{"id":"https://openalex.org/W2162366839","doi":"https://doi.org/10.1093/bioinformatics/btp019","title":"Sparse linear discriminant analysis for simultaneous testing for the significance of a gene set/pathway and gene selection","display_name":"Sparse linear discriminant analysis for simultaneous testing for the significance of a gene set/pathway and gene selection","publication_year":2009,"publication_date":"2009-01-25","ids":{"openalex":"https://openalex.org/W2162366839","doi":"https://doi.org/10.1093/bioinformatics/btp019","mag":"2162366839","pmid":"https://pubmed.ncbi.nlm.nih.gov/19168911"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btp019","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp019","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/9/1145/48985709/bioinformatics_25_9_1145.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/25/9/1145/48985709/bioinformatics_25_9_1145.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000129649","display_name":"Michael C. Wu","orcid":"https://orcid.org/0000-0002-3357-6570"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C. Wu","raw_affiliation_strings":["1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health, 655 Huntington Ave., Boston, MA 02115, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health, 655 Huntington Ave., Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085279200","display_name":"Lingsong Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lingsong Zhang","raw_affiliation_strings":["1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health, 655 Huntington Ave., Boston, MA 02115, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health, 655 Huntington Ave., Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043889376","display_name":"Zhao\u2010Xi Wang","orcid":"https://orcid.org/0000-0002-2689-7034"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhaoxi Wang","raw_affiliation_strings":["1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health, 655 Huntington Ave., Boston, MA 02115, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health, 655 Huntington Ave., Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091331939","display_name":"David C. Christiani","orcid":"https://orcid.org/0000-0002-0301-0242"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David C. Christiani","raw_affiliation_strings":["1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health, 655 Huntington Ave., Boston, MA 02115, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health, 655 Huntington Ave., Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030660111","display_name":"Xihong Lin","orcid":"https://orcid.org/0000-0001-7067-7752"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xihong Lin","raw_affiliation_strings":["1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health, 655 Huntington Ave., Boston, MA 02115, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Biostatistics and 2Department of Environmental Health, Harvard School of Public Health, 655 Huntington Ave., Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5030660111"],"corresponding_institution_ids":["https://openalex.org/I136199984"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.2351,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.92557404,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"25","issue":"9","first_page":"1145","last_page":"1151"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6425386667251587},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5365422368049622},{"id":"https://openalex.org/keywords/linear-discriminant-analysis","display_name":"Linear discriminant analysis","score":0.5249338746070862},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4809941053390503},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.45794811844825745},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.44604742527008057},{"id":"https://openalex.org/keywords/gene-selection","display_name":"Gene selection","score":0.4349609315395355},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3799826204776764},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3561030626296997},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34190666675567627},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.23374447226524353},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.17334148287773132}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6425386667251587},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5365422368049622},{"id":"https://openalex.org/C69738355","wikidata":"https://www.wikidata.org/wiki/Q1228929","display_name":"Linear discriminant analysis","level":2,"score":0.5249338746070862},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4809941053390503},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.45794811844825745},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.44604742527008057},{"id":"https://openalex.org/C2984324147","wikidata":"https://www.wikidata.org/wiki/Q3080021","display_name":"Gene selection","level":5,"score":0.4349609315395355},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3799826204776764},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3561030626296997},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34190666675567627},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.23374447226524353},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.17334148287773132}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btp019","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp019","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/9/1145/48985709/bioinformatics_25_9_1145.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19168911","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19168911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:biostats.bepress.com:harvardbiostat-1102","is_oa":false,"landing_page_url":"https://biostats.bepress.com/harvardbiostat/paper95","pdf_url":null,"source":{"id":"https://openalex.org/S4377196124","display_name":"Collection of Biostatistics Research Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Harvard University Biostatistics Working Paper Series","raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2732305","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2732305","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btp019","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btp019","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/9/1145/48985709/bioinformatics_25_9_1145.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.7099999785423279}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2162366839.pdf","grobid_xml":"https://content.openalex.org/works/W2162366839.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1132211547","https://openalex.org/W1535641839","https://openalex.org/W1559431399","https://openalex.org/W1708068686","https://openalex.org/W1920934057","https://openalex.org/W1966748110","https://openalex.org/W2001619934","https://openalex.org/W2018158023","https://openalex.org/W2018504516","https://openalex.org/W2019176983","https://openalex.org/W2020775181","https://openalex.org/W2028739675","https://openalex.org/W2041756206","https://openalex.org/W2053786812","https://openalex.org/W2103017472","https://openalex.org/W2110065044","https://openalex.org/W2118069309","https://openalex.org/W2122825543","https://openalex.org/W2123106337","https://openalex.org/W2130102937","https://openalex.org/W2130410032","https://openalex.org/W2134736660","https://openalex.org/W2135046866","https://openalex.org/W2138550913","https://openalex.org/W2158384363","https://openalex.org/W2167119716","https://openalex.org/W2168175751","https://openalex.org/W2319899703","https://openalex.org/W6627364165","https://openalex.org/W6700213204"],"related_works":["https://openalex.org/W2052655934","https://openalex.org/W4313016600","https://openalex.org/W2278736760","https://openalex.org/W1533508595","https://openalex.org/W104645380","https://openalex.org/W2027213253","https://openalex.org/W2017047508","https://openalex.org/W2023641020","https://openalex.org/W2794352724","https://openalex.org/W2188530857"],"abstract_inverted_index":{"Supplementary":[0],"data":[1],"are":[2],"available":[3],"at":[4],"Bioinformatics":[5],"online.":[6]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":10}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}