{"id":"https://openalex.org/W2134091971","doi":"https://doi.org/10.1093/bioinformatics/btp370","title":"Reliable prediction of protein thermostability change upon double mutation from amino acid sequence","display_name":"Reliable prediction of protein thermostability change upon double mutation from amino acid sequence","publication_year":2009,"publication_date":"2009-06-17","ids":{"openalex":"https://openalex.org/W2134091971","doi":"https://doi.org/10.1093/bioinformatics/btp370","mag":"2134091971","pmid":"https://pubmed.ncbi.nlm.nih.gov/19535532"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btp370","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp370","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110147122","display_name":"Liang\u2010Tsung Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Liang-Tsung Huang","raw_affiliation_strings":["1 Department of Computer Science and Information Engineering, Mingdao University, Changhua 523, Taiwan and 2 Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), AIST Tokyo Waterfront Bio-IT Research Building, 2-42 Aomi, Koto-ku, Tokyo 135-0064, Japan"],"affiliations":[{"raw_affiliation_string":"1 Department of Computer Science and Information Engineering, Mingdao University, Changhua 523, Taiwan and 2 Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), AIST Tokyo Waterfront Bio-IT Research Building, 2-42 Aomi, Koto-ku, Tokyo 135-0064, Japan","institution_ids":["https://openalex.org/I73613424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046879365","display_name":"M. Michael Gromiha","orcid":"https://orcid.org/0000-0002-1776-4096"},"institutions":[{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Michael Gromiha","raw_affiliation_strings":["1 Department of Computer Science and Information Engineering, Mingdao University, Changhua 523, Taiwan and 2 Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), AIST Tokyo Waterfront Bio-IT Research Building, 2-42 Aomi, Koto-ku, Tokyo 135-0064, Japan"],"affiliations":[{"raw_affiliation_string":"1 Department of Computer Science and Information Engineering, Mingdao University, Changhua 523, Taiwan and 2 Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), AIST Tokyo Waterfront Bio-IT Research Building, 2-42 Aomi, Koto-ku, Tokyo 135-0064, Japan","institution_ids":["https://openalex.org/I73613424"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110147122"],"corresponding_institution_ids":["https://openalex.org/I73613424"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.706,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.83947522,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"25","issue":"17","first_page":"2181","last_page":"2187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thermostability","display_name":"Thermostability","score":0.916221022605896},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.8224998712539673},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.6035852432250977},{"id":"https://openalex.org/keywords/denaturation","display_name":"Denaturation (fissile materials)","score":0.5653247237205505},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5272851586341858},{"id":"https://openalex.org/keywords/amino-acid-residue","display_name":"Amino acid residue","score":0.4926064610481262},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.49032333493232727},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47793132066726685},{"id":"https://openalex.org/keywords/wild-type","display_name":"Wild type","score":0.4736821949481964},{"id":"https://openalex.org/keywords/protein-sequencing","display_name":"Protein sequencing","score":0.4560515880584717},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.4339030086994171},{"id":"https://openalex.org/keywords/protein-stability","display_name":"Protein stability","score":0.42180973291397095},{"id":"https://openalex.org/keywords/protein-design","display_name":"Protein design","score":0.41707974672317505},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3640623092651367},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3360958695411682},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.33084607124328613},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.30419808626174927},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.2617601156234741},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1097562313079834},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.08451607823371887},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.06243699789047241}],"concepts":[{"id":"https://openalex.org/C2781216036","wikidata":"https://www.wikidata.org/wiki/Q902494","display_name":"Thermostability","level":3,"score":0.916221022605896},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.8224998712539673},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6035852432250977},{"id":"https://openalex.org/C2776923230","wikidata":"https://www.wikidata.org/wiki/Q16955798","display_name":"Denaturation (fissile materials)","level":2,"score":0.5653247237205505},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5272851586341858},{"id":"https://openalex.org/C2994376932","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Amino acid residue","level":4,"score":0.4926064610481262},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.49032333493232727},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47793132066726685},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.4736821949481964},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.4560515880584717},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4339030086994171},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.42180973291397095},{"id":"https://openalex.org/C152769699","wikidata":"https://www.wikidata.org/wiki/Q410814","display_name":"Protein design","level":3,"score":0.41707974672317505},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3640623092651367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3360958695411682},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33084607124328613},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.30419808626174927},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.2617601156234741},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1097562313079834},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.08451607823371887},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06243699789047241},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050505","descriptor_name":"Mutant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btp370","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp370","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19535532","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19535532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.5899999737739563,"display_name":"Reduced inequalities"},{"id":"https://metadata.un.org/sdg/16","score":0.4300000071525574,"display_name":"Peace, Justice and strong institutions"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1630964756","https://openalex.org/W1829746528","https://openalex.org/W1964196548","https://openalex.org/W1966480910","https://openalex.org/W1966844407","https://openalex.org/W1966979475","https://openalex.org/W1975936149","https://openalex.org/W1994983243","https://openalex.org/W2005383565","https://openalex.org/W2020248033","https://openalex.org/W2025389130","https://openalex.org/W2026339550","https://openalex.org/W2029999655","https://openalex.org/W2031397067","https://openalex.org/W2036634847","https://openalex.org/W2046763527","https://openalex.org/W2049576685","https://openalex.org/W2070783701","https://openalex.org/W2071328252","https://openalex.org/W2082222554","https://openalex.org/W2083624153","https://openalex.org/W2085657257","https://openalex.org/W2092387745","https://openalex.org/W2099672241","https://openalex.org/W2103578846","https://openalex.org/W2113534530","https://openalex.org/W2113710405","https://openalex.org/W2119549626","https://openalex.org/W2120701908","https://openalex.org/W2120949690","https://openalex.org/W2121208681","https://openalex.org/W2121519777","https://openalex.org/W2133067061","https://openalex.org/W2134488721","https://openalex.org/W2135503340","https://openalex.org/W2136513422","https://openalex.org/W2143994417","https://openalex.org/W2146606022","https://openalex.org/W2149313395","https://openalex.org/W2151373045","https://openalex.org/W2161199282","https://openalex.org/W2912934387","https://openalex.org/W4212883601","https://openalex.org/W6658188502"],"related_works":["https://openalex.org/W3215076145","https://openalex.org/W2613332373","https://openalex.org/W2005824433","https://openalex.org/W84994589","https://openalex.org/W2461736353","https://openalex.org/W1586693356","https://openalex.org/W2048537773","https://openalex.org/W3207150965","https://openalex.org/W1605533832","https://openalex.org/W1988730649"],"abstract_inverted_index":{"The":[0],"accurate":[1],"prediction":[2],"of":[3,11,28,46,53,74,92,99,105],"protein":[4,16],"stability":[5,26,72,100],"change":[6,27],"upon":[7],"mutation":[8],"is":[9],"one":[10],"the":[12,25,34,50,71,109],"important":[13],"issues":[14],"for":[15,69,107],"design.":[17],"In":[18],"this":[19],"work,":[20],"we":[21,60],"have":[22,61],"focused":[23],"on":[24,49],"double":[29,76],"mutations":[30],"and":[31,36,44,56,96,102,111],"systematically":[32],"analyzed":[33],"wild-type":[35],"mutant":[37,55],"residues,":[38,59],"patterns":[39],"in":[40],"amino":[41],"acid":[42],"sequence":[43,51],"locations":[45],"mutants.":[47,113],"Based":[48],"information":[52],"wild-type,":[54],"three":[57],"neighboring":[58],"presented":[62],"a":[63,90],"weighted":[64],"decision":[65],"table":[66],"method":[67,88],"(WET)":[68],"predicting":[70],"changes":[73],"180":[75],"mutants":[77],"obtained":[78],"from":[79],"thermal":[80],"(DeltaDeltaG)":[81],"denaturation.":[82],"Using":[83],"10-fold":[84],"cross-validation":[85],"test,":[86],"our":[87],"showed":[89],"correlation":[91],"0.75":[93],"between":[94],"experimental":[95],"predicted":[97],"values":[98],"changes,":[101],"an":[103],"accuracy":[104],"82.2%":[106],"discriminating":[108],"stabilizing":[110],"destabilizing":[112]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":7}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}