{"id":"https://openalex.org/W2147623982","doi":"https://doi.org/10.1093/bioinformatics/btn008","title":"Effect of spatial distribution of T-Cells and HIV load on HIV progression","display_name":"Effect of spatial distribution of T-Cells and HIV load on HIV progression","publication_year":2008,"publication_date":"2008-01-10","ids":{"openalex":"https://openalex.org/W2147623982","doi":"https://doi.org/10.1093/bioinformatics/btn008","mag":"2147623982","pmid":"https://pubmed.ncbi.nlm.nih.gov/18187444"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btn008","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn008","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/6/855/49048185/bioinformatics_24_6_855.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/24/6/855/49048185/bioinformatics_24_6_855.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085465762","display_name":"Frank M. Graziano","orcid":null},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I2799905417","display_name":"UW Health University Hospital","ror":"https://ror.org/02mqqhj42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799905417","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank M. Graziano","raw_affiliation_strings":["1 University of Wisconsin Hospital and Clinics, Wisconsin-Madison, USA, 2Department of Computer Science, 3Department of Mathematics, Clarke College, Dubuque, IA and 4Department of Internal Medicine, University of Iowa, Iowa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 University of Wisconsin Hospital and Clinics, Wisconsin-Madison, USA, 2Department of Computer Science, 3Department of Mathematics, Clarke College, Dubuque, IA and 4Department of Internal Medicine, University of Iowa, Iowa, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I2799905417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007509371","display_name":"Samira Kettoola","orcid":null},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I2799905417","display_name":"UW Health University Hospital","ror":"https://ror.org/02mqqhj42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799905417","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samira Y. Kettoola","raw_affiliation_strings":["1 University of Wisconsin Hospital and Clinics, Wisconsin-Madison, USA, 2Department of Computer Science, 3Department of Mathematics, Clarke College, Dubuque, IA and 4Department of Internal Medicine, University of Iowa, Iowa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 University of Wisconsin Hospital and Clinics, Wisconsin-Madison, USA, 2Department of Computer Science, 3Department of Mathematics, Clarke College, Dubuque, IA and 4Department of Internal Medicine, University of Iowa, Iowa, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I2799905417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001612397","display_name":"Judy Munshower","orcid":null},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I2799905417","display_name":"UW Health University Hospital","ror":"https://ror.org/02mqqhj42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799905417","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judy M. Munshower","raw_affiliation_strings":["1 University of Wisconsin Hospital and Clinics, Wisconsin-Madison, USA, 2Department of Computer Science, 3Department of Mathematics, Clarke College, Dubuque, IA and 4Department of Internal Medicine, University of Iowa, Iowa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 University of Wisconsin Hospital and Clinics, Wisconsin-Madison, USA, 2Department of Computer Science, 3Department of Mathematics, Clarke College, Dubuque, IA and 4Department of Internal Medicine, University of Iowa, Iowa, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I2799905417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016070837","display_name":"Jack T. Stapleton","orcid":"https://orcid.org/0000-0002-2302-9055"},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I2799905417","display_name":"UW Health University Hospital","ror":"https://ror.org/02mqqhj42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799905417","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack T. Stapleton","raw_affiliation_strings":["1 University of Wisconsin Hospital and Clinics, Wisconsin-Madison, USA, 2Department of Computer Science, 3Department of Mathematics, Clarke College, Dubuque, IA and 4Department of Internal Medicine, University of Iowa, Iowa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 University of Wisconsin Hospital and Clinics, Wisconsin-Madison, USA, 2Department of Computer Science, 3Department of Mathematics, Clarke College, Dubuque, IA and 4Department of Internal Medicine, University of Iowa, Iowa, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I2799905417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066666499","display_name":"George Towfic","orcid":null},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I2799905417","display_name":"UW Health University Hospital","ror":"https://ror.org/02mqqhj42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799905417","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George J. Towfic","raw_affiliation_strings":["1 University of Wisconsin Hospital and Clinics, Wisconsin-Madison, USA, 2Department of Computer Science, 3Department of Mathematics, Clarke College, Dubuque, IA and 4Department of Internal Medicine, University of Iowa, Iowa, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 University of Wisconsin Hospital and Clinics, Wisconsin-Madison, USA, 2Department of Computer Science, 3Department of Mathematics, Clarke College, Dubuque, IA and 4Department of Internal Medicine, University of Iowa, Iowa, USA","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I2799905417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5066666499"],"corresponding_institution_ids":["https://openalex.org/I126307644","https://openalex.org/I2799905417"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.1102791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"24","issue":"6","first_page":"855","last_page":"860"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9254000186920166,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9254000186920166,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.02969999983906746,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.7832636833190918},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.5329108238220215},{"id":"https://openalex.org/keywords/spatial-distribution","display_name":"Spatial distribution","score":0.4775874614715576},{"id":"https://openalex.org/keywords/distribution","display_name":"Distribution (mathematics)","score":0.46513786911964417},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4580378532409668},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.42601072788238525},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39972352981567383},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.36287549138069153},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.27928626537323},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.1963636577129364},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.09688326716423035}],"concepts":[{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.7832636833190918},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.5329108238220215},{"id":"https://openalex.org/C2777016058","wikidata":"https://www.wikidata.org/wiki/Q7574061","display_name":"Spatial distribution","level":2,"score":0.4775874614715576},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.46513786911964417},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4580378532409668},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.42601072788238525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39972352981567383},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36287549138069153},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.27928626537323},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1963636577129364},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.09688326716423035}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018894","descriptor_name":"Reverse Transcriptase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btn008","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn008","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/6/855/49048185/bioinformatics_24_6_855.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18187444","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18187444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btn008","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btn008","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/6/855/49048185/bioinformatics_24_6_855.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309272","display_name":"Wayne State University","ror":"https://ror.org/01070mq45"},{"id":"https://openalex.org/F4320333063","display_name":"Stanford Bio-X","ror":"https://ror.org/00f54p054"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147623982.pdf","grobid_xml":"https://content.openalex.org/works/W2147623982.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1489238133","https://openalex.org/W1549990412","https://openalex.org/W1575398236","https://openalex.org/W2000618553","https://openalex.org/W2003391047","https://openalex.org/W2014544882","https://openalex.org/W2029546093","https://openalex.org/W2081175663","https://openalex.org/W2108704847","https://openalex.org/W2120497284","https://openalex.org/W2129836134","https://openalex.org/W2134268006","https://openalex.org/W2147615990","https://openalex.org/W2150215096","https://openalex.org/W2411560930","https://openalex.org/W4297914773","https://openalex.org/W6629364547","https://openalex.org/W6634298700"],"related_works":["https://openalex.org/W4288713694","https://openalex.org/W2087771447","https://openalex.org/W2614902832","https://openalex.org/W2055280854","https://openalex.org/W2334605091","https://openalex.org/W2973584526","https://openalex.org/W2036827172","https://openalex.org/W2057291925","https://openalex.org/W4280642433","https://openalex.org/W2391142751"],"abstract_inverted_index":{"MOTIVATION:":[0],"We":[1,95],"present":[2],"a":[3,36,122,149,227,238],"spatial-temporal":[4],"(ST)":[5],"human":[6],"immunodeficiency":[7],"virus":[8],"(HIV)":[9],"simulation":[10],"model":[11,27],"to":[12,34,62,72,81,108,231,266],"investigate":[13],"the":[14,29,83,110,119,142,154,165,174,180,190,198,207,211,221,234,256,268],"spatial":[15,91,111],"distribution":[16,219],"of":[17,77,100,115,121,134,153,164,168,177,179,189,193,197,210,220,240],"viral":[18,45,52,103,222,242],"load":[19,53,104,223],"and":[20,47,51,56,59,80,92,102,106,113,173,224,249,261],"T-cells":[21,50,101,225],"during":[22,233],"HIV":[23,49,78,88,116,235],"progression.":[24],"The":[25,69,195,218],"proposed":[26],"uses":[28],"Finite":[30],"Element":[31],"(FE)":[32],"method":[33],"divide":[35],"considered":[37,228],"infected":[38],"region":[39,229],"into":[40],"interconnected":[41],"subregions":[42,61],"each":[43],"containing":[44],"population":[46],"T-cells.":[48],"are":[54,252],"traced":[55],"counted":[57],"within":[58],"between":[60],"estimate":[63,73,109],"their":[64],"effect":[65,86],"upon":[66,87],"neighboring":[67],"regions.":[68],"objective":[70],"is":[71,158,183,202,244,277],"overall":[74],"ST":[75,84,155,181,199],"changes":[76],"progression":[79,236],"study":[82],"therapeutic":[85],"dynamics":[89,117],"in":[90,170,226],"temporal":[93],"domains.":[94],"introduce":[96],"sub-regional":[97],"(spatial)":[98],"parameters":[99],"production":[105],"elimination":[107],"propagation":[112],"interaction":[114],"under":[118],"influence":[120],"3TC":[123],"D4T":[124],"Reverse":[125],"Transcriptase":[126],"Inhibitors":[127],"(RTI)":[128],"drug":[129],"regimen.":[130],"RESULTS:":[131],"In":[132],"terms":[133],"percentage":[135],"change":[136,157,169,178],"standard":[137],"deviation,":[138],"we":[139],"show":[140],"that":[141,163,188],"average":[143,175],"rate":[144,167,176,192],"per":[145],"10":[146],"weeks":[147],"(throughout":[148],"10-year":[150],"clinical":[151],"trial)":[152],"CD4+":[156,166,200,212],"5.35%":[159],"1.3":[160],"different":[161,186,205],"than":[162,187,206],"laboratory":[171,216],"datasets,":[172],"CD8+":[182,191],"4.98%":[184],"1.93":[185],"change.":[194],"half-life":[196,209],"count":[201,213],"1.68%":[203],"3.381":[204],"actual":[208],"obtained":[214],"from":[215],"datasets.":[217],"tends":[230],"cluster":[232],"once":[237],"threshold":[239],"86-89%":[241],"accumulation":[243],"reached.":[245],"AVAILABILITY:":[246],"Executable":[247],"code":[248],"data":[250],"libraries":[251],"available":[253],"by":[254],"contacting":[255],"corresponding":[257],"author.":[258],"IMPLEMENTATION:":[259],"C++":[260],"Java":[262],"have":[263],"been":[264],"used":[265],"simulate":[267],"suggested":[269],"model.":[270],"A":[271],"Pentium":[272],"III":[273],"or":[274],"higher":[275],"platform":[276],"recommended.":[278]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}