{"id":"https://openalex.org/W2157750836","doi":"https://doi.org/10.1093/bioinformatics/btn402","title":"An HMM approach to genome-wide identification of differential histone modification sites from ChIP-seq data","display_name":"An HMM approach to genome-wide identification of differential histone modification sites from ChIP-seq data","publication_year":2008,"publication_date":"2008-07-29","ids":{"openalex":"https://openalex.org/W2157750836","doi":"https://doi.org/10.1093/bioinformatics/btn402","mag":"2157750836","pmid":"https://pubmed.ncbi.nlm.nih.gov/18667444"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btn402","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn402","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/20/2344/16882799/btn402.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/24/20/2344/16882799/btn402.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100659719","display_name":"Xu Han","orcid":"https://orcid.org/0000-0001-7915-8609"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Han Xu","raw_affiliation_strings":["1 Computational & Mathematical Biology Group, Genome Institute of Singapore, 138672 Singapore, 2School of Computer Engineering, Nanyang Technological University, 637553 Singapore, 3Genome Technology & Biology Group, Genome Institute of Singapore, 138672 Singapore and 4School of Computing, National University of Singapore, 117543 Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Computational & Mathematical Biology Group, Genome Institute of Singapore, 138672 Singapore, 2School of Computer Engineering, Nanyang Technological University, 637553 Singapore, 3Genome Technology & Biology Group, Genome Institute of Singapore, 138672 Singapore and 4School of Computing, National University of Singapore, 117543 Singapore","institution_ids":["https://openalex.org/I66068411","https://openalex.org/I165932596","https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025894522","display_name":"Chia\u2010Lin Wei","orcid":"https://orcid.org/0000-0001-6820-0461"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Chia-Lin Wei","raw_affiliation_strings":["1 Computational & Mathematical Biology Group, Genome Institute of Singapore, 138672 Singapore, 2School of Computer Engineering, Nanyang Technological University, 637553 Singapore, 3Genome Technology & Biology Group, Genome Institute of Singapore, 138672 Singapore and 4School of Computing, National University of Singapore, 117543 Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Computational & Mathematical Biology Group, Genome Institute of Singapore, 138672 Singapore, 2School of Computer Engineering, Nanyang Technological University, 637553 Singapore, 3Genome Technology & Biology Group, Genome Institute of Singapore, 138672 Singapore and 4School of Computing, National University of Singapore, 117543 Singapore","institution_ids":["https://openalex.org/I66068411","https://openalex.org/I165932596","https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101414835","display_name":"Feng Lin","orcid":"https://orcid.org/0000-0001-5536-0634"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Feng Lin","raw_affiliation_strings":["1 Computational & Mathematical Biology Group, Genome Institute of Singapore, 138672 Singapore, 2School of Computer Engineering, Nanyang Technological University, 637553 Singapore, 3Genome Technology & Biology Group, Genome Institute of Singapore, 138672 Singapore and 4School of Computing, National University of Singapore, 117543 Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Computational & Mathematical Biology Group, Genome Institute of Singapore, 138672 Singapore, 2School of Computer Engineering, Nanyang Technological University, 637553 Singapore, 3Genome Technology & Biology Group, Genome Institute of Singapore, 138672 Singapore and 4School of Computing, National University of Singapore, 117543 Singapore","institution_ids":["https://openalex.org/I66068411","https://openalex.org/I165932596","https://openalex.org/I172675005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012563463","display_name":"Wing\u2010Kin Sung","orcid":"https://orcid.org/0000-0001-7806-7086"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Wing-Kin Sung","raw_affiliation_strings":["1 Computational & Mathematical Biology Group, Genome Institute of Singapore, 138672 Singapore, 2School of Computer Engineering, Nanyang Technological University, 637553 Singapore, 3Genome Technology & Biology Group, Genome Institute of Singapore, 138672 Singapore and 4School of Computing, National University of Singapore, 117543 Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Computational & Mathematical Biology Group, Genome Institute of Singapore, 138672 Singapore, 2School of Computer Engineering, Nanyang Technological University, 637553 Singapore, 3Genome Technology & Biology Group, Genome Institute of Singapore, 138672 Singapore and 4School of Computing, National University of Singapore, 117543 Singapore","institution_ids":["https://openalex.org/I66068411","https://openalex.org/I165932596","https://openalex.org/I172675005"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":5.0545,"has_fulltext":true,"cited_by_count":147,"citation_normalized_percentile":{"value":0.961518,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"24","issue":"20","first_page":"2344","last_page":"2349"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7781999707221985,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7781999707221985,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.08330000191926956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.06360000371932983,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/h3k4me3","display_name":"H3K4me3","score":0.8532125949859619},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.6927191019058228},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6779589056968689},{"id":"https://openalex.org/keywords/histone","display_name":"Histone","score":0.6432734727859497},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5899415612220764},{"id":"https://openalex.org/keywords/hidden-markov-model","display_name":"Hidden Markov model","score":0.5811928510665894},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5235295295715332},{"id":"https://openalex.org/keywords/epigenomics","display_name":"Epigenomics","score":0.4270581007003784},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4001295566558838},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3933649957180023},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34008508920669556},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2628054618835449},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.25145310163497925},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.14045411348342896},{"id":"https://openalex.org/keywords/promoter","display_name":"Promoter","score":0.1211942732334137}],"concepts":[{"id":"https://openalex.org/C2780914512","wikidata":"https://www.wikidata.org/wiki/Q25323943","display_name":"H3K4me3","level":5,"score":0.8532125949859619},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6927191019058228},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6779589056968689},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6432734727859497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5899415612220764},{"id":"https://openalex.org/C23224414","wikidata":"https://www.wikidata.org/wiki/Q176769","display_name":"Hidden Markov model","level":2,"score":0.5811928510665894},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5235295295715332},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.4270581007003784},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4001295566558838},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3933649957180023},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34008508920669556},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2628054618835449},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.25145310163497925},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.14045411348342896},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.1211942732334137}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btn402","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn402","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/20/2344/16882799/btn402.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18667444","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18667444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/39851","is_oa":false,"landing_page_url":"http://scholarbank.nus.edu.sg/handle/10635/39851","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btn402","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn402","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/20/2344/16882799/btn402.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.5799999833106995}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2157750836.pdf","grobid_xml":"https://content.openalex.org/works/W2157750836.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1968931043","https://openalex.org/W1980303046","https://openalex.org/W1985180051","https://openalex.org/W2015416439","https://openalex.org/W2017840637","https://openalex.org/W2040404307","https://openalex.org/W2042087070","https://openalex.org/W2059699217","https://openalex.org/W2065579185","https://openalex.org/W2067563155","https://openalex.org/W2086699924","https://openalex.org/W2104582547","https://openalex.org/W2107903949","https://openalex.org/W2118675686","https://openalex.org/W2125838338","https://openalex.org/W2129795133","https://openalex.org/W2132508108","https://openalex.org/W2133111499","https://openalex.org/W2133938268","https://openalex.org/W2152556351","https://openalex.org/W2158610627","https://openalex.org/W2171256063","https://openalex.org/W2171407623","https://openalex.org/W2477633158","https://openalex.org/W2795495912","https://openalex.org/W4230932396","https://openalex.org/W4232528534","https://openalex.org/W6676124918"],"related_works":["https://openalex.org/W2017030427","https://openalex.org/W2911709708","https://openalex.org/W2622572573","https://openalex.org/W2098986187","https://openalex.org/W4318473910","https://openalex.org/W2149952464","https://openalex.org/W1970102465","https://openalex.org/W2339914654","https://openalex.org/W2329375094","https://openalex.org/W2947476200"],"abstract_inverted_index":{"MOTIVATION:":[0],"Epigenetic":[1],"modifications":[2,53],"are":[3,26,70,172],"one":[4],"of":[5,27,35,103,114,131,143,173],"the":[6,20,32,51,68,100,112,118,129,141,147,165,186],"critical":[7],"factors":[8],"to":[9,30,127,184],"regulate":[10],"gene":[11,38],"expression":[12,39],"and":[13,37,64,157,177,189],"genome":[14,56],"function.":[15],"Among":[16],"different":[17,193],"epigenetic":[18,36],"modifications,":[19],"differential":[21,187],"histone":[22,52,104,132],"modification":[23,105,133,149],"sites":[24,106,150,191],"(DHMSs)":[25],"great":[28],"interest":[29],"study":[31],"dynamic":[33],"nature":[34],"regulations":[40],"among":[41],"various":[42],"cell":[43,155,160,194],"types,":[44],"stages":[45],"or":[46],"environmental":[47],"responses.":[48],"To":[49],"capture":[50],"at":[54,90,135],"whole":[55],"scale,":[57],"ChIP-seq":[58,76],"technology":[59],"is":[60],"becoming":[61],"a":[62,122],"robust":[63],"comprehensive":[65],"approach.":[66],"Thus":[67],"DHMSs":[69,167],"potentially":[71],"identifiable":[72],"by":[73,108,145,169],"comparing":[74,146],"two":[75],"libraries.":[77],"However,":[78],"little":[79],"has":[80],"been":[81],"addressed":[82],"on":[83,111],"this":[84],"issue":[85],"in":[86,204],"literature.":[87],"RESULTS:":[88],"Aiming":[89],"identifying":[91],"DHMSs,":[92],"we":[93],"propose":[94],"an":[95],"approach":[96,120,171],"called":[97],"ChIPDiff":[98,144,180],"for":[99],"genome-wide":[101],"comparison":[102,203],"identified":[107,168],"ChIP-seq.":[109],"Based":[110],"observations":[113],"ChIP":[115],"fragment":[116],"counts,":[117],"proposed":[119],"employs":[121],"hidden":[123],"Markov":[124],"model":[125],"(HMM)":[126],"infer":[128],"states":[130],"changes":[134],"each":[136],"genomic":[137],"location.":[138],"We":[139,162],"evaluated":[140],"performance":[142],"H3K27me3":[148,166],"between":[151,192],"mouse":[152],"embryonic":[153],"stem":[154],"(ESC)":[156],"neural":[158],"progenitor":[159],"(NPC).":[161],"demonstrated":[163],"that":[164],"our":[170,205],"high":[174],"sensitivity,":[175],"specificity":[176],"technical":[178],"reproducibility.":[179],"was":[181],"further":[182],"applied":[183],"uncover":[185],"H3K4me3":[188],"H3K36me3":[190],"states.":[195],"Interesting":[196],"biological":[197],"discoveries":[198],"were":[199],"achieved":[200],"from":[201],"such":[202],"study.":[206]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":15}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
