{"id":"https://openalex.org/W2152036878","doi":"https://doi.org/10.1093/bioinformatics/btp708","title":"CMDS: a population-based method for identifying recurrent DNA copy number aberrations in cancer from high-resolution data","display_name":"CMDS: a population-based method for identifying recurrent DNA copy number aberrations in cancer from high-resolution data","publication_year":2009,"publication_date":"2009-12-23","ids":{"openalex":"https://openalex.org/W2152036878","doi":"https://doi.org/10.1093/bioinformatics/btp708","mag":"2152036878","pmid":"https://pubmed.ncbi.nlm.nih.gov/20031968"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btp708","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp708","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/4/464/48855297/bioinformatics_26_4_464.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/26/4/464/48855297/bioinformatics_26_4_464.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088266338","display_name":"Qunyuan Zhang","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Qunyuan Zhang","raw_affiliation_strings":["1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100449520","display_name":"Li Ding","orcid":"https://orcid.org/0000-0003-1517-2975"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Ding","raw_affiliation_strings":["1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021913825","display_name":"David E. Larson","orcid":"https://orcid.org/0000-0001-7934-5906"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David E. Larson","raw_affiliation_strings":["1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022808238","display_name":"Daniel C. Koboldt","orcid":"https://orcid.org/0000-0002-7290-3482"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel C. Koboldt","raw_affiliation_strings":["1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089826284","display_name":"Michael D. McLellan","orcid":"https://orcid.org/0000-0002-2703-8784"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael D. McLellan","raw_affiliation_strings":["1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420347","display_name":"Ken Chen","orcid":"https://orcid.org/0000-0003-4013-5279"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ken Chen","raw_affiliation_strings":["1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017118856","display_name":"Xiaoqi Shi","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoqi Shi","raw_affiliation_strings":["1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112055873","display_name":"Aldi T. Kraja","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aldi Kraja","raw_affiliation_strings":["1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054642128","display_name":"Elaine R. Mardis","orcid":"https://orcid.org/0000-0002-5892-1553"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elaine R. Mardis","raw_affiliation_strings":["1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014714324","display_name":"Richard K. Wilson","orcid":"https://orcid.org/0000-0002-1992-1358"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard K. Wilson","raw_affiliation_strings":["1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108223133","display_name":"Ingrid B. Borecki","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ingrid B. Borecki","raw_affiliation_strings":["1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004832167","display_name":"Michael A. Province","orcid":"https://orcid.org/0000-0001-6102-774X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael A. Province","raw_affiliation_strings":["1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Division of Statistical Genomics and 2 The Genome Center, Washington University School of Medicine, St Louis, MO, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5088266338"],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.4675,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.93131504,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"26","issue":"4","first_page":"464","last_page":"469"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9539999961853027,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9539999961853027,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6377636194229126},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5449501276016235},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.451337605714798},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.42462190985679626},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3814193606376648},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3692486882209778},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24226826429367065},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1632215678691864},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.09981134533882141}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6377636194229126},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5449501276016235},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.451337605714798},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42462190985679626},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3814193606376648},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3692486882209778},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24226826429367065},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1632215678691864},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.09981134533882141},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btp708","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp708","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/4/464/48855297/bioinformatics_26_4_464.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20031968","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20031968","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:2040786","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2852218","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btp708","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp708","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/26/4/464/48855297/bioinformatics_26_4_464.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2152036878.pdf","grobid_xml":"https://content.openalex.org/works/W2152036878.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1559899545","https://openalex.org/W1966321968","https://openalex.org/W1978645448","https://openalex.org/W2017535462","https://openalex.org/W2023369015","https://openalex.org/W2024077732","https://openalex.org/W2025183726","https://openalex.org/W2047361940","https://openalex.org/W2047432537","https://openalex.org/W2065141457","https://openalex.org/W2100725331","https://openalex.org/W2104224322","https://openalex.org/W2110012127","https://openalex.org/W2113574907","https://openalex.org/W2118184985","https://openalex.org/W2121978507","https://openalex.org/W2122769974","https://openalex.org/W2127710810","https://openalex.org/W2133174470","https://openalex.org/W2148133654","https://openalex.org/W2151820600","https://openalex.org/W2997696222"],"related_works":["https://openalex.org/W3030972949","https://openalex.org/W4306404900","https://openalex.org/W4229832877","https://openalex.org/W3111812619","https://openalex.org/W4248366929","https://openalex.org/W2590035663","https://openalex.org/W2914997899","https://openalex.org/W4229670017","https://openalex.org/W4226309907","https://openalex.org/W2603467863"],"abstract_inverted_index":{"MOTIVATION:":[0],"DNA":[1],"copy":[2],"number":[3],"aberration":[4],"(CNA)":[5],"is":[6,94,162],"a":[7,56,63,81,119,135,210],"hallmark":[8],"of":[9,65,75,90,160,166,180,198,221],"genomic":[10],"abnormality":[11],"in":[12,19,32,55],"tumor":[13],"cells.":[14],"Recurrent":[15],"CNA":[16,42,168,199],"(RCNA)":[17],"occurs":[18],"multiple":[20],"cancer":[21,182,185,225],"samples":[22,46,132],"across":[23],"the":[24,66,125,157,218],"same":[25],"chromosomal":[26],"region":[27],"and":[28,73,99,104,133,144,183,188,193,204,213],"has":[29],"greater":[30],"implication":[31],"tumorigenesis.":[33],"Current":[34],"commonly":[35],"used":[36],"methods":[37],"for":[38,44,84,102,217],"RCNA":[39,85,219],"identification":[40],"require":[41],"calling":[43,169],"individual":[45,76],"before":[47],"cross-sample":[48],"analysis.":[49,122],"This":[50],"two-step":[51,171],"strategy":[52],"may":[53],"result":[54],"heavy":[57],"computational":[58,142],"burden,":[59],"as":[60,62],"well":[61],"loss":[64],"overall":[67],"statistical":[68,158],"power":[69,159],"due":[70],"to":[71,176],"segmentation":[72,113],"discretization":[74],"sample's":[77],"data.":[78],"We":[79,173],"propose":[80],"population-based":[82],"approach":[83],"detection":[86],"with":[87,201],"no":[88],"need":[89],"single-sample":[91,167],"analysis,":[92],"which":[93],"statistically":[95],"powerful,":[96],"computationally":[97],"efficient":[98],"particularly":[100],"suitable":[101],"high-resolution":[103],"large-population":[105],"studies.":[106],"RESULTS:":[107],"Our":[108,153],"approach,":[109],"correlation":[110,121],"matrix":[111],"diagonal":[112,136],"(CMDS),":[114],"identifies":[115],"RCNAs":[116],"based":[117,170],"on":[118],"between-chromosomal-site":[120],"Directly":[123],"using":[124],"raw":[126],"intensity":[127],"ratio":[128],"data":[129,223],"from":[130,150,186,224],"all":[131],"adopting":[134],"transformation":[137],"strategy,":[138],"CMDS":[139,161,175,208],"substantially":[140],"reduces":[141],"burden":[143],"can":[145],"obtain":[146],"results":[147],"very":[148],"quickly":[149],"large":[151],"datasets.":[152],"simulation":[154],"indicates":[155],"that":[156,165],"higher":[163],"than":[164],"approaches.":[172],"applied":[174],"two":[177],"real":[178],"datasets":[179],"lung":[181],"brain":[184],"Affymetrix":[187],"Illumina":[189],"array":[190],"platforms,":[191],"respectively,":[192],"successfully":[194],"identified":[195],"known":[196],"regions":[197],"associated":[200],"EGFR,":[202],"KRAS":[203],"other":[205],"important":[206],"oncogenes.":[207],"provides":[209],"fast,":[211],"powerful":[212],"easily":[214],"implemented":[215],"tool":[216],"analysis":[220],"large-scale":[222],"genomes.":[226]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}