{"id":"https://openalex.org/W2111485477","doi":"https://doi.org/10.1093/bioinformatics/btn445","title":"Empirical profile mixture models for phylogenetic reconstruction","display_name":"Empirical profile mixture models for phylogenetic reconstruction","publication_year":2008,"publication_date":"2008-08-21","ids":{"openalex":"https://openalex.org/W2111485477","doi":"https://doi.org/10.1093/bioinformatics/btn445","mag":"2111485477","pmid":"https://pubmed.ncbi.nlm.nih.gov/18718941"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btn445","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn445","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/20/2317/16884250/btn445.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/24/20/2317/16884250/btn445.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051648291","display_name":"Si Quang Le","orcid":"https://orcid.org/0000-0002-3715-210X"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210101743","display_name":"Laboratoire d'Informatique, de Robotique et de Micro\u00e9lectronique de Montpellier","ror":"https://ror.org/013yean28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I151295451","https://openalex.org/I19894307","https://openalex.org/I4210101743","https://openalex.org/I4210159245","https://openalex.org/I4412460525"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Le Si Quang","raw_affiliation_strings":["M\u00e9thodes et Algorithmes pour la Bioinformatique. LIRMM, CNRS-UM2, 141 rue Ada, 34392 Montpellier Cedex 5, France"],"affiliations":[{"raw_affiliation_string":"M\u00e9thodes et Algorithmes pour la Bioinformatique. LIRMM, CNRS-UM2, 141 rue Ada, 34392 Montpellier Cedex 5, France","institution_ids":["https://openalex.org/I4210101743","https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078068308","display_name":"Olivier Gascuel","orcid":"https://orcid.org/0000-0002-9412-9723"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210101743","display_name":"Laboratoire d'Informatique, de Robotique et de Micro\u00e9lectronique de Montpellier","ror":"https://ror.org/013yean28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I151295451","https://openalex.org/I19894307","https://openalex.org/I4210101743","https://openalex.org/I4210159245","https://openalex.org/I4412460525"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Gascuel","raw_affiliation_strings":["M\u00e9thodes et Algorithmes pour la Bioinformatique. LIRMM, CNRS-UM2, 141 rue Ada, 34392 Montpellier Cedex 5, France"],"affiliations":[{"raw_affiliation_string":"M\u00e9thodes et Algorithmes pour la Bioinformatique. LIRMM, CNRS-UM2, 141 rue Ada, 34392 Montpellier Cedex 5, France","institution_ids":["https://openalex.org/I4210101743","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057909697","display_name":"Nicolas Lartillot","orcid":"https://orcid.org/0000-0002-9973-7760"},"institutions":[{"id":"https://openalex.org/I4210101743","display_name":"Laboratoire d'Informatique, de Robotique et de Micro\u00e9lectronique de Montpellier","ror":"https://ror.org/013yean28","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I151295451","https://openalex.org/I19894307","https://openalex.org/I4210101743","https://openalex.org/I4210159245","https://openalex.org/I4412460525"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Lartillot","raw_affiliation_strings":["M\u00e9thodes et Algorithmes pour la Bioinformatique. LIRMM, CNRS-UM2, 141 rue Ada, 34392 Montpellier Cedex 5, France"],"affiliations":[{"raw_affiliation_string":"M\u00e9thodes et Algorithmes pour la Bioinformatique. LIRMM, CNRS-UM2, 141 rue Ada, 34392 Montpellier Cedex 5, France","institution_ids":["https://openalex.org/I4210101743","https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5051648291"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210101743"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":3.1806,"has_fulltext":false,"cited_by_count":390,"citation_normalized_percentile":{"value":0.92175777,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"24","issue":"20","first_page":"2317","last_page":"2323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.9832000136375427,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11901","display_name":"Bayesian Methods and Mixture Models","score":0.9775999784469604,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6510929465293884},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.5549517273902893},{"id":"https://openalex.org/keywords/phylogenetic-tree","display_name":"Phylogenetic tree","score":0.524486243724823},{"id":"https://openalex.org/keywords/expectation\u2013maximization-algorithm","display_name":"Expectation\u2013maximization algorithm","score":0.5160260200500488},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5099455118179321},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5056748390197754},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.472115159034729},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.43078330159187317},{"id":"https://openalex.org/keywords/maximization","display_name":"Maximization","score":0.41569453477859497},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.35635852813720703},{"id":"https://openalex.org/keywords/maximum-likelihood","display_name":"Maximum likelihood","score":0.34971296787261963},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32283303141593933},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.19434690475463867},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.15155288577079773},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1145918071269989},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.1132250428199768},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.09087586402893066}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6510929465293884},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.5549517273902893},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.524486243724823},{"id":"https://openalex.org/C182081679","wikidata":"https://www.wikidata.org/wiki/Q1275153","display_name":"Expectation\u2013maximization algorithm","level":3,"score":0.5160260200500488},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5099455118179321},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5056748390197754},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.472115159034729},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.43078330159187317},{"id":"https://openalex.org/C2776330181","wikidata":"https://www.wikidata.org/wiki/Q18358244","display_name":"Maximization","level":2,"score":0.41569453477859497},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.35635852813720703},{"id":"https://openalex.org/C49781872","wikidata":"https://www.wikidata.org/wiki/Q1045555","display_name":"Maximum likelihood","level":2,"score":0.34971296787261963},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32283303141593933},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.19434690475463867},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.15155288577079773},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1145918071269989},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.1132250428199768},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.09087586402893066},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016013","descriptor_name":"Likelihood Functions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btn445","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn445","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/20/2317/16884250/btn445.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18718941","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18718941","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:HAL:lirmm-00324090v1","is_oa":true,"landing_page_url":"https://hal-lirmm.ccsd.cnrs.fr/lirmm-00324090","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://atgc.lirmm.fr/cat/","raw_type":"Journal articles"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btn445","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn445","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/20/2317/16884250/btn445.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2111485477.pdf","grobid_xml":"https://content.openalex.org/works/W2111485477.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1602925841","https://openalex.org/W1963957860","https://openalex.org/W1965184313","https://openalex.org/W1967687583","https://openalex.org/W1969620339","https://openalex.org/W2017519756","https://openalex.org/W2024341709","https://openalex.org/W2031206741","https://openalex.org/W2037456534","https://openalex.org/W2037667459","https://openalex.org/W2039625353","https://openalex.org/W2047445405","https://openalex.org/W2049633694","https://openalex.org/W2060555982","https://openalex.org/W2061140759","https://openalex.org/W2062018285","https://openalex.org/W2069429561","https://openalex.org/W2080972498","https://openalex.org/W2085637422","https://openalex.org/W2096702350","https://openalex.org/W2098538101","https://openalex.org/W2099254366","https://openalex.org/W2099364951","https://openalex.org/W2100381682","https://openalex.org/W2101546326","https://openalex.org/W2102424972","https://openalex.org/W2103513093","https://openalex.org/W2103546861","https://openalex.org/W2107010419","https://openalex.org/W2112111732","https://openalex.org/W2112956791","https://openalex.org/W2120864016","https://openalex.org/W2124790653","https://openalex.org/W2131527832","https://openalex.org/W2133571659","https://openalex.org/W2135753651","https://openalex.org/W2136096754","https://openalex.org/W2142635246","https://openalex.org/W2147307434","https://openalex.org/W2156521045","https://openalex.org/W2160364329","https://openalex.org/W2160659074","https://openalex.org/W2163627198","https://openalex.org/W2163941254","https://openalex.org/W2168175751","https://openalex.org/W2169444195","https://openalex.org/W2600349519","https://openalex.org/W2601913882","https://openalex.org/W2778879526","https://openalex.org/W6654563908"],"related_works":["https://openalex.org/W1978153144","https://openalex.org/W2090308851","https://openalex.org/W1976188970","https://openalex.org/W102848802","https://openalex.org/W2982058819","https://openalex.org/W2130734797","https://openalex.org/W3176361882","https://openalex.org/W2025556230","https://openalex.org/W2889559465","https://openalex.org/W2150061385"],"abstract_inverted_index":{"In":[0],"this":[1],"work,":[2],"we":[3],"introduce":[4],"an":[5],"expectation-maximization":[6],"algorithm":[7],"for":[8],"estimating":[9],"amino":[10],"acid":[11],"profile":[12],"mixtures":[13],"from":[14],"alignment":[15],"databases.":[16],"We":[17],"apply":[18],"it,":[19],"learning":[20],"on":[21,50],"the":[22],"HSSP":[23],"database,":[24],"and":[25],"observe":[26],"that":[27],"a":[28,37],"set":[29],"of":[30],"20":[31],"profiles":[32],"is":[33],"enough":[34],"to":[35],"provide":[36],"better":[38],"statistical":[39],"fit":[40],"than":[41],"currently":[42],"available":[43],"empirical":[44],"matrices":[45],"(WAG,":[46],"JTT),":[47],"in":[48],"particular":[49],"saturated":[51],"data.":[52]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":49},{"year":2024,"cited_by_count":37},{"year":2023,"cited_by_count":41},{"year":2022,"cited_by_count":36},{"year":2021,"cited_by_count":46},{"year":2020,"cited_by_count":32},{"year":2019,"cited_by_count":33},{"year":2018,"cited_by_count":28},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":6}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}