{"id":"https://openalex.org/W2107599130","doi":"https://doi.org/10.1093/bioinformatics/btn450","title":"Optimal design of thermally stable proteins","display_name":"Optimal design of thermally stable proteins","publication_year":2008,"publication_date":"2008-08-22","ids":{"openalex":"https://openalex.org/W2107599130","doi":"https://doi.org/10.1093/bioinformatics/btn450","mag":"2107599130","pmid":"https://pubmed.ncbi.nlm.nih.gov/18723523"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btn450","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn450","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/20/2339/49050085/bioinformatics_24_20_2339.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/24/20/2339/49050085/bioinformatics_24_20_2339.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059883019","display_name":"Ryan M. Bannen","orcid":"https://orcid.org/0000-0002-6001-3060"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ryan M. Bannen","raw_affiliation_strings":["1 Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, 2Department of Computer Science, University of Wisconsin-Madison, 1210 W. Dayton and 3Department of Mathematics, University of Wisconsin-Madison, 480 Lincoln Drive, Madison, WI 53706, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, 2Department of Computer Science, University of Wisconsin-Madison, 1210 W. Dayton and 3Department of Mathematics, University of Wisconsin-Madison, 480 Lincoln Drive, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103539814","display_name":"Vanitha Suresh","orcid":null},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vanitha Suresh","raw_affiliation_strings":["1 Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, 2Department of Computer Science, University of Wisconsin-Madison, 1210 W. Dayton and 3Department of Mathematics, University of Wisconsin-Madison, 480 Lincoln Drive, Madison, WI 53706, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, 2Department of Computer Science, University of Wisconsin-Madison, 1210 W. Dayton and 3Department of Mathematics, University of Wisconsin-Madison, 480 Lincoln Drive, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"George N. Phillips","orcid":null},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George N. Phillips","raw_affiliation_strings":["1 Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, 2Department of Computer Science, University of Wisconsin-Madison, 1210 W. Dayton and 3Department of Mathematics, University of Wisconsin-Madison, 480 Lincoln Drive, Madison, WI 53706, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, 2Department of Computer Science, University of Wisconsin-Madison, 1210 W. Dayton and 3Department of Mathematics, University of Wisconsin-Madison, 480 Lincoln Drive, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046109083","display_name":"Stephen J. Wright","orcid":"https://orcid.org/0000-0001-6815-7379"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Wright","raw_affiliation_strings":["1 Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, 2Department of Computer Science, University of Wisconsin-Madison, 1210 W. Dayton and 3Department of Mathematics, University of Wisconsin-Madison, 480 Lincoln Drive, Madison, WI 53706, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, 2Department of Computer Science, University of Wisconsin-Madison, 1210 W. Dayton and 3Department of Mathematics, University of Wisconsin-Madison, 480 Lincoln Drive, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076752685","display_name":"Julie C. Mitchell","orcid":"https://orcid.org/0000-0002-5031-7343"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie C. Mitchell","raw_affiliation_strings":["1 Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, 2Department of Computer Science, University of Wisconsin-Madison, 1210 W. Dayton and 3Department of Mathematics, University of Wisconsin-Madison, 480 Lincoln Drive, Madison, WI 53706, USA"],"affiliations":[{"raw_affiliation_string":"1 Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, 2Department of Computer Science, University of Wisconsin-Madison, 1210 W. Dayton and 3Department of Mathematics, University of Wisconsin-Madison, 480 Lincoln Drive, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5059883019"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":0.4149,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.64562096,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"24","issue":"20","first_page":"2339","last_page":"2343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/minification","display_name":"Minification","score":0.6735140681266785},{"id":"https://openalex.org/keywords/dijkstras-algorithm","display_name":"Dijkstra's algorithm","score":0.5939131379127502},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.49645310640335083},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.47646641731262207},{"id":"https://openalex.org/keywords/entropy","display_name":"Entropy (arrow of time)","score":0.4629915654659271},{"id":"https://openalex.org/keywords/shortest-path-problem","display_name":"Shortest path problem","score":0.42728540301322937},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.37566936016082764},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3379629850387573},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3262215256690979},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.19694441556930542},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.1505764126777649},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.09761673212051392}],"concepts":[{"id":"https://openalex.org/C147764199","wikidata":"https://www.wikidata.org/wiki/Q6865248","display_name":"Minification","level":2,"score":0.6735140681266785},{"id":"https://openalex.org/C173870130","wikidata":"https://www.wikidata.org/wiki/Q8548","display_name":"Dijkstra's algorithm","level":4,"score":0.5939131379127502},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.49645310640335083},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47646641731262207},{"id":"https://openalex.org/C106301342","wikidata":"https://www.wikidata.org/wiki/Q4117933","display_name":"Entropy (arrow of time)","level":2,"score":0.4629915654659271},{"id":"https://openalex.org/C22590252","wikidata":"https://www.wikidata.org/wiki/Q1058754","display_name":"Shortest path problem","level":3,"score":0.42728540301322937},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.37566936016082764},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3379629850387573},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3262215256690979},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.19694441556930542},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.1505764126777649},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09761673212051392}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btn450","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn450","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/20/2339/49050085/bioinformatics_24_20_2339.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18723523","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18723523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2562006","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2562006","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btn450","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn450","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/20/2339/49050085/bioinformatics_24_20_2339.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.47999998927116394,"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure"}],"awards":[{"id":"https://openalex.org/G143312111","display_name":null,"funder_award_id":"U54 GM074901","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4359693134","display_name":null,"funder_award_id":"NIGMS","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5219260752","display_name":null,"funder_award_id":"DE-FG","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G8557279192","display_name":null,"funder_award_id":"GM074901","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2107599130.pdf","grobid_xml":"https://content.openalex.org/works/W2107599130.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1552660489","https://openalex.org/W1972798923","https://openalex.org/W1978419375","https://openalex.org/W1996320633","https://openalex.org/W1999919945","https://openalex.org/W2002770341","https://openalex.org/W2042181696","https://openalex.org/W2047659421","https://openalex.org/W2051419400","https://openalex.org/W2060986889","https://openalex.org/W2078067526","https://openalex.org/W2084224084","https://openalex.org/W2087357689","https://openalex.org/W2092845657","https://openalex.org/W2097054029","https://openalex.org/W2130479394","https://openalex.org/W2139418286","https://openalex.org/W2143402734","https://openalex.org/W2154998149","https://openalex.org/W2155837032","https://openalex.org/W2158543301","https://openalex.org/W2614130212","https://openalex.org/W2753176400","https://openalex.org/W4249958171","https://openalex.org/W6644659136","https://openalex.org/W6671329661"],"related_works":["https://openalex.org/W3209137076","https://openalex.org/W4223969905","https://openalex.org/W2374560440","https://openalex.org/W1490490684","https://openalex.org/W2887026015","https://openalex.org/W2361442013","https://openalex.org/W2373384475","https://openalex.org/W4310124294","https://openalex.org/W4318196244","https://openalex.org/W143403600"],"abstract_inverted_index":{"For":[0,20],"many":[1],"biotechnological":[2],"purposes,":[3],"it":[4],"is":[5,97,112],"desirable":[6],"to":[7,10,41,63,67],"redesign":[8,64],"proteins":[9],"be":[11,61,68,79],"more":[12,42,69],"structurally":[13],"and":[14,50,111],"functionally":[15],"stable":[16,35,71,73],"at":[17,27,36,74],"higher":[18,28,37],"temperatures.":[19],"example,":[21],"chemical":[22],"reactions":[23],"are":[24,34],"intrinsically":[25],"faster":[26],"temperatures,":[29],"so":[30],"using":[31,115],"enzymes":[32],"that":[33],"temperatures":[38],"would":[39],"lead":[40],"efficient":[43,52],"industrial":[44],"processes.":[45],"We":[46],"describe":[47],"an":[48,105],"innovative":[49],"computationally":[51],"method":[53],"called":[54],"Improved":[55],"Configurational":[56],"Entropy":[57],"(ICE),":[58],"which":[59],"can":[60,78],"used":[62],"a":[65,100],"protein":[66],"thermally":[70],"(i.e.":[72],"high":[75],"temperatures).":[76],"This":[77],"accomplished":[80],"by":[81],"systematically":[82],"modifying":[83],"the":[84],"amino":[85],"acid":[86],"sequence":[87],"via":[88],"local":[89],"structural":[90],"entropy":[91],"(LSE)":[92],"minimization.":[93],"The":[94],"minimization":[95],"problem":[96,103],"modeled":[98],"as":[99],"shortest":[101],"path":[102],"in":[104],"acyclic":[106],"graph":[107],"with":[108],"nonnegative":[109],"weights":[110],"solved":[113],"efficiently":[114],"Dijkstra's":[116],"method.":[117]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-04-16T08:26:57.006410","created_date":"2025-10-10T00:00:00"}