{"id":"https://openalex.org/W2150904363","doi":"https://doi.org/10.1093/bioinformatics/btn239","title":"EM-random forest and new measures of variable importance for multi-locus quantitative trait linkage analysis","display_name":"EM-random forest and new measures of variable importance for multi-locus quantitative trait linkage analysis","publication_year":2008,"publication_date":"2008-05-21","ids":{"openalex":"https://openalex.org/W2150904363","doi":"https://doi.org/10.1093/bioinformatics/btn239","mag":"2150904363","pmid":"https://pubmed.ncbi.nlm.nih.gov/18499695"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btn239","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn239","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/14/1603/16881741/btn239.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/24/14/1603/16881741/btn239.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015661407","display_name":"Sophia S. F. Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I4210141030","display_name":"SickKids Foundation","ror":"https://ror.org/04374qe70","country_code":"CA","type":"funder","lineage":["https://openalex.org/I4210141030"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sophia S. F. Lee","raw_affiliation_strings":["1 Department of Public Health Sciences, University of Toronto, Toronto M5T 3M7, 2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5 and 3Genetics and Genomic Biology, The Hospital for Sick Children Research Institute, Toronto M5G 1L7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Public Health Sciences, University of Toronto, Toronto M5T 3M7, 2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5 and 3Genetics and Genomic Biology, The Hospital for Sick Children Research Institute, Toronto M5G 1L7, Canada","institution_ids":["https://openalex.org/I210557978","https://openalex.org/I185261750","https://openalex.org/I2801317318","https://openalex.org/I1291836623","https://openalex.org/I4210141030"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014594202","display_name":"Lei Sun","orcid":"https://orcid.org/0000-0002-5640-937X"},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I4210141030","display_name":"SickKids Foundation","ror":"https://ror.org/04374qe70","country_code":"CA","type":"funder","lineage":["https://openalex.org/I4210141030"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lei Sun","raw_affiliation_strings":["1 Department of Public Health Sciences, University of Toronto, Toronto M5T 3M7, 2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5 and 3Genetics and Genomic Biology, The Hospital for Sick Children Research Institute, Toronto M5G 1L7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Public Health Sciences, University of Toronto, Toronto M5T 3M7, 2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5 and 3Genetics and Genomic Biology, The Hospital for Sick Children Research Institute, Toronto M5G 1L7, Canada","institution_ids":["https://openalex.org/I210557978","https://openalex.org/I185261750","https://openalex.org/I2801317318","https://openalex.org/I1291836623","https://openalex.org/I4210141030"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057280139","display_name":"Rafal Kustra","orcid":"https://orcid.org/0000-0002-5949-8718"},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I4210141030","display_name":"SickKids Foundation","ror":"https://ror.org/04374qe70","country_code":"CA","type":"funder","lineage":["https://openalex.org/I4210141030"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rafal Kustra","raw_affiliation_strings":["1 Department of Public Health Sciences, University of Toronto, Toronto M5T 3M7, 2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5 and 3Genetics and Genomic Biology, The Hospital for Sick Children Research Institute, Toronto M5G 1L7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Public Health Sciences, University of Toronto, Toronto M5T 3M7, 2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5 and 3Genetics and Genomic Biology, The Hospital for Sick Children Research Institute, Toronto M5G 1L7, Canada","institution_ids":["https://openalex.org/I210557978","https://openalex.org/I185261750","https://openalex.org/I2801317318","https://openalex.org/I1291836623","https://openalex.org/I4210141030"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078691217","display_name":"Shelley B. Bull","orcid":"https://orcid.org/0000-0002-3280-7154"},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I4210141030","display_name":"SickKids Foundation","ror":"https://ror.org/04374qe70","country_code":"CA","type":"funder","lineage":["https://openalex.org/I4210141030"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Shelley B. Bull","raw_affiliation_strings":["1 Department of Public Health Sciences, University of Toronto, Toronto M5T 3M7, 2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5 and 3Genetics and Genomic Biology, The Hospital for Sick Children Research Institute, Toronto M5G 1L7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Public Health Sciences, University of Toronto, Toronto M5T 3M7, 2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5 and 3Genetics and Genomic Biology, The Hospital for Sick Children Research Institute, Toronto M5G 1L7, Canada","institution_ids":["https://openalex.org/I210557978","https://openalex.org/I185261750","https://openalex.org/I2801317318","https://openalex.org/I1291836623","https://openalex.org/I4210141030"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5078691217"],"corresponding_institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I185261750","https://openalex.org/I210557978","https://openalex.org/I2801317318","https://openalex.org/I4210141030"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":1.7528,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.86090695,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"24","issue":"14","first_page":"1603","last_page":"1610"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9524000287055969,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9524000287055969,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linkage","display_name":"Linkage (software)","score":0.6753586530685425},{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.5892411470413208},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.5081374645233154},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4955803155899048},{"id":"https://openalex.org/keywords/trait","display_name":"Trait","score":0.48865798115730286},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.48351553082466125},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.42781734466552734},{"id":"https://openalex.org/keywords/tree","display_name":"Tree (set theory)","score":0.42007771134376526},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3484898805618286},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3441088795661926},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1476019322872162},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14728274941444397},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.08327871561050415}],"concepts":[{"id":"https://openalex.org/C31266012","wikidata":"https://www.wikidata.org/wiki/Q6554340","display_name":"Linkage (software)","level":3,"score":0.6753586530685425},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.5892411470413208},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.5081374645233154},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4955803155899048},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.48865798115730286},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.48351553082466125},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.42781734466552734},{"id":"https://openalex.org/C113174947","wikidata":"https://www.wikidata.org/wiki/Q2859736","display_name":"Tree (set theory)","level":2,"score":0.42007771134376526},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3484898805618286},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3441088795661926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1476019322872162},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14728274941444397},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.08327871561050415},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008126","descriptor_name":"Lod Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008126","descriptor_name":"Lod Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008126","descriptor_name":"Lod Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008126","descriptor_name":"Lod Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011381","descriptor_name":"Programming Languages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011381","descriptor_name":"Programming Languages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011381","descriptor_name":"Programming Languages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011381","descriptor_name":"Programming Languages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019655","descriptor_name":"Quantitative Trait, Heritable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019655","descriptor_name":"Quantitative Trait, Heritable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019655","descriptor_name":"Quantitative Trait, Heritable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019655","descriptor_name":"Quantitative Trait, Heritable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btn239","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn239","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/14/1603/16881741/btn239.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18499695","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18499695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2638262","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2638262","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btn239","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn239","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/14/1603/16881741/btn239.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.699999988079071,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G1375708207","display_name":null,"funder_award_id":"MOP-84287","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G5488772279","display_name":null,"funder_award_id":"N01-HC-25195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5780067080","display_name":null,"funder_award_id":"N01-HC-25195","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G843896706","display_name":null,"funder_award_id":"N01-HC-25195","funder_id":"https://openalex.org/F4320309647","funder_display_name":"School of Medicine, Boston University"}],"funders":[{"id":"https://openalex.org/F4320309647","display_name":"School of Medicine, Boston University","ror":"https://ror.org/05qwgg493"},{"id":"https://openalex.org/F4320322675","display_name":"Mitacs","ror":"https://ror.org/00cjrc276"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2150904363.pdf","grobid_xml":"https://content.openalex.org/works/W2150904363.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W273955616","https://openalex.org/W1539593569","https://openalex.org/W1678356000","https://openalex.org/W1966360257","https://openalex.org/W1966363110","https://openalex.org/W1968673914","https://openalex.org/W1969833652","https://openalex.org/W1977104259","https://openalex.org/W1982110398","https://openalex.org/W1984147133","https://openalex.org/W1989656083","https://openalex.org/W1991311566","https://openalex.org/W1998158007","https://openalex.org/W2016738793","https://openalex.org/W2035300844","https://openalex.org/W2043134049","https://openalex.org/W2049633694","https://openalex.org/W2073738917","https://openalex.org/W2083384274","https://openalex.org/W2083702632","https://openalex.org/W2086099578","https://openalex.org/W2088276287","https://openalex.org/W2089221493","https://openalex.org/W2105660961","https://openalex.org/W2107705873","https://openalex.org/W2107871825","https://openalex.org/W2119842880","https://openalex.org/W2120389517","https://openalex.org/W2125860227","https://openalex.org/W2141088880","https://openalex.org/W2145126338","https://openalex.org/W2156559062","https://openalex.org/W2160729986","https://openalex.org/W2164265846","https://openalex.org/W2582743722","https://openalex.org/W2604607099","https://openalex.org/W2911964244","https://openalex.org/W2912934387","https://openalex.org/W3129711340","https://openalex.org/W4206471153","https://openalex.org/W4212883601","https://openalex.org/W4231990549","https://openalex.org/W4319590830","https://openalex.org/W6610017368","https://openalex.org/W6671359787","https://openalex.org/W6676126879","https://openalex.org/W6683911342"],"related_works":["https://openalex.org/W3193043704","https://openalex.org/W4386259002","https://openalex.org/W1546989560","https://openalex.org/W3171520305","https://openalex.org/W2048488252","https://openalex.org/W4289884158","https://openalex.org/W4288365262","https://openalex.org/W2940614149","https://openalex.org/W2787485953","https://openalex.org/W3217432596"],"abstract_inverted_index":{"MOTIVATION:":[0],"We":[1,60],"developed":[2],"an":[3],"EM-random":[4],"forest":[5,34],"(EMRF)":[6],"for":[7,15,44,110,134],"Haseman-Elston":[8],"quantitative":[9],"trait":[10],"linkage":[11,53,78],"analysis":[12],"that":[13,65,85],"accounts":[14],"marker":[16],"ambiguity":[17],"and":[18,100,117],"weighs":[19],"each":[20,123],"sib-pair":[21],"according":[22],"to":[23,41,52],"the":[24,72,86,95],"posterior":[25],"identical":[26],"by":[27],"descent":[28],"(IBD)":[29],"distribution.":[30],"The":[31,131],"usual":[32],"random":[33],"(RF)":[35],"variable":[36,45],"importance":[37],"(VI)":[38],"index":[39,99],"used":[40],"rank":[42],"markers":[43,70,118],"selection":[46],"is":[47,139],"not":[48],"optimal":[49],"when":[50],"applied":[51],"data":[54],"because":[55],"of":[56],"correlation":[57,73],"between":[58],"markers.":[59],"define":[61],"new":[62,87],"VI":[63,88,98],"indices":[64,89],"borrow":[66],"information":[67],"from":[68],"linked":[69],"using":[71],"structure":[74],"inherent":[75],"in":[76,90,128,137],"IBD":[77],"data.":[79],"RESULTS:":[80],"Using":[81],"simulations,":[82],"we":[83],"find":[84],"EMRF":[91,135],"performed":[92,101],"better":[93,104],"than":[94,105],"original":[96],"RF":[97],"similarly":[102],"or":[103],"EM-Haseman-Elston":[106],"regression":[107],"LOD":[108],"score":[109],"various":[111],"genetic":[112],"models.":[113],"Moreover,":[114],"tree":[115],"size":[116,120],"subset":[119],"evaluated":[121],"at":[122,141],"node":[124],"are":[125],"important":[126],"considerations":[127],"RFs.":[129],"AVAILABILITY:":[130],"source":[132],"code":[133],"written":[136],"C":[138],"available":[140],"www.infornomics.utoronto.ca/downloads/EMRF.":[142]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}