{"id":"https://openalex.org/W2142893849","doi":"https://doi.org/10.1093/bioinformatics/btn635","title":"Simulation of crosstalk between small GTPase RhoA and EGFR-ERK signaling pathway via MEKK1","display_name":"Simulation of crosstalk between small GTPase RhoA and EGFR-ERK signaling pathway via MEKK1","publication_year":2008,"publication_date":"2008-12-11","ids":{"openalex":"https://openalex.org/W2142893849","doi":"https://doi.org/10.1093/bioinformatics/btn635","mag":"2142893849","pmid":"https://pubmed.ncbi.nlm.nih.gov/19074159"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btn635","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn635","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/3/358/48981869/bioinformatics_25_3_358.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/25/3/358/48981869/bioinformatics_25_3_358.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100444593","display_name":"Hu Li","orcid":"https://orcid.org/0000-0001-5957-5472"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Hu Li","raw_affiliation_strings":["1 Bioinformatics and Drug Design Group, Department of Pharmacy, 2Center of Computational Science and Engineering, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, 3Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, 4Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542, 5Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 and 6Shanghai Center for Bioinformation Technology, Shanghai 201203, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bioinformatics and Drug Design Group, Department of Pharmacy, 2Center of Computational Science and Engineering, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, 3Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, 4Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542, 5Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 and 6Shanghai Center for Bioinformation Technology, Shanghai 201203, P. R. China","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072127156","display_name":"Choong Yong Ung","orcid":"https://orcid.org/0000-0002-9876-3473"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Choong Yong Ung","raw_affiliation_strings":["1 Bioinformatics and Drug Design Group, Department of Pharmacy, 2Center of Computational Science and Engineering, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, 3Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, 4Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542, 5Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 and 6Shanghai Center for Bioinformation Technology, Shanghai 201203, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bioinformatics and Drug Design Group, Department of Pharmacy, 2Center of Computational Science and Engineering, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, 3Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, 4Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542, 5Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 and 6Shanghai Center for Bioinformation Technology, Shanghai 201203, P. R. China","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016053889","display_name":"Hua Xiao","orcid":"https://orcid.org/0000-0002-2831-0436"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Xiao Hua Ma","raw_affiliation_strings":["1 Bioinformatics and Drug Design Group, Department of Pharmacy, 2Center of Computational Science and Engineering, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, 3Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, 4Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542, 5Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 and 6Shanghai Center for Bioinformation Technology, Shanghai 201203, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bioinformatics and Drug Design Group, Department of Pharmacy, 2Center of Computational Science and Engineering, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, 3Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, 4Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542, 5Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 and 6Shanghai Center for Bioinformation Technology, Shanghai 201203, P. R. China","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115636442","display_name":"Bao Wen Li","orcid":null},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Bao Wen Li","raw_affiliation_strings":["1 Bioinformatics and Drug Design Group, Department of Pharmacy, 2Center of Computational Science and Engineering, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, 3Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, 4Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542, 5Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 and 6Shanghai Center for Bioinformation Technology, Shanghai 201203, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bioinformatics and Drug Design Group, Department of Pharmacy, 2Center of Computational Science and Engineering, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, 3Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, 4Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542, 5Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 and 6Shanghai Center for Bioinformation Technology, Shanghai 201203, P. R. China","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055998574","display_name":"Boon Chuan Low","orcid":"https://orcid.org/0000-0003-0756-096X"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Boon Chuan Low","raw_affiliation_strings":["1 Bioinformatics and Drug Design Group, Department of Pharmacy, 2Center of Computational Science and Engineering, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, 3Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, 4Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542, 5Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 and 6Shanghai Center for Bioinformation Technology, Shanghai 201203, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bioinformatics and Drug Design Group, Department of Pharmacy, 2Center of Computational Science and Engineering, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, 3Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, 4Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542, 5Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 and 6Shanghai Center for Bioinformation Technology, Shanghai 201203, P. R. China","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057322838","display_name":"Zhi Cao","orcid":"https://orcid.org/0000-0002-4726-6047"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Zhi Wei Cao","raw_affiliation_strings":["1 Bioinformatics and Drug Design Group, Department of Pharmacy, 2Center of Computational Science and Engineering, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, 3Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, 4Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542, 5Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 and 6Shanghai Center for Bioinformation Technology, Shanghai 201203, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bioinformatics and Drug Design Group, Department of Pharmacy, 2Center of Computational Science and Engineering, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, 3Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, 4Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542, 5Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 and 6Shanghai Center for Bioinformation Technology, Shanghai 201203, P. R. China","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077700312","display_name":"Yu Chen","orcid":"https://orcid.org/0000-0002-5473-8022"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Yu Zong Chen","raw_affiliation_strings":["1 Bioinformatics and Drug Design Group, Department of Pharmacy, 2Center of Computational Science and Engineering, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, 3Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, 4Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542, 5Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 and 6Shanghai Center for Bioinformation Technology, Shanghai 201203, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Bioinformatics and Drug Design Group, Department of Pharmacy, 2Center of Computational Science and Engineering, National University of Singapore, Blk S16, Level 8, 3 Science Drive 2, 3Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, 4Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542, 5Cell Signaling and Developmental Biology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543 and 6Shanghai Center for Bioinformation Technology, Shanghai 201203, P. R. China","institution_ids":["https://openalex.org/I165932596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5077700312"],"corresponding_institution_ids":["https://openalex.org/I165932596"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.1232,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.77614643,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"25","issue":"3","first_page":"358","last_page":"364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7325000166893005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7325000166893005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.21310000121593475,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhoa","display_name":"RHOA","score":0.9885275363922119},{"id":"https://openalex.org/keywords/mapk/erk-pathway","display_name":"MAPK/ERK pathway","score":0.8408985137939453},{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.7989969849586487},{"id":"https://openalex.org/keywords/small-gtpase","display_name":"Small GTPase","score":0.5841923952102661},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5813179016113281},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.424194872379303},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.41116398572921753},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.38250988721847534},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.34767985343933105},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.18349972367286682}],"concepts":[{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.9885275363922119},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.8408985137939453},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.7989969849586487},{"id":"https://openalex.org/C2780298669","wikidata":"https://www.wikidata.org/wiki/Q415071","display_name":"Small GTPase","level":3,"score":0.5841923952102661},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5813179016113281},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.424194872379303},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41116398572921753},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.38250988721847534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34767985343933105},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.18349972367286682},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020559","descriptor_name":"Monomeric GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020559","descriptor_name":"Monomeric GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020559","descriptor_name":"Monomeric GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020742","descriptor_name":"rhoA GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020742","descriptor_name":"rhoA GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020742","descriptor_name":"rhoA GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048728","descriptor_name":"MAP Kinase Kinase Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048728","descriptor_name":"MAP Kinase Kinase Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048728","descriptor_name":"MAP Kinase Kinase Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btn635","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn635","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/3/358/48981869/bioinformatics_25_3_358.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19074159","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19074159","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/53170","is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/53170","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btn635","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn635","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/3/358/48981869/bioinformatics_25_3_358.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5899999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2142893849.pdf"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1536536328","https://openalex.org/W1667204010","https://openalex.org/W1964283170","https://openalex.org/W1964438177","https://openalex.org/W1966421023","https://openalex.org/W1969035452","https://openalex.org/W1971727526","https://openalex.org/W1971789342","https://openalex.org/W1972591285","https://openalex.org/W1973300115","https://openalex.org/W1981289239","https://openalex.org/W1986415115","https://openalex.org/W1987269574","https://openalex.org/W1988154515","https://openalex.org/W1990736894","https://openalex.org/W1995633212","https://openalex.org/W1995932087","https://openalex.org/W1995996832","https://openalex.org/W2001620484","https://openalex.org/W2005026826","https://openalex.org/W2008548958","https://openalex.org/W2009707997","https://openalex.org/W2010761126","https://openalex.org/W2011815143","https://openalex.org/W2013249463","https://openalex.org/W2014164383","https://openalex.org/W2017292900","https://openalex.org/W2019619408","https://openalex.org/W2019731805","https://openalex.org/W2025315052","https://openalex.org/W2034188706","https://openalex.org/W2041085998","https://openalex.org/W2055241999","https://openalex.org/W2060205349","https://openalex.org/W2062289724","https://openalex.org/W2069739160","https://openalex.org/W2073654181","https://openalex.org/W2074970823","https://openalex.org/W2075161553","https://openalex.org/W2077298757","https://openalex.org/W2082427792","https://openalex.org/W2083476264","https://openalex.org/W2085129546","https://openalex.org/W2086936470","https://openalex.org/W2088013881","https://openalex.org/W2088293068","https://openalex.org/W2088612535","https://openalex.org/W2102312968","https://openalex.org/W2103031848","https://openalex.org/W2104042512","https://openalex.org/W2109659042","https://openalex.org/W2113078630","https://openalex.org/W2115058107","https://openalex.org/W2117839670","https://openalex.org/W2150317682","https://openalex.org/W2159528039","https://openalex.org/W2167960994","https://openalex.org/W2169328538","https://openalex.org/W2293143569","https://openalex.org/W4237572013","https://openalex.org/W4238389754","https://openalex.org/W4246337031","https://openalex.org/W4248277281","https://openalex.org/W6638911209"],"related_works":["https://openalex.org/W2054259191","https://openalex.org/W1975128506","https://openalex.org/W2015096613","https://openalex.org/W1971820762","https://openalex.org/W2809706566","https://openalex.org/W2360066506","https://openalex.org/W2010009005","https://openalex.org/W4211148761","https://openalex.org/W3127906466","https://openalex.org/W2808743966"],"abstract_inverted_index":{"MOTIVATION:":[0],"Small":[1],"GTPase":[2],"RhoA":[3,16,35,46,92,123,146,155],"regulates":[4],"cell-cycle":[5],"progression":[6,185],"via":[7,14,41,89,160],"several":[8,171],"mechanisms.":[9],"Apart":[10],"from":[11,170],"its":[12],"actions":[13],"ROCK,":[15],"has":[17],"recently":[18],"been":[19],"found":[20],"to":[21,28,140,147,165],"activate":[22],"a":[23,64,75],"scaffold":[24],"protein":[25],"MEKK1":[26],"known":[27],"promote":[29],"ERK":[30,39,98,110,129,137,144,158],"activation.":[31],"We":[32],"examined":[33],"whether":[34],"can":[36],"substantially":[37,94],"affect":[38],"activity":[40],"this":[42,69,90],"MEKK1-mediated":[43,161],"crosstalk":[44],"between":[45,143],"and":[47,80,103,145,184,188],"EGFR-ERK":[48,54],"pathway.":[49],"By":[50],"extending":[51],"the":[52,115,133,178],"published":[53,81],"simulation":[55,65,82,86],"models":[56],"represented":[57],"by":[58,168],"ordinary":[59],"differential":[60],"equations,":[61],"we":[62],"developed":[63],"model":[66,108],"that":[67,174],"includes":[68],"crosstalk,":[70,91,162],"which":[71,163],"was":[72],"validated":[73],"with":[74],"number":[76],"of":[77,97,117,128,135,154,181,186],"experimental":[78,172],"findings":[79],"results.":[83],"RESULTS:":[84],"Our":[85,107,149],"suggested":[87],"that,":[88],"elevation":[93,124],"prolonged":[95],"duration":[96,127],"activation":[99,130],"at":[100],"both":[101],"normal":[102],"reduced":[104],"Ras":[105,120],"levels.":[106],"suggests":[109],"may":[111,175],"be":[112,166],"activated":[113],"in":[114,156],"absence":[116],"Ras.":[118],"When":[119],"is":[121],"overexpressed,":[122],"significantly":[125],"prolongs":[126],"but":[131],"reduces":[132],"amount":[134],"active":[136],"partly":[138],"due":[139],"competitive":[141],"binding":[142],"MEKK1.":[148],"results":[150],"indicated":[151],"possible":[152],"roles":[153],"affecting":[157],"activities":[159],"seems":[164],"supported":[167],"indications":[169],"studies":[173],"also":[176],"implicate":[177],"collective":[179],"regulation":[180],"cell":[182],"fate":[183],"cancer":[187],"other":[189],"diseases.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-06-23T06:36:01.041984","created_date":"2025-10-10T00:00:00"}
