{"id":"https://openalex.org/W2160960618","doi":"https://doi.org/10.1093/bioinformatics/btp298","title":"Genetic modification of flux for flux prediction of mutants","display_name":"Genetic modification of flux for flux prediction of mutants","publication_year":2009,"publication_date":"2009-05-25","ids":{"openalex":"https://openalex.org/W2160960618","doi":"https://doi.org/10.1093/bioinformatics/btp298","mag":"2160960618","pmid":"https://pubmed.ncbi.nlm.nih.gov/19468056"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btp298","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp298","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/13/1702/16888748/btp298.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/25/13/1702/16888748/btp298.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006184062","display_name":"Quanyu Zhao","orcid":"https://orcid.org/0000-0002-6608-4927"},"institutions":[{"id":"https://openalex.org/I207014233","display_name":"Kyushu Institute of Technology","ror":"https://ror.org/02278tr80","country_code":"JP","type":"education","lineage":["https://openalex.org/I207014233"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Quanyu Zhao","raw_affiliation_strings":["Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 680-4 Kawazu, Iizuka, Fukuoka, 820-8502, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 680-4 Kawazu, Iizuka, Fukuoka, 820-8502, Japan","institution_ids":["https://openalex.org/I207014233"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043771897","display_name":"Hiroyuki Kurata","orcid":"https://orcid.org/0000-0003-4254-2214"},"institutions":[{"id":"https://openalex.org/I207014233","display_name":"Kyushu Institute of Technology","ror":"https://ror.org/02278tr80","country_code":"JP","type":"education","lineage":["https://openalex.org/I207014233"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroyuki Kurata","raw_affiliation_strings":["Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 680-4 Kawazu, Iizuka, Fukuoka, 820-8502, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 680-4 Kawazu, Iizuka, Fukuoka, 820-8502, Japan","institution_ids":["https://openalex.org/I207014233"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043771897"],"corresponding_institution_ids":["https://openalex.org/I207014233"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":1.706,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.84074701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"25","issue":"13","first_page":"1702","last_page":"1708"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.8296561241149902},{"id":"https://openalex.org/keywords/flux-balance-analysis","display_name":"Flux balance analysis","score":0.7840313911437988},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.7633252739906311},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5965772867202759},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"Metabolic engineering","score":0.5849020481109619},{"id":"https://openalex.org/keywords/metabolic-flux-analysis","display_name":"Metabolic flux analysis","score":0.577129065990448},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5226325988769531},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5097193121910095},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5050318837165833},{"id":"https://openalex.org/keywords/corynebacterium-glutamicum","display_name":"Corynebacterium glutamicum","score":0.49976015090942383},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4395518898963928},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.4268905818462372},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.36680302023887634},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.15438607335090637},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.11355134844779968}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.8296561241149902},{"id":"https://openalex.org/C167091322","wikidata":"https://www.wikidata.org/wiki/Q5463029","display_name":"Flux balance analysis","level":2,"score":0.7840313911437988},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.7633252739906311},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5965772867202759},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.5849020481109619},{"id":"https://openalex.org/C160941953","wikidata":"https://www.wikidata.org/wiki/Q6822342","display_name":"Metabolic flux analysis","level":3,"score":0.577129065990448},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5226325988769531},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5097193121910095},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5050318837165833},{"id":"https://openalex.org/C2776260651","wikidata":"https://www.wikidata.org/wiki/Q292314","display_name":"Corynebacterium glutamicum","level":3,"score":0.49976015090942383},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4395518898963928},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4268905818462372},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.36680302023887634},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15438607335090637},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11355134844779968},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048230","descriptor_name":"Corynebacterium glutamicum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048230","descriptor_name":"Corynebacterium glutamicum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048230","descriptor_name":"Corynebacterium glutamicum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048230","descriptor_name":"Corynebacterium glutamicum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048230","descriptor_name":"Corynebacterium glutamicum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048230","descriptor_name":"Corynebacterium glutamicum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btp298","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp298","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/13/1702/16888748/btp298.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19468056","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19468056","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btp298","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp298","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/13/1702/16888748/btp298.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2160960618.pdf","grobid_xml":"https://content.openalex.org/works/W2160960618.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1504423416","https://openalex.org/W1642162696","https://openalex.org/W1684307508","https://openalex.org/W1758395617","https://openalex.org/W1967039865","https://openalex.org/W1969852704","https://openalex.org/W1978119727","https://openalex.org/W1980558594","https://openalex.org/W1981385284","https://openalex.org/W1982309495","https://openalex.org/W1983566611","https://openalex.org/W1994683277","https://openalex.org/W2006497076","https://openalex.org/W2006672203","https://openalex.org/W2012991302","https://openalex.org/W2023290064","https://openalex.org/W2023324052","https://openalex.org/W2023754149","https://openalex.org/W2026089579","https://openalex.org/W2037248648","https://openalex.org/W2045167474","https://openalex.org/W2054506883","https://openalex.org/W2061425168","https://openalex.org/W2082177941","https://openalex.org/W2094397891","https://openalex.org/W2094399313","https://openalex.org/W2099039198","https://openalex.org/W2102164505","https://openalex.org/W2111421616","https://openalex.org/W2111943920","https://openalex.org/W2119221480","https://openalex.org/W2123698848","https://openalex.org/W2127020923","https://openalex.org/W2133764438","https://openalex.org/W2135791865","https://openalex.org/W2139786345","https://openalex.org/W2141776893","https://openalex.org/W2144675661","https://openalex.org/W2144761508","https://openalex.org/W2147892681","https://openalex.org/W2148190806","https://openalex.org/W2155570608","https://openalex.org/W2166034700","https://openalex.org/W2168846334","https://openalex.org/W2170662273","https://openalex.org/W4235920957","https://openalex.org/W4253472439"],"related_works":["https://openalex.org/W1918238777","https://openalex.org/W2353873485","https://openalex.org/W2420406980","https://openalex.org/W2378251673","https://openalex.org/W2018212195","https://openalex.org/W2521105713","https://openalex.org/W2024297267","https://openalex.org/W1865302071","https://openalex.org/W2062245653","https://openalex.org/W2160960618"],"abstract_inverted_index":{"Supplementary":[0],"file":[1],"and":[2],"programs":[3],"are":[4],"available":[5],"at":[6],"Bioinformatics":[7],"online":[8],"or":[9],"http://www.cadlive.jp.":[10]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}