{"id":"https://openalex.org/W2114333898","doi":"https://doi.org/10.1093/bioinformatics/btn053","title":"Robustified MANOVA with applications in detecting differentially expressed genes from oligonucleotide arrays","display_name":"Robustified MANOVA with applications in detecting differentially expressed genes from oligonucleotide arrays","publication_year":2008,"publication_date":"2008-03-03","ids":{"openalex":"https://openalex.org/W2114333898","doi":"https://doi.org/10.1093/bioinformatics/btn053","mag":"2114333898","pmid":"https://pubmed.ncbi.nlm.nih.gov/18316342"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btn053","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn053","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/8/1056/49047559/bioinformatics_24_8_1056.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/24/8/1056/49047559/bioinformatics_24_8_1056.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028571716","display_name":"Jin Xu","orcid":"https://orcid.org/0000-0003-2434-7183"},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Jin Xu","raw_affiliation_strings":["1 Department of Statistics, East China Normal University, Shanghai 200241, China and 2Department of Statistics, University of California Riverside, Riverside 92521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Statistics, East China Normal University, Shanghai 200241, China and 2Department of Statistics, University of California Riverside, Riverside 92521, USA","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I66867065"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065998053","display_name":"Xinping Cui","orcid":"https://orcid.org/0000-0002-1420-2696"},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]},{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Xinping Cui","raw_affiliation_strings":["1 Department of Statistics, East China Normal University, Shanghai 200241, China and 2Department of Statistics, University of California Riverside, Riverside 92521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Statistics, East China Normal University, Shanghai 200241, China and 2Department of Statistics, University of California Riverside, Riverside 92521, USA","institution_ids":["https://openalex.org/I103635307","https://openalex.org/I66867065"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065998053"],"corresponding_institution_ids":["https://openalex.org/I103635307","https://openalex.org/I66867065"],"apc_list":{"value":3989,"currency":"USD","value_usd":3989},"apc_paid":null,"fwci":1.0392,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.75580554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"24","issue":"8","first_page":"1056","last_page":"1062"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.927299976348877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.927299976348877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11901","display_name":"Bayesian Methods and Mixture Models","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multivariate-analysis-of-variance","display_name":"Multivariate analysis of variance","score":0.6338964104652405},{"id":"https://openalex.org/keywords/oligonucleotide","display_name":"Oligonucleotide","score":0.6107761263847351},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5827271342277527},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4860427975654602},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.475582480430603},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44825032353401184},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.396634966135025},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.12163007259368896}],"concepts":[{"id":"https://openalex.org/C192424360","wikidata":"https://www.wikidata.org/wiki/Q929408","display_name":"Multivariate analysis of variance","level":2,"score":0.6338964104652405},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.6107761263847351},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5827271342277527},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4860427975654602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.475582480430603},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44825032353401184},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.396634966135025},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.12163007259368896}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016477","descriptor_name":"Artifacts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016477","descriptor_name":"Artifacts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016477","descriptor_name":"Artifacts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btn053","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn053","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/8/1056/49047559/bioinformatics_24_8_1056.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18316342","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18316342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btn053","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn053","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/8/1056/49047559/bioinformatics_24_8_1056.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3065074277","display_name":"Statistical and Computational Tools for Identifying Microarray-based Expression and Single Feature Polymorphism Markers in Crops","funder_award_id":"0646024","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320337398","display_name":"Division of Biological Infrastructure","ror":"https://ror.org/04qn9mx93"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2114333898.pdf","grobid_xml":"https://content.openalex.org/works/W2114333898.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1533335653","https://openalex.org/W1546952499","https://openalex.org/W1583052686","https://openalex.org/W1596515083","https://openalex.org/W1964895626","https://openalex.org/W1965019479","https://openalex.org/W1973614663","https://openalex.org/W1977481949","https://openalex.org/W1977799921","https://openalex.org/W2038437697","https://openalex.org/W2074089196","https://openalex.org/W2081098333","https://openalex.org/W2104695131","https://openalex.org/W2105494575","https://openalex.org/W2109453886","https://openalex.org/W2109972881","https://openalex.org/W2110065044","https://openalex.org/W2112440119","https://openalex.org/W2119274294","https://openalex.org/W2130494035","https://openalex.org/W2134384386","https://openalex.org/W2142432438","https://openalex.org/W2155199877","https://openalex.org/W2157795344","https://openalex.org/W2162871532","https://openalex.org/W2169320928","https://openalex.org/W2170989872","https://openalex.org/W4247420482","https://openalex.org/W4247934745","https://openalex.org/W4294107304","https://openalex.org/W4298870207"],"related_works":["https://openalex.org/W2899206237","https://openalex.org/W2371153315","https://openalex.org/W3178534496","https://openalex.org/W1537632507","https://openalex.org/W2049007670","https://openalex.org/W4237067643","https://openalex.org/W2996279731","https://openalex.org/W4244651717","https://openalex.org/W4236366586","https://openalex.org/W2034625591"],"abstract_inverted_index":{"MOTIVATION:":[0],"Oligonucleotide":[1],"arrays":[2],"such":[3,42],"as":[4,43],"Affymetrix":[5],"GeneChips":[6],"use":[7],"multiple":[8,32],"probes,":[9],"or":[10,68],"a":[11,55,59,79,145],"probe":[12],"set,":[13],"to":[14,29,99,112,157,172],"measure":[15],"the":[16,31,92,137,140,149,158,174,177,182,186,195,202,218,223],"abundance":[17],"of":[18,20,23,57,62,87,117,139,147,176,189,225,232],"mRNA":[19],"every":[21],"gene":[22,118],"interest.":[24],"Some":[25],"analysis":[26,41,86,122,169],"methods":[27],"attempt":[28],"summarize":[30],"observations":[33],"into":[34],"one":[35],"single":[36],"score":[37],"before":[38],"conducting":[39],"further":[40],"detecting":[44],"differentially":[45],"expressed":[46],"genes":[47],"(DEG),":[48],"clustering":[49],"and":[50,64,96,105,132,166,185,213],"classification.":[51],"However,":[52],"there":[53],"is":[54,199,214,227],"risk":[56],"losing":[58],"significant":[60],"amount":[61],"information":[63],"consequently":[65],"reaching":[66],"inaccurate":[67],"even":[69],"incorrect":[70],"conclusions":[71],"during":[72],"this":[73],"data":[74,131,168],"reduction.":[75],"RESULTS:":[76],"We":[77,142],"developed":[78],"novel":[80],"statistical":[81],"method":[82,128,146,160,179,184,204,220],"called":[83],"robustified":[84,233],"multivariate":[85],"variance":[88],"(MANOVA)":[89],"based":[90,193],"on":[91,194],"traditional":[93],"MANOVA":[94,234],"model":[95],"permutation":[97],"test":[98,192],"detect":[100,113],"DEG":[101,207],"for":[102],"both":[103],"one-way":[104],"two-way":[106],"cases.":[107],"It":[108,198],"can":[109,235],"be":[110,236],"extended":[111],"some":[114],"special":[115],"patterns":[116],"expression":[119],"through":[120],"profile":[121],"across":[123],"k":[124],"(>or=2)":[125],"populations.":[126],"The":[127,230],"utilizes":[129],"probe-level":[130],"requires":[133],"no":[134],"assumptions":[135],"about":[136],"distribution":[138,151],"dataset.":[141],"also":[143],"propose":[144],"estimating":[148],"null":[150],"using":[152],"quantile":[153],"normalization":[154],"in":[155],"contrast":[156],"'pooling'":[159,183],"(Section":[161],"3.1).":[162],"Monte":[163],"Carlo":[164],"simulation":[165],"real":[167],"are":[170],"conducted":[171],"demonstrate":[173],"performance":[175],"proposed":[178],"comparing":[180],"with":[181],"usual":[187],"Analysis":[188],"Variance":[190],"(ANOVA)":[191],"summarized":[196],"scores.":[197],"found":[200],"that":[201],"new":[203],"successfully":[205],"detects":[206],"under":[208],"desired":[209],"false":[210],"discovery":[211],"rate":[212],"more":[215],"powerful":[216],"than":[217],"competing":[219],"especially":[221],"when":[222],"number":[224],"groups":[226],"small.":[228],"AVAILABILITY:":[229],"package":[231],"downloaded":[237],"from":[238],"http://faculty.ucr.edu/~xpcui/software":[239]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
