{"id":"https://openalex.org/W2127382007","doi":"https://doi.org/10.1093/bioinformatics/btn141","title":"Selecting anti-HIV therapies based on a variety of genomic and clinical factors","display_name":"Selecting anti-HIV therapies based on a variety of genomic and clinical factors","publication_year":2008,"publication_date":"2008-06-27","ids":{"openalex":"https://openalex.org/W2127382007","doi":"https://doi.org/10.1093/bioinformatics/btn141","mag":"2127382007","pmid":"https://pubmed.ncbi.nlm.nih.gov/18586740"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btn141","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn141","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/13/i399/608351/btn141.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/24/13/i399/608351/btn141.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003092468","display_name":"Michal Rosen\u2010Zvi","orcid":"https://orcid.org/0000-0001-7616-9724"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Michal Rosen-Zvi","raw_affiliation_strings":["1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069743881","display_name":"Andr\u00e9 Altmann","orcid":"https://orcid.org/0000-0002-9265-2393"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andre Altmann","raw_affiliation_strings":["1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039419132","display_name":"Mattia Prosperi","orcid":"https://orcid.org/0000-0002-9021-5595"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mattia Prosperi","raw_affiliation_strings":["1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072874959","display_name":"Ehud Aharoni","orcid":"https://orcid.org/0000-0002-3647-1440"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ehud Aharoni","raw_affiliation_strings":["1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000588360","display_name":"Hani Neuvirth","orcid":null},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hani Neuvirth","raw_affiliation_strings":["1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034073363","display_name":"Anders S\u00f6nnerborg","orcid":"https://orcid.org/0000-0001-8928-3374"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anders S\u00f6nnerborg","raw_affiliation_strings":["1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028323563","display_name":"Eugen Sch\u00fclter","orcid":null},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eugen Sch\u00fclter","raw_affiliation_strings":["1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086826185","display_name":"Daniel Struck","orcid":null},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Struck","raw_affiliation_strings":["1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021331049","display_name":"Yardena Peres","orcid":null},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yardena Peres","raw_affiliation_strings":["1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014101140","display_name":"Francesca Incardona","orcid":"https://orcid.org/0000-0002-7386-8551"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Francesca Incardona","raw_affiliation_strings":["1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074420045","display_name":"Rolf Kaiser","orcid":"https://orcid.org/0000-0002-2640-2548"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rolf Kaiser","raw_affiliation_strings":["1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002487044","display_name":"Maurizio Zazzi","orcid":"https://orcid.org/0000-0002-0344-6281"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maurizio Zazzi","raw_affiliation_strings":["1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023556977","display_name":"Thomas Lengauer","orcid":"https://orcid.org/0000-0003-3801-2640"},"institutions":[{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Lengauer","raw_affiliation_strings":["1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Machine learning group, IBM Research Laboratory in Haifa, Israel, 2The Computational Biology and Applied Algorithmics Department, Max Planck Institute for Informatics, Saarbr\u00fccken, Germany, 3Computer Science and Automation Department, University of Rome TRE, Italy, 4Division of Infectious Diseases, Department of Medicine, Karolinska Institute, Sweden, 5Institute of Virology, University of Cologne, Cologne, Germany, 6Retrovirology Laboratory, CRP-Sant\u00e9, Luxembourg, 7Health care and Life sciences group, IBM Research Laboratory in Haifa, Israel, 8Informa srl, Rome, Italy and 9Department of Molecular Biology, University of Siena, Italy","institution_ids":["https://openalex.org/I4210109712"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5003092468"],"corresponding_institution_ids":["https://openalex.org/I4210109712"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":5.4917,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.96266859,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"24","issue":"13","first_page":"i399","last_page":"i406"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.2558000087738037,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.2558000087738037,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.16380000114440918,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.09780000150203705,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/variety","display_name":"Variety (cybernetics)","score":0.6949396729469299},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.6346580982208252},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.497452050447464},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4282345771789551},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.35464784502983093},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3210229277610779},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.30227944254875183},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2050991654396057}],"concepts":[{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.6949396729469299},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6346580982208252},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.497452050447464},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4282345771789551},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35464784502983093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3210229277610779},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.30227944254875183},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2050991654396057}],"mesh":[{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/btn141","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn141","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/13/i399/608351/btn141.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18586740","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18586740","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:edoc.mpg.de:428201","is_oa":true,"landing_page_url":"http://edoc.mpg.de/428201","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Valencia, Alfonso; Cases, Ildefonso: ISMB 2008 Conference Proceedings, Oxford University Press, i399-i406 (2008)","raw_type":"Conference-Paper"},{"id":"pmh:oai:pubmedcentral.nih.gov:2718619","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2718619","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:usiena-air.unisi.it:11365/25656","is_oa":false,"landing_page_url":"http://hdl.handle.net/11365/25656","pdf_url":null,"source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btn141","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn141","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/13/i399/608351/btn141.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6899999976158142,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311734","display_name":"Kingston University","ror":"https://ror.org/05bbqza97"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W56727962","https://openalex.org/W97603576","https://openalex.org/W1495061682","https://openalex.org/W1542608470","https://openalex.org/W1988215875","https://openalex.org/W2048610403","https://openalex.org/W2055043387","https://openalex.org/W2074877586","https://openalex.org/W2080926698","https://openalex.org/W2106393550","https://openalex.org/W2120199131","https://openalex.org/W2131082741","https://openalex.org/W2142635246","https://openalex.org/W2150215096","https://openalex.org/W2155676461","https://openalex.org/W2159080219","https://openalex.org/W2182593161","https://openalex.org/W2753635250","https://openalex.org/W3123294050","https://openalex.org/W3216067840","https://openalex.org/W4236479494","https://openalex.org/W4297914773","https://openalex.org/W6629652716","https://openalex.org/W6670844994","https://openalex.org/W6682978103","https://openalex.org/W6743659993"],"related_works":["https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W1971568933","https://openalex.org/W2013243191","https://openalex.org/W2117258802"],"abstract_inverted_index":{"MOTIVATION:":[0],"Optimizing":[1],"HIV":[2],"therapies":[3,31,202],"is":[4,48,60,175],"crucial":[5],"since":[6],"the":[7,28,52,93,130,158,163,170,198,210,213,226],"virus":[8],"rapidly":[9],"develops":[10],"mutations":[11,217],"to":[12,50,68,81,145,194],"evade":[13],"drug":[14],"pressure.":[15],"Recent":[16],"studies":[17],"have":[18],"shown":[19],"that":[20,33],"genotypic":[21,146],"information":[22,59,147],"might":[23],"not":[24],"be":[25,235],"sufficient":[26],"for":[27],"design":[29],"of":[30,76,91,95,118,136,140,152,157,173,200,209,225],"and":[32,36,80,113,218],"other":[34],"clinical":[35,84],"demographical":[37],"factors":[38,67],"may":[39],"play":[40],"a":[41,70,74,96,116],"role":[42],"in":[43,54,89],"therapy":[44,227],"failure.":[45],"This":[46],"study":[47],"designed":[49],"assess":[51],"improvement":[53],"prediction":[55,71,168,232],"achieved":[56,149],"when":[57,169],"such":[58],"taken":[61],"into":[62],"account.":[63],"We":[64],"use":[65],"these":[66],"generate":[69],"engine":[72,179,233],"using":[73],"variety":[75],"machine":[77,101],"learning":[78,102],"methods":[79,122],"determine":[82],"which":[83],"conditions":[85],"are":[86],"most":[87,220],"misleading":[88],"terms":[90],"predicting":[92],"outcome":[94,199],"therapy.":[97],"RESULTS:":[98],"Three":[99],"different":[100],"techniques":[103],"were":[104],"used:":[105],"generative-discriminative":[106],"method,":[107],"regression":[108,114],"with":[109,115,126,165,223],"derived":[110],"evolutionary":[111],"features,":[112],"mixture":[117],"effects.":[119],"All":[120],"three":[121,141,159],"had":[123],"similar":[124,142],"performances":[125],"an":[127,150,185],"area":[128],"under":[129],"receiver":[131],"operating":[132],"characteristic":[133],"curve":[134],"(AUC)":[135],"0.77.":[137],"A":[138,154],"set":[139,172],"engines":[143,160,192,214],"limited":[144],"only":[148],"AUC":[151],"0.75.":[153],"straightforward":[155],"combination":[156],"consistently":[161],"improves":[162,180],"prediction,":[164],"significantly":[166],"better":[167],"full":[171],"features":[174],"employed.":[176],"The":[177,230],"combined":[178,231],"on":[181,197],"predictions":[182],"obtained":[183],"from":[184,237],"online":[186],"state-of-the-art":[187],"resistance":[188],"interpretation":[189],"system.":[190],"Moreover,":[191],"tend":[193],"disagree":[195],"more":[196],"failure":[201],"than":[203],"regarding":[204],"successful":[205],"ones.":[206],"Careful":[207],"analysis":[208],"differences":[211],"between":[212],"revealed":[215],"those":[216],"drugs":[219],"closely":[221],"associated":[222],"uncertainty":[224],"outcome.":[228],"AVAILABILITY:":[229],"will":[234],"available":[236],"July":[238],"2008,":[239],"see":[240],"http://engine.euresist.org.":[241]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}