{"id":"https://openalex.org/W2114931104","doi":"https://doi.org/10.1093/bioinformatics/btn426","title":"Graphical methods for quantifying macromolecules through bright field imaging","display_name":"Graphical methods for quantifying macromolecules through bright field imaging","publication_year":2008,"publication_date":"2008-08-14","ids":{"openalex":"https://openalex.org/W2114931104","doi":"https://doi.org/10.1093/bioinformatics/btn426","mag":"2114931104","pmid":"https://pubmed.ncbi.nlm.nih.gov/18703588"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btn426","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn426","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/8/1070/48989255/bioinformatics_25_8_1070.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/25/8/1070/48989255/bioinformatics_25_8_1070.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047619963","display_name":"Hang Chang","orcid":"https://orcid.org/0000-0002-3773-6818"},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112150","display_name":"Institute of Automation","ror":"https://ror.org/022c3hy66","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112150"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Hang Chang","raw_affiliation_strings":["1 Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, 2Institute of Automation, Chinese Academy of Sciences, Beijing, China, 3Department of Pathology, University of California, San Francisco and 4Department of Electrical Engineering, University of California, Riverside, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, 2Institute of Automation, Chinese Academy of Sciences, Beijing, China, 3Department of Pathology, University of California, San Francisco and 4Department of Electrical Engineering, University of California, Riverside, USA","institution_ids":["https://openalex.org/I4210112150","https://openalex.org/I148283060","https://openalex.org/I19820366","https://openalex.org/I103635307","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079843936","display_name":"Rosa Anna DeFilippis","orcid":null},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112150","display_name":"Institute of Automation","ror":"https://ror.org/022c3hy66","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112150"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Rosa Anna DeFilippis","raw_affiliation_strings":["1 Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, 2Institute of Automation, Chinese Academy of Sciences, Beijing, China, 3Department of Pathology, University of California, San Francisco and 4Department of Electrical Engineering, University of California, Riverside, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, 2Institute of Automation, Chinese Academy of Sciences, Beijing, China, 3Department of Pathology, University of California, San Francisco and 4Department of Electrical Engineering, University of California, Riverside, USA","institution_ids":["https://openalex.org/I4210112150","https://openalex.org/I148283060","https://openalex.org/I19820366","https://openalex.org/I103635307","https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112516316","display_name":"Thea D. Tlsty","orcid":"https://orcid.org/0000-0003-0903-1631"},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112150","display_name":"Institute of Automation","ror":"https://ror.org/022c3hy66","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112150"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Thea D. Tlsty","raw_affiliation_strings":["1 Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, 2Institute of Automation, Chinese Academy of Sciences, Beijing, China, 3Department of Pathology, University of California, San Francisco and 4Department of Electrical Engineering, University of California, Riverside, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, 2Institute of Automation, Chinese Academy of Sciences, Beijing, China, 3Department of Pathology, University of California, San Francisco and 4Department of Electrical Engineering, University of California, Riverside, USA","institution_ids":["https://openalex.org/I4210112150","https://openalex.org/I148283060","https://openalex.org/I19820366","https://openalex.org/I103635307","https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103044353","display_name":"Bahram Parvin","orcid":null},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112150","display_name":"Institute of Automation","ror":"https://ror.org/022c3hy66","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112150"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Bahram Parvin","raw_affiliation_strings":["1 Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, 2Institute of Automation, Chinese Academy of Sciences, Beijing, China, 3Department of Pathology, University of California, San Francisco and 4Department of Electrical Engineering, University of California, Riverside, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, 2Institute of Automation, Chinese Academy of Sciences, Beijing, China, 3Department of Pathology, University of California, San Francisco and 4Department of Electrical Engineering, University of California, Riverside, USA","institution_ids":["https://openalex.org/I4210112150","https://openalex.org/I148283060","https://openalex.org/I19820366","https://openalex.org/I103635307","https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":1.4702,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.87319616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"25","issue":"8","first_page":"1070","last_page":"1075"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-decomposition","display_name":"Matrix decomposition","score":0.5214875936508179},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5134483575820923},{"id":"https://openalex.org/keywords/staining","display_name":"Staining","score":0.4911658465862274},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4573814570903778},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.4526417851448059},{"id":"https://openalex.org/keywords/sample","display_name":"Sample (material)","score":0.43241140246391296},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4273899495601654},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.37348076701164246},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.32570192217826843},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.26308509707450867},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.223951518535614},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.1727820336818695},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.14565187692642212},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09344315528869629}],"concepts":[{"id":"https://openalex.org/C42355184","wikidata":"https://www.wikidata.org/wiki/Q1361088","display_name":"Matrix decomposition","level":3,"score":0.5214875936508179},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5134483575820923},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.4911658465862274},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4573814570903778},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.4526417851448059},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.43241140246391296},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4273899495601654},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.37348076701164246},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.32570192217826843},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26308509707450867},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.223951518535614},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1727820336818695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14565187692642212},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09344315528869629},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1093/bioinformatics/btn426","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn426","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/8/1070/48989255/bioinformatics_25_8_1070.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18703588","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18703588","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:osti.gov:1625259","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1625259","pdf_url":"https://www.osti.gov/servlets/purl/1625259","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:info:ark/67531/metadc931502","is_oa":false,"landing_page_url":"https://digital.library.unt.edu/ark:/67531/metadc931502/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400792","display_name":"University of North Texas Digital Library (University of North Texas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I123534392","host_organization_name":"University of North Texas","host_organization_lineage":["https://openalex.org/I123534392"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.566.5589","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.566.5589","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bioinformatics.oxfordjournals.org/content/early/2008/08/14/bioinformatics.btn426.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.944.2702","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.944.2702","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Bahram_Parvin/publication/23171280_Graphical_methods_for_quantifying_macromolecules_through_bright_field_imaging/links/00b7d51848154800a2000000.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.958.6808","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.958.6808","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://vision.lbl.gov/Publications/Bioinformatics08/bio08.pdf","raw_type":"text"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt0z76f09r","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/0z76f09r","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:osti.gov:957401","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/957401","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2666809","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2666809","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:qt0z76f09r","is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/0z76f09r","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chang, Hang. (2009). Graphical Methods for Quantifying Macromolecules through Bright Field Imaging. Lawrence Berkeley National Laboratory. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/0z76f09r","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btn426","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn426","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/25/8/1070/48989255/bioinformatics_25_8_1070.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7245193638","display_name":null,"funder_award_id":"DE-AC03","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337509","display_name":"Biological and Environmental Research","ror":"https://ror.org/0114b2m14"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1902027874","https://openalex.org/W1964119857","https://openalex.org/W1994066954","https://openalex.org/W2020999234","https://openalex.org/W2077181969","https://openalex.org/W2090359754","https://openalex.org/W2092423825","https://openalex.org/W2100471550","https://openalex.org/W2118718620","https://openalex.org/W2124260943","https://openalex.org/W2151543996","https://openalex.org/W2169551590","https://openalex.org/W2340149117","https://openalex.org/W3044238769","https://openalex.org/W4211015501","https://openalex.org/W6674968941","https://openalex.org/W6677759377"],"related_works":["https://openalex.org/W2383463315","https://openalex.org/W2361625425","https://openalex.org/W2373675175","https://openalex.org/W2351810720","https://openalex.org/W2347460050","https://openalex.org/W2912451268","https://openalex.org/W2364311093","https://openalex.org/W2125266680","https://openalex.org/W2330132752","https://openalex.org/W4206758420"],"abstract_inverted_index":{"Bright":[0],"field":[1],"imaging":[2,27,52],"of":[3,23,51,60,97,105,112,141],"biological":[4],"samples":[5],"stained":[6,153],"with":[7,157],"antibodies":[8],"and/or":[9],"special":[10],"stains":[11],"provides":[12],"a":[13,68,117,125,139,178,192],"rapid":[14],"protocol":[15],"for":[16,31],"visualizing":[17],"various":[18],"macromolecules.":[19],"However,":[20],"this":[21],"method":[22,75],"sample":[24,39,142],"staining":[25,63,113],"and":[26,46,103,149,189],"is":[28,114,122,135,183],"rarely":[29],"employed":[30],"direct":[32],"quantitative":[33],"analysis":[34],"due":[35],"to":[36,76,165,186],"variations":[37],"in":[38],"fixations,":[40],"ambiguities":[41],"introduced":[42],"by":[43,116,124],"color":[44,61,98,118,174],"composition":[45],"the":[47,58,110],"limited":[48],"dynamic":[49],"range":[50],"instruments.":[53],"We":[54,71],"demonstrate":[55],"that,":[56],"through":[57,95],"decomposition":[59,119],"signals,":[62],"can":[64,146],"be":[65,147],"scored":[66],"on":[67],"cell-by-cell":[69],"basis.":[70],"have":[72],"applied":[73],"our":[74],"fibroblasts":[77],"grown":[78],"from":[79,86],"histologically":[80],"normal":[81],"breast":[82],"tissue":[83],"biopsies":[84],"obtained":[85],"two":[87],"distinct":[88],"populations.":[89],"Initially,":[90],"nuclear":[91,133,144,159],"regions":[92],"are":[93,155],"segmented":[94,152],"conversion":[96],"images":[99],"into":[100],"gray":[101],"scale,":[102],"detection":[104],"dark":[106],"elliptic":[107],"features.":[108],"Subsequently,":[109],"strength":[111],"quantified":[115],"model":[120],"that":[121],"optimized":[123],"graph":[126],"cut":[127],"algorithm.":[128],"In":[129],"rare":[130],"cases":[131],"where":[132],"signal":[134],"significantly":[136],"altered":[137],"as":[138],"result":[140],"preparation,":[143],"segmentation":[145],"validated":[148],"corrected.":[150],"Finally,":[151],"patterns":[154],"associated":[156],"each":[158],"region":[160],"following":[161],"region-based":[162],"tessellation.":[163],"Compared":[164],"classical":[166],"non-negative":[167],"matrix":[168],"factorization,":[169],"proposed":[170],"method:":[171],"(i)":[172],"improves":[173],"decomposition,":[175],"(ii)":[176],"has":[177,191],"better":[179],"noise":[180],"immunity,":[181],"(iii)":[182],"more":[184],"invariant":[185],"initial":[187],"conditions":[188],"(iv)":[190],"superior":[193],"computing":[194],"performance.":[195]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}