{"id":"https://openalex.org/W2144020570","doi":"https://doi.org/10.1093/bioinformatics/btn589","title":"Decomposition of complex microbial behaviors into resource-based stress responses","display_name":"Decomposition of complex microbial behaviors into resource-based stress responses","publication_year":2008,"publication_date":"2008-11-13","ids":{"openalex":"https://openalex.org/W2144020570","doi":"https://doi.org/10.1093/bioinformatics/btn589","mag":"2144020570","pmid":"https://pubmed.ncbi.nlm.nih.gov/19008248"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btn589","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn589","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/1/90/16887250/btn589.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/25/1/90/16887250/btn589.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006567804","display_name":"Ross P. Carlson","orcid":"https://orcid.org/0000-0002-2464-7111"},"institutions":[{"id":"https://openalex.org/I23732399","display_name":"Montana State University","ror":"https://ror.org/02w0trx84","country_code":"US","type":"education","lineage":["https://openalex.org/I23732399","https://openalex.org/I4210126032"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ross P. Carlson","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Center for Biofilm Engineering and Thermal Biology Institute, Montana State University, Bozeman, MT 59717, USA","Department of Chemical and Biological Engineering, Center for Biofilm Engineering and Thermal Biology Institute, Montana State University, Bozeman, MT, 59717, USA"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Center for Biofilm Engineering and Thermal Biology Institute, Montana State University, Bozeman, MT 59717, USA","institution_ids":["https://openalex.org/I23732399"]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Center for Biofilm Engineering and Thermal Biology Institute, Montana State University, Bozeman, MT, 59717, USA","institution_ids":["https://openalex.org/I23732399"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006567804"],"corresponding_institution_ids":["https://openalex.org/I23732399"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.6914,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.70608009,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"25","issue":"1","first_page":"90","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.989799976348877,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metric","display_name":"Metric (unit)","score":0.5808044075965881},{"id":"https://openalex.org/keywords/relevance","display_name":"Relevance (law)","score":0.527105450630188},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.5248827338218689},{"id":"https://openalex.org/keywords/range","display_name":"Range (aeronautics)","score":0.49403220415115356},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4919426143169403},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4876314699649811},{"id":"https://openalex.org/keywords/resource","display_name":"Resource (disambiguation)","score":0.4757918119430542},{"id":"https://openalex.org/keywords/decomposition","display_name":"Decomposition","score":0.4563397467136383},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.440864622592926},{"id":"https://openalex.org/keywords/euclidean-geometry","display_name":"Euclidean geometry","score":0.430833101272583},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41461366415023804},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3798920512199402},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.36527734994888306},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.31504207849502563},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.24997183680534363},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.13469049334526062},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.11490991711616516}],"concepts":[{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.5808044075965881},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.527105450630188},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5248827338218689},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.49403220415115356},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4919426143169403},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4876314699649811},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.4757918119430542},{"id":"https://openalex.org/C124681953","wikidata":"https://www.wikidata.org/wiki/Q339062","display_name":"Decomposition","level":2,"score":0.4563397467136383},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.440864622592926},{"id":"https://openalex.org/C129782007","wikidata":"https://www.wikidata.org/wiki/Q162886","display_name":"Euclidean geometry","level":2,"score":0.430833101272583},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41461366415023804},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3798920512199402},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36527734994888306},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.31504207849502563},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.24997183680534363},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13469049334526062},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11490991711616516},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bioinformatics/btn589","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn589","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/1/90/16887250/btn589.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19008248","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19008248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:scholarworks.montana.edu:1/13243","is_oa":false,"landing_page_url":"https://scholarworks.montana.edu/xmlui/handle/1/13243","pdf_url":null,"source":{"id":"https://openalex.org/S4306402563","display_name":"Montana State University ScholarWorks (Montana State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I23732399","host_organization_name":"Montana State University","host_organization_lineage":["https://openalex.org/I23732399"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:1941317","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2638933","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btn589","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn589","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/1/90/16887250/btn589.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/8","score":0.4399999976158142,"display_name":"Decent work and economic growth"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2144020570.pdf","grobid_xml":"https://content.openalex.org/works/W2144020570.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W562929058","https://openalex.org/W1512810258","https://openalex.org/W1570124823","https://openalex.org/W1758395617","https://openalex.org/W1787926142","https://openalex.org/W1966324534","https://openalex.org/W1966392395","https://openalex.org/W1969529366","https://openalex.org/W1973070864","https://openalex.org/W1973934170","https://openalex.org/W1996460711","https://openalex.org/W2022440628","https://openalex.org/W2026545217","https://openalex.org/W2029058413","https://openalex.org/W2047195788","https://openalex.org/W2061195384","https://openalex.org/W2069603408","https://openalex.org/W2070889260","https://openalex.org/W2075665712","https://openalex.org/W2090098817","https://openalex.org/W2091793452","https://openalex.org/W2107792766","https://openalex.org/W2108078368","https://openalex.org/W2111421616","https://openalex.org/W2116735729","https://openalex.org/W2127020923","https://openalex.org/W2144761508","https://openalex.org/W2149033595","https://openalex.org/W2153685804","https://openalex.org/W2163312331","https://openalex.org/W2163326970","https://openalex.org/W2163855763","https://openalex.org/W2164751533","https://openalex.org/W2167909188","https://openalex.org/W2169531463","https://openalex.org/W2170739315","https://openalex.org/W2174626282","https://openalex.org/W2989457786","https://openalex.org/W4235556009","https://openalex.org/W6641601612","https://openalex.org/W6816778343"],"related_works":["https://openalex.org/W2380059383","https://openalex.org/W2063679720","https://openalex.org/W2067481825","https://openalex.org/W2075046161","https://openalex.org/W2185495545","https://openalex.org/W2547083368","https://openalex.org/W2031856784","https://openalex.org/W2510721029","https://openalex.org/W2385335131","https://openalex.org/W239705756"],"abstract_inverted_index":{"Wide":[0],"ranging,":[1],"seemingly":[2],"unrelated":[3],"Escherichia":[4],"coli":[5],"physiological":[6],"fluxes":[7,161],"can":[8,199],"be":[9],"simply":[10],"and":[11,42,178,207],"accurately":[12,123],"described":[13,158],"as":[14,122,124],"linear":[15,143],"combinations":[16,224],"of":[17,33,79,85,93,107,117,196,204,215],"a":[18,193,201,213],"few":[19],"ecologically":[20,80],"relevant":[21],"stress":[22],"adaptations.":[23],"These":[24],"strategies":[25,96,133,197,218],"were":[26,112,140],"identified":[27],"by":[28],"decomposing":[29],"the":[30,44,56,71,86,94,108,118,125,149,159,166],"central":[31],"metabolism":[32],"E.coli":[34],"into":[35,66,184],"elementary":[36],"modes":[37],"(mathematically":[38],"defined":[39],"biochemical":[40],"pathways)":[41],"assessing":[43],"resource":[45],"investment":[46],"cost-benefit":[47],"properties":[48],"for":[49],"each":[50],"pathway.":[51],"The":[52,77,90,128,137,153,187],"approach":[53],"capitalizes":[54],"on":[55],"inherent":[57],"tradeoffs":[58],"related":[59],"to":[60,114,171,191,225,227],"investing":[61],"finite":[62],"resources":[63],"like":[64],"nitrogen":[65],"different":[67,223],"pathway":[68,104,156],"enzymes":[69],"when":[70],"pathways":[72,82,189],"have":[73],"varying":[74],"metabolic":[75,132,217],"efficiencies.":[76],"subset":[78,157],"competitive":[81],"represented":[83],"0.02%":[84],"total":[87],"permissible":[88],"pathways.":[89],"biological":[91],"relevance":[92],"assembled":[95,110,188],"was":[97],"tested":[98],"against":[99],"10":[100],"000":[101],"randomly":[102,109],"constructed":[103],"subsets.":[105],"None":[106],"collections":[111],"able":[113],"describe":[115,200],"all":[116],"considered":[119],"experimental":[120,160],"data":[121],"cost-based":[126],"subset.":[127],"results":[129,168],"suggest":[130],"these":[131],"are":[134,219],"biologically":[135],"significant.":[136],"current":[138,154],"descriptions":[139,147],"compared":[141],"with":[142,162],"programming":[144],"(LP)-based":[145],"flux":[146],"using":[148],"Euclidean":[150],"distance":[151],"metric.":[152],"study's":[155],"better":[163],"accuracy":[164],"than":[165],"LP":[167],"without":[169],"having":[170],"test":[172],"multiple":[173],"objective":[174],"functions":[175],"or":[176],"constraints":[177],"while":[179],"providing":[180],"additional":[181],"ecological":[182],"insight":[183],"microbial":[185,205],"behavior.":[186],"seem":[190],"represent":[192],"generalized":[194],"set":[195],"that":[198],"wide":[202],"range":[203],"responses":[206],"hint":[208],"at":[209],"evolutionary":[210],"processes":[211],"where":[212],"handful":[214],"successful":[216],"utilized":[220],"simultaneously":[221],"in":[222],"adapt":[226],"diverse":[228],"conditions.":[229]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}