{"id":"https://openalex.org/W2154218709","doi":"https://doi.org/10.1093/bioinformatics/btn028","title":"SVM-HUSTLE\u2014an iterative semi-supervised machine learning approach for pairwise protein remote homology detection","display_name":"SVM-HUSTLE\u2014an iterative semi-supervised machine learning approach for pairwise protein remote homology detection","publication_year":2008,"publication_date":"2008-02-01","ids":{"openalex":"https://openalex.org/W2154218709","doi":"https://doi.org/10.1093/bioinformatics/btn028","mag":"2154218709","pmid":"https://pubmed.ncbi.nlm.nih.gov/18245127"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btn028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn028","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/6/783/49046720/bioinformatics_24_6_783.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/24/6/783/49046720/bioinformatics_24_6_783.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113935679","display_name":"Anuj Shah","orcid":null},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anuj R. Shah","raw_affiliation_strings":["1 Scientific Data Management and 2Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Scientific Data Management and 2Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013287908","display_name":"Christopher Oehmen","orcid":"https://orcid.org/0009-0004-5246-930X"},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher S. Oehmen","raw_affiliation_strings":["1 Scientific Data Management and 2Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Scientific Data Management and 2Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020443342","display_name":"Bobbie\u2010Jo Webb\u2010Robertson","orcid":"https://orcid.org/0000-0002-4744-2397"},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bobbie-Jo Webb-Robertson","raw_affiliation_strings":["1 Scientific Data Management and 2Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Scientific Data Management and 2Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, WA, USA","institution_ids":["https://openalex.org/I142606810"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113935679"],"corresponding_institution_ids":["https://openalex.org/I142606810"],"apc_list":{"value":3989,"currency":"USD","value_usd":3989},"apc_paid":null,"fwci":2.2083,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.87911178,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"24","issue":"6","first_page":"783","last_page":"790"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9628000259399414,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9628000259399414,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.8488134145736694},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6531787514686584},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6053309440612793},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5787632465362549},{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.545081377029419},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.4742566645145416},{"id":"https://openalex.org/keywords/protein-function-prediction","display_name":"Protein function prediction","score":0.45258060097694397},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4270186722278595},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.364820659160614},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16256314516067505},{"id":"https://openalex.org/keywords/protein-function","display_name":"Protein function","score":0.1087111234664917}],"concepts":[{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.8488134145736694},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6531787514686584},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6053309440612793},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5787632465362549},{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.545081377029419},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.4742566645145416},{"id":"https://openalex.org/C207060522","wikidata":"https://www.wikidata.org/wiki/Q7251473","display_name":"Protein function prediction","level":4,"score":0.45258060097694397},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4270186722278595},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.364820659160614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16256314516067505},{"id":"https://openalex.org/C2986374874","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Protein function","level":3,"score":0.1087111234664917},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btn028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn028","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/6/783/49046720/bioinformatics_24_6_783.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18245127","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18245127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":"Evaluation Study"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btn028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn028","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/6/783/49046720/bioinformatics_24_6_783.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1095041162","display_name":null,"funder_award_id":"DE-AC06\u201376RL01830","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G1724155629","display_name":null,"funder_award_id":"76RL01830","funder_id":"https://openalex.org/F4320337547","funder_display_name":"Laboratory Directed Research and Development"},{"id":"https://openalex.org/G1828715329","display_name":null,"funder_award_id":"DE-AC06\u201376RL01830","funder_id":"https://openalex.org/F4320306250","funder_display_name":"Battelle"},{"id":"https://openalex.org/G2506945562","display_name":null,"funder_award_id":"76RL01830","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G5303665158","display_name":null,"funder_award_id":"DE\u2010AC06\u201076RL01830","funder_id":"https://openalex.org/F4320338354","funder_display_name":"Pacific Northwest National Laboratory"},{"id":"https://openalex.org/G5321382714","display_name":null,"funder_award_id":"76RL01830","funder_id":"https://openalex.org/F4320338354","funder_display_name":"Pacific Northwest National Laboratory"},{"id":"https://openalex.org/G590814090","display_name":null,"funder_award_id":"DEAC06-76RL01830","funder_id":"https://openalex.org/F4320337506","funder_display_name":"Advanced Scientific Computing Research"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306250","display_name":"Battelle","ror":"https://ror.org/01h5tnr73"},{"id":"https://openalex.org/F4320337506","display_name":"Advanced Scientific Computing Research","ror":"https://ror.org/0012c7r22"},{"id":"https://openalex.org/F4320337547","display_name":"Laboratory Directed Research and Development","ror":"https://ror.org/01e41cf67"},{"id":"https://openalex.org/F4320338354","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2154218709.pdf","grobid_xml":"https://content.openalex.org/works/W2154218709.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1537662695","https://openalex.org/W1558365920","https://openalex.org/W1973714307","https://openalex.org/W1975394843","https://openalex.org/W1995918845","https://openalex.org/W2013570924","https://openalex.org/W2022247199","https://openalex.org/W2045564656","https://openalex.org/W2055043387","https://openalex.org/W2058336694","https://openalex.org/W2071495971","https://openalex.org/W2073745520","https://openalex.org/W2084787613","https://openalex.org/W2087064593","https://openalex.org/W2099075703","https://openalex.org/W2101220662","https://openalex.org/W2108079689","https://openalex.org/W2112865076","https://openalex.org/W2123467136","https://openalex.org/W2124709175","https://openalex.org/W2127464112","https://openalex.org/W2128328428","https://openalex.org/W2133075481","https://openalex.org/W2133312664","https://openalex.org/W2136490963","https://openalex.org/W2136504847","https://openalex.org/W2141779955","https://openalex.org/W2142013909","https://openalex.org/W2145268834","https://openalex.org/W2148603752","https://openalex.org/W2149255331","https://openalex.org/W2153720577","https://openalex.org/W2156909104","https://openalex.org/W2157825442","https://openalex.org/W2158714788","https://openalex.org/W2170960297","https://openalex.org/W2283504545","https://openalex.org/W6655894870","https://openalex.org/W6678280271","https://openalex.org/W6685351247"],"related_works":["https://openalex.org/W2487162673","https://openalex.org/W2942366970","https://openalex.org/W2793211469","https://openalex.org/W2949152769","https://openalex.org/W4372354731","https://openalex.org/W2562400057","https://openalex.org/W1692008701","https://openalex.org/W2597588799","https://openalex.org/W4360593462","https://openalex.org/W1737699519"],"abstract_inverted_index":{"MOTIVATION:":[0],"As":[1,111],"the":[2,14,36,74,207,211,240],"amount":[3],"of":[4,17,35,73,135,148,153,158,206,242],"biological":[5],"sequence":[6,107,129],"data":[7],"continues":[8],"to":[9,20,30,56,90,113,165,170,226,248],"grow":[10],"exponentially":[11],"we":[12,236],"face":[13],"increasing":[15],"challenge":[16,32],"assigning":[18],"function":[19,63],"this":[21,31],"enormous":[22],"molecular":[23],"'parts":[24],"list'.":[25],"The":[26,245],"most":[27,212],"popular":[28],"approaches":[29],"make":[33],"use":[34],"simplifying":[37],"assumption":[38],"that":[39,98],"similar":[40,47,62],"functional":[41],"molecules,":[42],"or":[43,49,108,116],"proteins,":[44],"sometimes":[45],"have":[46],"composition,":[48],"sequence.":[50,81],"However,":[51],"these":[52],"algorithms":[53],"often":[54,68],"fail":[55],"identify":[57],"remote":[58,102],"homologs":[59,103,188],"(proteins":[60],"with":[61,162,216],"but":[64,228],"dissimilar":[65],"sequence)":[66],"which":[67],"are":[69],"a":[70,79,84,127,133,145,151,230],"significant":[71],"fraction":[72],"total":[75],"homolog":[76],"collection":[77,134],"for":[78,126,185],"given":[80],"We":[82],"introduce":[83],"Support":[85],"Vector":[86],"Machine":[87],"(SVM)-based":[88],"tool":[89],"detect":[91,172],"homology":[92,149],"using":[93,210],"semi-supervised":[94,159],"iterative":[95],"learning":[96,160],"(SVM-HUSTLE)":[97],"identifies":[99],"significantly":[100,203],"more":[101],"than":[104,219],"current":[105],"state-of-the-art":[106],"cluster-based":[109],"methods.":[110],"opposed":[112],"building":[114],"profiles":[115],"position":[117],"specific":[118],"scoring":[119],"matrices,":[120],"SVM-HUSTLE":[121,155,202,221,250],"builds":[122],"an":[123],"SVM":[124],"classifier":[125],"query":[128],"by":[130],"training":[131,138],"on":[132,197],"representative":[136],"high-confidence":[137],"sets,":[139],"recruits":[140],"additional":[141],"sequences":[142],"and":[143,173,194],"assigns":[144],"statistical":[146,163],"measure":[147],"between":[150],"pair":[152],"sequences.":[154],"combines":[156],"principles":[157],"theory":[161],"sampling":[164],"create":[166],"many":[167],"concurrent":[168],"classifiers":[169],"iteratively":[171],"refine,":[174],"on-the-fly,":[175],"patterns":[176],"indicating":[177],"homology.":[178],"RESULTS:":[179],"When":[180],"compared":[181],"against":[182],"existing":[183],"methods":[184,209],"identifying":[186],"protein":[187],"(BLAST,":[189],"PSI-BLAST,":[190],"COMPASS,":[191],"PROF_SIM,":[192],"RANKPROP":[193],"their":[195],"variants)":[196],"two":[198],"different":[199],"benchmark":[200],"datasets":[201],"outperforms":[204],"each":[205],"above":[208],"stringent":[213],"ROC(1)":[214],"statistic":[215],"P-values":[217],"less":[218],"1e-20.":[220],"also":[222],"yields":[223],"results":[224],"comparable":[225],"HHSearch":[227],"at":[229],"substantially":[231],"reduced":[232],"computational":[233],"cost":[234],"since":[235],"do":[237],"not":[238],"require":[239],"construction":[241],"HMMs.":[243],"AVAILABILITY:":[244],"software":[246],"executable":[247],"run":[249],"can":[251],"be":[252],"downloaded":[253],"from":[254],"http://www.sysbio.org/sysbio/networkbio/svm_hustle":[255]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}