https://openalex.org/W2004145234","https://openalex.org/W2014186056","https://openalex.org/W2020047082","https://openalex.org/W2024603281","https://openalex.org/W2031315451","https://openalex.org/W2041226065","https://openalex.org/W2051809150","https://openalex.org/W2062332993","https://openalex.org/W2079724736","https://openalex.org/W2088366062","https://openalex.org/W2095419014","https://openalex.org/W2107903949","https://openalex.org/W2116184147","https://openalex.org/W2120604922","https://openalex.org/W2168987227","https://openalex.org/W2171033594","https://openalex.org/W2582743722","https://openalex.org/W2911964244","https://openalex.org/W3135010051","https://openalex.org/W4399531763","https://openalex.org/W6610017368"],"related_works":["https://openalex.org/W998478742","https://openalex.org/W264734435","https://openalex.org/W1967823674","https://openalex.org/W2137528709","https://openalex.org/W1988017117","https://openalex.org/W2118896269","https://openalex.org/W4249823562","https://openalex.org/W2063819904","https://openalex.org/W2921230360","https://openalex.org/W1997533132"],"abstract_inverted_index":{"MOTIVATION:":[0],"Mass":[1],"spectrometry":[2],"(MS)":[3],"has":[4],"become":[5],"the":[6,32,89,188,195],"method":[7],"of":[8,74,92,115,117,146,148,162,190,194],"choice":[9],"for":[10,29,38,142,159],"protein/peptide":[11],"sequence":[12],"and":[13,31,61,126,182],"modification":[14],"analysis.":[15,40],"The":[16,198],"technology":[17],"employs":[18],"a":[19,66,121,127],"two-step":[20],"approach:":[21],"ionized":[22],"peptide":[23],"precursor":[24,42,94],"masses":[25],"are":[26,36,45,57,62,200,224],"detected,":[27],"selected":[28,58],"fragmentation,":[30],"fragment":[33],"mass":[34,55,91,95,110,140],"spectra":[35],"collected":[37],"computational":[39],"Current":[41],"selection":[43],"schemes":[44],"based":[46],"on":[47,187],"data-":[48],"or":[49,164],"information-dependent":[50],"acquisition":[51],"(DDA/IDA),":[52],"where":[53],"fragmentation":[54,114,157,168],"candidates":[56],"by":[59,98],"intensity":[60],"subsequently":[63],"included":[64],"in":[65,88,211],"dynamic":[67],"exclusion":[68],"list":[69],"to":[70,135,155,165,202],"avoid":[71],"constant":[72],"refragmentation":[73],"highly":[75],"abundant":[76],"species.":[77],"DDA/IDA":[78],"methods":[79,151,199],"do":[80],"not":[81],"exploit":[82],"valuable":[83],"information":[84,111],"that":[85,106,108,173,183],"is":[86,214],"contained":[87],"fractional":[90,109,139],"high-accuracy":[93],"measurements":[96],"delivered":[97],"current":[99],"instrumentation.":[100],"RESULTS:":[101],"We":[102,119,171],"extend":[103],"previous":[104],"contributions":[105],"suggest":[107],"allows":[112],"targeted":[113],"analytes":[116,163],"interest.":[118],"introduce":[120],"non-linear":[122],"Random":[123],"Forest":[124],"classification":[125],"discrete":[128],"mapping":[129],"approach,":[130],"which":[131],"can":[132,152],"be":[133,153],"trained":[134],"discriminate":[136],"among":[137],"arbitrary":[138,144],"patterns":[141],"an":[143],"number":[145],"classes":[147],"analytes.":[149],"These":[150],"used":[154,210],"increase":[156],"efficiency":[158],"specific":[160],"subsets":[161],"select":[166],"suitable":[167],"technologies":[169],"on-the-fly.":[170],"show":[172],"theoretical":[174],"generalization":[175],"error":[176],"estimates":[177],"transfer":[178],"into":[179],"practical":[180],"application,":[181],"their":[184],"quality":[185],"depends":[186],"accuracy":[189],"prior":[191],"distribution":[192],"estimate":[193],"analyte":[196],"classes.":[197],"applied":[201],"two":[203],"real-world":[204],"proteomics":[205],"datasets.":[206],"AVAILABILITY:":[207],"All":[208],"software":[209],"this":[212],"study":[213],"available":[215,225],"from":[216],"http://software.steenlab.org/fmf":[217],"CONTACT:":[218],"hanno.steen@childrens.harvard.edu":[219],"SUPPLEMENTARY":[220],"INFORMATION:":[221],"Supplementary":[222],"data":[223],"at":[226],"Bioinformatics":[227],"online.":[228]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}
