{"id":"https://openalex.org/W2099086736","doi":"https://doi.org/10.1093/bioinformatics/btn563","title":"A multivariate test of association","display_name":"A multivariate test of association","publication_year":2008,"publication_date":"2008-11-19","ids":{"openalex":"https://openalex.org/W2099086736","doi":"https://doi.org/10.1093/bioinformatics/btn563","mag":"2099086736","pmid":"https://pubmed.ncbi.nlm.nih.gov/19019849"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btn563","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn563","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/1/132/48983220/bioinformatics_25_1_132.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/25/1/132/48983220/bioinformatics_25_1_132.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074490470","display_name":"Manuel A. R. Ferreira","orcid":"https://orcid.org/0000-0001-9059-1825"},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"funder","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Manuel A. R. Ferreira","raw_affiliation_strings":["1 Department of Psychiatry, Massachusetts General Hospital, 2Department of Psychiatry, Harvard Medical School, 3Center for Human Genetic Research, Massachusetts General Hospital, Boston, 4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 5Genetic Epidemiology, Queensland Institute of Medical Research, QLD, Australia, 6Broad Institute of Harvard and MIT, Cambridge and 7Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Psychiatry, Massachusetts General Hospital, 2Department of Psychiatry, Harvard Medical School, 3Center for Human Genetic Research, Massachusetts General Hospital, Boston, 4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 5Genetic Epidemiology, Queensland Institute of Medical Research, QLD, Australia, 6Broad Institute of Harvard and MIT, Cambridge and 7Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051460895","display_name":"Shaun Purcell","orcid":"https://orcid.org/0000-0002-7402-5812"},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"funder","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaun M. Purcell","raw_affiliation_strings":["1 Department of Psychiatry, Massachusetts General Hospital, 2Department of Psychiatry, Harvard Medical School, 3Center for Human Genetic Research, Massachusetts General Hospital, Boston, 4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 5Genetic Epidemiology, Queensland Institute of Medical Research, QLD, Australia, 6Broad Institute of Harvard and MIT, Cambridge and 7Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Psychiatry, Massachusetts General Hospital, 2Department of Psychiatry, Harvard Medical School, 3Center for Human Genetic Research, Massachusetts General Hospital, Boston, 4Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 5Genetic Epidemiology, Queensland Institute of Medical Research, QLD, Australia, 6Broad Institute of Harvard and MIT, Cambridge and 7Psychiatric & Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074490470"],"corresponding_institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":7.3692,"has_fulltext":false,"cited_by_count":264,"citation_normalized_percentile":{"value":0.96721873,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"25","issue":"1","first_page":"132","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11229","display_name":"Genetics and Plant Breeding","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11229","display_name":"Genetics and Plant Breeding","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.7831973433494568},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.7385318875312805},{"id":"https://openalex.org/keywords/association-test","display_name":"Association test","score":0.6574305891990662},{"id":"https://openalex.org/keywords/multivariate-analysis","display_name":"Multivariate analysis","score":0.6402684450149536},{"id":"https://openalex.org/keywords/test","display_name":"Test (biology)","score":0.6145882606506348},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5709154605865479},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48904356360435486},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.461089551448822},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.32719993591308594},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.32323509454727173},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21640747785568237},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.20228463411331177},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1772216260433197},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15227791666984558},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.14989134669303894},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.14182376861572266},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13918322324752808},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.09149229526519775}],"concepts":[{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.7831973433494568},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.7385318875312805},{"id":"https://openalex.org/C2994538360","wikidata":"https://www.wikidata.org/wiki/Q774081","display_name":"Association test","level":5,"score":0.6574305891990662},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.6402684450149536},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.6145882606506348},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5709154605865479},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48904356360435486},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.461089551448822},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.32719993591308594},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.32323509454727173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21640747785568237},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.20228463411331177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1772216260433197},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15227791666984558},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.14989134669303894},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.14182376861572266},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13918322324752808},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.09149229526519775},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btn563","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn563","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/1/132/48983220/bioinformatics_25_1_132.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:19019849","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19019849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btn563","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn563","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/1/132/48983220/bioinformatics_25_1_132.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2099086736.pdf","grobid_xml":"https://content.openalex.org/works/W2099086736.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1968008611","https://openalex.org/W2025341678","https://openalex.org/W2032349148","https://openalex.org/W2040764129","https://openalex.org/W2078343620","https://openalex.org/W2161633633","https://openalex.org/W2167697360"],"related_works":["https://openalex.org/W2406638334","https://openalex.org/W40745829","https://openalex.org/W1978357124","https://openalex.org/W1578824628","https://openalex.org/W2032728545","https://openalex.org/W1570805059","https://openalex.org/W4250754046","https://openalex.org/W4318262572","https://openalex.org/W2036849593","https://openalex.org/W1978174651"],"abstract_inverted_index":{"A":[0],"C++":[1],"implementation":[2],"can":[3],"be":[4],"obtained":[5],"from":[6],"the":[7],"authors.":[8]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":25},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":21},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":11}],"updated_date":"2026-03-18T14:38:29.013473","created_date":"2025-10-10T00:00:00"}