{"id":"https://openalex.org/W2113836227","doi":"https://doi.org/10.1093/bioinformatics/btp106","title":"A neural network model for constructing endophenotypes of common complex diseases: an application to male young-onset hypertension microarray data","display_name":"A neural network model for constructing endophenotypes of common complex diseases: an application to male young-onset hypertension microarray data","publication_year":2009,"publication_date":"2009-02-23","ids":{"openalex":"https://openalex.org/W2113836227","doi":"https://doi.org/10.1093/bioinformatics/btp106","mag":"2113836227","pmid":"https://pubmed.ncbi.nlm.nih.gov/19237446"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btp106","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp106","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/8/981/50287571/bioinformatics_25_8_981.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/25/8/981/50287571/bioinformatics_25_8_981.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059348844","display_name":"Ke\u2010Shiuan Lynn","orcid":"https://orcid.org/0000-0002-4570-8809"},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Ke-Shiuan Lynn","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"],"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060347417","display_name":"Lilan Li","orcid":"https://orcid.org/0000-0002-0852-3661"},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I142066694","display_name":"ITRI International","ror":"https://ror.org/04wwsbd59","country_code":"US","type":"facility","lineage":["https://openalex.org/I142066694"]},{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Li-Lan Li","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","ITRI International, San Jose, United States"],"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]},{"raw_affiliation_string":"ITRI International, San Jose, United States","institution_ids":["https://openalex.org/I142066694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101474679","display_name":"Yen-Ju Lin","orcid":"https://orcid.org/0000-0002-8848-7778"},"institutions":[{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I142066694","display_name":"ITRI International","ror":"https://ror.org/04wwsbd59","country_code":"US","type":"facility","lineage":["https://openalex.org/I142066694"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Yen-Ju Lin","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","ITRI International, San Jose, United States"],"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]},{"raw_affiliation_string":"ITRI International, San Jose, United States","institution_ids":["https://openalex.org/I142066694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004798037","display_name":"Chiuen-Huei Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I142066694","display_name":"ITRI International","ror":"https://ror.org/04wwsbd59","country_code":"US","type":"facility","lineage":["https://openalex.org/I142066694"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Chiuen-Huei Wang","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","ITRI International, San Jose, United States"],"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]},{"raw_affiliation_string":"ITRI International, San Jose, United States","institution_ids":["https://openalex.org/I142066694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018760634","display_name":"Shu-Hui Sheng","orcid":null},"institutions":[{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I142066694","display_name":"ITRI International","ror":"https://ror.org/04wwsbd59","country_code":"US","type":"facility","lineage":["https://openalex.org/I142066694"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Shu-Hui Sheng","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","ITRI International, San Jose, United States"],"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]},{"raw_affiliation_string":"ITRI International, San Jose, United States","institution_ids":["https://openalex.org/I142066694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066102105","display_name":"Ju\u2010Hwa Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]},{"id":"https://openalex.org/I142066694","display_name":"ITRI International","ror":"https://ror.org/04wwsbd59","country_code":"US","type":"facility","lineage":["https://openalex.org/I142066694"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Ju-Hwa Lin","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","ITRI International, San Jose, United States"],"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]},{"raw_affiliation_string":"ITRI International, San Jose, United States","institution_ids":["https://openalex.org/I142066694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102153664","display_name":"Wayne C. Liao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I142066694","display_name":"ITRI International","ror":"https://ror.org/04wwsbd59","country_code":"US","type":"facility","lineage":["https://openalex.org/I142066694"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Wayne Liao","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","ITRI International, San Jose, United States"],"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]},{"raw_affiliation_string":"ITRI International, San Jose, United States","institution_ids":["https://openalex.org/I142066694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119558606","display_name":"Wen\u2212Lian Hsu","orcid":"https://orcid.org/0000-0001-7061-3513"},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I142066694","display_name":"ITRI International","ror":"https://ror.org/04wwsbd59","country_code":"US","type":"facility","lineage":["https://openalex.org/I142066694"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Wen-Lian Hsu","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","ITRI International, San Jose, United States"],"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]},{"raw_affiliation_string":"ITRI International, San Jose, United States","institution_ids":["https://openalex.org/I142066694"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076915459","display_name":"Wen\u2010Harn Pan","orcid":"https://orcid.org/0000-0001-9136-0658"},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]},{"id":"https://openalex.org/I142066694","display_name":"ITRI International","ror":"https://ror.org/04wwsbd59","country_code":"US","type":"facility","lineage":["https://openalex.org/I142066694"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Wen-Harn Pan","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","ITRI International, San Jose, United States"],"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]},{"raw_affiliation_string":"ITRI International, San Jose, United States","institution_ids":["https://openalex.org/I142066694"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5059348844"],"corresponding_institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.9407,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.74563957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"25","issue":"8","first_page":"981","last_page":"988"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9684000015258789,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endophenotype","display_name":"Endophenotype","score":0.9862046241760254},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.6725335717201233},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.6121301054954529},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.520809531211853},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5197070240974426},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5075415372848511},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48567521572113037},{"id":"https://openalex.org/keywords/gene-chip-analysis","display_name":"Gene chip analysis","score":0.42372000217437744},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3561632037162781},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.32879751920700073},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2725733518600464},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.20551756024360657}],"concepts":[{"id":"https://openalex.org/C187869287","wikidata":"https://www.wikidata.org/wiki/Q2032061","display_name":"Endophenotype","level":3,"score":0.9862046241760254},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.6725335717201233},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.6121301054954529},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.520809531211853},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5197070240974426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5075415372848511},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48567521572113037},{"id":"https://openalex.org/C24361400","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Gene chip analysis","level":5,"score":0.42372000217437744},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3561632037162781},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32879751920700073},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2725733518600464},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.20551756024360657},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btp106","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp106","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/8/981/50287571/bioinformatics_25_8_981.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19237446","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19237446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2666815","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2666815","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btp106","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp106","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/8/981/50287571/bioinformatics_25_8_981.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1840987498","display_name":null,"funder_award_id":"AS 95ASIA02","funder_id":"https://openalex.org/F4320321041","funder_display_name":"Academia Sinica"}],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2113836227.pdf","grobid_xml":"https://content.openalex.org/works/W2113836227.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W116063010","https://openalex.org/W1904402936","https://openalex.org/W1966253115","https://openalex.org/W1973384716","https://openalex.org/W1976821007","https://openalex.org/W1983192360","https://openalex.org/W1991790856","https://openalex.org/W1991920897","https://openalex.org/W2031562416","https://openalex.org/W2042571270","https://openalex.org/W2047928920","https://openalex.org/W2053032375","https://openalex.org/W2069663235","https://openalex.org/W2074754379","https://openalex.org/W2080298091","https://openalex.org/W2101737761","https://openalex.org/W2106334424","https://openalex.org/W2108491719","https://openalex.org/W2120914564","https://openalex.org/W2121365620","https://openalex.org/W2133111499","https://openalex.org/W2134718106","https://openalex.org/W2138956360","https://openalex.org/W2144622860","https://openalex.org/W2145229405","https://openalex.org/W2146738944","https://openalex.org/W2169113244","https://openalex.org/W2614800967","https://openalex.org/W4253588582","https://openalex.org/W6677882344"],"related_works":["https://openalex.org/W2998765584","https://openalex.org/W74695042","https://openalex.org/W2358165473","https://openalex.org/W3164243671","https://openalex.org/W2900947575","https://openalex.org/W2374175389","https://openalex.org/W2358820710","https://openalex.org/W2362238002","https://openalex.org/W2352228920","https://openalex.org/W3144956976"],"abstract_inverted_index":{"We":[0],"successfully":[1],"constructed":[2],"a":[3],"three-endophenotype":[4],"model":[5],"for":[6],"Taiwanese":[7],"hypertensive":[8],"males":[9],"with":[10,32],"high":[11],"identification":[12,72],"accuracy.":[13],"Of":[14],"the":[15,27,39,49,102],"three":[16],"endophenotypes,":[17],"one":[18],"is":[19,23,29],"strongly":[20],"protective,":[21],"another":[22],"weakly":[24],"protective":[25],"and":[26,45,55,63,71,76,84],"third":[28],"highly":[30,44],"correlated":[31],"developing":[33],"young-onset":[34],"male":[35],"hypertension.":[36,93],"Sixteen":[37],"of":[38,52,73,104],"involved":[40,95],"101":[41],"genes":[42,96],"were":[43],"consistently":[46],"influential":[47],"to":[48],"endophenotypes.":[50],"Identification":[51],"SLC4A5,":[53],"SLC5A10":[54],"LDOC1":[56,77],"indicated":[57],"that":[58,79],"sodium/bicarbonate":[59],"transport,":[60],"sodium/glucose":[61],"transport":[62],"cell-proliferation":[64,85],"regulation":[65,86],"may":[66,87],"play":[67,88],"important":[68,89],"upstream":[69],"roles":[70,91],"BNIP1,":[74],"APOBEC3F":[75],"suggested":[78],"apoptosis,":[80],"innate":[81],"immune":[82],"response":[83],"downstream":[90],"in":[92,111],"The":[94],"not":[97],"only":[98],"provide":[99],"insights":[100],"into":[101],"mechanism":[103],"hypertension":[105],"but":[106],"should":[107],"also":[108],"be":[109],"considered":[110],"future":[112],"gene":[113],"mapping":[114],"endeavors.":[115]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}