{"id":"https://openalex.org/W2168627286","doi":"https://doi.org/10.1093/bioinformatics/btm528","title":"Unsupervised feature selection under perturbations: meeting the challenges of biological data","display_name":"Unsupervised feature selection under perturbations: meeting the challenges of biological data","publication_year":2007,"publication_date":"2007-11-07","ids":{"openalex":"https://openalex.org/W2168627286","doi":"https://doi.org/10.1093/bioinformatics/btm528","mag":"2168627286","pmid":"https://pubmed.ncbi.nlm.nih.gov/17989091"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btm528","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm528","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/24/3343/16861997/btm528.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bioinformatics/article-pdf/23/24/3343/16861997/btm528.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090731305","display_name":"Roy Varshavsky","orcid":null},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]},{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Roy Varshavsky","raw_affiliation_strings":["1 School of Computer Science and Engineering, The Hebrew University of Jerusalem 91904, 2School of Physics and Astronomy, Tel Aviv University 69978 and 3Deptartment of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem 91904, Israel"],"affiliations":[{"raw_affiliation_string":"1 School of Computer Science and Engineering, The Hebrew University of Jerusalem 91904, 2School of Physics and Astronomy, Tel Aviv University 69978 and 3Deptartment of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002513351","display_name":"Assaf Gottlieb","orcid":"https://orcid.org/0000-0003-4904-631X"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Assaf Gottlieb","raw_affiliation_strings":["1 School of Computer Science and Engineering, The Hebrew University of Jerusalem 91904, 2School of Physics and Astronomy, Tel Aviv University 69978 and 3Deptartment of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem 91904, Israel"],"affiliations":[{"raw_affiliation_string":"1 School of Computer Science and Engineering, The Hebrew University of Jerusalem 91904, 2School of Physics and Astronomy, Tel Aviv University 69978 and 3Deptartment of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001249894","display_name":"D. Horn","orcid":"https://orcid.org/0000-0003-2708-186X"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"David Horn","raw_affiliation_strings":["1 School of Computer Science and Engineering, The Hebrew University of Jerusalem 91904, 2School of Physics and Astronomy, Tel Aviv University 69978 and 3Deptartment of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem 91904, Israel"],"affiliations":[{"raw_affiliation_string":"1 School of Computer Science and Engineering, The Hebrew University of Jerusalem 91904, 2School of Physics and Astronomy, Tel Aviv University 69978 and 3Deptartment of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085924022","display_name":"Michal Linial","orcid":"https://orcid.org/0000-0002-9357-4526"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Michal Linial","raw_affiliation_strings":["1 School of Computer Science and Engineering, The Hebrew University of Jerusalem 91904, 2School of Physics and Astronomy, Tel Aviv University 69978 and 3Deptartment of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem 91904, Israel"],"affiliations":[{"raw_affiliation_string":"1 School of Computer Science and Engineering, The Hebrew University of Jerusalem 91904, 2School of Physics and Astronomy, Tel Aviv University 69978 and 3Deptartment of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160","https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5090731305"],"corresponding_institution_ids":["https://openalex.org/I16391192","https://openalex.org/I197251160"],"apc_list":{"value":3618,"currency":"USD","value_usd":3618},"apc_paid":null,"fwci":1.4398,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.81192273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"23","issue":"24","first_page":"3343","last_page":"3349"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.989799976348877,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.7186354398727417},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7057424187660217},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5415447354316711},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.5199233889579773},{"id":"https://openalex.org/keywords/imputation","display_name":"Imputation (statistics)","score":0.49769285321235657},{"id":"https://openalex.org/keywords/missing-data","display_name":"Missing data","score":0.48992103338241577},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4532833695411682},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.44178470969200134},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4390425980091095},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.42183464765548706},{"id":"https://openalex.org/keywords/information-loss","display_name":"Information loss","score":0.41431349515914917},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3759205937385559},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.19785764813423157},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12590095400810242}],"concepts":[{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.7186354398727417},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7057424187660217},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5415447354316711},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.5199233889579773},{"id":"https://openalex.org/C58041806","wikidata":"https://www.wikidata.org/wiki/Q1660484","display_name":"Imputation (statistics)","level":3,"score":0.49769285321235657},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.48992103338241577},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4532833695411682},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.44178470969200134},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4390425980091095},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.42183464765548706},{"id":"https://openalex.org/C2988416141","wikidata":"https://www.wikidata.org/wiki/Q6031139","display_name":"Information loss","level":2,"score":0.41431349515914917},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3759205937385559},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.19785764813423157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12590095400810242},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016247","descriptor_name":"Information Storage and Retrieval","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bioinformatics/btm528","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm528","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/24/3343/16861997/btm528.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17989091","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17989091","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bioinformatics/btm528","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btm528","pdf_url":"https://academic.oup.com/bioinformatics/article-pdf/23/24/3343/16861997/btm528.pdf","source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321950","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2168627286.pdf","grobid_xml":"https://content.openalex.org/works/W2168627286.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1532319248","https://openalex.org/W1727290854","https://openalex.org/W1836115926","https://openalex.org/W1991537543","https://openalex.org/W2000771269","https://openalex.org/W2010637767","https://openalex.org/W2095732971","https://openalex.org/W2096863518","https://openalex.org/W2097554668","https://openalex.org/W2099322651","https://openalex.org/W2106801905","https://openalex.org/W2107383984","https://openalex.org/W2109204369","https://openalex.org/W2120246066","https://openalex.org/W2135805255","https://openalex.org/W2140703956","https://openalex.org/W2148541040","https://openalex.org/W2152491277","https://openalex.org/W2165767110","https://openalex.org/W2166902257","https://openalex.org/W2166913844","https://openalex.org/W2998216295","https://openalex.org/W4285719527","https://openalex.org/W6632180156","https://openalex.org/W6674952872","https://openalex.org/W7066667914"],"related_works":["https://openalex.org/W2181530120","https://openalex.org/W4211215373","https://openalex.org/W2024529227","https://openalex.org/W1574575415","https://openalex.org/W3144172081","https://openalex.org/W3179858851","https://openalex.org/W3028371478","https://openalex.org/W2081476516","https://openalex.org/W2581984549","https://openalex.org/W3123177881"],"abstract_inverted_index":{"We":[0],"find":[1],"that":[2],"the":[3],"UFF":[4],"quality":[5],"degrades":[6],"smoothly":[7],"with":[8,50],"information":[9,43],"loss.":[10],"It":[11],"remains":[12],"successful":[13],"even":[14],"under":[15,42],"substantial":[16],"damage.":[17],"Our":[18],"method":[19,27],"allows":[20],"for":[21],"selection":[22],"of":[23],"a":[24,29],"best":[25],"imputation":[26],"on":[28],"dataset":[30],"treated":[31],"by":[32],"UFF.":[33],"More":[34],"importantly,":[35],"scoring":[36,57],"features":[37],"according":[38],"to":[39,47,60],"their":[40],"stability":[41],"loss":[44],"is":[45],"shown":[46],"be":[48],"correlated":[49],"biological":[51,62],"importance":[52],"in":[53],"cancer":[54],"studies.":[55],"This":[56],"may":[58],"lead":[59],"novel":[61],"insights.":[63]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}