{"id":"https://openalex.org/W2132663737","doi":"https://doi.org/10.1093/bioinformatics/btp199","title":"Grouped graphical Granger modeling for gene expression regulatory networks discovery","display_name":"Grouped graphical Granger modeling for gene expression regulatory networks discovery","publication_year":2009,"publication_date":"2009-05-27","ids":{"openalex":"https://openalex.org/W2132663737","doi":"https://doi.org/10.1093/bioinformatics/btp199","mag":"2132663737","pmid":"https://pubmed.ncbi.nlm.nih.gov/19477976"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btp199","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp199","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/12/i110/48992805/bioinformatics_25_12_i110.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/25/12/i110/48992805/bioinformatics_25_12_i110.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055054658","display_name":"Aur\u00e9lie Lozano","orcid":null},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Aur\u00e9lie C. Lozano","raw_affiliation_strings":["1 Mathematical Sciences Department, IBM T.J. Watson Research Center, Yorktown Heights, NY, 10598, USA and 2School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Mathematical Sciences Department, IBM T.J. Watson Research Center, Yorktown Heights, NY, 10598, USA and 2School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060856151","display_name":"Naoki Abe","orcid":"https://orcid.org/0000-0002-4048-3989"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Naoki Abe","raw_affiliation_strings":["1 Mathematical Sciences Department, IBM T.J. Watson Research Center, Yorktown Heights, NY, 10598, USA and 2School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Mathematical Sciences Department, IBM T.J. Watson Research Center, Yorktown Heights, NY, 10598, USA and 2School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351175","display_name":"Yan Liu","orcid":"https://orcid.org/0000-0003-4242-4840"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yan Liu","raw_affiliation_strings":["1 Mathematical Sciences Department, IBM T.J. Watson Research Center, Yorktown Heights, NY, 10598, USA and 2School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Mathematical Sciences Department, IBM T.J. Watson Research Center, Yorktown Heights, NY, 10598, USA and 2School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039021124","display_name":"Saharon Rosset","orcid":"https://orcid.org/0000-0002-4458-9545"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Saharon Rosset","raw_affiliation_strings":["1 Mathematical Sciences Department, IBM T.J. Watson Research Center, Yorktown Heights, NY, 10598, USA and 2School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Mathematical Sciences Department, IBM T.J. Watson Research Center, Yorktown Heights, NY, 10598, USA and 2School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055054658"],"corresponding_institution_ids":["https://openalex.org/I16391192"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":4.4103,"has_fulltext":true,"cited_by_count":162,"citation_normalized_percentile":{"value":0.95480805,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"25","issue":"12","first_page":"i110","last_page":"i118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granger-causality","display_name":"Granger causality","score":0.7889566421508789},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.6298519968986511},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6264585256576538},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.6222652196884155},{"id":"https://openalex.org/keywords/graphical-model","display_name":"Graphical model","score":0.6129080653190613},{"id":"https://openalex.org/keywords/time-series","display_name":"Time series","score":0.5616297125816345},{"id":"https://openalex.org/keywords/causal-inference","display_name":"Causal inference","score":0.5416948795318604},{"id":"https://openalex.org/keywords/causality","display_name":"Causality (physics)","score":0.5163953900337219},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5024664402008057},{"id":"https://openalex.org/keywords/series","display_name":"Series (stratigraphy)","score":0.46674638986587524},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.41506949067115784},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.35020148754119873},{"id":"https://openalex.org/keywords/econometrics","display_name":"Econometrics","score":0.329493910074234},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18900233507156372},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18741676211357117},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.17522883415222168},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.15382152795791626}],"concepts":[{"id":"https://openalex.org/C129824826","wikidata":"https://www.wikidata.org/wiki/Q2630107","display_name":"Granger causality","level":2,"score":0.7889566421508789},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.6298519968986511},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6264585256576538},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6222652196884155},{"id":"https://openalex.org/C155846161","wikidata":"https://www.wikidata.org/wiki/Q1143367","display_name":"Graphical model","level":2,"score":0.6129080653190613},{"id":"https://openalex.org/C151406439","wikidata":"https://www.wikidata.org/wiki/Q186588","display_name":"Time series","level":2,"score":0.5616297125816345},{"id":"https://openalex.org/C158600405","wikidata":"https://www.wikidata.org/wiki/Q5054566","display_name":"Causal inference","level":2,"score":0.5416948795318604},{"id":"https://openalex.org/C64357122","wikidata":"https://www.wikidata.org/wiki/Q1149766","display_name":"Causality (physics)","level":2,"score":0.5163953900337219},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5024664402008057},{"id":"https://openalex.org/C143724316","wikidata":"https://www.wikidata.org/wiki/Q312468","display_name":"Series (stratigraphy)","level":2,"score":0.46674638986587524},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.41506949067115784},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35020148754119873},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.329493910074234},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18900233507156372},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18741676211357117},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17522883415222168},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15382152795791626},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btp199","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp199","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/12/i110/48992805/bioinformatics_25_12_i110.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19477976","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19477976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:europepmc.org:1855984","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2687953","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.358.7418","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.358.7418","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/9b/43/Bioinformatics_2009_Jun_15_25(12)_i110-i118.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btp199","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp199","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/12/i110/48992805/bioinformatics_25_12_i110.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2132663737.pdf","grobid_xml":"https://content.openalex.org/works/W2132663737.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W145994340","https://openalex.org/W1531406273","https://openalex.org/W1607114662","https://openalex.org/W1981547652","https://openalex.org/W1994309289","https://openalex.org/W1995691260","https://openalex.org/W2010824638","https://openalex.org/W2020925091","https://openalex.org/W2034567120","https://openalex.org/W2049058758","https://openalex.org/W2065515536","https://openalex.org/W2065540158","https://openalex.org/W2069020547","https://openalex.org/W2069562617","https://openalex.org/W2073068681","https://openalex.org/W2084833542","https://openalex.org/W2088323624","https://openalex.org/W2097879961","https://openalex.org/W2104854813","https://openalex.org/W2105712639","https://openalex.org/W2108122190","https://openalex.org/W2118418963","https://openalex.org/W2135046866","https://openalex.org/W2138019504","https://openalex.org/W2140176439","https://openalex.org/W2149579404","https://openalex.org/W2155982020","https://openalex.org/W2167190345","https://openalex.org/W2390150621","https://openalex.org/W2797463641","https://openalex.org/W3098834468","https://openalex.org/W3106266785","https://openalex.org/W3140874755","https://openalex.org/W3199465508","https://openalex.org/W4246362381","https://openalex.org/W4323359902","https://openalex.org/W4388322883","https://openalex.org/W6648924909","https://openalex.org/W6711422703","https://openalex.org/W6786051415","https://openalex.org/W7018004935"],"related_works":["https://openalex.org/W2035792466","https://openalex.org/W2977645287","https://openalex.org/W4251418261","https://openalex.org/W1972675643","https://openalex.org/W2911392473","https://openalex.org/W2154758532","https://openalex.org/W1547624382","https://openalex.org/W2574301230","https://openalex.org/W4320159092","https://openalex.org/W2153244486"],"abstract_inverted_index":{"We":[0,168],"consider":[1],"the":[2,40,64,69,76,102,116,134,152,156,162,170,173,185,198,207,213],"problem":[3],"of":[4,42,63,109,172,228],"discovering":[5],"gene":[6,181,214],"regulatory":[7],"networks":[8],"from":[9],"time-series":[10,36],"microarray":[11],"data.":[12,192],"Recently,":[13],"graphical":[14,32,128],"Granger":[15,129],"modeling":[16,33,130],"has":[17],"gained":[18],"considerable":[19],"attention":[20],"as":[21,91,93],"a":[22,106,121,140],"promising":[23],"direction":[24],"for":[25,144],"addressing":[26],"this":[27,89],"problem.":[28],"These":[29],"methods":[30,34,84],"apply":[31],"on":[35,48,52,176,212],"data":[37,113,216],"and":[38,111,146,149,179,231],"invoke":[39],"notion":[41],"'Granger":[43],"causality'":[44],"to":[45,101,161,221,226],"make":[46],"assertions":[47],"causality":[49],"through":[50],"inference":[51],"time-lagged":[53],"effects.":[54],"Existing":[55],"algorithms,":[56],"however,":[57],"have":[58],"neglected":[59],"an":[60],"important":[61],"aspect":[62],"problem--the":[65],"group":[66,153],"structure":[67,154],"among":[68,155],"lagged":[70,157],"temporal":[71,158],"variables":[72,159],"naturally":[73],"imposed":[74],"by":[75,138,150,238],"time":[77,163],"series":[78,164],"they":[79,165],"belong":[80,166],"to.":[81,167],"Specifically,":[82],"existing":[83],"in":[85,205],"computational":[86,95],"biology":[87],"share":[88],"shortcoming,":[90],"well":[92],"additional":[94,234],"limitations,":[96],"prohibiting":[97],"their":[98],"effective":[99],"applications":[100],"large":[103,107,147],"datasets":[104],"including":[105],"number":[108],"genes":[110],"many":[112],"points.":[114],"In":[115],"present":[117],"article,":[118],"we":[119,125],"propose":[120],"novel":[122],"methodology":[123,175,200],"which":[124,132],"term":[126],"'grouped":[127],"method',":[131],"overcomes":[133],"limitations":[135],"mentioned":[136],"above":[137],"applying":[139],"regression":[141],"method":[142],"suited":[143],"high-dimensional":[145],"data,":[148,183],"leveraging":[151],"according":[160],"demonstrate":[169,217],"effectiveness":[171],"proposed":[174,199],"both":[177],"simulated":[178],"actual":[180],"expression":[182,215],"specifically":[184],"human":[186],"cancer":[187],"cell":[188],"(HeLa":[189],"S3)":[190],"cycle":[191],"The":[193],"simulation":[194],"results":[195],"show":[196],"that":[197,218],"generally":[201],"exhibits":[202],"higher":[203],"accuracy":[204,223],"recovering":[206],"underlying":[208],"causal":[209,235],"structure.":[210],"Those":[211],"it":[219],"leads":[220],"improved":[222],"with":[224],"respect":[225],"prediction":[227],"known":[229],"links,":[230],"also":[232],"uncovers":[233],"relationships":[236],"uncaptured":[237],"earlier":[239],"works.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":14}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}