{"id":"https://openalex.org/W2113836227","doi":"https://doi.org/10.1093/bioinformatics/btp106","title":"A neural network model for constructing endophenotypes of common complex diseases: an application to male young-onset hypertension microarray data","display_name":"A neural network model for constructing endophenotypes of common complex diseases: an application to male young-onset hypertension microarray data","publication_year":2009,"publication_date":"2009-02-23","ids":{"openalex":"https://openalex.org/W2113836227","doi":"https://doi.org/10.1093/bioinformatics/btp106","mag":"2113836227","pmid":"https://pubmed.ncbi.nlm.nih.gov/19237446"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btp106","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp106","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/8/981/50287571/bioinformatics_25_8_981.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/25/8/981/50287571/bioinformatics_25_8_981.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059348844","display_name":"Ke\u2010Shiuan Lynn","orcid":"https://orcid.org/0000-0002-4570-8809"},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ke-Shiuan Lynn","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060347417","display_name":"Lilan Li","orcid":"https://orcid.org/0000-0002-0852-3661"},"institutions":[{"id":"https://openalex.org/I142066694","display_name":"ITRI International","ror":"https://ror.org/04wwsbd59","country_code":"US","type":"facility","lineage":["https://openalex.org/I142066694"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Li-Lan Li","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","ITRI International, San Jose, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]},{"raw_affiliation_string":"ITRI International, San Jose, United States","institution_ids":["https://openalex.org/I142066694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101474679","display_name":"Yen-Ju Lin","orcid":"https://orcid.org/0000-0002-8848-7778"},"institutions":[{"id":"https://openalex.org/I142066694","display_name":"ITRI International","ror":"https://ror.org/04wwsbd59","country_code":"US","type":"facility","lineage":["https://openalex.org/I142066694"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Yen-Ju Lin","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","ITRI International, San Jose, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]},{"raw_affiliation_string":"ITRI International, San Jose, United States","institution_ids":["https://openalex.org/I142066694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004798037","display_name":"Chiuen-Huei Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I142066694","display_name":"ITRI International","ror":"https://ror.org/04wwsbd59","country_code":"US","type":"facility","lineage":["https://openalex.org/I142066694"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Chiuen-Huei Wang","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","ITRI International, San Jose, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]},{"raw_affiliation_string":"ITRI International, San Jose, United States","institution_ids":["https://openalex.org/I142066694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018760634","display_name":"Shu-Hui Sheng","orcid":null},"institutions":[{"id":"https://openalex.org/I142066694","display_name":"ITRI International","ror":"https://ror.org/04wwsbd59","country_code":"US","type":"facility","lineage":["https://openalex.org/I142066694"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Shu-Hui Sheng","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","ITRI International, San Jose, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]},{"raw_affiliation_string":"ITRI International, San Jose, United States","institution_ids":["https://openalex.org/I142066694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066102105","display_name":"Ju\u2010Hwa Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I142066694","display_name":"ITRI International","ror":"https://ror.org/04wwsbd59","country_code":"US","type":"facility","lineage":["https://openalex.org/I142066694"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Ju-Hwa Lin","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","ITRI International, San Jose, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]},{"raw_affiliation_string":"ITRI International, San Jose, United States","institution_ids":["https://openalex.org/I142066694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102153664","display_name":"Wayne C. Liao","orcid":null},"institutions":[{"id":"https://openalex.org/I142066694","display_name":"ITRI International","ror":"https://ror.org/04wwsbd59","country_code":"US","type":"facility","lineage":["https://openalex.org/I142066694"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]}],"countries":["TW","US"],"is_corresponding":false,"raw_author_name":"Wayne Liao","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","ITRI International, San Jose, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]},{"raw_affiliation_string":"ITRI International, San Jose, United States","institution_ids":["https://openalex.org/I142066694"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119558606","display_name":"Wen\u2212Lian Hsu","orcid":"https://orcid.org/0000-0001-7061-3513"},"institutions":[{"id":"https://openalex.org/I142066694","display_name":"ITRI International","ror":"https://ror.org/04wwsbd59","country_code":"US","type":"facility","lineage":["https://openalex.org/I142066694"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]}],"countries":["TW","US"],"is_corresponding":true,"raw_author_name":"Wen-Lian Hsu","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","ITRI International, San Jose, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]},{"raw_affiliation_string":"ITRI International, San Jose, United States","institution_ids":["https://openalex.org/I142066694"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076915459","display_name":"Wen\u2010Harn Pan","orcid":"https://orcid.org/0000-0001-9136-0658"},"institutions":[{"id":"https://openalex.org/I142066694","display_name":"ITRI International","ror":"https://ror.org/04wwsbd59","country_code":"US","type":"facility","lineage":["https://openalex.org/I142066694"]},{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]},{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I4210148468","display_name":"Industrial Technology Research Institute","ror":"https://ror.org/05szzwt63","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210148468"]}],"countries":["TW","US"],"is_corresponding":true,"raw_author_name":"Wen-Harn Pan","raw_affiliation_strings":["1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","ITRI International, San Jose, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Institute of Information Sciences, Academia Sinica, Taipei, 2Industrial Technology Research Institute, Hsinchu, 3Department of Biological Science and Technology, Hsinchu, China Medical University, Taichung, 4Phalanx Biotech Group, Inc., Hsinchu and 5Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan","institution_ids":["https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"]},{"raw_affiliation_string":"ITRI International, San Jose, United States","institution_ids":["https://openalex.org/I142066694"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5076915459","https://openalex.org/A5119558606"],"corresponding_institution_ids":["https://openalex.org/I142066694","https://openalex.org/I184693016","https://openalex.org/I4210096666","https://openalex.org/I4210148468"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":1.6756,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.83795407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"25","issue":"8","first_page":"981","last_page":"988"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":0.5759000182151794,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":0.5759000182151794,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.09210000187158585,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.08299999684095383,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endophenotype","display_name":"Endophenotype","score":0.9862046241760254},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.6725335717201233},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.6121301054954529},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.520809531211853},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5197070240974426},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5075415372848511},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48567521572113037},{"id":"https://openalex.org/keywords/gene-chip-analysis","display_name":"Gene chip analysis","score":0.42372000217437744},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3561632037162781},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.32879751920700073},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2725733518600464},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.20551756024360657}],"concepts":[{"id":"https://openalex.org/C187869287","wikidata":"https://www.wikidata.org/wiki/Q2032061","display_name":"Endophenotype","level":3,"score":0.9862046241760254},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.6725335717201233},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.6121301054954529},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.520809531211853},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5197070240974426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5075415372848511},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48567521572113037},{"id":"https://openalex.org/C24361400","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Gene chip analysis","level":5,"score":0.42372000217437744},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3561632037162781},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32879751920700073},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2725733518600464},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.20551756024360657},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btp106","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp106","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/8/981/50287571/bioinformatics_25_8_981.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19237446","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19237446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2666815","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2666815","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btp106","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp106","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/8/981/50287571/bioinformatics_25_8_981.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1840987498","display_name":null,"funder_award_id":"AS 95ASIA02","funder_id":"https://openalex.org/F4320321041","funder_display_name":"Academia Sinica"}],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2113836227.pdf","grobid_xml":"https://content.openalex.org/works/W2113836227.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W116063010","https://openalex.org/W1904402936","https://openalex.org/W1966253115","https://openalex.org/W1973384716","https://openalex.org/W1976821007","https://openalex.org/W1983192360","https://openalex.org/W1991790856","https://openalex.org/W1991920897","https://openalex.org/W2031562416","https://openalex.org/W2042571270","https://openalex.org/W2047928920","https://openalex.org/W2053032375","https://openalex.org/W2069663235","https://openalex.org/W2074754379","https://openalex.org/W2080298091","https://openalex.org/W2101737761","https://openalex.org/W2106334424","https://openalex.org/W2108491719","https://openalex.org/W2120914564","https://openalex.org/W2121365620","https://openalex.org/W2133111499","https://openalex.org/W2134718106","https://openalex.org/W2138956360","https://openalex.org/W2144622860","https://openalex.org/W2145229405","https://openalex.org/W2146738944","https://openalex.org/W2169113244","https://openalex.org/W2614800967","https://openalex.org/W4253588582","https://openalex.org/W6677882344"],"related_works":["https://openalex.org/W2998765584","https://openalex.org/W74695042","https://openalex.org/W2358165473","https://openalex.org/W3164243671","https://openalex.org/W2900947575","https://openalex.org/W2374175389","https://openalex.org/W2358820710","https://openalex.org/W2362238002","https://openalex.org/W2352228920","https://openalex.org/W3144956976"],"abstract_inverted_index":{"MOTIVATION:":[0],"Identification":[1,134],"of":[2,34,121,135,156,187],"disease-related":[3],"genes":[4,35,125,179],"using":[5],"high-throughput":[6],"microarray":[7],"data":[8,28],"is":[9,29,47,102,106,112],"more":[10],"difficult":[11],"for":[12,89],"complex":[13,45],"diseases":[14],"as":[15],"compared":[16],"with":[17,31,49,93,115],"monogenic":[18],"ones.":[19],"We":[20,41,83],"hypothesized":[21],"that":[22,43,141,162],"an":[23],"endophenotype":[24],"derived":[25],"from":[26],"transcriptional":[27],"associated":[30,48],"a":[32,38,44,63,86],"set":[33],"corresponding":[36],"to":[37,69,131],"pathway":[39],"cluster.":[40],"assumed":[42],"disease":[46],"multiple":[50],"endophenotypes":[51,76],"and":[52,109,128,138,146,154,159,167],"can":[53],"be":[54,192],"induced":[55],"by":[56,79],"their":[57],"up/downregulated":[58],"gene":[59,196],"expression":[60],"patterns.":[61],"Thus,":[62],"neural":[64],"network":[65],"model":[66,88],"was":[67],"adopted":[68],"simulate":[70],"the":[71,98,110,122,132,185],"gene-endophenotype-disease":[72],"relationship":[73],"in":[74,175,194],"which":[75],"were":[77,126],"represented":[78],"hidden":[80],"nodes.":[81],"RESULTS:":[82],"successfully":[84],"constructed":[85],"three-endophenotype":[87],"Taiwanese":[90],"hypertensive":[91],"males":[92],"high":[94],"identification":[95,155],"accuracy.":[96],"Of":[97],"three":[99],"endophenotypes,":[100],"one":[101],"strongly":[103],"protective,":[104],"another":[105],"weakly":[107],"protective":[108],"third":[111],"highly":[113,127],"correlated":[114],"developing":[116],"young-onset":[117],"male":[118],"hypertension.":[119,176],"Sixteen":[120],"involved":[123,178],"101":[124],"consistently":[129],"influential":[130],"endophenotypes.":[133],"SLC4A5,":[136],"SLC5A10":[137],"LDOC1":[139,160],"indicated":[140],"sodium/bicarbonate":[142],"transport,":[143],"sodium/glucose":[144],"transport":[145],"cell-proliferation":[147,168],"regulation":[148,169],"may":[149,170],"play":[150,171],"important":[151,172],"upstream":[152],"roles":[153,174],"BNIP1,":[157],"APOBEC3F":[158],"suggested":[161],"apoptosis,":[163],"innate":[164],"immune":[165],"response":[166],"downstream":[173],"The":[177],"not":[180],"only":[181],"provide":[182],"insights":[183],"into":[184],"mechanism":[186],"hypertension":[188],"but":[189],"should":[190],"also":[191],"considered":[193],"future":[195],"mapping":[197],"endeavors.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}
