{"id":"https://openalex.org/W2158020463","doi":"https://doi.org/10.1093/bioinformatics/btm626","title":"Prediction of protein functional residues from sequence by probability density estimation","display_name":"Prediction of protein functional residues from sequence by probability density estimation","publication_year":2008,"publication_date":"2008-01-02","ids":{"openalex":"https://openalex.org/W2158020463","doi":"https://doi.org/10.1093/bioinformatics/btm626","mag":"2158020463","pmid":"https://pubmed.ncbi.nlm.nih.gov/18174181"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btm626","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm626","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/5/613/16885521/btm626.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/24/5/613/16885521/btm626.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055443993","display_name":"Johannes Fischer","orcid":"https://orcid.org/0000-0002-3384-597X"},"institutions":[{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. D. Fischer","raw_affiliation_strings":["Department for Protein Evolution, Max Planck Institute for Developmental Biology, Spemannstr. 35, 72076 T\u00fcbingen, Germany"],"affiliations":[{"raw_affiliation_string":"Department for Protein Evolution, Max Planck Institute for Developmental Biology, Spemannstr. 35, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063897974","display_name":"C. Mayer","orcid":null},"institutions":[{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. E. Mayer","raw_affiliation_strings":["Department for Protein Evolution, Max Planck Institute for Developmental Biology, Spemannstr. 35, 72076 T\u00fcbingen, Germany"],"affiliations":[{"raw_affiliation_string":"Department for Protein Evolution, Max Planck Institute for Developmental Biology, Spemannstr. 35, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010030898","display_name":"Johannes S\u00f6ding","orcid":"https://orcid.org/0000-0001-9642-8244"},"institutions":[{"id":"https://openalex.org/I4210112458","display_name":"Max Planck Institute for Developmental Biology","ror":"https://ror.org/022jc0g24","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210112458"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"J. S\u00f6ding","raw_affiliation_strings":["Department for Protein Evolution, Max Planck Institute for Developmental Biology, Spemannstr. 35, 72076 T\u00fcbingen, Germany"],"affiliations":[{"raw_affiliation_string":"Department for Protein Evolution, Max Planck Institute for Developmental Biology, Spemannstr. 35, 72076 T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I4210112458"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010030898"],"corresponding_institution_ids":["https://openalex.org/I4210112458"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":{"value":3618,"currency":"USD","value_usd":3618},"fwci":6.5004,"has_fulltext":true,"cited_by_count":128,"citation_normalized_percentile":{"value":0.97450872,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"24","issue":"5","first_page":"613","last_page":"620"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.4745153784751892},{"id":"https://openalex.org/keywords/probability-distribution","display_name":"Probability distribution","score":0.46757131814956665},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.4590418040752411},{"id":"https://openalex.org/keywords/amino-acid-residue","display_name":"Amino acid residue","score":0.4306647479534149},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.395190954208374},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3410970866680145},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3281843066215515},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3266577124595642},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.2550683319568634},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2498829960823059},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18159374594688416},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10527804493904114},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.09790512919425964},{"id":"https://openalex.org/keywords/geography","display_name":"Geography","score":0.07544970512390137}],"concepts":[{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.4745153784751892},{"id":"https://openalex.org/C149441793","wikidata":"https://www.wikidata.org/wiki/Q200726","display_name":"Probability distribution","level":2,"score":0.46757131814956665},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.4590418040752411},{"id":"https://openalex.org/C2994376932","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Amino acid residue","level":4,"score":0.4306647479534149},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.395190954208374},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3410970866680145},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3281843066215515},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3266577124595642},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.2550683319568634},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2498829960823059},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18159374594688416},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10527804493904114},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09790512919425964},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.07544970512390137},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bioinformatics/btm626","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm626","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/5/613/16885521/btm626.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18174181","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18174181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1033.8681","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1033.8681","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://bioinformatics.oxfordjournals.org/content/early/2008/01/02/bioinformatics.btm626.full.pdf","raw_type":"text"},{"id":"pmh:oai:edoc.mpg.de:420399","is_oa":false,"landing_page_url":"http://edoc.mpg.de/420399","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioinformatics, v.24, 613-620 (2008)","raw_type":"Article"},{"id":"pmh:oai:escidoc.org:escidoc:1944237","is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0017-D9B6-9","pdf_url":null,"source":{"id":"https://openalex.org/S7407052962","display_name":"Max Planck Digital Library","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btm626","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm626","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/24/5/613/16885521/btm626.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.7200000286102295,"display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2158020463.pdf"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1561011671","https://openalex.org/W1964640688","https://openalex.org/W1965582988","https://openalex.org/W1967293793","https://openalex.org/W1967408543","https://openalex.org/W1976526581","https://openalex.org/W1982481323","https://openalex.org/W1995924392","https://openalex.org/W2009570821","https://openalex.org/W2027036222","https://openalex.org/W2030817247","https://openalex.org/W2043904638","https://openalex.org/W2057573682","https://openalex.org/W2060791849","https://openalex.org/W2078866107","https://openalex.org/W2089933214","https://openalex.org/W2090699441","https://openalex.org/W2099886875","https://openalex.org/W2116099439","https://openalex.org/W2117625122","https://openalex.org/W2126048802","https://openalex.org/W2128478556","https://openalex.org/W2138289501","https://openalex.org/W2139919097","https://openalex.org/W2143004134","https://openalex.org/W2153187042","https://openalex.org/W2154333184","https://openalex.org/W2155469822","https://openalex.org/W2158714788","https://openalex.org/W2162574056","https://openalex.org/W2163352757","https://openalex.org/W2164841125","https://openalex.org/W2168029153","https://openalex.org/W2807981689","https://openalex.org/W3021510377","https://openalex.org/W4245668478","https://openalex.org/W4388247078","https://openalex.org/W6644307160","https://openalex.org/W6664951748"],"related_works":["https://openalex.org/W2378211422","https://openalex.org/W2745001401","https://openalex.org/W4321353415","https://openalex.org/W2130974462","https://openalex.org/W972276598","https://openalex.org/W4246352526","https://openalex.org/W2028665553","https://openalex.org/W2086519370","https://openalex.org/W2087343574","https://openalex.org/W4230315250"],"abstract_inverted_index":{"Server:":[0],"http://frpred.tuebingen.mpg.de.":[1],"Data":[2],"sets:":[3],"ftp://ftp.tuebingen.mpg.de/pub/protevo/FRpred/.":[4]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":8}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}