{"id":"https://openalex.org/W2108700752","doi":"https://doi.org/10.1093/bioinformatics/btp073","title":"Meta-analysis of age-related gene expression profiles identifies common signatures of aging","display_name":"Meta-analysis of age-related gene expression profiles identifies common signatures of aging","publication_year":2009,"publication_date":"2009-02-02","ids":{"openalex":"https://openalex.org/W2108700752","doi":"https://doi.org/10.1093/bioinformatics/btp073","mag":"2108700752","pmid":"https://pubmed.ncbi.nlm.nih.gov/19189975"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btp073","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp073","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/7/875/48983088/bioinformatics_25_7_875.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/25/7/875/48983088/bioinformatics_25_7_875.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054858013","display_name":"Jo\u00e3o Pedro de Magalh\u00e3es","orcid":"https://orcid.org/0000-0002-6363-2465"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Pedro de Magalh\u00e3es","raw_affiliation_strings":["1 Department of Genetics, Harvard Medical School, Boston, MA 02115, USA and 2Escola Superior de Biotecnologia, 4200 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Genetics, Harvard Medical School, Boston, MA 02115, USA and 2Escola Superior de Biotecnologia, 4200 Porto, Portugal","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024035504","display_name":"Jo\u00e3o Curado","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Curado","raw_affiliation_strings":["1 Department of Genetics, Harvard Medical School, Boston, MA 02115, USA and 2Escola Superior de Biotecnologia, 4200 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Genetics, Harvard Medical School, Boston, MA 02115, USA and 2Escola Superior de Biotecnologia, 4200 Porto, Portugal","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103076360","display_name":"George M. Church","orcid":"https://orcid.org/0000-0003-3535-2076"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George M. Church","raw_affiliation_strings":["1 Department of Genetics, Harvard Medical School, Boston, MA 02115, USA and 2Escola Superior de Biotecnologia, 4200 Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Genetics, Harvard Medical School, Boston, MA 02115, USA and 2Escola Superior de Biotecnologia, 4200 Porto, Portugal","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":17.8583,"has_fulltext":true,"cited_by_count":762,"citation_normalized_percentile":{"value":0.99627019,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"25","issue":"7","first_page":"875","last_page":"881"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.39809998869895935,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.39809998869895935,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.18330000340938568,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.05979999899864197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7711473107337952},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.725064754486084},{"id":"https://openalex.org/keywords/senescence","display_name":"Senescence","score":0.7230591773986816},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.6453238129615784},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.6024442315101624},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.55660480260849},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.5242828726768494},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4439387023448944},{"id":"https://openalex.org/keywords/ageing","display_name":"Ageing","score":0.43590623140335083},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.4340997636318207},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4334614872932434},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.430713415145874},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4296700954437256},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.42575913667678833}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7711473107337952},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.725064754486084},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.7230591773986816},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6453238129615784},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.6024442315101624},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.55660480260849},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5242828726768494},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4439387023448944},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.43590623140335083},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4340997636318207},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4334614872932434},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.430713415145874},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4296700954437256},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.42575913667678833}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btp073","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp073","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/7/875/48983088/bioinformatics_25_7_875.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19189975","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19189975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2732303","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2732303","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btp073","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp073","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/7/875/48983088/bioinformatics_25_7_875.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2108700752.pdf","grobid_xml":"https://content.openalex.org/works/W2108700752.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W22062734","https://openalex.org/W44581492","https://openalex.org/W84118062","https://openalex.org/W104552217","https://openalex.org/W1529945694","https://openalex.org/W1697139149","https://openalex.org/W1964895626","https://openalex.org/W1968475125","https://openalex.org/W1977868384","https://openalex.org/W1978027075","https://openalex.org/W1979369962","https://openalex.org/W1982012806","https://openalex.org/W1989271916","https://openalex.org/W1994917595","https://openalex.org/W2004833000","https://openalex.org/W2005989770","https://openalex.org/W2017841009","https://openalex.org/W2024853484","https://openalex.org/W2030134419","https://openalex.org/W2032528091","https://openalex.org/W2047495640","https://openalex.org/W2054686729","https://openalex.org/W2069049877","https://openalex.org/W2071314267","https://openalex.org/W2089870793","https://openalex.org/W2091600573","https://openalex.org/W2093346922","https://openalex.org/W2094542138","https://openalex.org/W2095286897","https://openalex.org/W2096525273","https://openalex.org/W2099943275","https://openalex.org/W2103017472","https://openalex.org/W2107105699","https://openalex.org/W2115596765","https://openalex.org/W2118852675","https://openalex.org/W2122683221","https://openalex.org/W2122955968","https://openalex.org/W2124201592","https://openalex.org/W2124959176","https://openalex.org/W2131078803","https://openalex.org/W2131433803","https://openalex.org/W2148139839","https://openalex.org/W2150926065","https://openalex.org/W2151309890","https://openalex.org/W2154362705","https://openalex.org/W2154437541","https://openalex.org/W2154981570","https://openalex.org/W2158940923","https://openalex.org/W2169113244","https://openalex.org/W4239678514","https://openalex.org/W6683356575"],"related_works":["https://openalex.org/W1996185163","https://openalex.org/W170658859","https://openalex.org/W2081127504","https://openalex.org/W1483316219","https://openalex.org/W4310366902","https://openalex.org/W3023720143","https://openalex.org/W2183420549","https://openalex.org/W2490137852","https://openalex.org/W2039699813","https://openalex.org/W2081507994"],"abstract_inverted_index":{"MOTIVATION:":[0],"Numerous":[1],"microarray":[2],"studies":[3],"of":[4,14,24,45,64,76,107,114,122,126,142,188,198,213],"aging":[5,25,214],"have":[6],"been":[7],"conducted,":[8],"yet":[9],"given":[10],"the":[11,21,73,88,118,140,196,211],"noisy":[12],"nature":[13],"gene":[15,47,99],"expression":[16,48,100,141],"changes":[17,35,101,171,208],"with":[18,71,84,92,117,129,172],"age,":[19,72],"elucidating":[20],"transcriptional":[22,170,193,207],"features":[23],"and":[26,33,56,80,95,109,113,125,149,178,215],"how":[27,206],"these":[28,93,182],"relate":[29,209],"to":[30,145,195,204,210],"physiological,":[31],"biochemical":[32],"pathological":[34],"remains":[36],"a":[37,43,158,186],"critical":[38],"problem.":[39],"RESULTS:":[40],"We":[41,86,180],"performed":[42],"meta-analysis":[44],"age-related":[46,98],"profiles":[49],"using":[50],"27":[51],"datasets":[52],"from":[53],"mice,":[54],"rats":[55],"humans.":[57],"Our":[58],"results":[59,202],"reveal":[60],"several":[61],"common":[62],"signatures":[63,94,184],"aging,":[65],"including":[66],"56":[67],"genes":[68,82,112,115,124,127,143],"consistently":[69],"overexpressed":[70],"most":[74,102],"significant":[75],"which":[77],"was":[78],"APOD,":[79],"17":[81],"underexpressed":[83],"age.":[85],"characterized":[87],"biological":[89],"processes":[90,177,190],"associated":[91,116,128],"found":[96],"that":[97,161],"notably":[103],"involve":[104],"an":[105],"overexpression":[106],"inflammation":[108],"immune":[110],"response":[111],"lysosome.":[119],"An":[120],"underexpression":[121],"collagen":[123],"energy":[130],"metabolism,":[131],"particularly":[132],"mitochondrial":[133],"genes,":[134,176],"as":[135,137,218],"well":[136],"alterations":[138],"in":[139,174],"related":[144],"apoptosis,":[146],"cell":[147],"cycle":[148],"cellular":[150],"senescence":[151],"biomarkers,":[152],"were":[153],"also":[154,192],"observed.":[155],"By":[156],"employing":[157],"new":[159],"method":[160],"emphasizes":[162],"sensitivity,":[163],"our":[164,201],"work":[165],"further":[166],"reveals":[167],"previously":[168],"unknown":[169],"age":[173],"many":[175],"functions.":[179],"suggest":[181],"molecular":[183],"reflect":[185],"combination":[187],"degenerative":[189],"but":[191],"responses":[194],"process":[197,212],"aging.":[199],"Overall,":[200],"help":[203],"understand":[205],"could":[216],"serve":[217],"targets":[219],"for":[220],"future":[221],"studies.":[222],"AVAILABILITY:":[223],"http://genomics.senescence.info/uarrays/signatures.html.":[224],"SUPPLEMENTARY":[225],"INFORMATION:":[226],"Supplementary":[227],"data":[228],"are":[229],"available":[230],"at":[231],"Bioinformatics":[232],"online.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":31},{"year":2024,"cited_by_count":44},{"year":2023,"cited_by_count":60},{"year":2022,"cited_by_count":53},{"year":2021,"cited_by_count":66},{"year":2020,"cited_by_count":63},{"year":2019,"cited_by_count":49},{"year":2018,"cited_by_count":55},{"year":2017,"cited_by_count":46},{"year":2016,"cited_by_count":39},{"year":2015,"cited_by_count":58},{"year":2014,"cited_by_count":34},{"year":2013,"cited_by_count":46},{"year":2012,"cited_by_count":40}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}
